Hyaluronic acid supplement as an alternative acne treatment

[LVZZO]

Hyaluronic acid can be used as an alternative to isotretinoin because both decrease sebum production.
Could resolve seborrheic dermatitis as well, since isotretinoin also resolves it

https://www.sciencedirect.com/science/article/pii/S0022202X17301082

To my knowledge this has never been theorized or studied in form of a scientific publication.

 

[hilley]

There's no acne treatment other than Accutane. Fat fucks takes steroids that increases the chances of having cancer by 300% but is scared to take a fucking pill that makes your skin dry, dumbass monkeys.

 

[LVZZO]

100-200mg/day is the normal dose
500 mg/day is high dose
1-2g is very high dose

100mg is just as effective as 200mg when measuring several skin markers.
Not much information for higher doses I believe, unless it's safety data.
I wouldn't go over 2-3g per day.

There's no acne treatment other than Accutane. Fat fucks takes steroids that increases the chances of having cancer by 300% but is scared to take a fucking pill that makes your skin dry, dumbass monkeys.

Accutane is the most effective, hyaluronic acid has never been tested.
Some people don't need a reduction in 80-90% of sebum production, which causes side effects.
HA reduces it in 20-40%, it may be enough for many people.

 

[Jonas2k7]

Good thread

 

[mfk]

100-200mg/day is the normal dose
500 mg/day is high dose
1-2g is very high dose

100mg is just as effective as 200mg when measuring several skin markers.
Not much information for higher doses I believe, unless it's safety data.
I wouldn't go over 2-3g per day.


Accutane is the most effective, hyaluronic acid has never been tested.
Some people don't need a reduction in 80-90% of sebum production, which causes side effects.
HA reduces it in 20-40%, it may be enough for many people.

HA is very common in skincare products, and is frequently used in skincare routines without people even realizing. There’s a decent chance your moisturizer has HA or its derivatives (sodium hyaluronate, etc)

Then there’s the argument that it’s topical. Well, the study had HA injected into the skin. Oral and topical are both going to be quite different than HA injections regardless.

It’s understood that sebum over-production can be a result of the skin compensating for a lack of moisture/water content. So these results align with what is expected, given that HA holds water in the skin.

But if the aforementioned is why sebum production was reduced, then you’d see topical HA serums (which boost skin moisture content) as a treatment for acne. But you don’t. There’s a complex pathology behind acne which includes androgens, blood glucose, and more.

So it’s not possible to argue that HA would be as effective as Isotretinoin for that reason.

But if you’d like to give it a go, you need to take an oral micronized form of HA like Injuv. As the normal form lacks oral bioavailability.

 

[Kelly Oubre Jr]

There's no acne treatment other than Accutane. Fat fucks takes steroids that increases the chances of having cancer by 300% but is scared to take a fucking pill that makes your skin dry, dumbass monkeys.

jay ef el

 

[LVZZO]

HA is very common in skincare products, and is frequently used in skincare routines without people even realizing. There’s a decent chance your moisturizer has HA or its derivatives (sodium hyaluronate, etc)

Then there’s the argument that it’s topical. Well, the study had HA injected into the skin. Oral and topical are both going to be quite different than HA injections regardless.

It’s understood that sebum over-production can be a result of the skin compensating for a lack of moisture/water content. So these results align with what is expected, given that HA holds water in the skin.

But if the aforementioned is why sebum production was reduced, then you’d see topical HA serums (which boost skin moisture content) as a treatment for acne. But you don’t. There’s a complex pathology behind acne which includes androgens, blood glucose, and more.

So it’s not possible to argue that HA would be as effective as Isotretinoin for that reason.

But if you’d like to give it a go, you need to take an oral micronized form of HA like Injuv. As the normal form lacks oral bioavailability.

I said it's going to be less effective already, the biodistributionof HA varies greatly, it may or may not happen that enough gets in the sebaceous glands or in some way affect them, but it should have some effect.
Just need some kiddos to test it