The Obsession about blocking DHT should end

[mvp2v1]

"Denial about dht " you are in denial over the side effects of 5AR inhibitors we discussed all aspects about DHT in the thread

View attachment 3268523
Yes saar block dht you won't need a wife anymore because your dick can't get hard anymore

It’s funny he talks about anti aging but the shit he’s been doing doesn’t seem to have stopped his aging at all. He looks aged. Inb4: Muh he would have looked even worse if he hadn’t done bla bla…. Nah his shit didn’t work

Plus it’s not suprising that he is a fin user AND a vegan AND a Kamla Harris voter

 

[SlayerJonas]

Thoughts on ideal concentration of dht to apply to dick in conjunction with dickpump for enhanced results?

Anything from 0.5-2%, start with the lower end

 

[mvp2v1]

What’s the

Anything from 0.5-2%, start with the lower end

Upper end I could get to. I vaguely recall people using 10% ?

 

[DR. NICKGA]

Anything from 0.5-2%, start with the lower end

Why do you want to increase you dick size and treat ED? I thought you are a masculine alpha

Alright nigga dont blame finasteride for you ed and small dick

 

[SlayerJonas]

What’s the

Upper end I could get to. I vaguely recall people using 10% ?

Experiment with it I guess

It could most likely only enhance regeneration from PE, so using it as some sort of extra care to the dick after PE would be optimal.

I think lower doses also should have the same healing properties to the skin

 

[SlayerJonas]

Why do you want to increase you dick size and treat ED? I thought you are a masculine alpha

Alright nigga dont blame finasteride for you ed and small dick

You stupid faggot (indeed a faggot as you use DHT muh alpha hormone blockers) he asked me a question and I tried to help him

You most likely have a micropenis and just want to tell everybody that DHT is useless so that their dicks don't grow to their full potential

= this is your type of argumenting btw

 

[DR. NICKGA]

View attachment 3268512
"guys don't trust them they are a cult they are contrarians you should trust me instead"

Jews dont have a masterplan to castrate all males with hairloss medicine? the jews also did not paid the FDA verifcation and 100+ verified good studies

I have nothing to gain

I don't have any side effects best scientific argument (totally not anecdotal)

That was not me argument, you are again straight up lying
I sended you a verified study ,

"Saar yes saar watch all these videos" (* deep inside this jew knows that no one will watch videos longer than 3h in total *)

I sended 3 vids, only one vid is 1 hour long, the others were 10 minutes , again you are straight up lying

 

[DR. NICKGA]

You stupid faggot (indeed a faggot as you use DHT muh alpha hormone blockers) he asked me a question and I tried to help him

You most likely have a micropenis and just want to tell everybody that DHT is useless so that their dicks don't grow to their full potential

= this is your type of argumenting btw

Me dick is pretty huge and big

I dont need to apply dht to me dick
You are the one who do that , not me

 

[DR. NICKGA]

Plus it’s not suprising that he is a fin user AND a vegan AND a Kamla Harris voter

Trump is also a finasteride user

 

[SlayerJonas]

Jews dont have a masterplan to castrate all males with hairloss medicine? the jews also did not paid the FDA verifcation and 100+ verified good studies

For profit nigga, this world is capitalistic. Radioactive tooth paste was sold in germany with the promise that it could make your teeth shinier or something. Same shit

I have nothing to gain

That was not me argument, you are again straight up lying
I sended you a verified study ,

> verified study
> * sends 2 videos again *

I sended 3 vids, only one vid is 1 hour long, the others were 10 minutes , again you are straight up lying

Again you aren't explaining what his key points of the videos are

 

[DR. NICKGA]

Plus it’s not suprising that he is a fin user AND a vegan AND a Kamla Harris voter

You beloved alpha male donald trump use finasteride too

Idk what point you are making

 

[SlayerJonas]

Me dick is pretty huge and big

I dont need to apply dht to me dick
You are the one who do that , not me

I never even said that nigga

yes saars use fin/dut trust the government!

 

[DR. NICKGA]

For profit nigga, this world is capitalistic. Radioactive tooth paste was sold in germany with the promise that it could make your teeth shinier or something. Same shit
View attachment 3268552

What a stupid comparison is that, we live in 2024 now, all studies and verified studies are online.. all news etc..... all information is online

Or let me guess? This 1000+ studies and fda approved is also jews owned?

 

[DR. NICKGA]

I never even said that nigga
View attachment 3268556
yes saars use fin/dut trust the government!

This photo you sended is disgusting

Anyway
No the jews dont have a masterplan to castrate all males with hairloss medicine

Sorry bro you are not a worth opponent against the governement , they dont care about you

 

[DR. NICKGA]

Again you aren't explaining what his key points of the videos are

Watch it

 

[DR. NICKGA]

I never even said that nigga

How do you know the information then? You lying ass nigga

 

[SlayerJonas]

What a stupid comparison is that, we live in 2024 now, all studies and verified studies are online.. all news etc..... all information is online

Or let me guess? This 1000+ studies and fda approved is also jews owned?

This photo you sended is disgusting

Anyway
No the jews dont have a masterplan to castrate all males with hairloss medicine

Sorry bro you are not a worth opponent against the governement , they dont care about you

Nigga I'm going to be the adult now.

You, yes you Dr Nickga, you didn't provide any studies except some video that I didn't watch. You also don't want to provide the key points of his videos. This doesn't provide any value to our discussion other than some fun that I had while eating some stuff I found in my kitchen

Now back to the roots of the discussion

5ARIs have side effects like listed in the thread. Other hair loss fighting methods work better with less side effects, like my friend 20/04 wrote Estriol estradiol creme > topical dut fin > dut fin

Also to my favorite topic about ze jews and government: Everything not backed up by studies/experiments (and other objective measurements that can prove that something = something) is anecdotal

Don't get this wrong tho, if I say that ze jews also did studies those studies aren't 100% good, because the conflict of interest wasn't noted or the study could have been manipulated or the study could have been biased to show that a certain drug for example finasteride/dut have more benefits than side effects by not including important parameters etc.

to be strict, I could even argue that everything not seen with your own eyes is subjective or could not be true. (not even that if we are 100% strict)

 

[SlayerJonas]

How do you know the information then? You lying ass nigga

Wrong, you don't have to be a bodybuilder to know how to build muscle.

That's the same logic as you don't have to use topical DHT to my dick with PE to know the benefits of that.

 

[DR. NICKGA]

Nigga I'm going to be the adult now.

You, yes you Dr Nickga, you didn't provide any studies except some video that I didn't watch. You also don't want to provide the key points of his videos.

I cannot cure stupidness, me purpose was to cure the viewers in this thread so they will know the truth, as they see the vid they will know the anti science bullshit the dht lovers do, and finasteride haters with psuedo science as arguments

Even if i did , you gonna say "no those studies are paid by the jews"

Now back to the roots of the discussion


5ARIs have side effects like listed in the thread. Other hair loss fighting methods work better with less side effects, like my friend 20/04 wrote Estriol estradiol creme > topical dut fin > dut fin

Yess !! Topical estrogen will surely work on the scalp........

The only evidence of that is anecdotal evidence from reddit or obscure forums.....

Topical estrogen > a fda approved medicine FIN?????

This logic is very flawed and stupid

Also the 2nd is .. topical dut and fin? So you stop the cope think that dht is the cause of baldness...... (100000+ hairloss researchers think that too) or what you gonna say,100000+ jews

Also to my favorite topic about ze jews and government: Everything not backed up by studies/experiments (and other objective measurements that can prove that something = something) is anecdotal

Don't get this wrong tho, if I say that ze jews also did studies those studies aren't 100% good, because the conflict of interest wasn't noted or the study could have been manipulated or the study could have been biased to show that a certain drug for example finasteride/dut have more benefits than side effects by not including important parameters etc.

to be strict, I could even argue that everything not seen with your own eyes is subjective or could not be true. (not even that if we are 100% strict)

Yes so argumenting with logic and verified studies is impossibly with you

You believe what you believe with you own eyes
Cult thinking

 

[SlayerJonas]

bro i already read this, these people in denial about dht is the funniest shit ever

never gets old

Jews dont have a masterplan to castrate all males with hairloss medicine? the jews also did not paid the FDA verifcation and 100+ verified good studies

I have nothing to gain

That was not me argument, you are again straight up lying
I sended you a verified study ,




I sended 3 vids, only one vid is 1 hour long, the others were 10 minutes , again you are straight up lying

 

[SlayerJonas]

I cannot cure stupidness, me purpose was to cure the viewers in this thread so they will know the truth, as they see the vid they will know the anti science bullshit the dht lovers do, and finasteride haters with psuedo science as arguments

There is no pseudo science, just arguments with good studies to back them up.

Even if i did , you gonna say "no those studies are paid by the jews"

You don't provide any studies

Yess !! Topical estrogen will surely work on the scalp........

The only evidence of that is anecdotal evidence from reddit or obscure forums.....

Explain why it wouldn't work topically

Topical estrogen > a fda approved medicine FIN?????

Wow! It's fda approved! So what? red 40 is also fda approved is it healthy now

This logic is very flawed and stupid

Again no argument

Also the 2nd is .. topical dut and fin? So you stop the cope think that dht is the cause of baldness...... (100000+ hairloss researchers think that too) or what you gonna say,100000+ jews

Topical dut and fin decrease DHT levels in the scalp which increases test which then aromatizes estrogen and less DHT against estrogen = less hair loss. So less DHT means indirectly less hair loss. We never said anything against that
correct me if I'm wrong @20/04/2008

Yes so argumenting with logic and verified studies is impossibly with you

You believe what you believe with you own eyes
Cult thinking

 

[DR. NICKGA]

Topical dut and fin decrease DHT levels in the scalp which increases test which then aromatizes estrogen and less DHT against estrogen = less hair loss. So less DHT means indirectly less hair loss. We never said anything against that
correct me if I'm wrong

So low estrogen cause baldness?

 

[SlayerJonas]

So low estrogen cause baldness?

Multiple factors, but yes it can cause mpb

 

[DR. NICKGA]

Multiple factors, but yes it can cause mpb

What are the multiple factors , tell us

 

[SlayerJonas]

What are the multiple factors , tell us

Vitamin/mineral deficiencies, scalp damage through sun, overall bla bla damage, hair damage bla bla, I'm talking to one of my girlfriends rn lil bro, so excuse me. age?, growth hormone, stress, oxidative stress, me bonesmashing your brain, low estrogen, thyroid, massages, blalblbalbblab

 

[DR. NICKGA]

Vitamin/mineral deficiencies, scalp damage through sun, overall bla bla damage, hair damage bla bla, I'm talking to one of my girlfriends rn lil bro, so excuse me. age?, growth hormone, stress, oxidative stress, me bonesmashing your brain, low estrogen, thyroid, massages, blalblbalbblab

Alright so the top that you mentoined is

1. Low estrogen (which 0.0001% of people have)

Estrogen in Men: How It Works and What High or Low Levels Mean

Both high and low estrogen levels can cause some long-term complications or indicate that there’s an underlying condition that should be treated. Here's what you need to know.

www.healthline.com

2. Vitamine / mineral defiences?
3. Scalp damage?? Due to the sun?
4. Growth hormone?
5. Oxiditave stress?

Yea you are full of shit , literaly the definition of bro science

All millions of hair researchers agreed that high level of androgen receptors + dht is the cause of baldness aka androgenetic alopecia

You thinking otherwise is the definition of pure narcassism and high ego

Readers in this thread
Dont believe those "broscience" people in this thread
Believe in science

Haircafe

The world's finest source of hair loss information. Subscribe now to become a Hair Loss Witcher and defeat the slaphead curse once and for all.

youtube.com

 

[SlayerJonas]

Alright so the top that you mentoined is

1. Low estrogen (which 0.0001% of people have)

Estrogen in Men: How It Works and What High or Low Levels Mean

Both high and low estrogen levels can cause some long-term complications or indicate that there’s an underlying condition that should be treated. Here's what you need to know.

www.healthline.com

2. Vitamine mineral defiences
3. Scalp damage?? Due to the sun?
4. Growth hormone?
5. Oxiditave stress?

Yea you are full of shit , literaly the definition of bro science

All millions of hair researchers agreed that high level of androgen receptors + dht is the cause of baldness aka androgenetic alopecia

You thinking otherwise is the definition of pure narcassism and high ego

@20/04/2008 talk to this nigga

 

[DR. NICKGA]

@20/04/2008 talk to this nigga

I am talking to me girlfriend rn lil boy

I absolute destroyed you with science , facts and logic

Now its time for you both to shut the fuck up

 

[SlayerJonas]

I am talking to me girlfriend rn lil boy

 

[SlayerJonas]

View attachment 3268733View attachment 3268734View attachment 3268736View attachment 3268738
View attachment 3268739 View attachment 3268740View attachment 3268741View attachment 3268744

@Dyorotic thoughts? @hiku @fluoride1337 ->

 

[Deleted member 77820]

I am talking to me girlfriend rn lil boy

I absolute destroyed you with science , facts and logic

Now its time for you both to shut the fuck up

Nigga you showed videos
And contrairely to both of you i was actually talking to my girlfriend

 

[Deleted member 77820]

What are the multiple factors , tell us

Nigga can’t you read
Go atleat read the abstract and the results
Stop coping budhyboyos
And even if you wanted to run finasteride you wouldn’t be able to because of your limited knowledge

 

[Deleted member 77820]

What’s the

Upper end I could get to. I vaguely recall people using 10% ?

Me

 

[Deleted member 77820]

Alright so the top that you mentoined is

1. Low estrogen (which 0.0001% of people have)

Estrogen in Men: How It Works and What High or Low Levels Mean

Both high and low estrogen levels can cause some long-term complications or indicate that there’s an underlying condition that should be treated. Here's what you need to know.

www.healthline.com

2. Vitamine / mineral defiences?
3. Scalp damage?? Due to the sun?
4. Growth hormone?
5. Oxiditave stress?

Yea you are full of shit , literaly the definition of bro science

All millions of hair researchers agreed that high level of androgen receptors + dht is the cause of baldness aka androgenetic alopecia

You thinking otherwise is the definition of pure narcassism and high ego

Readers in this thread
Dont believe those "broscience" people in this thread
Believe in science

Haircafe

The world's finest source of hair loss information. Subscribe now to become a Hair Loss Witcher and defeat the slaphead curse once and for all.

youtube.com

No actually 10% of the population have low estrogen like 10-20 range not 0.001%
Then why is oestroposis levels so high
And why our generation suffer from delayed puberty
Why are we much taller than the previous generation

 

[Deleted member 77820]

Alright so the top that you mentoined is

1. Low estrogen (which 0.0001% of people have)

Estrogen in Men: How It Works and What High or Low Levels Mean

Both high and low estrogen levels can cause some long-term complications or indicate that there’s an underlying condition that should be treated. Here's what you need to know.

www.healthline.com

2. Vitamine / mineral defiences?
3. Scalp damage?? Due to the sun?
4. Growth hormone?
5. Oxiditave stress?

Yea you are full of shit , literaly the definition of bro science

All millions of hair researchers agreed that high level of androgen receptors + dht is the cause of baldness aka androgenetic alopecia

You thinking otherwise is the definition of pure narcassism and high ego

Readers in this thread
Dont believe those "broscience" people in this thread
Believe in science

Haircafe

The world's finest source of hair loss information. Subscribe now to become a Hair Loss Witcher and defeat the slaphead curse once and for all.

youtube.com

2)yes proven by science
3)he didn’t write it i did
4)The damage to the sun is due to th e lack of oxygen (just do a little experience take a hat and pur in your head for 6 hours then remove it youll notice that your hair got thinner)
5)he meant igf-1
6)yes it has a really big impact its the number 2 reason of hairloss
You can find hypogonadal 25 year old mf who are going bald they have high estrogen high insulin sensitivity high stresdbecause they are fat and low dht if they use finasteride they wouldn’t see much results because their estrogen is already high
While someone who’s on gear keep in mind when your using anything more than 1g of test you don’t need ai ask bodybuilders roufly 10% of your testosterone concerts to dht so when you ise 1g testosterone the sheer amount of dht is enough to regulate estrogen so in that case fin could be a good alternative

 

[DR. NICKGA]

No actually 10% of the population have low estrogen like 10-20 range not 0.001%
Then why is oestroposis levels so high
And why our generation suffer from delayed puberty
Why are we much taller than the previous generation

Wrong its the opposite

We are suffering from early puberty, aka puberty beginning at a young age

Certain chemicals may trigger early puberty in girls

Compounds found in fragrances and other products triggered signaling pathways in mouse and human cells that might help jump-start early puberty.

www.nih.gov

A biological trigger of early puberty is uncovered by Northeastern scientists

New research reveals how trauma triggers early puberty and later anxiety, paving the way for potential interventions.

news.northeastern.edu

Its due to chemicals, stress and food etc..... complex reasons

People in the west grow taller is because of the goyslop western diet

Overall high glycemic load during times of growth = taller, wider, bigger (PUBERTYCELS GIH)

“Chad eats candy and icecream everyday and is 6’3 with a 25inch bideltoid and has fucked loads of women” Many ppl say something along the lines of this to combat the idea diet can “improve your aesthetics”. The problem with this is that “Chad’s” diet consists of “candy and icecream” which of...

looksmax.org

 

[DR. NICKGA]

No actually 10% of the population have low estrogen like 10-20 range not 0.001%
Then why is oestroposis levels so high
And why our generation suffer from delayed puberty
Why are we much taller than the previous generation

I was not serious when i said 0.001%

10% is still very very low, no one suffer from low estrogen

 

[Deleted member 77820]

Wrong its the opposite

We are suffering from early puberty, aka puberty beginning at a young age

Certain chemicals may trigger early puberty in girls

Compounds found in fragrances and other products triggered signaling pathways in mouse and human cells that might help jump-start early puberty.

www.nih.gov

A biological trigger of early puberty is uncovered by Northeastern scientists

New research reveals how trauma triggers early puberty and later anxiety, paving the way for potential interventions.

news.northeastern.edu

Its due to chemicals, stress and food etc..... complex reasons

People in the west grow taller is because of the goyslop western diet

Overall high glycemic load during times of growth = taller, wider, bigger (PUBERTYCELS GIH)

“Chad eats candy and icecream everyday and is 6’3 with a 25inch bideltoid and has fucked loads of women” Many ppl say something along the lines of this to combat the idea diet can “improve your aesthetics”. The problem with this is that “Chad’s” diet consists of “candy and icecream” which of...

looksmax.org

Both
Back then growth plates closed between 16-18
Now its 14-21

 

[SlayerJonas]

Heightmog you ass
And started heightmaxxing at 15

Nothing personal bro but I really didn't grow after 14, I think it has some correlation with the beginning of my gymmaxxing or smth

 

[Deleted member 77820]

Nothing personal bro but I really didn't grow after 14, I think it has some correlation with the beginning of my gymmaxxing or smth

Your retarded jfl
How did you know you shopped growing you just had a really slow growth you didn’t notice
Cause even women their growth don’t close at 14

 

[SlayerJonas]

Your retarded jfl
How did you know you shopped growing you just had a really slow growth you didn’t notice
Cause even women their growth don’t close at 14

I sent you a x ray.

 

[JohnDoe]

Anything from 0.5-2%, start with the lower end

I haven't looked into the whole applying DHT gel on penis to increase size but i'm assuming it goes systemic right and so affects hairloss due to DHT > low estrogen?
Somehow i doubt applying DHT gel even 1-2% would be side-effect free.

 

[JohnDoe]

Topical dut and fin decrease DHT levels in the scalp which increases test which then aromatizes estrogen and less DHT against estrogen = less hair loss. So less DHT means indirectly less hair loss. We never said anything against that
correct me if I'm wrong @20/04/2008

I'm pretty sure topical fin/dut goes systemic and eventually the % that goes systemic or changes DHT in body is close or almost same as taking oral. Either way these drugs are no good.
@20/04/2008 @Jonas2k7 Thoughts on DNA methylation & Insulin sensitivity/resistance or basically balding being a metabolic disease? i know it's kinda what you have said already but not directly.

 

[JohnDoe]

Nigga your retarded
Also your not 5ft11 stop coping
The guys that were 5ft9 when they were 14 all lf them that i know ended up being 6ft3-5
I was 5ft6 when i was 14 i am now 6ft1
You were 5ft9 at 14 you grew really slowly to 5ft11 and now your coping saying your griwth closed at 14 you should really be super unlucky for that to happen

Brutal. I was like 5'8 after i hit my growth spurt at 14-15 years old and then i stopped growing and never grew. I grew like 2cm in my early 20s but that's it. Now perma stuck 5'8.5/174. Insane but i attribute it to insufficient sleep + nutrition. Jonas you should be happy you are atleast 5'11, it could be worse. at 5'11 atleast you can fraud to 6'1 and be more than okay.

 

[piec]

Vitamine / mineral defiences?

biotin(extremely rare) vitamin d (extremely rare that its so severe it results in hair loss, must be retarded level neglectful and not notice 10 other symptoms)

also will NOT be in the pattern of male pattern baldness which is very obvious to tell
also obviously a bunch of other shit like iron but same thing applies

Scalp damage?? Due to the sun?

apparently nigger tanned his scalp so hard while being clean shaven on the head it scrapped his entire skin off and caused fibrosis

4. Growth hormone?

extremely extremely rare, and you would be diagnosed with GH deficiency at 8 years old

also not in the pattern of male pattern baldness and very obvious to tell

Oxiditave stress?

only thing coming to my mind is tellogen effluvium, which is also not in the pattern of male pattern baldness

 

[SlayerJonas]

I haven't looked into the whole applying DHT gel on penis to increase size but i'm assuming it goes systemic right and so affects hairloss due to DHT > low estrogen?
Somehow i doubt applying DHT gel even 1-2% would be side-effect free.

If you experience any side effects you can stop instantly. It is just to maximize possible gains with PE as it increases regeneration in penile tissue. Lower doses should have an effect too.

I'm pretty sure topical fin/dut goes systemic and eventually the % that goes systemic or changes DHT in body is close or almost same as taking oral. Either way these drugs are no good.

When taken orally, fin enters the bloodstream and affects the whole body. When applied topically, it primarely targets the scalp and is less likely to cause the same sides as oral fin.

@20/04/2008 @Jonas2k7 Thoughts on DNA methylation & Insulin sensitivity/resistance or basically balding being a metabolic disease? i know it's kinda what you have said already but not directly.

Yes, a lot of things can contribute to hair loss like discussed in the thread. Could you specify "metabolic diseases", do you mean stuff like diabetes mellitus? Insulin affects HGH and this affects ofc hair too. So yeah, the body is pretty complex.

 

[AustrianMogger]

DHT is an essential male hormone, not just for libido or feeling manly, but for health as a whole. This guide will cover all aspects of the importance of the hormone DHT for the human body.

DHT is synthesized from:

• Testosterone through the enzyme 5 alpha reductase (5AR)
• 17-hydroxypregnenolone and 17-hydroxyprogesterone via the “backdoor” pathway
• 5α-androstane-3α, 17-β-diol (dihydroandrosterone/3α-diol) through the intracrine reverse synthesis pathway involving 3α-hydroxysteroid dehydrogenase (3α-HSD)

DHT is 2.5-10 times more potent than testosterone and here’s why:

1. DHT has 4 times higher affinity to androgen receptors (AR) than Testosterone
2. Binding of DHT to the AR transforms the AR into it's DNA-binding state
3. DHT upregulates AR synthesis and reduces AR turnover
4. The dissociation rate of testosterone from it's receptors is 3-5 times faster than that of DHT (meaning DHT exerts a much more powerful effect on AR than testosterone)

However, circulating DHT is usually only about 10% or less that of testosterone and high concentrations of intracellular T can shift androgen receptor binding away from DHT by mass action

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels

Circulating levels of DHT in response to testosterone replacement therapy (TRT) do not correlate with those found in androgen sensitive tissue due to homeo

academic.oup.com

In the blood SHBG binds with 5 times higher affinity and for more than 3 times longer to DHT compared to testosterone.

To maximize the androgenic benefits of DHT we have to maximize 5AR and inhibit the binding of DHT to SHBG.

This article presents you what happens when men have high DHT or supraphysiological amounts of it.

---

DHT is essential for libido and sexual function​

It’s probably well known that DHT is very important when it comes to libido and sexual function.

According to this study, serum DHT concentration was the only independent hormonal predictor of the frequency of orgasms. An increase in concentration of 1.36 nmol/l corresponded to an average increase of one orgasm a week.

This shows that DHT directly opposes the anti-libido effects of prolactin.

Inhibiting DHT synthesis impairs corpus cavernosum growth and trabecular smooth muscle relaxation, endothelial function and increases connective tissue deposition. This all contributes to erectile dysfunction, even in the presence of physiological levels of total testosterone.

DHT is also critical for activating gene expression of neuronal and endothelial nitric oxide synthases, which are critical physiological mediators of penile erection.

Furthermore, DHT is also essential for spermatogenesis and thus fertility.

Estrogen is thought to be essential for sexual function in men. However, administrating high doses of DHT lowers estrogen dramatically and doesn’t reduce sexual function.

DHT isn’t just neutral towards sexual function as shown below, but is essential for it.

https://www.tandfonline.com/doi/abs/10.1080/13685530400016672

Human male sexual functions do not require aromatization of testosterone: A study using tamoxifen, testolactone, and dihydrotestosterone - Archives of Sexual Behavior

This study was designed to examine whether testosterone needs to be converted to estradiol in order to exert fully its effects on sexuality in the human male. Administration of the estrogen receptor antagonist tamoxifen and the aromatase inhibitor testolactone were without effect on parameters...

link.springer.com

DHT doesn’t cause prostate cancer​

For many decades it was thought that DHT promotes prostate cancer. However that thinking is luckily starting to change. It’s about time, since there has been a lot of research in the last two decades showing that DHT doesn’t promote prostate cancer.

There isn’t a correlation between circulating DHT and intraprostatic DHT. The prostate regulates it’s own DHT levels, which is about 10 times higher than circulation.

Giving testosterone might cause issues, since it can convert to estrogen, but giving DHT directly could actually help shrinking the prostate as it can lower estrogen. Estrogen and Prolactin are the driving causes that promote prostate cancer.

A few studies (1, 2, 3)found that supraphysiological amounts of serum DHT levels and DHT gel treatment didn't significantly increase total, central or peripheral prostate volumes, as measured by ultrasonography, nor was serum prostate-specific antigen (PSA) elevated. Additionally, International Prostate Symptom Scores (IPSS) remained unchanged in men treated with DHT gel for 6-24 months.

This 1.8 year old survey of 37 men aged between 55-70 years treated with daily percutaneous DHT suggested that high plasma levels of DHT (> 8.5 nmol/l) effectively inducing clinical benefits while slightly but significantly reducing prostate size.

DHT isn’t the bad guy when it comes to hair loss​

Hair loss and prostate cancer are two of the main reasons why people want to lower their DHT.

DHT is needed for beard growth, but it’s thought that DHT promotes scalp hair loss.

Take a look at this reference:

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels - PMC

Benefits associated with lowered serum DHT levels after 5α-reductase inhibitor (5AR-I) therapy in men have contributed to a misconception that circulating DHT levels are an important stimulus for androgenic action in target tissues (e.g., prostate). ...

pmc.ncbi.nlm.nih.gov

The claim above is supported by the fact that men who are exposed to exceptionally high levels of DHT in response to the daily application of DHT for a long period of time didn’t experience acne, male androgenic alopecia or other androgen-associated skin pathology.

Furthermore, the differences in mean values of DHT were not significant according to the types of alopecia and the control group. And increased serum concentrations of DHT is not correlated with the advance of alopecia. This study speculates that hair loss severity is affected by factors other than DHT, such as the duration of alopecia or the sensitivity of hair follicle cells to androgens.

Some people with hair loss have high DHT and others don’t. Some with high DHT have normal hair whereas others don’t.

https://www.researchgate.net/publication/328980562_A_New_Approach_to_Hair_Loss_Management_without_DHT_Blockers

So what’s going on with hairloss, if it’s not DHT?

You also might be wondering: “If DHT is not involved, why does 5-AR inhibitors work?“

This study found that although 5α-reductase inhibitors are effective in treating male androgenic alopecia, DHT does not appear to play a primary role in the pathogenesis of male androgenic alopecia or acne.

Reasons for hair loss are:

1. Androgen receptor polymorphism and differences in androgen receptor concentrations and steroid-converting enzymes as the principal contributors to male androgenic alopecia
2. An initial experimental study by Eun discovered that DHT does not directly cause inhibition of hair growth but it induces the release of transforming growth factor beta 1 (TGFß1) which results in the miniaturization and hair loss.

Controlled clinical trial for evaluation of hair growth with low dose cyclical nutrition therapy in men and women without the use of finasteride

Aim: To evaluate possible results with the stimulation use of minoxidil and the strengthening of hair roots with nutritional cyclical supplements, resulting in increased hair regrowth, without the use of anti androgens and enzyme blockers.Methods: This prospective controlled clinical trial...

www.oaepublish.com

Shin et al followed this research further with cultured androgen sensitive dermal papilla cells and the addition of DHT to this androgen sensitive cell caused an accumulation of free radicles ROS within the cultured cells, which in turn induced the release of TGFß1.”

So a better approach than lowering DHT is to:

• Positively modulate the skin microbiome (think sunlight, micronutrients, clean environment, etc.)
• Inhibit excess ROS production
• Prevent excess activation of TGFß1
• Reduce stress

There are many more reasons for hair loss, but I won’t be diving into that in this article.

DHT for metabolic syndrome​

Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke and diabetes. Metabolic syndrome includes high blood pressure, high blood sugar, excess body fat around the waist and abnormal cholesterol levels. The syndrome increases a person’s risk of heart attack and stroke.

Insulin sensitivity​

This randomized, controlled, double-blind trial provides evidence that DHT specifically (and to a much lesser extent, testosterone), improves insulin sensitivity and decreases plasma leptin level without notable side effects

Testosterone treatment caused prostatic nodular hyperplasia, benign at biopsy, whereas DHT didn’t.

Androgens, especially DHT, upregulate insulin receptor expression and activity and increase glycogen synthesis and cholesterol uptake in the liver.

Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm - PMC

5α-dihydrotestosterone (5α-DHT) is the most potent natural androgen. 5α-DHT elicits a multitude of physiological actions, in a host of tissues, including prostate, seminal vesicles, hair follicles, skin, kidney, and lacrimal and meibomian glands. ...

pmc.ncbi.nlm.nih.gov

Low DHT or lowering DHT with a 5AR inhibitor, such as Finasteride or Dutasteride, is associated with an increase in blood glucose and glycosylated hemoglobin A as well as the risk of type 2 diabetes. Studies: 1, 2, 3

5AR is necessary to inactivate cortisol, so blocking 5AR increases cortisol, which promotes insulin resistance and liver disorders, such as NAFLD, steatosis, etc. Studies: 1, 2

Heart, liver and kidney function​

DHT therapy in men with coronary artery disease (CAD) decreased myocardial ischemia and improved left ventricular diastolic function.

This in vitro study found:


The findings above could explain some of the previously described clinical observations of the relationship between low T and DHT and peripheral vascular disease and the anti-ischemic effects of acute infusion of testosterone in men with CAD and similar effects by DHT gel treatment.

A few more facts:

• 5AR inhibition may result in the development of kidney dysfunction.
• Dutasteride, a 5AR inhibitor, treatment increased activities of liver alanine aminotransferase and aspartate aminotransferase, suggesting dysregulation of liver metabolism.
• DHT is a biomarker for reduced risk of stroke, which means that DHT is inversely correlated with stroke
• Higher DHT was associated with lower ischemic heart disease mortality in older men

Vascular function​

Blood pressure

• DHT increases the synthesis of nitric oxide through eNOS phosphorylation thus improving circulation and vascularity (R).

The following in vitro study shows that DHT has anti-inflammatory and protective effects in the vascular system:


Cholesterol

DHT:

• Reduces lipid accumulation and cholesterol synthesis via increasing expression of carnitine palmitotyltransferase1 (CPT-1) and phosphorylation of 3-hydroxy-3-methyl-glutaryl-CoA reductase
• Inhibits ox-LDL–induced foam cell formation and atherosclerosis
• DHT administration for up to 2 years in normal men, didn’t cause any thrombotic events or detrimental shifts in total cholesterol, HDL and LDL cholesterol, or triglycerides. Nor were exceptionally high levels of DHT associated with a change in right carotid intima-media thickening
• Inhibiting 5AR with dutasteride resulted in increased total cholesterol, and low-density lipoprotein cholesterol levels

Georgi (Haidut) posted a while ago:

Lowering DHT synthesis causes severe hypothyroidism, despite higher T levels – To Extract Knowledge from Matter

Mitochondrial function and energy production​

Androgens, especially DHT:

• Stimulate lipolysis and down-regulates lipoprotein lipase activity and increases the expression of fatty acid-binding protein leading to an increase in fatty acid oxidation and in oxidative phosphorylation.
• Increase the expression of pyruvate dehydrogenase, which increases the production of oxaloacetate and acetyl-CoA leading to a stimulation of the tricarboxylic acid (TCA) cycle.
• Increase the expression of succinate dehydrogenase and aconitase, also upregulating TCA and increasing oxidative phosphorylation.
• Increase the expression of cytochrome c oxidase, which leads to an increase in oxidative phosphorylation. The increase in oxidative phosphorylation leads to a decrease in reactive oxygen species and an increase in insulin sensitivity

Fat loss​

DHT:

• Inhibits preadipocyte proliferation and adipocyte differentiation, which prevents the excess formation of fat cells
• Stimulates lipolysis
• Stimulates lipid disposal
• Downregulates lipogenesis, which reduces the conversion of carbs to fat
• Prevents the downregulation of the leptin receptor

Gynecomastia

Gyno is known to be due to high estrogen and prolactin and low DHT and DHT treatment can reverse it.

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels - PMC

Benefits associated with lowered serum DHT levels after 5α-reductase inhibitor (5AR-I) therapy in men have contributed to a misconception that circulating DHT levels are an important stimulus for androgenic action in target tissues (e.g., prostate). ...

pmc.ncbi.nlm.nih.gov

Fun fact: One of the most known treatment of gynocomastia isn’t a SERM but transdermal DHT.

Brain & cognition

• DHT promotes stress resiliency. Blocking 5AR enhances cortisol release during stress, whereas DHT blunts it, most likely through CRH suppression.
• DHT promote insane memory.
• DHT protects against neurodegeneration, by antagonizing TGF beta.

Studies: 1, 2, 3, 4

In this case study someone with a demyelinating disease (Charcot-Marie-Toot 1) was able to induce neuroregeneration with 20mg/day of Anavar (Oxandrolone).

Lastly:


DHT is needed for blood flow

Lower T or DHT levels, but not E2, is associated with symptoms of intermittent claudication in older men.

Bone

High doses of DHT can completely shut down LH and testosterone production and cause a major drop in estrogen. This might be a concern for some people because it’s mainly estrogen that’s been thought to be beneficial for bone, however, there is evidence that estrogen isn’t needed for bone strength/growth.

Finasteride increases the risk of fractures, which indicates that it weakens muscle strength and bone quality.

Eyes

DHT is needed to keep the eyes moist and prevent dry eyes. 5AR inhibition may result in the development of dry eye disease.

Androgen deficiency produces pathophysiological changes manifested in the reduction of tear production and evaporative dry eye conditions.

Suppression

DHT doesn’t have a suppressive effect on testicular steroidogenesis, similar to estrogen. DHT actually suppresses testicular aromatase. DHT inhibits steroidogenesis on a hypothalamic level, and doesn’t affect LH secretion at a pituitary level.

Anabolism/Catabolism

DHT isn’t very anabolic, however, DHT derivatives, such as Anavar or Masteron are much more anabolic than DHT, and this is partly due to much slower clearance through the liver.

Apart from it not being very anabolic, DHT is anti-catabolic. This study found that people who experience muscle wasting from AIDS, retained more muscle mass if their DHT was normal, compared to those with low DHT.

Low dihydrotestosterone and weight loss in the AIDS wasting syndrome - PubMed

24 consecutive AIDS patients with wasting, and who had never received anabolic therapies, were evaluated to determine their profile of sex hormones and whether transformation of testosterone (T) to the nuclear androgen, dihydrotestosterone (DHT), was impaired. Eleven (46%) patients had normal...

pubmed.ncbi.nlm.nih.gov

Anavar, a DHT derivative, is used to preserve muscle mass in people with wasting disease and to help them add more muscle for recovery.

Even 5mg was enough to stop catabolism, whereas higher doses such as 15mg daily were needed for muscle growth in these patients.

Furthermore, DHT upregulates androgen receptors.

Serotonin excess and cancer

DHT downregulates tryptophan hydroxylase 1 (TPH1; the rate-limited enzyme in serotonin synthesis in the body), thus protecting against the formation of tumors. Serotonin is also potent inflammatory and causes vasoconstriction, so DHT protects against that as well.

This is why DHT is an essential hormone for the human body and why the use of 5AR's should be refrained from.

Other cool studies:

• PMID: 20927745
• PMID: 29224108
• PMID: 32869255
• PMID: 30206635
• PMID: 30905792
• PMID: 34479019
• PMID: 33814544
• PMID: 30863034
• PMID: 34741573
• PMID: 37697052

All credits to @20/04/2008, he did all of the research for this work.

Hopefully all our frends
@NZb6Air @4lt.Real @Bars @chudlite @Gaygymmaxx @Gengar @lestoa @sub5incel125 @thebuffdon690 @wastedspermcel @yayatourer @MA_ascender

@CoreSchizo @klimo @Chintuck22 @heyheyheybro22 @SecularIslamist @looksmaxxing223 @NorwoodAscender @elemanzelvadre @shia.jihadist @Sapieeen

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Average finasteride/dutasteride user who claims he has no side

Massiv cope

 

[SlayerJonas]

Massiv cope

Could you explain why? Nigga

 

[AustrianMogger]

Beard is a massiv cope

 

[shredded4summer]

if you have blocked DHT before the age of 20 then it is completely over. DHT is what grows frame, face, dick, bones, makes you masculine and low inhib.