The Obsession about blocking DHT should end

[Outerz14]

Doubt that happened bud

Yo hallo how do you like get away with smoking loud from your parents and stuff

 

[halloweed]

Yo hallo how do you like get away with smoking loud from your parents and stuff

I don’t smoke often because of the risks now im doing roids but if I do I do it with my friends

 

[Outerz14]

I don’t smoke often because of the risks now im doing roids but if I do I do it with my friends

I smoke weed outside my window and my mum said "are you smoking" how

 

[halloweed]

I smoke weed outside my window and my mum said "are you smoking" how

AHAHAHAHAHAHAHASS

 

[Outerz14]

AHAHAHAHAHAHAHASS

Fuck this mawn how bro

 

[halloweed]

Fuck this mawn how bro

She got the bumbaclaat whip?

 

[Outerz14]

She got the bumbaclaat whip?

Smart whip fam

 

[halloweed]

Smart whip fam

How does being black feel in 2024

 

[Jonas2k7]

How does being black feel in 2024

 

[halloweed]

View attachment 3287508

Manipulate your pituitary gland by making the mind think there is no testosterone in the body.

 

[Jonas2k7]

Manipulate your pituitary gland by making the mind think there is no testosterone in the body.

Just block testosterone in the hypothalamus and pituitary gland bro so that the testosterone can't agonize the AR there so no negative feedback loop exists anymore that way more GnRH is produced

GnRH is life

 

[halloweed]

Just block testosterone in the hypothalamus and pituitary gland bro so that the testosterone can't agonize the AR there so no negative feedback loop exists anymore that way more GnRH is produced

GnRH is life

Just inject testosterone

 

[Jonas2k7]

Just inject testosterone

Kisspeptin-10 could mog tho

 

[halloweed]

Kisspeptin-10 could mog tho

NOPE HAHAHAHAHAHAAHHAAHHAHAHAHAH
It’s better for dodging side effects though
But will not get you 5000ng/dl

 

[Jonas2k7]

NOPE HAHAHAHAHAHAAHHAAHHAHAHAHAH
It’s better for dodging side effects though
But will not get you 5000ng/dl

Genetics are so mean nigga

Why can't some genes just tell my HPA-axis to produce constantly over 5000ng/dl of test

 

[halloweed]

Genetics are so mean nigga

Why can't some genes just tell my HPA-axis to produce constantly over 5000ng/dl of test

You’ll be dead at age 9 from a heart attack while playing football due to atherosclerosis.

 

[Jonas2k7]

You’ll be dead at age 9 from a heart attack while playing football due to atherosclerosis.

I could drink some NW (those who know) to counteract this side effect

 

[20/04/2008]

@Bitchwhipper2

 

[Bitchwhipper2]

@Bitchwhipper2

Basicly is it boils down to this. .

Positively modulate the skin microbiome (think sunlight, micronutrients, clean environment, etc.)
Inhibit excess ROS production
Prevent excess activation of TGFß1
Reduce stress

But theres no live studies to back this up. Its all speculation
What we do have legit studies on is blocking DHT and it works good as fuck.

But sure I encourage people to try this, even though im 99% sure its cope. Because all research is beneficial

 

[20/04/2008]

Basicly is it boils down to this. .

Positively modulate the skin microbiome (think sunlight, micronutrients, clean environment, etc.)
Inhibit excess ROS production
Prevent excess activation of TGFß1
Reduce stress

But theres no live studies to back this up. Its all speculation
What we do have legit studies on is blocking DHT and it works good as fuck.

But sure I encourage people to try this, even though im 99% sure its cope. Because all research is beneficial

Read the studies nigga their are like a 100 in this thread
I am 100% sure this is the truth
Their is some oher shit I’m gatekeeping ”FOR NOW”

 

[Bitchwhipper2]

Read the studies nigga their are like a 100 in this thread
I am 100% sure this is the truth
Their is some oher shit I’m gatekeeping ”FOR NOW”

0 studies with living people involved where they are testing any of his proposed alternative solutions.

Its a reasonable hypothesis at best

 

[übermog]

Kisspeptin-10 could mog tho

what do you know about kp10, ive got it in my fridge

 

[PTOSIS]

Me and my dutasteride didn't read this thread

 

[Jonas2k7]

what do you know about kp10, ive got it in my fridge

Increases GnRH

 

[übermog]

Increases GnRH

yeah no shit thats why i bought it but theres zero information on it

 

[GreekGenes]

Yes please don't block Dht so you can become a volbaldie

 

[halloweed]

Yes please don't block Dht so you can become a volbaldie

 

[Jonas2k7]

View attachment 3321594

 

[PTOSIS]

View attachment 3321594

Chico and O'pry are both on it lol. O'pry said he started fin at 27 and he still has all of his hair in his mid 30s.

 

[mogtivism]

Op wants you to be a bald subhuman who can’t piss without popping a blood vessel

@androgenic nukes his DHT and looks more like a man than u can ever dream of

Hair is life. Imagine DHTcoping and DHTmaxxing so your browridge gets 0.0000000001% bigger( it doesn’t). Like yay!! You look more androgenic, but at what cost? Skin done goes to shit, so does hair

 

[mogtivism]

Yes guys , while 10000+ researchers tried to find the solution (which they did), this guy @noodlelover found the solution true solution to baldness!!

Its sun light + ofcourse biotin , collagen supplementation , thank you @noodlelover

It’s like the retards who claim it’s all bloodflow and tell balding guys to rub essential oils into their scalp instead of just getting on proven, functional, medication with low instances of side effects!

Alternative fitness/medicine/diet advice is mostly crap.

The alternative diet guys will have you eating raw meat drinking raw milk for free parasites(yay!) and avoiding carbs till you feel tired asf.

The alternative hair loss medication shills will have you rubbing essential oils and using electric wands JFL till you finally at NW7 crying how you were fleeced.

The alternative fitness guys will have you doing starting strength and bloatmaxxing into a 300lb whale with 12 inch arms yet a 240lb bench.


So silly.

 

[jefty]

DHT is an essential male hormone, not just for libido or feeling manly, but for health as a whole. This guide will cover all aspects of the importance of the hormone DHT for the human body.

DHT is synthesized from:

• Testosterone through the enzyme 5 alpha reductase (5AR)
• 17-hydroxypregnenolone and 17-hydroxyprogesterone via the “backdoor” pathway
• 5α-androstane-3α, 17-β-diol (dihydroandrosterone/3α-diol) through the intracrine reverse synthesis pathway involving 3α-hydroxysteroid dehydrogenase (3α-HSD)

DHT is 2.5-10 times more potent than testosterone and here’s why:

1. DHT has 4 times higher affinity to androgen receptors (AR) than Testosterone
2. Binding of DHT to the AR transforms the AR into it's DNA-binding state
3. DHT upregulates AR synthesis and reduces AR turnover
4. The dissociation rate of testosterone from it's receptors is 3-5 times faster than that of DHT (meaning DHT exerts a much more powerful effect on AR than testosterone)

However, circulating DHT is usually only about 10% or less that of testosterone and high concentrations of intracellular T can shift androgen receptor binding away from DHT by mass action

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels

Circulating levels of DHT in response to testosterone replacement therapy (TRT) do not correlate with those found in androgen sensitive tissue due to homeo

academic.oup.com

In the blood SHBG binds with 5 times higher affinity and for more than 3 times longer to DHT compared to testosterone.

To maximize the androgenic benefits of DHT we have to maximize 5AR and inhibit the binding of DHT to SHBG.

This article presents you what happens when men have high DHT or supraphysiological amounts of it.

---

DHT is essential for libido and sexual function​

It’s probably well known that DHT is very important when it comes to libido and sexual function.

According to this study, serum DHT concentration was the only independent hormonal predictor of the frequency of orgasms. An increase in concentration of 1.36 nmol/l corresponded to an average increase of one orgasm a week.

This shows that DHT directly opposes the anti-libido effects of prolactin.

Inhibiting DHT synthesis impairs corpus cavernosum growth and trabecular smooth muscle relaxation, endothelial function and increases connective tissue deposition. This all contributes to erectile dysfunction, even in the presence of physiological levels of total testosterone.

DHT is also critical for activating gene expression of neuronal and endothelial nitric oxide synthases, which are critical physiological mediators of penile erection.

Furthermore, DHT is also essential for spermatogenesis and thus fertility.

Estrogen is thought to be essential for sexual function in men. However, administrating high doses of DHT lowers estrogen dramatically and doesn’t reduce sexual function.

DHT isn’t just neutral towards sexual function as shown below, but is essential for it.

https://www.tandfonline.com/doi/abs/10.1080/13685530400016672

Human male sexual functions do not require aromatization of testosterone: A study using tamoxifen, testolactone, and dihydrotestosterone - Archives of Sexual Behavior

This study was designed to examine whether testosterone needs to be converted to estradiol in order to exert fully its effects on sexuality in the human male. Administration of the estrogen receptor antagonist tamoxifen and the aromatase inhibitor testolactone were without effect on parameters...

link.springer.com

DHT doesn’t cause prostate cancer​

For many decades it was thought that DHT promotes prostate cancer. However that thinking is luckily starting to change. It’s about time, since there has been a lot of research in the last two decades showing that DHT doesn’t promote prostate cancer.

There isn’t a correlation between circulating DHT and intraprostatic DHT. The prostate regulates it’s own DHT levels, which is about 10 times higher than circulation.

Giving testosterone might cause issues, since it can convert to estrogen, but giving DHT directly could actually help shrinking the prostate as it can lower estrogen. Estrogen and Prolactin are the driving causes that promote prostate cancer.

A few studies (1, 2, 3)found that supraphysiological amounts of serum DHT levels and DHT gel treatment didn't significantly increase total, central or peripheral prostate volumes, as measured by ultrasonography, nor was serum prostate-specific antigen (PSA) elevated. Additionally, International Prostate Symptom Scores (IPSS) remained unchanged in men treated with DHT gel for 6-24 months.

This 1.8 year old survey of 37 men aged between 55-70 years treated with daily percutaneous DHT suggested that high plasma levels of DHT (> 8.5 nmol/l) effectively inducing clinical benefits while slightly but significantly reducing prostate size.

DHT isn’t the bad guy when it comes to hair loss​

Hair loss and prostate cancer are two of the main reasons why people want to lower their DHT.

DHT is needed for beard growth, but it’s thought that DHT promotes scalp hair loss.

Take a look at this reference:

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels - PMC

Benefits associated with lowered serum DHT levels after 5α-reductase inhibitor (5AR-I) therapy in men have contributed to a misconception that circulating DHT levels are an important stimulus for androgenic action in target tissues (e.g., prostate). ...

pmc.ncbi.nlm.nih.gov

The claim above is supported by the fact that men who are exposed to exceptionally high levels of DHT in response to the daily application of DHT for a long period of time didn’t experience acne, male androgenic alopecia or other androgen-associated skin pathology.

Furthermore, the differences in mean values of DHT were not significant according to the types of alopecia and the control group. And increased serum concentrations of DHT is not correlated with the advance of alopecia. This study speculates that hair loss severity is affected by factors other than DHT, such as the duration of alopecia or the sensitivity of hair follicle cells to androgens.

Some people with hair loss have high DHT and others don’t. Some with high DHT have normal hair whereas others don’t.

https://www.researchgate.net/publication/328980562_A_New_Approach_to_Hair_Loss_Management_without_DHT_Blockers

So what’s going on with hairloss, if it’s not DHT?

You also might be wondering: “If DHT is not involved, why does 5-AR inhibitors work?“

This study found that although 5α-reductase inhibitors are effective in treating male androgenic alopecia, DHT does not appear to play a primary role in the pathogenesis of male androgenic alopecia or acne.

Reasons for hair loss are:

1. Androgen receptor polymorphism and differences in androgen receptor concentrations and steroid-converting enzymes as the principal contributors to male androgenic alopecia
2. An initial experimental study by Eun discovered that DHT does not directly cause inhibition of hair growth but it induces the release of transforming growth factor beta 1 (TGFß1) which results in the miniaturization and hair loss.

Controlled clinical trial for evaluation of hair growth with low dose cyclical nutrition therapy in men and women without the use of finasteride

Aim: To evaluate possible results with the stimulation use of minoxidil and the strengthening of hair roots with nutritional cyclical supplements, resulting in increased hair regrowth, without the use of anti androgens and enzyme blockers.Methods: This prospective controlled clinical trial...

www.oaepublish.com

Shin et al followed this research further with cultured androgen sensitive dermal papilla cells and the addition of DHT to this androgen sensitive cell caused an accumulation of free radicles ROS within the cultured cells, which in turn induced the release of TGFß1.”

So a better approach than lowering DHT is to:

• Positively modulate the skin microbiome (think sunlight, micronutrients, clean environment, etc.)
• Inhibit excess ROS production
• Prevent excess activation of TGFß1
• Reduce stress

There are many more reasons for hair loss, but I won’t be diving into that in this article.

DHT for metabolic syndrome​

Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke and diabetes. Metabolic syndrome includes high blood pressure, high blood sugar, excess body fat around the waist and abnormal cholesterol levels. The syndrome increases a person’s risk of heart attack and stroke.

Insulin sensitivity​

This randomized, controlled, double-blind trial provides evidence that DHT specifically (and to a much lesser extent, testosterone), improves insulin sensitivity and decreases plasma leptin level without notable side effects

Testosterone treatment caused prostatic nodular hyperplasia, benign at biopsy, whereas DHT didn’t.

Androgens, especially DHT, upregulate insulin receptor expression and activity and increase glycogen synthesis and cholesterol uptake in the liver.

Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm - PMC

5α-dihydrotestosterone (5α-DHT) is the most potent natural androgen. 5α-DHT elicits a multitude of physiological actions, in a host of tissues, including prostate, seminal vesicles, hair follicles, skin, kidney, and lacrimal and meibomian glands. ...

pmc.ncbi.nlm.nih.gov

Low DHT or lowering DHT with a 5AR inhibitor, such as Finasteride or Dutasteride, is associated with an increase in blood glucose and glycosylated hemoglobin A as well as the risk of type 2 diabetes. Studies: 1, 2, 3

5AR is necessary to inactivate cortisol, so blocking 5AR increases cortisol, which promotes insulin resistance and liver disorders, such as NAFLD, steatosis, etc. Studies: 1, 2

Heart, liver and kidney function​

DHT therapy in men with coronary artery disease (CAD) decreased myocardial ischemia and improved left ventricular diastolic function.

This in vitro study found:


The findings above could explain some of the previously described clinical observations of the relationship between low T and DHT and peripheral vascular disease and the anti-ischemic effects of acute infusion of testosterone in men with CAD and similar effects by DHT gel treatment.

A few more facts:

• 5AR inhibition may result in the development of kidney dysfunction.
• Dutasteride, a 5AR inhibitor, treatment increased activities of liver alanine aminotransferase and aspartate aminotransferase, suggesting dysregulation of liver metabolism.
• DHT is a biomarker for reduced risk of stroke, which means that DHT is inversely correlated with stroke
• Higher DHT was associated with lower ischemic heart disease mortality in older men

Vascular function​

Blood pressure

• DHT increases the synthesis of nitric oxide through eNOS phosphorylation thus improving circulation and vascularity (R).

The following in vitro study shows that DHT has anti-inflammatory and protective effects in the vascular system:


Cholesterol

DHT:

• Reduces lipid accumulation and cholesterol synthesis via increasing expression of carnitine palmitotyltransferase1 (CPT-1) and phosphorylation of 3-hydroxy-3-methyl-glutaryl-CoA reductase
• Inhibits ox-LDL–induced foam cell formation and atherosclerosis
• DHT administration for up to 2 years in normal men, didn’t cause any thrombotic events or detrimental shifts in total cholesterol, HDL and LDL cholesterol, or triglycerides. Nor were exceptionally high levels of DHT associated with a change in right carotid intima-media thickening
• Inhibiting 5AR with dutasteride resulted in increased total cholesterol, and low-density lipoprotein cholesterol levels

Georgi (Haidut) posted a while ago:

Lowering DHT synthesis causes severe hypothyroidism, despite higher T levels – To Extract Knowledge from Matter

Mitochondrial function and energy production​

Androgens, especially DHT:

• Stimulate lipolysis and down-regulates lipoprotein lipase activity and increases the expression of fatty acid-binding protein leading to an increase in fatty acid oxidation and in oxidative phosphorylation.
• Increase the expression of pyruvate dehydrogenase, which increases the production of oxaloacetate and acetyl-CoA leading to a stimulation of the tricarboxylic acid (TCA) cycle.
• Increase the expression of succinate dehydrogenase and aconitase, also upregulating TCA and increasing oxidative phosphorylation.
• Increase the expression of cytochrome c oxidase, which leads to an increase in oxidative phosphorylation. The increase in oxidative phosphorylation leads to a decrease in reactive oxygen species and an increase in insulin sensitivity

Fat loss​

DHT:

• Inhibits preadipocyte proliferation and adipocyte differentiation, which prevents the excess formation of fat cells
• Stimulates lipolysis
• Stimulates lipid disposal
• Downregulates lipogenesis, which reduces the conversion of carbs to fat
• Prevents the downregulation of the leptin receptor

Gynecomastia

Gyno is known to be due to high estrogen and prolactin and low DHT and DHT treatment can reverse it.

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels - PMC

Benefits associated with lowered serum DHT levels after 5α-reductase inhibitor (5AR-I) therapy in men have contributed to a misconception that circulating DHT levels are an important stimulus for androgenic action in target tissues (e.g., prostate). ...

pmc.ncbi.nlm.nih.gov

Fun fact: One of the most known treatment of gynocomastia isn’t a SERM but transdermal DHT.

Brain & cognition

• DHT promotes stress resiliency. Blocking 5AR enhances cortisol release during stress, whereas DHT blunts it, most likely through CRH suppression.
• DHT promote insane memory.
• DHT protects against neurodegeneration, by antagonizing TGF beta.

Studies: 1, 2, 3, 4

In this case study someone with a demyelinating disease (Charcot-Marie-Toot 1) was able to induce neuroregeneration with 20mg/day of Anavar (Oxandrolone).

Lastly:


DHT is needed for blood flow

Lower T or DHT levels, but not E2, is associated with symptoms of intermittent claudication in older men.

Bone

High doses of DHT can completely shut down LH and testosterone production and cause a major drop in estrogen. This might be a concern for some people because it’s mainly estrogen that’s been thought to be beneficial for bone, however, there is evidence that estrogen isn’t needed for bone strength/growth.

Finasteride increases the risk of fractures, which indicates that it weakens muscle strength and bone quality.

Eyes

DHT is needed to keep the eyes moist and prevent dry eyes. 5AR inhibition may result in the development of dry eye disease.

Androgen deficiency produces pathophysiological changes manifested in the reduction of tear production and evaporative dry eye conditions.

Suppression

DHT doesn’t have a suppressive effect on testicular steroidogenesis, similar to estrogen. DHT actually suppresses testicular aromatase. DHT inhibits steroidogenesis on a hypothalamic level, and doesn’t affect LH secretion at a pituitary level.

Anabolism/Catabolism

DHT isn’t very anabolic, however, DHT derivatives, such as Anavar or Masteron are much more anabolic than DHT, and this is partly due to much slower clearance through the liver.

Apart from it not being very anabolic, DHT is anti-catabolic. This study found that people who experience muscle wasting from AIDS, retained more muscle mass if their DHT was normal, compared to those with low DHT.

Low dihydrotestosterone and weight loss in the AIDS wasting syndrome - PubMed

24 consecutive AIDS patients with wasting, and who had never received anabolic therapies, were evaluated to determine their profile of sex hormones and whether transformation of testosterone (T) to the nuclear androgen, dihydrotestosterone (DHT), was impaired. Eleven (46%) patients had normal...

pubmed.ncbi.nlm.nih.gov

Anavar, a DHT derivative, is used to preserve muscle mass in people with wasting disease and to help them add more muscle for recovery.

Even 5mg was enough to stop catabolism, whereas higher doses such as 15mg daily were needed for muscle growth in these patients.

Furthermore, DHT upregulates androgen receptors.

Serotonin excess and cancer

DHT downregulates tryptophan hydroxylase 1 (TPH1; the rate-limited enzyme in serotonin synthesis in the body), thus protecting against the formation of tumors. Serotonin is also potent inflammatory and causes vasoconstriction, so DHT protects against that as well.

This is why DHT is an essential hormone for the human body and why the use of 5AR's should be refrained from.

Other cool studies:

• PMID: 20927745
• PMID: 29224108
• PMID: 32869255
• PMID: 30206635
• PMID: 30905792
• PMID: 34479019
• PMID: 33814544
• PMID: 30863034
• PMID: 34741573
• PMID: 37697052

All credits to @20/04/2008, he did all of the research for this work.

Hopefully all our frends
@NZb6Air @4lt.Real @Bars @chudlite @Gaygymmaxx @Gengar @lestoa @sub5incel125 @thebuffdon690 @wastedspermcel @yayatourer @MA_ascender

@CoreSchizo @klimo @Chintuck22 @heyheyheybro22 @SecularIslamist @looksmaxxing223 @NorwoodAscender @elemanzelvadre @shia.jihadist @Sapieeen

View attachment 3263029View attachment 3263030View attachment 3263031View attachment 3263032View attachment 3263033

View attachment 3263034View attachment 3263176

View attachment 3263177
Average finasteride/dutasteride user who claims he has no side

FINALLYYYYY, someone to know why we shouldn't block dht during puberty, can u help me? I dont know what to eat to increase dht

 

[jefty]

It’s like the retards who claim it’s all bloodflow and tell balding guys to rub essential oils into their scalp instead of just getting on proven, functional, medication with low instances of side effects!

Alternative fitness/medicine/diet advice is mostly crap.

The alternative diet guys will have you eating raw meat drinking raw milk for free parasites(yay!) and avoiding carbs till you feel tired asf.

The alternative hair loss medication shills will have you rubbing essential oils and using electric wands JFL till you finally at NW7 crying how you were fleeced.

The alternative fitness guys will have you doing starting strength and bloatmaxxing into a 300lb whale with 12 inch arms yet a 240lb bench.


So silly.

Then to increase dht what i have to eat?

 

[TitusA]

DHT is an essential male hormone, not just for libido or feeling manly, but for health as a whole. This guide will cover all aspects of the importance of the hormone DHT for the human body.

DHT is synthesized from:

• Testosterone through the enzyme 5 alpha reductase (5AR)
• 17-hydroxypregnenolone and 17-hydroxyprogesterone via the “backdoor” pathway
• 5α-androstane-3α, 17-β-diol (dihydroandrosterone/3α-diol) through the intracrine reverse synthesis pathway involving 3α-hydroxysteroid dehydrogenase (3α-HSD)

DHT is 2.5-10 times more potent than testosterone and here’s why:

1. DHT has 4 times higher affinity to androgen receptors (AR) than Testosterone
2. Binding of DHT to the AR transforms the AR into it's DNA-binding state
3. DHT upregulates AR synthesis and reduces AR turnover
4. The dissociation rate of testosterone from it's receptors is 3-5 times faster than that of DHT (meaning DHT exerts a much more powerful effect on AR than testosterone)

However, circulating DHT is usually only about 10% or less that of testosterone and high concentrations of intracellular T can shift androgen receptor binding away from DHT by mass action

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels

Circulating levels of DHT in response to testosterone replacement therapy (TRT) do not correlate with those found in androgen sensitive tissue due to homeo

academic.oup.com

In the blood SHBG binds with 5 times higher affinity and for more than 3 times longer to DHT compared to testosterone.

To maximize the androgenic benefits of DHT we have to maximize 5AR and inhibit the binding of DHT to SHBG.

This article presents you what happens when men have high DHT or supraphysiological amounts of it.

---

DHT is essential for libido and sexual function​

It’s probably well known that DHT is very important when it comes to libido and sexual function.

According to this study, serum DHT concentration was the only independent hormonal predictor of the frequency of orgasms. An increase in concentration of 1.36 nmol/l corresponded to an average increase of one orgasm a week.

This shows that DHT directly opposes the anti-libido effects of prolactin.

Inhibiting DHT synthesis impairs corpus cavernosum growth and trabecular smooth muscle relaxation, endothelial function and increases connective tissue deposition. This all contributes to erectile dysfunction, even in the presence of physiological levels of total testosterone.

DHT is also critical for activating gene expression of neuronal and endothelial nitric oxide synthases, which are critical physiological mediators of penile erection.

Furthermore, DHT is also essential for spermatogenesis and thus fertility.

Estrogen is thought to be essential for sexual function in men. However, administrating high doses of DHT lowers estrogen dramatically and doesn’t reduce sexual function.

DHT isn’t just neutral towards sexual function as shown below, but is essential for it.

https://www.tandfonline.com/doi/abs/10.1080/13685530400016672

Human male sexual functions do not require aromatization of testosterone: A study using tamoxifen, testolactone, and dihydrotestosterone - Archives of Sexual Behavior

This study was designed to examine whether testosterone needs to be converted to estradiol in order to exert fully its effects on sexuality in the human male. Administration of the estrogen receptor antagonist tamoxifen and the aromatase inhibitor testolactone were without effect on parameters...

link.springer.com

DHT doesn’t cause prostate cancer​

For many decades it was thought that DHT promotes prostate cancer. However that thinking is luckily starting to change. It’s about time, since there has been a lot of research in the last two decades showing that DHT doesn’t promote prostate cancer.

There isn’t a correlation between circulating DHT and intraprostatic DHT. The prostate regulates it’s own DHT levels, which is about 10 times higher than circulation.

Giving testosterone might cause issues, since it can convert to estrogen, but giving DHT directly could actually help shrinking the prostate as it can lower estrogen. Estrogen and Prolactin are the driving causes that promote prostate cancer.

A few studies (1, 2, 3)found that supraphysiological amounts of serum DHT levels and DHT gel treatment didn't significantly increase total, central or peripheral prostate volumes, as measured by ultrasonography, nor was serum prostate-specific antigen (PSA) elevated. Additionally, International Prostate Symptom Scores (IPSS) remained unchanged in men treated with DHT gel for 6-24 months.

This 1.8 year old survey of 37 men aged between 55-70 years treated with daily percutaneous DHT suggested that high plasma levels of DHT (> 8.5 nmol/l) effectively inducing clinical benefits while slightly but significantly reducing prostate size.

DHT isn’t the bad guy when it comes to hair loss​

Hair loss and prostate cancer are two of the main reasons why people want to lower their DHT.

DHT is needed for beard growth, but it’s thought that DHT promotes scalp hair loss.

Take a look at this reference:

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels - PMC

Benefits associated with lowered serum DHT levels after 5α-reductase inhibitor (5AR-I) therapy in men have contributed to a misconception that circulating DHT levels are an important stimulus for androgenic action in target tissues (e.g., prostate). ...

pmc.ncbi.nlm.nih.gov

The claim above is supported by the fact that men who are exposed to exceptionally high levels of DHT in response to the daily application of DHT for a long period of time didn’t experience acne, male androgenic alopecia or other androgen-associated skin pathology.

Furthermore, the differences in mean values of DHT were not significant according to the types of alopecia and the control group. And increased serum concentrations of DHT is not correlated with the advance of alopecia. This study speculates that hair loss severity is affected by factors other than DHT, such as the duration of alopecia or the sensitivity of hair follicle cells to androgens.

Some people with hair loss have high DHT and others don’t. Some with high DHT have normal hair whereas others don’t.

https://www.researchgate.net/publication/328980562_A_New_Approach_to_Hair_Loss_Management_without_DHT_Blockers

So what’s going on with hairloss, if it’s not DHT?

You also might be wondering: “If DHT is not involved, why does 5-AR inhibitors work?“

This study found that although 5α-reductase inhibitors are effective in treating male androgenic alopecia, DHT does not appear to play a primary role in the pathogenesis of male androgenic alopecia or acne.

Reasons for hair loss are:

1. Androgen receptor polymorphism and differences in androgen receptor concentrations and steroid-converting enzymes as the principal contributors to male androgenic alopecia
2. An initial experimental study by Eun discovered that DHT does not directly cause inhibition of hair growth but it induces the release of transforming growth factor beta 1 (TGFß1) which results in the miniaturization and hair loss.

Controlled clinical trial for evaluation of hair growth with low dose cyclical nutrition therapy in men and women without the use of finasteride

Aim: To evaluate possible results with the stimulation use of minoxidil and the strengthening of hair roots with nutritional cyclical supplements, resulting in increased hair regrowth, without the use of anti androgens and enzyme blockers.Methods: This prospective controlled clinical trial...

www.oaepublish.com

Shin et al followed this research further with cultured androgen sensitive dermal papilla cells and the addition of DHT to this androgen sensitive cell caused an accumulation of free radicles ROS within the cultured cells, which in turn induced the release of TGFß1.”

So a better approach than lowering DHT is to:

• Positively modulate the skin microbiome (think sunlight, micronutrients, clean environment, etc.)
• Inhibit excess ROS production
• Prevent excess activation of TGFß1
• Reduce stress

There are many more reasons for hair loss, but I won’t be diving into that in this article.

DHT for metabolic syndrome​

Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke and diabetes. Metabolic syndrome includes high blood pressure, high blood sugar, excess body fat around the waist and abnormal cholesterol levels. The syndrome increases a person’s risk of heart attack and stroke.

Insulin sensitivity​

This randomized, controlled, double-blind trial provides evidence that DHT specifically (and to a much lesser extent, testosterone), improves insulin sensitivity and decreases plasma leptin level without notable side effects

Testosterone treatment caused prostatic nodular hyperplasia, benign at biopsy, whereas DHT didn’t.

Androgens, especially DHT, upregulate insulin receptor expression and activity and increase glycogen synthesis and cholesterol uptake in the liver.

Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm - PMC

5α-dihydrotestosterone (5α-DHT) is the most potent natural androgen. 5α-DHT elicits a multitude of physiological actions, in a host of tissues, including prostate, seminal vesicles, hair follicles, skin, kidney, and lacrimal and meibomian glands. ...

pmc.ncbi.nlm.nih.gov

Low DHT or lowering DHT with a 5AR inhibitor, such as Finasteride or Dutasteride, is associated with an increase in blood glucose and glycosylated hemoglobin A as well as the risk of type 2 diabetes. Studies: 1, 2, 3

5AR is necessary to inactivate cortisol, so blocking 5AR increases cortisol, which promotes insulin resistance and liver disorders, such as NAFLD, steatosis, etc. Studies: 1, 2

Heart, liver and kidney function​

DHT therapy in men with coronary artery disease (CAD) decreased myocardial ischemia and improved left ventricular diastolic function.

This in vitro study found:


The findings above could explain some of the previously described clinical observations of the relationship between low T and DHT and peripheral vascular disease and the anti-ischemic effects of acute infusion of testosterone in men with CAD and similar effects by DHT gel treatment.

A few more facts:

• 5AR inhibition may result in the development of kidney dysfunction.
• Dutasteride, a 5AR inhibitor, treatment increased activities of liver alanine aminotransferase and aspartate aminotransferase, suggesting dysregulation of liver metabolism.
• DHT is a biomarker for reduced risk of stroke, which means that DHT is inversely correlated with stroke
• Higher DHT was associated with lower ischemic heart disease mortality in older men

Vascular function​

Blood pressure

• DHT increases the synthesis of nitric oxide through eNOS phosphorylation thus improving circulation and vascularity (R).

The following in vitro study shows that DHT has anti-inflammatory and protective effects in the vascular system:


Cholesterol

DHT:

• Reduces lipid accumulation and cholesterol synthesis via increasing expression of carnitine palmitotyltransferase1 (CPT-1) and phosphorylation of 3-hydroxy-3-methyl-glutaryl-CoA reductase
• Inhibits ox-LDL–induced foam cell formation and atherosclerosis
• DHT administration for up to 2 years in normal men, didn’t cause any thrombotic events or detrimental shifts in total cholesterol, HDL and LDL cholesterol, or triglycerides. Nor were exceptionally high levels of DHT associated with a change in right carotid intima-media thickening
• Inhibiting 5AR with dutasteride resulted in increased total cholesterol, and low-density lipoprotein cholesterol levels

Georgi (Haidut) posted a while ago:

Lowering DHT synthesis causes severe hypothyroidism, despite higher T levels – To Extract Knowledge from Matter

Mitochondrial function and energy production​

Androgens, especially DHT:

• Stimulate lipolysis and down-regulates lipoprotein lipase activity and increases the expression of fatty acid-binding protein leading to an increase in fatty acid oxidation and in oxidative phosphorylation.
• Increase the expression of pyruvate dehydrogenase, which increases the production of oxaloacetate and acetyl-CoA leading to a stimulation of the tricarboxylic acid (TCA) cycle.
• Increase the expression of succinate dehydrogenase and aconitase, also upregulating TCA and increasing oxidative phosphorylation.
• Increase the expression of cytochrome c oxidase, which leads to an increase in oxidative phosphorylation. The increase in oxidative phosphorylation leads to a decrease in reactive oxygen species and an increase in insulin sensitivity

Fat loss​

DHT:

• Inhibits preadipocyte proliferation and adipocyte differentiation, which prevents the excess formation of fat cells
• Stimulates lipolysis
• Stimulates lipid disposal
• Downregulates lipogenesis, which reduces the conversion of carbs to fat
• Prevents the downregulation of the leptin receptor

Gynecomastia

Gyno is known to be due to high estrogen and prolactin and low DHT and DHT treatment can reverse it.

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels - PMC

Benefits associated with lowered serum DHT levels after 5α-reductase inhibitor (5AR-I) therapy in men have contributed to a misconception that circulating DHT levels are an important stimulus for androgenic action in target tissues (e.g., prostate). ...

pmc.ncbi.nlm.nih.gov

Fun fact: One of the most known treatment of gynocomastia isn’t a SERM but transdermal DHT.

Brain & cognition

• DHT promotes stress resiliency. Blocking 5AR enhances cortisol release during stress, whereas DHT blunts it, most likely through CRH suppression.
• DHT promote insane memory.
• DHT protects against neurodegeneration, by antagonizing TGF beta.

Studies: 1, 2, 3, 4

In this case study someone with a demyelinating disease (Charcot-Marie-Toot 1) was able to induce neuroregeneration with 20mg/day of Anavar (Oxandrolone).

Lastly:


DHT is needed for blood flow

Lower T or DHT levels, but not E2, is associated with symptoms of intermittent claudication in older men.

Bone

High doses of DHT can completely shut down LH and testosterone production and cause a major drop in estrogen. This might be a concern for some people because it’s mainly estrogen that’s been thought to be beneficial for bone, however, there is evidence that estrogen isn’t needed for bone strength/growth.

Finasteride increases the risk of fractures, which indicates that it weakens muscle strength and bone quality.

Eyes

DHT is needed to keep the eyes moist and prevent dry eyes. 5AR inhibition may result in the development of dry eye disease.

Androgen deficiency produces pathophysiological changes manifested in the reduction of tear production and evaporative dry eye conditions.

Suppression

DHT doesn’t have a suppressive effect on testicular steroidogenesis, similar to estrogen. DHT actually suppresses testicular aromatase. DHT inhibits steroidogenesis on a hypothalamic level, and doesn’t affect LH secretion at a pituitary level.

Anabolism/Catabolism

DHT isn’t very anabolic, however, DHT derivatives, such as Anavar or Masteron are much more anabolic than DHT, and this is partly due to much slower clearance through the liver.

Apart from it not being very anabolic, DHT is anti-catabolic. This study found that people who experience muscle wasting from AIDS, retained more muscle mass if their DHT was normal, compared to those with low DHT.

Low dihydrotestosterone and weight loss in the AIDS wasting syndrome - PubMed

24 consecutive AIDS patients with wasting, and who had never received anabolic therapies, were evaluated to determine their profile of sex hormones and whether transformation of testosterone (T) to the nuclear androgen, dihydrotestosterone (DHT), was impaired. Eleven (46%) patients had normal...

pubmed.ncbi.nlm.nih.gov

Anavar, a DHT derivative, is used to preserve muscle mass in people with wasting disease and to help them add more muscle for recovery.

Even 5mg was enough to stop catabolism, whereas higher doses such as 15mg daily were needed for muscle growth in these patients.

Furthermore, DHT upregulates androgen receptors.

Serotonin excess and cancer

DHT downregulates tryptophan hydroxylase 1 (TPH1; the rate-limited enzyme in serotonin synthesis in the body), thus protecting against the formation of tumors. Serotonin is also potent inflammatory and causes vasoconstriction, so DHT protects against that as well.

This is why DHT is an essential hormone for the human body and why the use of 5AR's should be refrained from.

Other cool studies:

• PMID: 20927745
• PMID: 29224108
• PMID: 32869255
• PMID: 30206635
• PMID: 30905792
• PMID: 34479019
• PMID: 33814544
• PMID: 30863034
• PMID: 34741573
• PMID: 37697052

All credits to @20/04/2008, he did all of the research for this work.

Hopefully all our frends
@NZb6Air @4lt.Real @Bars @chudlite @Gaygymmaxx @Gengar @lestoa @sub5incel125 @thebuffdon690 @wastedspermcel @yayatourer @MA_ascender

@CoreSchizo @klimo @Chintuck22 @heyheyheybro22 @SecularIslamist @looksmaxxing223 @NorwoodAscender @elemanzelvadre @shia.jihadist @Sapieeen

View attachment 3263029View attachment 3263030View attachment 3263031View attachment 3263032View attachment 3263033

View attachment 3263034View attachment 3263176

View attachment 3263177
Average finasteride/dutasteride user who claims he has no side

Frankly I think its massively specific on the person (talking negative mental sides etc). Also anybody on test (which most on this forum should be on) rly does not need to worry about dht to the same extent and should be blocking it at this point. Would I recommend immediately blocking it after puberty to somebody? maybe not. I would say use finasteride if u are against using test if not jump straight to dut.

Personally I got no sides from blocking it but I didnt start using it untill i was injecting test.

 

[mogtivism]

Then to increase dht what i have to eat?

Why the fuck would you want more DHT? If you’re out of puberty, not growing any more, there is literally no reason to want more DHT

 

[jefty]

Why the fuck would you want more DHT? If you’re out of puberty, not growing any more, there is literally no reason to want more DHT

Im in puberty, im 14

 

[mogtivism]

Im in puberty, im 14

Eat lots of protein, exercise, consume eggs, beef, dairy in big amounts, and gymmax. You’ll be fine

 

[jefty]

Eat lots of protein, exercise, consume eggs, beef, dairy in big amounts, and gymmax. You’ll be fine

That Will promote bone mass in face?

 

[mogtivism]

That Will promote bone mass in face?

It’s mostly genetic. For example I had a shitty ass diet in puberty and was overweight yet still ended up with wide shoulders.

What you should be most concerned about right now is taking full advantage of the steroid-like effects of puberty to gymmaxx and pack on a ton of mass quickly, gymcelling during puberty on a proper diet will give you bonemass, and won’t make you short or any dumb crap like that. Height is genetics + not being a starved african

 

[jefty]

It’s mostly genetic. For example I had a shitty ass diet in puberty and was overweight yet still ended up with wide shoulders.

What you should be most concerned about right now is taking full advantage of the steroid-like effects of puberty to gymmaxx and pack on a ton of mass quickly, gymcelling during puberty on a proper diet will give you bonemass, and won’t make you short or any dumb crap like that. Height is genetics + not being a starved african

Im talking about zygos

 

[mogtivism]

Im talking about zygos

That’s mostly genetics

 

[jefty]

That’s mostly genetics

But i can do anything to make them bigger?

 

[Jonas2k7]

FINALLYYYYY, someone to know why we shouldn't block dht during puberty, can u help me? I dont know what to eat to increase dht

No diet will significantly increase your DHT, but a healthy diet (focus on zinc, healthy fats, etc.) basically precursors of testosterone should indirectly increase your DHT through 5AR.

You could start DHT derivates and testosterone itself for all the androgenic effects during puberty.

 

[Jstart1337]

Nigga stop bringing capitalism as an excuse. Patent of finasteride is long gone from merck. I am buying generic finasteride for fuckin 4 dollars and splitting it to the 4. I am spending 12 dollars per year for finasteride. now calculate cost/benefit ratio and compare it with hair transplant. According to your muh capitalism logic big pharma would push the anti-finasteride narrative to sold you hair transplant and expensive care products.

 

[DR. NICKGA]

Nigga stop bringing capitalism as an excuse. Patent of finasteride is long gone from merck. I am buying generic finasteride for fuckin 4 dollars and splitting it to the 4. I am spending 12 dollars per year for finasteride. now calculate cost/benefit ratio and compare it with hair transplant. According to your muh capitalism logic big pharma would push the anti-finasteride narrative to sold you hair transplant and expensive care products.

Balding is caused by DHT

BALDING (ANDROGENETIC ALOPECIA) IS CAUSED BY DHT the strongest evidence I can think of right now.. If it's not enough to convince someone of the causal role of androgens in baldness then that person is brain dead or willfully ignorant. Common male pattern baldness is a highly heritable trait...

looksmax.org

 

[20/04/2008]

DHT is an essential male hormone, not just for libido or feeling manly, but for health as a whole. This guide will cover all aspects of the importance of the hormone DHT for the human body.

DHT is synthesized from:

• Testosterone through the enzyme 5 alpha reductase (5AR)
• 17-hydroxypregnenolone and 17-hydroxyprogesterone via the “backdoor” pathway
• 5α-androstane-3α, 17-β-diol (dihydroandrosterone/3α-diol) through the intracrine reverse synthesis pathway involving 3α-hydroxysteroid dehydrogenase (3α-HSD)

DHT is 2.5-10 times more potent than testosterone and here’s why:

1. DHT has 4 times higher affinity to androgen receptors (AR) than Testosterone
2. Binding of DHT to the AR transforms the AR into it's DNA-binding state
3. DHT upregulates AR synthesis and reduces AR turnover
4. The dissociation rate of testosterone from it's receptors is 3-5 times faster than that of DHT (meaning DHT exerts a much more powerful effect on AR than testosterone)

However, circulating DHT is usually only about 10% or less that of testosterone and high concentrations of intracellular T can shift androgen receptor binding away from DHT by mass action

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels

Circulating levels of DHT in response to testosterone replacement therapy (TRT) do not correlate with those found in androgen sensitive tissue due to homeo

academic.oup.com

In the blood SHBG binds with 5 times higher affinity and for more than 3 times longer to DHT compared to testosterone.

To maximize the androgenic benefits of DHT we have to maximize 5AR and inhibit the binding of DHT to SHBG.

This article presents you what happens when men have high DHT or supraphysiological amounts of it.

---

DHT is essential for libido and sexual function​

It’s probably well known that DHT is very important when it comes to libido and sexual function.

According to this study, serum DHT concentration was the only independent hormonal predictor of the frequency of orgasms. An increase in concentration of 1.36 nmol/l corresponded to an average increase of one orgasm a week.

This shows that DHT directly opposes the anti-libido effects of prolactin.

Inhibiting DHT synthesis impairs corpus cavernosum growth and trabecular smooth muscle relaxation, endothelial function and increases connective tissue deposition. This all contributes to erectile dysfunction, even in the presence of physiological levels of total testosterone.

DHT is also critical for activating gene expression of neuronal and endothelial nitric oxide synthases, which are critical physiological mediators of penile erection.

Furthermore, DHT is also essential for spermatogenesis and thus fertility.

Estrogen is thought to be essential for sexual function in men. However, administrating high doses of DHT lowers estrogen dramatically and doesn’t reduce sexual function.

DHT isn’t just neutral towards sexual function as shown below, but is essential for it.

https://www.tandfonline.com/doi/abs/10.1080/13685530400016672

Human male sexual functions do not require aromatization of testosterone: A study using tamoxifen, testolactone, and dihydrotestosterone - Archives of Sexual Behavior

This study was designed to examine whether testosterone needs to be converted to estradiol in order to exert fully its effects on sexuality in the human male. Administration of the estrogen receptor antagonist tamoxifen and the aromatase inhibitor testolactone were without effect on parameters...

link.springer.com

DHT doesn’t cause prostate cancer​

For many decades it was thought that DHT promotes prostate cancer. However that thinking is luckily starting to change. It’s about time, since there has been a lot of research in the last two decades showing that DHT doesn’t promote prostate cancer.

There isn’t a correlation between circulating DHT and intraprostatic DHT. The prostate regulates it’s own DHT levels, which is about 10 times higher than circulation.

Giving testosterone might cause issues, since it can convert to estrogen, but giving DHT directly could actually help shrinking the prostate as it can lower estrogen. Estrogen and Prolactin are the driving causes that promote prostate cancer.

A few studies (1, 2, 3)found that supraphysiological amounts of serum DHT levels and DHT gel treatment didn't significantly increase total, central or peripheral prostate volumes, as measured by ultrasonography, nor was serum prostate-specific antigen (PSA) elevated. Additionally, International Prostate Symptom Scores (IPSS) remained unchanged in men treated with DHT gel for 6-24 months.

This 1.8 year old survey of 37 men aged between 55-70 years treated with daily percutaneous DHT suggested that high plasma levels of DHT (> 8.5 nmol/l) effectively inducing clinical benefits while slightly but significantly reducing prostate size.

DHT isn’t the bad guy when it comes to hair loss​

Hair loss and prostate cancer are two of the main reasons why people want to lower their DHT.

DHT is needed for beard growth, but it’s thought that DHT promotes scalp hair loss.

Take a look at this reference:

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels - PMC

Benefits associated with lowered serum DHT levels after 5α-reductase inhibitor (5AR-I) therapy in men have contributed to a misconception that circulating DHT levels are an important stimulus for androgenic action in target tissues (e.g., prostate). ...

pmc.ncbi.nlm.nih.gov

The claim above is supported by the fact that men who are exposed to exceptionally high levels of DHT in response to the daily application of DHT for a long period of time didn’t experience acne, male androgenic alopecia or other androgen-associated skin pathology.

Furthermore, the differences in mean values of DHT were not significant according to the types of alopecia and the control group. And increased serum concentrations of DHT is not correlated with the advance of alopecia. This study speculates that hair loss severity is affected by factors other than DHT, such as the duration of alopecia or the sensitivity of hair follicle cells to androgens.

Some people with hair loss have high DHT and others don’t. Some with high DHT have normal hair whereas others don’t.

https://www.researchgate.net/publication/328980562_A_New_Approach_to_Hair_Loss_Management_without_DHT_Blockers

So what’s going on with hairloss, if it’s not DHT?

You also might be wondering: “If DHT is not involved, why does 5-AR inhibitors work?“

This study found that although 5α-reductase inhibitors are effective in treating male androgenic alopecia, DHT does not appear to play a primary role in the pathogenesis of male androgenic alopecia or acne.

Reasons for hair loss are:

1. Androgen receptor polymorphism and differences in androgen receptor concentrations and steroid-converting enzymes as the principal contributors to male androgenic alopecia
2. An initial experimental study by Eun discovered that DHT does not directly cause inhibition of hair growth but it induces the release of transforming growth factor beta 1 (TGFß1) which results in the miniaturization and hair loss.

Controlled clinical trial for evaluation of hair growth with low dose cyclical nutrition therapy in men and women without the use of finasteride

Aim: To evaluate possible results with the stimulation use of minoxidil and the strengthening of hair roots with nutritional cyclical supplements, resulting in increased hair regrowth, without the use of anti androgens and enzyme blockers.Methods: This prospective controlled clinical trial...

www.oaepublish.com

Shin et al followed this research further with cultured androgen sensitive dermal papilla cells and the addition of DHT to this androgen sensitive cell caused an accumulation of free radicles ROS within the cultured cells, which in turn induced the release of TGFß1.”

So a better approach than lowering DHT is to:

• Positively modulate the skin microbiome (think sunlight, micronutrients, clean environment, etc.)
• Inhibit excess ROS production
• Prevent excess activation of TGFß1
• Reduce stress

There are many more reasons for hair loss, but I won’t be diving into that in this article.

DHT for metabolic syndrome​

Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke and diabetes. Metabolic syndrome includes high blood pressure, high blood sugar, excess body fat around the waist and abnormal cholesterol levels. The syndrome increases a person’s risk of heart attack and stroke.

Insulin sensitivity​

This randomized, controlled, double-blind trial provides evidence that DHT specifically (and to a much lesser extent, testosterone), improves insulin sensitivity and decreases plasma leptin level without notable side effects

Testosterone treatment caused prostatic nodular hyperplasia, benign at biopsy, whereas DHT didn’t.

Androgens, especially DHT, upregulate insulin receptor expression and activity and increase glycogen synthesis and cholesterol uptake in the liver.

Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm - PMC

5α-dihydrotestosterone (5α-DHT) is the most potent natural androgen. 5α-DHT elicits a multitude of physiological actions, in a host of tissues, including prostate, seminal vesicles, hair follicles, skin, kidney, and lacrimal and meibomian glands. ...

pmc.ncbi.nlm.nih.gov

Low DHT or lowering DHT with a 5AR inhibitor, such as Finasteride or Dutasteride, is associated with an increase in blood glucose and glycosylated hemoglobin A as well as the risk of type 2 diabetes. Studies: 1, 2, 3

5AR is necessary to inactivate cortisol, so blocking 5AR increases cortisol, which promotes insulin resistance and liver disorders, such as NAFLD, steatosis, etc. Studies: 1, 2

Heart, liver and kidney function​

DHT therapy in men with coronary artery disease (CAD) decreased myocardial ischemia and improved left ventricular diastolic function.

This in vitro study found:


The findings above could explain some of the previously described clinical observations of the relationship between low T and DHT and peripheral vascular disease and the anti-ischemic effects of acute infusion of testosterone in men with CAD and similar effects by DHT gel treatment.

A few more facts:

• 5AR inhibition may result in the development of kidney dysfunction.
• Dutasteride, a 5AR inhibitor, treatment increased activities of liver alanine aminotransferase and aspartate aminotransferase, suggesting dysregulation of liver metabolism.
• DHT is a biomarker for reduced risk of stroke, which means that DHT is inversely correlated with stroke
• Higher DHT was associated with lower ischemic heart disease mortality in older men

Vascular function​

Blood pressure

• DHT increases the synthesis of nitric oxide through eNOS phosphorylation thus improving circulation and vascularity (R).

The following in vitro study shows that DHT has anti-inflammatory and protective effects in the vascular system:


Cholesterol

DHT:

• Reduces lipid accumulation and cholesterol synthesis via increasing expression of carnitine palmitotyltransferase1 (CPT-1) and phosphorylation of 3-hydroxy-3-methyl-glutaryl-CoA reductase
• Inhibits ox-LDL–induced foam cell formation and atherosclerosis
• DHT administration for up to 2 years in normal men, didn’t cause any thrombotic events or detrimental shifts in total cholesterol, HDL and LDL cholesterol, or triglycerides. Nor were exceptionally high levels of DHT associated with a change in right carotid intima-media thickening
• Inhibiting 5AR with dutasteride resulted in increased total cholesterol, and low-density lipoprotein cholesterol levels

Georgi (Haidut) posted a while ago:

Lowering DHT synthesis causes severe hypothyroidism, despite higher T levels – To Extract Knowledge from Matter

Mitochondrial function and energy production​

Androgens, especially DHT:

• Stimulate lipolysis and down-regulates lipoprotein lipase activity and increases the expression of fatty acid-binding protein leading to an increase in fatty acid oxidation and in oxidative phosphorylation.
• Increase the expression of pyruvate dehydrogenase, which increases the production of oxaloacetate and acetyl-CoA leading to a stimulation of the tricarboxylic acid (TCA) cycle.
• Increase the expression of succinate dehydrogenase and aconitase, also upregulating TCA and increasing oxidative phosphorylation.
• Increase the expression of cytochrome c oxidase, which leads to an increase in oxidative phosphorylation. The increase in oxidative phosphorylation leads to a decrease in reactive oxygen species and an increase in insulin sensitivity

Fat loss​

DHT:

• Inhibits preadipocyte proliferation and adipocyte differentiation, which prevents the excess formation of fat cells
• Stimulates lipolysis
• Stimulates lipid disposal
• Downregulates lipogenesis, which reduces the conversion of carbs to fat
• Prevents the downregulation of the leptin receptor

Gynecomastia

Gyno is known to be due to high estrogen and prolactin and low DHT and DHT treatment can reverse it.

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels - PMC

Benefits associated with lowered serum DHT levels after 5α-reductase inhibitor (5AR-I) therapy in men have contributed to a misconception that circulating DHT levels are an important stimulus for androgenic action in target tissues (e.g., prostate). ...

pmc.ncbi.nlm.nih.gov

Fun fact: One of the most known treatment of gynocomastia isn’t a SERM but transdermal DHT.

Brain & cognition

• DHT promotes stress resiliency. Blocking 5AR enhances cortisol release during stress, whereas DHT blunts it, most likely through CRH suppression.
• DHT promote insane memory.
• DHT protects against neurodegeneration, by antagonizing TGF beta.

Studies: 1, 2, 3, 4

In this case study someone with a demyelinating disease (Charcot-Marie-Toot 1) was able to induce neuroregeneration with 20mg/day of Anavar (Oxandrolone).

Lastly:


DHT is needed for blood flow

Lower T or DHT levels, but not E2, is associated with symptoms of intermittent claudication in older men.

Bone

High doses of DHT can completely shut down LH and testosterone production and cause a major drop in estrogen. This might be a concern for some people because it’s mainly estrogen that’s been thought to be beneficial for bone, however, there is evidence that estrogen isn’t needed for bone strength/growth.

Finasteride increases the risk of fractures, which indicates that it weakens muscle strength and bone quality.

Eyes

DHT is needed to keep the eyes moist and prevent dry eyes. 5AR inhibition may result in the development of dry eye disease.

Androgen deficiency produces pathophysiological changes manifested in the reduction of tear production and evaporative dry eye conditions.

Suppression

DHT doesn’t have a suppressive effect on testicular steroidogenesis, similar to estrogen. DHT actually suppresses testicular aromatase. DHT inhibits steroidogenesis on a hypothalamic level, and doesn’t affect LH secretion at a pituitary level.

Anabolism/Catabolism

DHT isn’t very anabolic, however, DHT derivatives, such as Anavar or Masteron are much more anabolic than DHT, and this is partly due to much slower clearance through the liver.

Apart from it not being very anabolic, DHT is anti-catabolic. This study found that people who experience muscle wasting from AIDS, retained more muscle mass if their DHT was normal, compared to those with low DHT.

Low dihydrotestosterone and weight loss in the AIDS wasting syndrome - PubMed

24 consecutive AIDS patients with wasting, and who had never received anabolic therapies, were evaluated to determine their profile of sex hormones and whether transformation of testosterone (T) to the nuclear androgen, dihydrotestosterone (DHT), was impaired. Eleven (46%) patients had normal...

pubmed.ncbi.nlm.nih.gov

Anavar, a DHT derivative, is used to preserve muscle mass in people with wasting disease and to help them add more muscle for recovery.

Even 5mg was enough to stop catabolism, whereas higher doses such as 15mg daily were needed for muscle growth in these patients.

Furthermore, DHT upregulates androgen receptors.

Serotonin excess and cancer

DHT downregulates tryptophan hydroxylase 1 (TPH1; the rate-limited enzyme in serotonin synthesis in the body), thus protecting against the formation of tumors. Serotonin is also potent inflammatory and causes vasoconstriction, so DHT protects against that as well.

This is why DHT is an essential hormone for the human body and why the use of 5AR's should be refrained from.

Other cool studies:

• PMID: 20927745
• PMID: 29224108
• PMID: 32869255
• PMID: 30206635
• PMID: 30905792
• PMID: 34479019
• PMID: 33814544
• PMID: 30863034
• PMID: 34741573
• PMID: 37697052

All credits to @20/04/2008, he did all of the research for this work.

Hopefully all our frends
@NZb6Air @4lt.Real @Bars @chudlite @Gaygymmaxx @Gengar @lestoa @sub5incel125 @thebuffdon690 @wastedspermcel @yayatourer @MA_ascender

@CoreSchizo @klimo @Chintuck22 @heyheyheybro22 @SecularIslamist @looksmaxxing223 @NorwoodAscender @elemanzelvadre @shia.jihadist @Sapieeen

View attachment 3263029View attachment 3263030View attachment 3263031View attachment 3263032View attachment 3263033

View attachment 3263034View attachment 3263176

View attachment 3263177
Average finasteride/dutasteride user who claims he has no side

@Mike141
Bro your smart pls read

 

[20/04/2008]

Nigga stop bringing capitalism as an excuse. Patent of finasteride is long gone from merck. I am buying generic finasteride for fuckin 4 dollars and splitting it to the 4. I am spending 12 dollars per year for finasteride. now calculate cost/benefit ratio and compare it with hair transplant. According to your muh capitalism logic big pharma would push the anti-finasteride narrative to sold you hair transplant and expensive care products.

Bro just read the end memes
Read the fucking studies

 

[Mike141]

@Mike141
Bro your smart pls read

bet imma read it

 

[20/04/2008]

Frankly I think its massively specific on the person (talking negative mental sides etc). Also anybody on test (which most on this forum should be on) rly does not need to worry about dht to the same extent and should be blocking it at this point. Would I recommend immediately blocking it after puberty to somebody? maybe not. I would say use finasteride if u are against using test if not jump straight to dut.

Personally I got no sides from blocking it but I didnt start using it untill i was injecting test.

Yes finally someone who understands me
Yes your 100% fucking right
@Jonas2k7 i told you to let me post this thread so i could reply to people

 

[Jonas2k7]

Yes finally someone who understands me
Yes your 100% fucking right
@Jonas2k7 i told you to let me post this thread so i could reply to people

Nigga is writing this in the bus