I'm literally immune to feeling pain from spicy food

[CupOfCoffee]

Since I took that spicy gummy (9 million Scoville) for losing fantasy football I do not feel any real pain from even extremely spicy food that I eat. I just had some Ghost pepper salsa that used to feel quite spicy but now I'm just eating it like regular dip. I can add tons of serrano/jalapeno peppers and tons of cayenne powder and hot sauce to my meals and honestly nothing, it just enhances the flavor.

Is this comparable to receptor downregulation?

@kjsbdfiusdf @lutte @TsarTsar444 @Tony @Baldingman1998

 

[Deleted member 6403]

I’ve noticed a higher pain tolerance when I’m at a better metabolic rate, not sure it’s to your extent though.

 

[Deleted member 9670]

eat a raw habanero or hotter you will feel it

you would be less sensitive from TRPV1 activation, eat enough capsacin and it will cause TRPV1 neurons to die

Desensitization[edit]​

Upon prolonged exposure to capsaicin, TRPV1 activity decreases, a phenomenon called desensitization. Extracellular calcium ions are required for this phenomenon, thus influx of calcium and the consequential increase of intracellular calcium mediate this effect.[15] Various signaling pathways such as phosphorylation by PKA and PKC, interaction with calmodulin, dephosphorylation by calcineurin,[16] and the decrease of PIP2, have been implicated in the regulation of desensitization of TRPV1. Desensitization of TRPV1 is thought to underlie the paradoxical analgesic effect of capsaicin.

TRPV1 - Wikipedia

en.wikipedia.org

 

[CupOfCoffee]

eat a raw habanero or hotter you will feel it

you would be less sensitive from TRPV1 activation, eat enough capsacin and it will cause TRPV1 neurons to die

TRPV1 - Wikipedia

en.wikipedia.org

I'll buy some habaneros and try them tomorrow raw. Not expecting anything crazy tho every spicy just tastes good now

 

[CupOfCoffee]

eat a raw habanero or hotter you will feel it

you would be less sensitive from TRPV1 activation, eat enough capsacin and it will cause TRPV1 neurons to die

TRPV1 - Wikipedia

en.wikipedia.org

I never thought of it as an analgesic but that makes sense, after the pain ended after the gummy I felt very very good, like almost felt high

 

[Deleted member 9670]

I'll buy some habaneros and try them tomorrow raw. Not expecting anything crazy tho every spicy just tastes good now

Eating large amounts makes you less sensitive to pain and could make you live longer

TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling - PubMed

The sensation of pain is associated with increased mortality, but it is unknown whether pain perception can directly affect aging. We find that mice lacking TRPV1 pain receptors are long-lived, displaying a youthful metabolic profile at old age. Loss of TRPV1 inactivates a calcium-signaling...

pubmed.ncbi.nlm.nih.gov

I used to grow my own superhots and eat heaps, I used to piss out capsaicin and it really hurts

 

[AllesScheiße]

Incel trait

 

[Deleted member 16834]

F A G G O T

 

[LooksOrDeath]

Incel trait

 

[lutte]

 

[Deleted member 9670]

View attachment 1533565

ray peat doesn't approve?

 

[lutte]

ray peat doesn't approve?

I don’t know if he does

 

[Deleted member 9670]

I don’t know if he does

I read he didn't like spices

it raises your metabolic rate tho