The Obsession about blocking DHT should end

[Jonasㅤㅤ]

if you have blocked DHT before the age of 20 then it is completely over. DHT is what grows frame, face, dick, bones, makes you masculine and low inhib.

Blocking DHT in general is bad

 

[FascisstChad]

Based, DHT is king. If you’re a man you should have a minimum of 1,850 ng/dl test and 375 ng/dl DHT. Anything less and your sub male. The reason people on this forum try to mess with it is that the dht lords didn’t bless them with dick growth.

 

[DR. NICKGA]

if you have blocked DHT before the age of 20 then it is completely over. DHT is what grows frame, face, dick, bones, makes you masculine and low inhib.

Based, DHT is king. If you’re a man you should have a minimum of 1,850 ng/dl test and 375 ng/dl DHT. Anything less and your sub male. The reason people on this forum try to mess with it is that the dht lords didn’t bless them with dick growth.

Guys i dont wanna sound blackpilled or nihilistic or break the fun but.......

Frame, face , dicksize or bones (aka facial development) is all pure genetics

The people who have big frames dont have more T or dht running in the body and vice versa.......

Bones? Yea facial development is alr decided in the womb

Stop the cope nigga

 

[Jonasㅤㅤ]

Guys i dont wanna sound blackpilled or nihilistic or break the fun but.......

Frame, face , dicksize or bones (aka facial development) is all pure genetics

The people who have big frames dont have more T or dht running in the body and vice versa.......

Bones? Yea facial development is alr decided in the womb

Stop the cope nigga

Maximizing these hormones allows for maximum growth of especially your dick during puberty.

 

[JohnDoe]

If you experience any side effects you can stop instantly. It is just to maximize possible gains with PE as it increases regeneration in penile tissue. Lower doses should have an effect too.

When taken orally, fin enters the bloodstream and affects the whole body. When applied topically, it primarely targets the scalp and is less likely to cause the same sides as oral fin.

Yes, a lot of things can contribute to hair loss like discussed in the thread. Could you specify "metabolic diseases", do you mean stuff like diabetes mellitus? Insulin affects HGH and this affects ofc hair too. So yeah, the body is pretty complex.

Yh PE is a tricky thing imo, the risk of permanent damage is there even if you're careful so not too sure about it.
Topical fin goes systemic too and does affect system DHT. I'm pretty sure i've read studies/etc that show topical fin causes same sides as oral evne if you microdose topical.
Insulin sensitivity/resistance as one of the main causes of hair loss is what i meant. Will maybe create a thread on it to get a discussion going.

 

[shredded4summer]

Guys i dont wanna sound blackpilled or nihilistic or break the fun but.......

Frame, face , dicksize or bones (aka facial development) is all pure genetics

The people who have big frames dont have more T or dht running in the body and vice versa.......

Bones? Yea facial development is alr decided in the womb

Stop the cope nigga

i see what you mean but its untrue. My face was underdeveloped until i improved my hormone profile.

 

[Vista]

Guys i dont wanna sound blackpilled or nihilistic or break the fun but.......

Frame, face , dicksize or bones (aka facial development) is all pure genetics

The people who have big frames dont have more T or dht running in the body and vice versa.......

Bones? Yea facial development is alr decided in the womb

Stop the cope nigga

this is the most retarded thing I have heard on this forum.

frame/face is a combination of genetics and environment (hormones), if you castrate a boy he's not going to have a mogger jawline and broad shoulders, he's going to look like a girl (look at mtf teenagers or ftm transgenders who start develop bigger jaws when they begin pinning androgens).

People who have big frames have more T, People who have bigger jaws have more T.
Testosterone and DHT= Dimorphism.

You have to be extremely retarded to think otherwise, go back to your indian slum and kill yourself u retarded subhuman dr nigger

 

[Blonde]

View attachment 3265587

please check dms saar

 

[Deleted member 4633]

please check dms saar

Get out of the kitchen if you can't handle the heat

that means, don't use steroids if you're gonna cry about stuff like "muh fertility"

 

[Deleted member 77820]

Testosterone make you more fertile are you retarded

Get out of the kitchen if you can't handle the heat

that means, don't use steroids if you're gonna cry about stuff like "muh fertility

 

[Deleted member 77820]

Guys i dont wanna sound blackpilled or nihilistic or break the fun but.......

Frame, face , dicksize or bones (aka facial development) is all pure genetics

The people who have big frames dont have more T or dht running in the body and vice versa.......

Bones? Yea facial development is alr decided in the womb

Stop the cope nigga

Nigga if we pumped you full of estrogen yiu will be hald as dimorphic
The reason why testosterone stop working at certain level is because when you go to supraphisiological dose your androgen receptors downregulate
The more test/dht = the more dimorphissim
The only thing you can change is muscle insertion waste size (even tho if you have high dht most of the ar would prevent progesterone from being too high)
And symetry testosterone grow everything ears nose dick frame so you would probably need to have rhino and long hair to fraud your ears

 

[DR. NICKGA]

this is the most retarded thing I have heard on this forum.

frame/face is a combination of genetics and environment (hormones), if you castrate a boy he's not going to have a mogger jawline and broad shoulders, he's going to look like a girl (look at mtf teenagers or ftm transgenders who start develop bigger jaws when they begin pinning androgens).

People who have big frames have more T, People who have bigger jaws have more T.
Testosterone and DHT= Dimorphism.

You have to be extremely retarded to think otherwise, go back to your indian slum and kill yourself u retarded subhuman dr nigger
View attachment 3273487

At the end
Are you Mad to me for saying the truth?

Sorry mister sir from india
Injecting you testosterone injections that you received from indian pharma will not make you a huge frame , masculine chadlite

You will still be the same , a little subhuman

Genetics will dictate how "masculine" features you got

Nigga if we pumped you full of estrogen yiu will be hald as dimorphic
The reason why testosterone stop working at certain level is because when you go to supraphisiological dose your androgen receptors downregulate
The more test/dht = the more dimorphissim
The only thing you can change is muscle insertion waste size (even tho if you have high dht most of the ar would prevent progesterone from being too high)
And symetry testosterone grow everything ears nose dick frame so you would probably need to have rhino and long hair to fraud your ears

Its time for you to shut the fuck up idiot

 

[Deleted member 77820]

At the end
Are you Mad to me for saying the truth?

Sorry mister sir from india
Injecting you testosterone injections that you received from indian pharma will not make you a huge frame , masculine chadlite

You will still be the same , a little subhuman

Genetics will dictate how "masculine" features you got


Its time for you to shut the fuck up idiot

Nigga has no argument
Proceed to just insult me come on
Don’t be cheap

 

[Deleted member 77820]

At the end
Are you Mad to me for saying the truth?

Sorry mister sir from india
Injecting you testosterone injections that you received from indian pharma will not make you a huge frame , masculine chadlite

You will still be the same , a little subhuman

Genetics will dictate how "masculine" features you got


Its time for you to shut the fuck up idiot

Nigga that retarded
@Spergi do you wanna make out with me ?

 

[DR. NICKGA]

Nigga that retarded
@Spergi do you wanna make out with me ?

Why the insults? Calm down mate

 

[Spergi]

Nigga that retarded
@Spergi do you wanna make out with me ?

I want you to take dutasteride nigga

 

[Deleted member 77820]

Me and halloweed will rape they buthole

You literally promote dht cream
Did your mom forget to give you your meds ?

 

[Deleted member 77820]

I want you to take dutasteride nigga

Would gladly take dizepam instead its safer

 

[Deleted member 77820]

Yh PE is a tricky thing imo, the risk of permanent damage is there even if you're careful so not too sure about it.
Topical fin goes systemic too and does affect system DHT. I'm pretty sure i've read studies/etc that show topical fin causes same sides as oral evne if you microdose topical.
Insulin sensitivity/resistance as one of the main causes of hair loss is what i meant. Will maybe create a thread on it to get a discussion going.

Its temporary anyway
If you stop Pe you lose your gains

 

[Deleted member 77820]

Guys i dont wanna sound blackpilled or nihilistic or break the fun but.......

Frame, face , dicksize or bones (aka facial development) is all pure genetics

The people who have big frames dont have more T or dht running in the body and vice versa.......

Bones? Yea facial development is alr decided in the womb

Stop the cope nigga

Nigga they all do
Just look at zyzz//togi/Cbum/arnold/jay cutler before and after gear
Or atleast they have slightly above average hormone profile
Gear ≠ Chad
But gear would really help if your recessed
We have people in their 20s growing bones on gear and your telling me dht is useless and we should block it from 16 onwards thats retarded

 

[Vista]

At the end
Are you Mad to me for saying the truth?

Sorry mister sir from india
Injecting you testosterone injections that you received from indian pharma will not make you a huge frame , masculine chadlite

lol jeet, to repeat myself: genetics + hormones = dimorphism. Is it really that hard for your little brain to comprehend? probably is since the average iq in India is 77 lmfao

You will still be the same , a little subhuman

Genetics will dictate how "masculine" features you got

I mog your entire subhuman bloodline

 

[Deleted member 77820]

Jews dont have a masterplan to castrate all males with hairloss medicine? the jews also did not paid the FDA verifcation and 100+ verified good studies

I have nothing to gain

That was not me argument, you are again straight up lying
I sended you a verified study ,




I sended 3 vids, only one vid is 1 hour long, the others were 10 minutes , again you are straight up lying

Nigga link us studies
I linked a lot of studies showing how fin sucks im waiting
@Spergi keep sucking my cock

 

[Spergi]

Nigga link us studies
I linked a lot of studies showing how fin sucks im waiting
@Spergi keep sucking my cock

 

[Deleted member 77820]

View attachment 3274713

Nigga the jews got into your head
This is propaganda
I tell him to send me studies he send me memes

 

[JohnDoe]

Its temporary anyway
If you stop Pe you lose your gains

The risk of permanent damage to nerves or penile tissue is there regardless of gains being temporary imo

 

[Jonasㅤㅤ]

The risk of permanent damage to nerves or penile tissue is there regardless of gains being temporary imo

Only with jelqing, not with basic stretches tho

 

[Deleted member 77820]

The risk of permanent damage to nerves or penile tissue is there regardless of gains being temporary imo

Isn’t it all fibrosis ?????

 

[Deleted member 4633]

Balding is a metabolic disease

....

in my opinion

So it's YOUR retarded opinion vs fucking years of research that has basically ruled out any other cause other than the androgenic theory?

I swear to god peattrannies are so fucking dumb it's unreal. Peat's dietary philosophy has been destroyed and overrun with some of the biggest subhumans imaginable.

Go inhale Co2 and be an insulin resistant subhuman with zero hair some place else

 

[SquareChinOrDeath]

View attachment 3263177
Average finasteride/dutasteride user who claims he has no side

4+ year Dutasteride user here, I literally take one 0.5mg pill once a week.

It is well known that finasteride can cause brain fog, I experienced it myself 5 years ago and it wasn't permanent.
But in my case now: Dutasteride and all of the aforementioned bodily functions are normal.
You try to debunk DHT but provide no real solution to hairloss.

I was on Duta for 3 years and then was off Duta for half a year and saw my hairline taking a blow and my beard growing faster.
Now I am on Duta in the last half year and hairloss just stopped again along with beard growth.
This is very clear DHT causation. Atleast for my case.

 

[Deleted member 77820]

....

So it's YOUR retarded opinion vs fucking years of research that has basically ruled out any other cause other than the androgenic theory?

I swear to god peattrannies are so fucking dumb it's unreal. Peat's dietary philosophy has been destroyed and overrun with some of the biggest subhumans imaginable.

Go inhale Co2 and be an insulin resistant subhuman with zero hair some place else

Didnt read a word you subhuman
Low iq

 

[Deleted member 77820]

....

So it's YOUR retarded opinion vs fucking years of research that has basically ruled out any other cause other than the androgenic theory?

I swear to god peattrannies are so fucking dumb it's unreal. Peat's dietary philosophy has been destroyed and overrun with some of the biggest subhumans imaginable.

Go inhale Co2 and be an insulin resistant subhuman with zero hair some place else

He didn’t write it i did why are you talking to him that’s another proof you didn’t read a single word let alone the studies you probably read the tiltles then went straight to the comments

 

[Deleted member 4633]

He didn’t write it i did why are you talking to him that’s another proof you didn’t read a single word let alone the studies you probably read the tiltles then went straight to the comments

you're so mad that I didn't read your tsunami-wave tier water thread

kill yourself

 

[justanothercurrycel]

bro is trying to eliminate the competition LMAO

 

[ezio6]

Joined 2024

 

[Maalik]

4+ year Dutasteride user here, I literally take one 0.5mg pill once a week.

It is well known that finasteride can cause brain fog, I experienced it myself 5 years ago and it wasn't permanent.
But in my case now: Dutasteride and all of the aforementioned bodily functions are normal.
You try to debunk DHT but provide no real solution to hairloss.

I was on Duta for 3 years and then was off Duta for half a year and saw my hairline taking a blow and my beard growing faster.
Now I am on Duta in the last half year and hairloss just stopped again along with beard growth.
This is very clear DHT causation. Atleast for my case.

bro just dont stress and take vitamins your hair will come back bro

 

[Jonasㅤㅤ]

bro just dont stress and take vitamins your hair will come back bro

Low iq

Don't get mad now!

 

[Deleted member 77820]

DHT is an essential male hormone, not just for libido or feeling manly, but for health as a whole. This guide will cover all aspects of the importance of the hormone DHT for the human body.

DHT is synthesized from:

• Testosterone through the enzyme 5 alpha reductase (5AR)
• 17-hydroxypregnenolone and 17-hydroxyprogesterone via the “backdoor” pathway
• 5α-androstane-3α, 17-β-diol (dihydroandrosterone/3α-diol) through the intracrine reverse synthesis pathway involving 3α-hydroxysteroid dehydrogenase (3α-HSD)

DHT is 2.5-10 times more potent than testosterone and here’s why:

1. DHT has 4 times higher affinity to androgen receptors (AR) than Testosterone
2. Binding of DHT to the AR transforms the AR into it's DNA-binding state
3. DHT upregulates AR synthesis and reduces AR turnover
4. The dissociation rate of testosterone from it's receptors is 3-5 times faster than that of DHT (meaning DHT exerts a much more powerful effect on AR than testosterone)

However, circulating DHT is usually only about 10% or less that of testosterone and high concentrations of intracellular T can shift androgen receptor binding away from DHT by mass action

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels

Circulating levels of DHT in response to testosterone replacement therapy (TRT) do not correlate with those found in androgen sensitive tissue due to homeo

academic.oup.com

In the blood SHBG binds with 5 times higher affinity and for more than 3 times longer to DHT compared to testosterone.

To maximize the androgenic benefits of DHT we have to maximize 5AR and inhibit the binding of DHT to SHBG.

This article presents you what happens when men have high DHT or supraphysiological amounts of it.

---

DHT is essential for libido and sexual function​

It’s probably well known that DHT is very important when it comes to libido and sexual function.

According to this study, serum DHT concentration was the only independent hormonal predictor of the frequency of orgasms. An increase in concentration of 1.36 nmol/l corresponded to an average increase of one orgasm a week.

This shows that DHT directly opposes the anti-libido effects of prolactin.

Inhibiting DHT synthesis impairs corpus cavernosum growth and trabecular smooth muscle relaxation, endothelial function and increases connective tissue deposition. This all contributes to erectile dysfunction, even in the presence of physiological levels of total testosterone.

DHT is also critical for activating gene expression of neuronal and endothelial nitric oxide synthases, which are critical physiological mediators of penile erection.

Furthermore, DHT is also essential for spermatogenesis and thus fertility.

Estrogen is thought to be essential for sexual function in men. However, administrating high doses of DHT lowers estrogen dramatically and doesn’t reduce sexual function.

DHT isn’t just neutral towards sexual function as shown below, but is essential for it.

https://www.tandfonline.com/doi/abs/10.1080/13685530400016672

Human male sexual functions do not require aromatization of testosterone: A study using tamoxifen, testolactone, and dihydrotestosterone - Archives of Sexual Behavior

This study was designed to examine whether testosterone needs to be converted to estradiol in order to exert fully its effects on sexuality in the human male. Administration of the estrogen receptor antagonist tamoxifen and the aromatase inhibitor testolactone were without effect on parameters...

link.springer.com

DHT doesn’t cause prostate cancer​

For many decades it was thought that DHT promotes prostate cancer. However that thinking is luckily starting to change. It’s about time, since there has been a lot of research in the last two decades showing that DHT doesn’t promote prostate cancer.

There isn’t a correlation between circulating DHT and intraprostatic DHT. The prostate regulates it’s own DHT levels, which is about 10 times higher than circulation.

Giving testosterone might cause issues, since it can convert to estrogen, but giving DHT directly could actually help shrinking the prostate as it can lower estrogen. Estrogen and Prolactin are the driving causes that promote prostate cancer.

A few studies (1, 2, 3)found that supraphysiological amounts of serum DHT levels and DHT gel treatment didn't significantly increase total, central or peripheral prostate volumes, as measured by ultrasonography, nor was serum prostate-specific antigen (PSA) elevated. Additionally, International Prostate Symptom Scores (IPSS) remained unchanged in men treated with DHT gel for 6-24 months.

This 1.8 year old survey of 37 men aged between 55-70 years treated with daily percutaneous DHT suggested that high plasma levels of DHT (> 8.5 nmol/l) effectively inducing clinical benefits while slightly but significantly reducing prostate size.

DHT isn’t the bad guy when it comes to hair loss​

Hair loss and prostate cancer are two of the main reasons why people want to lower their DHT.

DHT is needed for beard growth, but it’s thought that DHT promotes scalp hair loss.

Take a look at this reference:

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels - PMC

Benefits associated with lowered serum DHT levels after 5α-reductase inhibitor (5AR-I) therapy in men have contributed to a misconception that circulating DHT levels are an important stimulus for androgenic action in target tissues (e.g., prostate). ...

pmc.ncbi.nlm.nih.gov

The claim above is supported by the fact that men who are exposed to exceptionally high levels of DHT in response to the daily application of DHT for a long period of time didn’t experience acne, male androgenic alopecia or other androgen-associated skin pathology.

Furthermore, the differences in mean values of DHT were not significant according to the types of alopecia and the control group. And increased serum concentrations of DHT is not correlated with the advance of alopecia. This study speculates that hair loss severity is affected by factors other than DHT, such as the duration of alopecia or the sensitivity of hair follicle cells to androgens.

Some people with hair loss have high DHT and others don’t. Some with high DHT have normal hair whereas others don’t.

https://www.researchgate.net/publication/328980562_A_New_Approach_to_Hair_Loss_Management_without_DHT_Blockers

So what’s going on with hairloss, if it’s not DHT?

You also might be wondering: “If DHT is not involved, why does 5-AR inhibitors work?“

This study found that although 5α-reductase inhibitors are effective in treating male androgenic alopecia, DHT does not appear to play a primary role in the pathogenesis of male androgenic alopecia or acne.

Reasons for hair loss are:

1. Androgen receptor polymorphism and differences in androgen receptor concentrations and steroid-converting enzymes as the principal contributors to male androgenic alopecia
2. An initial experimental study by Eun discovered that DHT does not directly cause inhibition of hair growth but it induces the release of transforming growth factor beta 1 (TGFß1) which results in the miniaturization and hair loss.

Controlled clinical trial for evaluation of hair growth with low dose cyclical nutrition therapy in men and women without the use of finasteride

Aim: To evaluate possible results with the stimulation use of minoxidil and the strengthening of hair roots with nutritional cyclical supplements, resulting in increased hair regrowth, without the use of anti androgens and enzyme blockers.Methods: This prospective controlled clinical trial...

www.oaepublish.com

Shin et al followed this research further with cultured androgen sensitive dermal papilla cells and the addition of DHT to this androgen sensitive cell caused an accumulation of free radicles ROS within the cultured cells, which in turn induced the release of TGFß1.”

So a better approach than lowering DHT is to:

• Positively modulate the skin microbiome (think sunlight, micronutrients, clean environment, etc.)
• Inhibit excess ROS production
• Prevent excess activation of TGFß1
• Reduce stress

There are many more reasons for hair loss, but I won’t be diving into that in this article.

DHT for metabolic syndrome​

Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke and diabetes. Metabolic syndrome includes high blood pressure, high blood sugar, excess body fat around the waist and abnormal cholesterol levels. The syndrome increases a person’s risk of heart attack and stroke.

Insulin sensitivity​

This randomized, controlled, double-blind trial provides evidence that DHT specifically (and to a much lesser extent, testosterone), improves insulin sensitivity and decreases plasma leptin level without notable side effects

Testosterone treatment caused prostatic nodular hyperplasia, benign at biopsy, whereas DHT didn’t.

Androgens, especially DHT, upregulate insulin receptor expression and activity and increase glycogen synthesis and cholesterol uptake in the liver.

Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm - PMC

5α-dihydrotestosterone (5α-DHT) is the most potent natural androgen. 5α-DHT elicits a multitude of physiological actions, in a host of tissues, including prostate, seminal vesicles, hair follicles, skin, kidney, and lacrimal and meibomian glands. ...

pmc.ncbi.nlm.nih.gov

Low DHT or lowering DHT with a 5AR inhibitor, such as Finasteride or Dutasteride, is associated with an increase in blood glucose and glycosylated hemoglobin A as well as the risk of type 2 diabetes. Studies: 1, 2, 3

5AR is necessary to inactivate cortisol, so blocking 5AR increases cortisol, which promotes insulin resistance and liver disorders, such as NAFLD, steatosis, etc. Studies: 1, 2

Heart, liver and kidney function​

DHT therapy in men with coronary artery disease (CAD) decreased myocardial ischemia and improved left ventricular diastolic function.

This in vitro study found:


The findings above could explain some of the previously described clinical observations of the relationship between low T and DHT and peripheral vascular disease and the anti-ischemic effects of acute infusion of testosterone in men with CAD and similar effects by DHT gel treatment.

A few more facts:

• 5AR inhibition may result in the development of kidney dysfunction.
• Dutasteride, a 5AR inhibitor, treatment increased activities of liver alanine aminotransferase and aspartate aminotransferase, suggesting dysregulation of liver metabolism.
• DHT is a biomarker for reduced risk of stroke, which means that DHT is inversely correlated with stroke
• Higher DHT was associated with lower ischemic heart disease mortality in older men

Vascular function​

Blood pressure

• DHT increases the synthesis of nitric oxide through eNOS phosphorylation thus improving circulation and vascularity (R).

The following in vitro study shows that DHT has anti-inflammatory and protective effects in the vascular system:


Cholesterol

DHT:

• Reduces lipid accumulation and cholesterol synthesis via increasing expression of carnitine palmitotyltransferase1 (CPT-1) and phosphorylation of 3-hydroxy-3-methyl-glutaryl-CoA reductase
• Inhibits ox-LDL–induced foam cell formation and atherosclerosis
• DHT administration for up to 2 years in normal men, didn’t cause any thrombotic events or detrimental shifts in total cholesterol, HDL and LDL cholesterol, or triglycerides. Nor were exceptionally high levels of DHT associated with a change in right carotid intima-media thickening
• Inhibiting 5AR with dutasteride resulted in increased total cholesterol, and low-density lipoprotein cholesterol levels

Georgi (Haidut) posted a while ago:

Lowering DHT synthesis causes severe hypothyroidism, despite higher T levels – To Extract Knowledge from Matter

Mitochondrial function and energy production​

Androgens, especially DHT:

• Stimulate lipolysis and down-regulates lipoprotein lipase activity and increases the expression of fatty acid-binding protein leading to an increase in fatty acid oxidation and in oxidative phosphorylation.
• Increase the expression of pyruvate dehydrogenase, which increases the production of oxaloacetate and acetyl-CoA leading to a stimulation of the tricarboxylic acid (TCA) cycle.
• Increase the expression of succinate dehydrogenase and aconitase, also upregulating TCA and increasing oxidative phosphorylation.
• Increase the expression of cytochrome c oxidase, which leads to an increase in oxidative phosphorylation. The increase in oxidative phosphorylation leads to a decrease in reactive oxygen species and an increase in insulin sensitivity

Fat loss​

DHT:

• Inhibits preadipocyte proliferation and adipocyte differentiation, which prevents the excess formation of fat cells
• Stimulates lipolysis
• Stimulates lipid disposal
• Downregulates lipogenesis, which reduces the conversion of carbs to fat
• Prevents the downregulation of the leptin receptor

Gynecomastia

Gyno is known to be due to high estrogen and prolactin and low DHT and DHT treatment can reverse it.

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels - PMC

Benefits associated with lowered serum DHT levels after 5α-reductase inhibitor (5AR-I) therapy in men have contributed to a misconception that circulating DHT levels are an important stimulus for androgenic action in target tissues (e.g., prostate). ...

pmc.ncbi.nlm.nih.gov

Fun fact: One of the most known treatment of gynocomastia isn’t a SERM but transdermal DHT.

Brain & cognition

• DHT promotes stress resiliency. Blocking 5AR enhances cortisol release during stress, whereas DHT blunts it, most likely through CRH suppression.
• DHT promote insane memory.
• DHT protects against neurodegeneration, by antagonizing TGF beta.

Studies: 1, 2, 3, 4

In this case study someone with a demyelinating disease (Charcot-Marie-Toot 1) was able to induce neuroregeneration with 20mg/day of Anavar (Oxandrolone).

Lastly:


DHT is needed for blood flow

Lower T or DHT levels, but not E2, is associated with symptoms of intermittent claudication in older men.

Bone

High doses of DHT can completely shut down LH and testosterone production and cause a major drop in estrogen. This might be a concern for some people because it’s mainly estrogen that’s been thought to be beneficial for bone, however, there is evidence that estrogen isn’t needed for bone strength/growth.

Finasteride increases the risk of fractures, which indicates that it weakens muscle strength and bone quality.

Eyes

DHT is needed to keep the eyes moist and prevent dry eyes. 5AR inhibition may result in the development of dry eye disease.

Androgen deficiency produces pathophysiological changes manifested in the reduction of tear production and evaporative dry eye conditions.

Suppression

DHT doesn’t have a suppressive effect on testicular steroidogenesis, similar to estrogen. DHT actually suppresses testicular aromatase. DHT inhibits steroidogenesis on a hypothalamic level, and doesn’t affect LH secretion at a pituitary level.

Anabolism/Catabolism

DHT isn’t very anabolic, however, DHT derivatives, such as Anavar or Masteron are much more anabolic than DHT, and this is partly due to much slower clearance through the liver.

Apart from it not being very anabolic, DHT is anti-catabolic. This study found that people who experience muscle wasting from AIDS, retained more muscle mass if their DHT was normal, compared to those with low DHT.

Low dihydrotestosterone and weight loss in the AIDS wasting syndrome - PubMed

24 consecutive AIDS patients with wasting, and who had never received anabolic therapies, were evaluated to determine their profile of sex hormones and whether transformation of testosterone (T) to the nuclear androgen, dihydrotestosterone (DHT), was impaired. Eleven (46%) patients had normal...

pubmed.ncbi.nlm.nih.gov

Anavar, a DHT derivative, is used to preserve muscle mass in people with wasting disease and to help them add more muscle for recovery.

Even 5mg was enough to stop catabolism, whereas higher doses such as 15mg daily were needed for muscle growth in these patients.

Furthermore, DHT upregulates androgen receptors.

Serotonin excess and cancer

DHT downregulates tryptophan hydroxylase 1 (TPH1; the rate-limited enzyme in serotonin synthesis in the body), thus protecting against the formation of tumors. Serotonin is also potent inflammatory and causes vasoconstriction, so DHT protects against that as well.

This is why DHT is an essential hormone for the human body and why the use of 5AR's should be refrained from.

Other cool studies:

• PMID: 20927745
• PMID: 29224108
• PMID: 32869255
• PMID: 30206635
• PMID: 30905792
• PMID: 34479019
• PMID: 33814544
• PMID: 30863034
• PMID: 34741573
• PMID: 37697052

All credits to @20/04/2008, he did all of the research for this work.

Hopefully all our frends
@NZb6Air @4lt.Real @Bars @chudlite @Gaygymmaxx @Gengar @lestoa @sub5incel125 @thebuffdon690 @wastedspermcel @yayatourer @MA_ascender

@CoreSchizo @klimo @Chintuck22 @heyheyheybro22 @SecularIslamist @looksmaxxing223 @NorwoodAscender @elemanzelvadre @shia.jihadist @Sapieeen

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Average finasteride/dutasteride user who claims he has no side

@halloweed

 

[Deleted member 77820]

Me and halloweed will rape they buthole

@halloweed Do we rape Outerz14 ???

 

[halloweed]

@halloweed Do we rape Outerz14 ???

@Outerz14 is yet to provide something useful to the forum

 

[halloweed]

DHT is an essential male hormone, not just for libido or feeling manly, but for health as a whole. This guide will cover all aspects of the importance of the hormone DHT for the human body.

DHT is synthesized from:

• Testosterone through the enzyme 5 alpha reductase (5AR)
• 17-hydroxypregnenolone and 17-hydroxyprogesterone via the “backdoor” pathway
• 5α-androstane-3α, 17-β-diol (dihydroandrosterone/3α-diol) through the intracrine reverse synthesis pathway involving 3α-hydroxysteroid dehydrogenase (3α-HSD)

DHT is 2.5-10 times more potent than testosterone and here’s why:

1. DHT has 4 times higher affinity to androgen receptors (AR) than Testosterone
2. Binding of DHT to the AR transforms the AR into it's DNA-binding state
3. DHT upregulates AR synthesis and reduces AR turnover
4. The dissociation rate of testosterone from it's receptors is 3-5 times faster than that of DHT (meaning DHT exerts a much more powerful effect on AR than testosterone)

However, circulating DHT is usually only about 10% or less that of testosterone and high concentrations of intracellular T can shift androgen receptor binding away from DHT by mass action

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels

Circulating levels of DHT in response to testosterone replacement therapy (TRT) do not correlate with those found in androgen sensitive tissue due to homeo

academic.oup.com

In the blood SHBG binds with 5 times higher affinity and for more than 3 times longer to DHT compared to testosterone.

To maximize the androgenic benefits of DHT we have to maximize 5AR and inhibit the binding of DHT to SHBG.

This article presents you what happens when men have high DHT or supraphysiological amounts of it.

---

DHT is essential for libido and sexual function​

It’s probably well known that DHT is very important when it comes to libido and sexual function.

According to this study, serum DHT concentration was the only independent hormonal predictor of the frequency of orgasms. An increase in concentration of 1.36 nmol/l corresponded to an average increase of one orgasm a week.

This shows that DHT directly opposes the anti-libido effects of prolactin.

Inhibiting DHT synthesis impairs corpus cavernosum growth and trabecular smooth muscle relaxation, endothelial function and increases connective tissue deposition. This all contributes to erectile dysfunction, even in the presence of physiological levels of total testosterone.

DHT is also critical for activating gene expression of neuronal and endothelial nitric oxide synthases, which are critical physiological mediators of penile erection.

Furthermore, DHT is also essential for spermatogenesis and thus fertility.

Estrogen is thought to be essential for sexual function in men. However, administrating high doses of DHT lowers estrogen dramatically and doesn’t reduce sexual function.

DHT isn’t just neutral towards sexual function as shown below, but is essential for it.

https://www.tandfonline.com/doi/abs/10.1080/13685530400016672

Human male sexual functions do not require aromatization of testosterone: A study using tamoxifen, testolactone, and dihydrotestosterone - Archives of Sexual Behavior

This study was designed to examine whether testosterone needs to be converted to estradiol in order to exert fully its effects on sexuality in the human male. Administration of the estrogen receptor antagonist tamoxifen and the aromatase inhibitor testolactone were without effect on parameters...

link.springer.com

DHT doesn’t cause prostate cancer​

For many decades it was thought that DHT promotes prostate cancer. However that thinking is luckily starting to change. It’s about time, since there has been a lot of research in the last two decades showing that DHT doesn’t promote prostate cancer.

There isn’t a correlation between circulating DHT and intraprostatic DHT. The prostate regulates it’s own DHT levels, which is about 10 times higher than circulation.

Giving testosterone might cause issues, since it can convert to estrogen, but giving DHT directly could actually help shrinking the prostate as it can lower estrogen. Estrogen and Prolactin are the driving causes that promote prostate cancer.

A few studies (1, 2, 3)found that supraphysiological amounts of serum DHT levels and DHT gel treatment didn't significantly increase total, central or peripheral prostate volumes, as measured by ultrasonography, nor was serum prostate-specific antigen (PSA) elevated. Additionally, International Prostate Symptom Scores (IPSS) remained unchanged in men treated with DHT gel for 6-24 months.

This 1.8 year old survey of 37 men aged between 55-70 years treated with daily percutaneous DHT suggested that high plasma levels of DHT (> 8.5 nmol/l) effectively inducing clinical benefits while slightly but significantly reducing prostate size.

DHT isn’t the bad guy when it comes to hair loss​

Hair loss and prostate cancer are two of the main reasons why people want to lower their DHT.

DHT is needed for beard growth, but it’s thought that DHT promotes scalp hair loss.

Take a look at this reference:

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels - PMC

Benefits associated with lowered serum DHT levels after 5α-reductase inhibitor (5AR-I) therapy in men have contributed to a misconception that circulating DHT levels are an important stimulus for androgenic action in target tissues (e.g., prostate). ...

pmc.ncbi.nlm.nih.gov

The claim above is supported by the fact that men who are exposed to exceptionally high levels of DHT in response to the daily application of DHT for a long period of time didn’t experience acne, male androgenic alopecia or other androgen-associated skin pathology.

Furthermore, the differences in mean values of DHT were not significant according to the types of alopecia and the control group. And increased serum concentrations of DHT is not correlated with the advance of alopecia. This study speculates that hair loss severity is affected by factors other than DHT, such as the duration of alopecia or the sensitivity of hair follicle cells to androgens.

Some people with hair loss have high DHT and others don’t. Some with high DHT have normal hair whereas others don’t.

https://www.researchgate.net/publication/328980562_A_New_Approach_to_Hair_Loss_Management_without_DHT_Blockers

So what’s going on with hairloss, if it’s not DHT?

You also might be wondering: “If DHT is not involved, why does 5-AR inhibitors work?“

This study found that although 5α-reductase inhibitors are effective in treating male androgenic alopecia, DHT does not appear to play a primary role in the pathogenesis of male androgenic alopecia or acne.

Reasons for hair loss are:

1. Androgen receptor polymorphism and differences in androgen receptor concentrations and steroid-converting enzymes as the principal contributors to male androgenic alopecia
2. An initial experimental study by Eun discovered that DHT does not directly cause inhibition of hair growth but it induces the release of transforming growth factor beta 1 (TGFß1) which results in the miniaturization and hair loss.

Controlled clinical trial for evaluation of hair growth with low dose cyclical nutrition therapy in men and women without the use of finasteride

Aim: To evaluate possible results with the stimulation use of minoxidil and the strengthening of hair roots with nutritional cyclical supplements, resulting in increased hair regrowth, without the use of anti androgens and enzyme blockers.Methods: This prospective controlled clinical trial...

www.oaepublish.com

Shin et al followed this research further with cultured androgen sensitive dermal papilla cells and the addition of DHT to this androgen sensitive cell caused an accumulation of free radicles ROS within the cultured cells, which in turn induced the release of TGFß1.”

So a better approach than lowering DHT is to:

• Positively modulate the skin microbiome (think sunlight, micronutrients, clean environment, etc.)
• Inhibit excess ROS production
• Prevent excess activation of TGFß1
• Reduce stress

There are many more reasons for hair loss, but I won’t be diving into that in this article.

DHT for metabolic syndrome​

Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke and diabetes. Metabolic syndrome includes high blood pressure, high blood sugar, excess body fat around the waist and abnormal cholesterol levels. The syndrome increases a person’s risk of heart attack and stroke.

Insulin sensitivity​

This randomized, controlled, double-blind trial provides evidence that DHT specifically (and to a much lesser extent, testosterone), improves insulin sensitivity and decreases plasma leptin level without notable side effects

Testosterone treatment caused prostatic nodular hyperplasia, benign at biopsy, whereas DHT didn’t.

Androgens, especially DHT, upregulate insulin receptor expression and activity and increase glycogen synthesis and cholesterol uptake in the liver.

Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm - PMC

5α-dihydrotestosterone (5α-DHT) is the most potent natural androgen. 5α-DHT elicits a multitude of physiological actions, in a host of tissues, including prostate, seminal vesicles, hair follicles, skin, kidney, and lacrimal and meibomian glands. ...

pmc.ncbi.nlm.nih.gov

Low DHT or lowering DHT with a 5AR inhibitor, such as Finasteride or Dutasteride, is associated with an increase in blood glucose and glycosylated hemoglobin A as well as the risk of type 2 diabetes. Studies: 1, 2, 3

5AR is necessary to inactivate cortisol, so blocking 5AR increases cortisol, which promotes insulin resistance and liver disorders, such as NAFLD, steatosis, etc. Studies: 1, 2

Heart, liver and kidney function​

DHT therapy in men with coronary artery disease (CAD) decreased myocardial ischemia and improved left ventricular diastolic function.

This in vitro study found:


The findings above could explain some of the previously described clinical observations of the relationship between low T and DHT and peripheral vascular disease and the anti-ischemic effects of acute infusion of testosterone in men with CAD and similar effects by DHT gel treatment.

A few more facts:

• 5AR inhibition may result in the development of kidney dysfunction.
• Dutasteride, a 5AR inhibitor, treatment increased activities of liver alanine aminotransferase and aspartate aminotransferase, suggesting dysregulation of liver metabolism.
• DHT is a biomarker for reduced risk of stroke, which means that DHT is inversely correlated with stroke
• Higher DHT was associated with lower ischemic heart disease mortality in older men

Vascular function​

Blood pressure

• DHT increases the synthesis of nitric oxide through eNOS phosphorylation thus improving circulation and vascularity (R).

The following in vitro study shows that DHT has anti-inflammatory and protective effects in the vascular system:


Cholesterol

DHT:

• Reduces lipid accumulation and cholesterol synthesis via increasing expression of carnitine palmitotyltransferase1 (CPT-1) and phosphorylation of 3-hydroxy-3-methyl-glutaryl-CoA reductase
• Inhibits ox-LDL–induced foam cell formation and atherosclerosis
• DHT administration for up to 2 years in normal men, didn’t cause any thrombotic events or detrimental shifts in total cholesterol, HDL and LDL cholesterol, or triglycerides. Nor were exceptionally high levels of DHT associated with a change in right carotid intima-media thickening
• Inhibiting 5AR with dutasteride resulted in increased total cholesterol, and low-density lipoprotein cholesterol levels

Georgi (Haidut) posted a while ago:

Lowering DHT synthesis causes severe hypothyroidism, despite higher T levels – To Extract Knowledge from Matter

Mitochondrial function and energy production​

Androgens, especially DHT:

• Stimulate lipolysis and down-regulates lipoprotein lipase activity and increases the expression of fatty acid-binding protein leading to an increase in fatty acid oxidation and in oxidative phosphorylation.
• Increase the expression of pyruvate dehydrogenase, which increases the production of oxaloacetate and acetyl-CoA leading to a stimulation of the tricarboxylic acid (TCA) cycle.
• Increase the expression of succinate dehydrogenase and aconitase, also upregulating TCA and increasing oxidative phosphorylation.
• Increase the expression of cytochrome c oxidase, which leads to an increase in oxidative phosphorylation. The increase in oxidative phosphorylation leads to a decrease in reactive oxygen species and an increase in insulin sensitivity

Fat loss​

DHT:

• Inhibits preadipocyte proliferation and adipocyte differentiation, which prevents the excess formation of fat cells
• Stimulates lipolysis
• Stimulates lipid disposal
• Downregulates lipogenesis, which reduces the conversion of carbs to fat
• Prevents the downregulation of the leptin receptor

Gynecomastia

Gyno is known to be due to high estrogen and prolactin and low DHT and DHT treatment can reverse it.

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels - PMC

Benefits associated with lowered serum DHT levels after 5α-reductase inhibitor (5AR-I) therapy in men have contributed to a misconception that circulating DHT levels are an important stimulus for androgenic action in target tissues (e.g., prostate). ...

pmc.ncbi.nlm.nih.gov

Fun fact: One of the most known treatment of gynocomastia isn’t a SERM but transdermal DHT.

Brain & cognition

• DHT promotes stress resiliency. Blocking 5AR enhances cortisol release during stress, whereas DHT blunts it, most likely through CRH suppression.
• DHT promote insane memory.
• DHT protects against neurodegeneration, by antagonizing TGF beta.

Studies: 1, 2, 3, 4

In this case study someone with a demyelinating disease (Charcot-Marie-Toot 1) was able to induce neuroregeneration with 20mg/day of Anavar (Oxandrolone).

Lastly:


DHT is needed for blood flow

Lower T or DHT levels, but not E2, is associated with symptoms of intermittent claudication in older men.

Bone

High doses of DHT can completely shut down LH and testosterone production and cause a major drop in estrogen. This might be a concern for some people because it’s mainly estrogen that’s been thought to be beneficial for bone, however, there is evidence that estrogen isn’t needed for bone strength/growth.

Finasteride increases the risk of fractures, which indicates that it weakens muscle strength and bone quality.

Eyes

DHT is needed to keep the eyes moist and prevent dry eyes. 5AR inhibition may result in the development of dry eye disease.

Androgen deficiency produces pathophysiological changes manifested in the reduction of tear production and evaporative dry eye conditions.

Suppression

DHT doesn’t have a suppressive effect on testicular steroidogenesis, similar to estrogen. DHT actually suppresses testicular aromatase. DHT inhibits steroidogenesis on a hypothalamic level, and doesn’t affect LH secretion at a pituitary level.

Anabolism/Catabolism

DHT isn’t very anabolic, however, DHT derivatives, such as Anavar or Masteron are much more anabolic than DHT, and this is partly due to much slower clearance through the liver.

Apart from it not being very anabolic, DHT is anti-catabolic. This study found that people who experience muscle wasting from AIDS, retained more muscle mass if their DHT was normal, compared to those with low DHT.

Low dihydrotestosterone and weight loss in the AIDS wasting syndrome - PubMed

24 consecutive AIDS patients with wasting, and who had never received anabolic therapies, were evaluated to determine their profile of sex hormones and whether transformation of testosterone (T) to the nuclear androgen, dihydrotestosterone (DHT), was impaired. Eleven (46%) patients had normal...

pubmed.ncbi.nlm.nih.gov

Anavar, a DHT derivative, is used to preserve muscle mass in people with wasting disease and to help them add more muscle for recovery.

Even 5mg was enough to stop catabolism, whereas higher doses such as 15mg daily were needed for muscle growth in these patients.

Furthermore, DHT upregulates androgen receptors.

Serotonin excess and cancer

DHT downregulates tryptophan hydroxylase 1 (TPH1; the rate-limited enzyme in serotonin synthesis in the body), thus protecting against the formation of tumors. Serotonin is also potent inflammatory and causes vasoconstriction, so DHT protects against that as well.

This is why DHT is an essential hormone for the human body and why the use of 5AR's should be refrained from.

Other cool studies:

• PMID: 20927745
• PMID: 29224108
• PMID: 32869255
• PMID: 30206635
• PMID: 30905792
• PMID: 34479019
• PMID: 33814544
• PMID: 30863034
• PMID: 34741573
• PMID: 37697052

All credits to @20/04/2008, he did all of the research for this work.

Hopefully all our frends
@NZb6Air @4lt.Real @Bars @chudlite @Gaygymmaxx @Gengar @lestoa @sub5incel125 @thebuffdon690 @wastedspermcel @yayatourer @MA_ascender

@CoreSchizo @klimo @Chintuck22 @heyheyheybro22 @SecularIslamist @looksmaxxing223 @NorwoodAscender @elemanzelvadre @shia.jihadist @Sapieeen

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Average finasteride/dutasteride user who claims he has no side

@20/04/2008 one of the best threads this year
I didn’t even know DHT has an inverse relationship with stroke, running this alongside testosterone should reduce the side effects of the high RBC hence why my blood pressure is normal etc.
I didn’t know it also kept lipids in range so there’s no need for a statin depending which compounds you are running and dosages.

However, for the hair loss you need to decrease androgen sensitivity in the scalp if you want to increase hair growth while you’re DHT levels are super physiological because this obviously shortens the hair growth cycle and will lead to androgenic alopecia and MPB if you are genetically predisposed to it. The estrogen cream is probably for hair regeneration purposes but you need to block one of the main root causes which is DHT in the scalp. Blocking this hormone throughout your body is undeniably stupid. Whether you believe in a god or evolution there is a reason this is still in your body. It’s only until now that faggots have started to nuke this hormone.

 

[Deleted member 77820]

@20/04/2008 one of the best threads this year
I didn’t even know DHT has an inverse relationship with stroke, running this alongside testosterone should reduce the side effects of the high RBC hence why my blood pressure is normal etc.
I didn’t know it also kept lipids in range so there’s no need for a statin depending which compounds you are running and dosages.

However, for the hair loss you need to decrease androgen sensitivity in the scalp if you want to increase hair growth while you’re DHT levels are super physiological because this obviously shortens the hair growth cycle and will lead to androgenic alopecia and MPB if you are genetically predisposed to it. The estrogen cream is probably for hair regeneration purposes but you need to block one of the main root causes which is DHT in the scalp. Blocking this hormone throughout your body is undeniably stupid. Whether you believe in a god or evolution there is a reason this is still in your body. It’s only until now that faggots have started to nuke this hormone.

It only cause hairloss through 1 pathway unless your have 100 grams ++ of dht in your blood daily you wouldn’t have hairloss
The problem is a lot of people think dht is the only driver of hairloss and that retarded its a contributer
Low estrogen is the main thing not dht for god sake one day someone would point that out gain so much money and credit
And I’ll be a forgotten genius in an incel forum

 

[DR. NICKGA]

It only cause hairloss through 1 pathway unless your have 100 grams ++ of dht in your blood daily you wouldn’t have hairloss
The problem is a lot of people think dht is the only driver of hairloss and that retarded its a contributer
Low estrogen is the main thing not dht for god sake one day someone would point that out gain so much money and credit
And I’ll be a forgotten genius in an incel forum

That low estrogen causing male pattern baldness
That idea , you pulled that literaly in from you ass fucking tard

 

[Deleted member 83600]

@Outerz14 is yet to provide something useful to the forum

Jfl o forgot about this forum

 

[halloweed]

Jfl o forgot about this forum

Same im back after 2 wk

 

[Deleted member 83600]

Same im back after 2 wk

Bro I just put cannabis wax oil in some eggs I may get faded

 

[halloweed]

Bro I just put cannabis wax oil in some eggs I may get faded

Doubt that happened bud

 

[Deleted member 83600]

Doubt that happened bud

Yo hallo how do you like get away with smoking loud from your parents and stuff

 

[halloweed]

Yo hallo how do you like get away with smoking loud from your parents and stuff

I don’t smoke often because of the risks now im doing roids but if I do I do it with my friends

 

[Deleted member 83600]

I don’t smoke often because of the risks now im doing roids but if I do I do it with my friends

I smoke weed outside my window and my mum said "are you smoking" how

 

[halloweed]

I smoke weed outside my window and my mum said "are you smoking" how

AHAHAHAHAHAHAHASS