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7evenvox22
Iron
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- May 29, 2025
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Do you want to grow your bones, remodel them, and increase your lower jaw size? Then look no further. To grow bones, you need an absence of osteoclasts, which are cells that stimulate bone resorption. The proliferation, activation, and survival of these cells is heavily dictated by a protein called RANKL, which is a protein heavily upregulated in bone wasting diseases like osteoporosis. When RANKL activates these osteoclasts, it also activates intracellular signaling pathways like NF-kappa B or NF-ATC1, which is a central transcription factor directly controlling genes needed for osteoclast development and function. These activated pathways can promote transcription of inflammatory genes like IL-6 or TNF-alpha, which are proinflammatory cytokines produced downstream of RANKL signaling that accelerate joint damage and bone degradation. But there are things you can take to reduce osteoclasts activation by RANKL inhibition, like denosumab. Denosumab is a monoclonal antibody that binds directly to RANKL and blocks its interaction with osteoclast precursors, and thus reduces bone resorption. Denosumab treatment is associated with rapid, sustained, and reversible reduction in bone turnover markers, a continuous significant increase in overall bone mineral density, significant decrease of risk of vertebral, hip, and non-vertebral fractures in humans with osteoporosis. But denosumab is not inherently anabolic for bone on its own. It just inhibits bone resorption from catabolic agents, which is why it has great synergy with a compound called teriparatide, which is a PTH analog that stimulates osteoblasts and should be taken alongside denosumab for maximum bone growth, especially for the jaw. Or testosterone and IGF-1, since they are extremely anabolic for bone. This is a very nuanced topic, and there is side effect risk for calcium blood levels, immune function, and orthostatic hypotension, which is a slight drop in blood pressure. So take these compounds under medical supervision.
