If you re still supplementing mk-4 in 2022 you re a retard

[HOLYFUARK]

We conclude that MK-4 present in food does not contribute to the vitamin K status as measured by serum vitamin K levels. MK-7, however significantly increases serum MK-7 levels and therefore may be of particular importance for extrahepatic tissues.

Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women

Vitamin K[2] contributes to bone and cardiovascular health. Therefore, two vitamin K[2] homologues, menaquinone-4 (MK-4) and menaquinone-7 (MK-7), have been used as nutrients by the food industry and as nutritional supplements to support bone and cardiovascular ...

www.ncbi.nlm.nih.gov

Considering that MK-4 derives from the endogenous conversion of phylloquinone, the specific tissue distribution of MK-4 is suggestive of local synthesis from phylloquinone. MK-4 is synthetized in testes, pancreas and blood vessels. In particular, the conversion of phylloquinone into MK-4 occurs either directly or by interconversion to menadione (K3), followed by prenylation to MK-4 [21]. Therefore, the biological activity of K3 is entirely dependent on its prenylation to MK-4.

https://air.unimi.it/retrieve/handle/2434/449996/963018/Fusaro%20-%20Vitamin%20K%20plasma%20levels%20determination%20in%20human%20health%20-%20CCLM%202017.pdf

vitamin k1 is where it's at .

 

[Deleted member 17174]

ah ok

 

[Deleted member 6423]

How much k1 converts to k2?

 

[Lawton88]

Mk-4 is deposited where it needs to be and works just fine if taken daily. This is a marketing gimmick to sell MK7 just because the serum levels drop fast with MK4.

 

[Deleted member 17345]

We conclude that MK-4 present in food does not contribute to the vitamin K status as measured by serum vitamin K levels. MK-7, however significantly increases serum MK-7 levels and therefore may be of particular importance for extrahepatic tissues.

Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women

Vitamin K[2] contributes to bone and cardiovascular health. Therefore, two vitamin K[2] homologues, menaquinone-4 (MK-4) and menaquinone-7 (MK-7), have been used as nutrients by the food industry and as nutritional supplements to support bone and cardiovascular ...

www.ncbi.nlm.nih.gov

Considering that MK-4 derives from the endogenous conversion of phylloquinone, the specific tissue distribution of MK-4 is suggestive of local synthesis from phylloquinone. MK-4 is synthetized in testes, pancreas and blood vessels. In particular, the conversion of phylloquinone into MK-4 occurs either directly or by interconversion to menadione (K3), followed by prenylation to MK-4 [21]. Therefore, the biological activity of K3 is entirely dependent on its prenylation to MK-4.

https://air.unimi.it/retrieve/handle/2434/449996/963018/Fusaro%20-%20Vitamin%20K%20plasma%20levels%20determination%20in%20human%20health%20-%20CCLM%202017.pdf

vitamin k1 is where it's at .

totally wrong,mk4 is the more natural form and its not in blood as it quickly moves into bones and has a shorter half life

 

[Lawton88]

How much k1 converts to k2?

Not much in some people. I would assume most people not getting much K2 in their diet or from a supplement are a at least a little deficient.