Isotretinoin (accutane) will stunt your growth and affect how you develop in puberty

[cancsrs]

same goes for topical isotret

how?

 

[peterk1287]

from what age did you take and how tall where you back then? (and what dose?)

I took at beginning 14 Im almost 16, I took 80 mgs

 

[peter pan]

I dont understand what is the need for this test stuff that makes you a little boy in a big body. Cant U just workout normally with some Peptides ?

 

[peter pan]

I took at beginning 14 Im almost 16, I took 80 mgs

and how long did you take it?
and how tall where you before you started?

 

[pegorino]

View attachment 5226275

Stop disrespecting me newfag

 

[peterk1287]

and how long did you take it?
and how tall where you before you started?

I took it for like half a year, cause I had really bad acne, I was probably 6’0 when I took it, evey 2 months Im measuring myself and Im still growing lol

 

[peter pan]

I took it for like half a year, cause I had really bad acne, I was probably 6’0 when I took it, evey 2 months Im measuring myself and Im still growing lol

interesting ok thanks for the info

 

[infrainfra]

Dnr didnt stunt my growth, Im 6’4

u could’ve been 6,6

 

[infrainfra]

I am 17 and 2.5 months old is it okay to take or still too early

if your still growing dont

 

[peterk1287]

u could’ve been 6,6

My dad is 5’11 Jfl, like I said Im still growing

 

[infrainfra]

My dad is 5’11 Jfl, like I said Im still growing

yeah my cousins dad is 5,6 and he is 6,3 and he literally has some serious liver sickness. and accutane will speed up the time in which u stop growing

 

[satangoy]

fear monger it won't make a significant change

 

[infrainfra]

fear monger it won't make a significant change

you are an idiot. provide evidence it won’t. ill provide evidence it will (significantly)

 

[satangoy]

you are an idiot. provide evidence it won’t. ill provide evidence it will (significantly)

your trying too put accutane as harmful using studies on rats with extremely high doses, accutane might cause temporary negative side effects not forever you'll develop as you should

 

[infrainfra]

your trying too put accutane as harmful using studies on rats with extremely high doses, accutane might cause temporary negative side effects not forever you'll develop as you should

you have the whole proces broken down and human studies nigga scroll up. and the doses they used where human equivalent X/mg/Kg

 

[Firstname.Lastname]

There is more. Study on humans :

in 47 patients (15–40 years)

105 patients with acne (14–42 years), the participants were divided into three groups based on the isotretinoin dose: 0.5–1.0 mg/kg/day (high dose—group 1), 0.2–0.5 mg/kg/day (low dose—group 2), and an intermittent 0.5–1.0 mg/kg/day only one week per month (intermittent dose—group 3). After 3 months of therapy, the isotretinoin significantly reduced the IGF-I and random GH levels in groups 1 and 2, and these effects were more pronounced in the high-dose group. The IGFBP3 levels were significantly reduced in all three groups, and the weakest effect was seen in the intermittent-dose group .

I swear to god, org users have zero ability to understand anything.

AH LET ME QUOTE THESE "STUDIES" WITH NO CONTROL GROUPS WITH STATISTICALLY MEANINGLESS SAMPLE SIZES. THIS IS VERY VAILD MUCH WOW.

NOW LET ME REFUSE TO PROVIDE LINKS FOR THE "STUDY". LETS NOT MENTION HOW MUCH THE REDUCTION IS BY. ITS SIGNIFANCAT AMOUNTS BECUSE WORDS.





Shut the fuck up sit the fuck down until you understand what a methodology even is. retard.

 

[bombastik]

dose dependent. Super low doses like 5mg won't affect growth noticeably

What about 16mg?

 

[infrainfra]

I swear to god, org users have zero ability to understand anything.

AH LET ME QUOTE THESE "STUDIES" WITH NO CONTROL GROUPS WITH STATISTICALLY MEANINGLESS SAMPLE SIZES. THIS IS VERY VAILD MUCH WOW.

NOW LET ME REFUSE TO PROVIDE LINKS FOR THE "STUDY". LETS NOT MENTION HOW MUCH THE REDUCTION IS BY. ITS SIGNIFANCAT AMOUNTS BECUSE WORDS.





Shut the fuck up sit the fuck down until you understand what a methodology even is. retard.

you fucking idiot i wouldnt just pull this up my ass if i want paste in into google and find it

 

[SwordofGod]

Does tretinoin show any similar affects? I presume not.

 

[alinahes]

same goes for topical isotret

Does topical tretinoin stunt growth to?

 

[alsayan]

Dnr , thread's true already knew this

 

[infrainfra]

Does topical tretinoin stunt growth to?

negligible

 

[rsj]

long story short


Isotretinoin undergoes isomerization to all-trans-retinoic acid. so just tretinoin.

retinoic acid binds to retinoic acid receptors and RXR (retinoid x receptors)

this directly changes the transcription of genes controlling cartilage maturation

look at this :
„Twenty 3-week-old male rats were randomly divided into a control group and an experimental group (n = 10). The experimental rats were treated by gavage with high-dose ATRA for 10 days. After this period, the experimental rats exhibited a lower body weight and shorter nasal-tail and radial tibial length than the controls. CYP26B1 enzyme activity in the liver was elevated, and histopathological staining revealed a narrowed cartilaginous epiphyseal plate, a sparse medullary cavity of trabecular bone, fewer trabecular bones, and advanced bone marrow mineralization. The circulating GH, IGF-I, and IGFBP3 levels decreased. The authors concluded that high-dose ATRA intake over a brief period reduces GH, IGF-I, and IGFBP3 levels, affects cartilage and bone homeostasis, and inhibits bone growth in developing animals ”

ATRA = all trans retinoic acid*

There is more. Study on humans :

„Karadag et al. studied the effect of isotretinoin on the GH-IGF-I axis in 47 patients (15–40 years) with acne. The therapy was initiated at a dose of 0.5–0.75 mg/kg/day and adjusted to 0.88 mg/kg/day as a maintenance dosage after 1 month. After 3 months of treatment, the IGF-I and IGFBP3 levels significantly decreased, while the mean basal GH levels did not change.”

„In another study of the same group of researchers including 105 patients with acne (14–42 years), the participants were divided into three groups based on the isotretinoin dose: 0.5–1.0 mg/kg/day (high dose—group 1), 0.2–0.5 mg/kg/day (low dose—group 2), and an intermittent 0.5–1.0 mg/kg/day only one week per month (intermittent dose—group 3). After 3 months of therapy, the isotretinoin significantly reduced the IGF-I and random GH levels in groups 1 and 2, and these effects were more pronounced in the high-dose group. The IGFBP3 levels were significantly reduced in all three groups, and the weakest effect was seen in the intermittent-dose group . The total testosterone and cortisol levels decreased, and the sex hormone-binding globulin (SHBG) levels increased significantly in the three groups after therapy.”

look at this : „The total testosterone and cortisol levels decreased, and the sex hormone-binding globulin (SHBG) levels increased significantly”


SO IT ALSO FUCKS WITH OTHER HORMONES.




View attachment 5167822

take a look at that for a little summary


doesnt stop here. take a look at this




View attachment 5167844



Now recently a clinical case of a boy suggests that elevated retinoic acid concentrations accelerate bone and dental maturation in humans.


„The patient was a 10-year-old prepubertal boy with retinal scarring, photophobia, autism spectrum disease, markedly advanced bone age, and accelerated dental development. He was born full term after an uncomplicated pregnancy and delivery, with a birth weight of 2.98 kg [−1.3 standard deviation score (SDS)] and birth length of 46 cm (−2.3 SDS). At the physical exam, he had pubic hair Tanner II, a testicular size of 3–4 mL bilaterally, and no gynecomastia. He presented with low serum vitamin A and elevated total and 13-cis-retinoc acid concentrations and a 3-year advance in bone age, which was advanced in relation to the chronological age without elevated estrogen levels. This syndrome was associated with a deletion on chromosome 10q23, which included the genes of the major retinoic acid-metabolizing enzymes”





okay enough of in vivo studies
i will just type out the mechanisms it fucks your puberty so you can understand it


It pushes chondros into hypertrophy faster so just less bone lengthening.
it also supresses chondrocyte proliferation.

The growth plate only has a finite number of proliferative chondrocytes. Anything that causes these cells to stop dividing or disappear faster will just accelerate growth plate aging. this is also called senescence


it increases mineralization and ossification so cartilage becomes bone faster. so growth potential is lost sooner.




there is more mechanisms in which isotret (accutane) will fuck you up. IDK AND IDC this is enough not to use it.




is there any solution? yes - topical anti androgens with low systemic absorption for the same use-case of isotret (acne)






View attachment 5167898



Stupid chatgpt

bump and its a brutal BP

 

[stnr74]

long story short


Isotretinoin undergoes isomerization to all-trans-retinoic acid. so just tretinoin.

retinoic acid binds to retinoic acid receptors and RXR (retinoid x receptors)

this directly changes the transcription of genes controlling cartilage maturation

look at this :
„Twenty 3-week-old male rats were randomly divided into a control group and an experimental group (n = 10). The experimental rats were treated by gavage with high-dose ATRA for 10 days. After this period, the experimental rats exhibited a lower body weight and shorter nasal-tail and radial tibial length than the controls. CYP26B1 enzyme activity in the liver was elevated, and histopathological staining revealed a narrowed cartilaginous epiphyseal plate, a sparse medullary cavity of trabecular bone, fewer trabecular bones, and advanced bone marrow mineralization. The circulating GH, IGF-I, and IGFBP3 levels decreased. The authors concluded that high-dose ATRA intake over a brief period reduces GH, IGF-I, and IGFBP3 levels, affects cartilage and bone homeostasis, and inhibits bone growth in developing animals ”

ATRA = all trans retinoic acid*

There is more. Study on humans :

„Karadag et al. studied the effect of isotretinoin on the GH-IGF-I axis in 47 patients (15–40 years) with acne. The therapy was initiated at a dose of 0.5–0.75 mg/kg/day and adjusted to 0.88 mg/kg/day as a maintenance dosage after 1 month. After 3 months of treatment, the IGF-I and IGFBP3 levels significantly decreased, while the mean basal GH levels did not change.”

„In another study of the same group of researchers including 105 patients with acne (14–42 years), the participants were divided into three groups based on the isotretinoin dose: 0.5–1.0 mg/kg/day (high dose—group 1), 0.2–0.5 mg/kg/day (low dose—group 2), and an intermittent 0.5–1.0 mg/kg/day only one week per month (intermittent dose—group 3). After 3 months of therapy, the isotretinoin significantly reduced the IGF-I and random GH levels in groups 1 and 2, and these effects were more pronounced in the high-dose group. The IGFBP3 levels were significantly reduced in all three groups, and the weakest effect was seen in the intermittent-dose group . The total testosterone and cortisol levels decreased, and the sex hormone-binding globulin (SHBG) levels increased significantly in the three groups after therapy.”

look at this : „The total testosterone and cortisol levels decreased, and the sex hormone-binding globulin (SHBG) levels increased significantly”


SO IT ALSO FUCKS WITH OTHER HORMONES.




View attachment 5167822

take a look at that for a little summary


doesnt stop here. take a look at this




View attachment 5167844



Now recently a clinical case of a boy suggests that elevated retinoic acid concentrations accelerate bone and dental maturation in humans.


„The patient was a 10-year-old prepubertal boy with retinal scarring, photophobia, autism spectrum disease, markedly advanced bone age, and accelerated dental development. He was born full term after an uncomplicated pregnancy and delivery, with a birth weight of 2.98 kg [−1.3 standard deviation score (SDS)] and birth length of 46 cm (−2.3 SDS). At the physical exam, he had pubic hair Tanner II, a testicular size of 3–4 mL bilaterally, and no gynecomastia. He presented with low serum vitamin A and elevated total and 13-cis-retinoc acid concentrations and a 3-year advance in bone age, which was advanced in relation to the chronological age without elevated estrogen levels. This syndrome was associated with a deletion on chromosome 10q23, which included the genes of the major retinoic acid-metabolizing enzymes”





okay enough of in vivo studies
i will just type out the mechanisms it fucks your puberty so you can understand it


It pushes chondros into hypertrophy faster so just less bone lengthening.
it also supresses chondrocyte proliferation.

The growth plate only has a finite number of proliferative chondrocytes. Anything that causes these cells to stop dividing or disappear faster will just accelerate growth plate aging. this is also called senescence


it increases mineralization and ossification so cartilage becomes bone faster. so growth potential is lost sooner.




there is more mechanisms in which isotret (accutane) will fuck you up. IDK AND IDC this is enough not to use it.




is there any solution? yes - topical anti androgens with low systemic absorption for the same use-case of isotret (acne)






View attachment 5167898



Stupid chatgpt

dnr

 

[jubilation]

Analysis: Pediatric Isotretinoin Use Not Linked to Shorter Adult Height | HCPLive

Isotretinoin was actually linked to a taller adult height among those who took it to treat acne in childhood versus doxycycline, in a new study.

www.hcplive.com

 

[infrainfra]

Analysis: Pediatric Isotretinoin Use Not Linked to Shorter Adult Height | HCPLive

Isotretinoin was actually linked to a taller adult height among those who took it to treat acne in childhood versus doxycycline, in a new study.

www.hcplive.com

„Isotretinoin was actually linked to a taller adult height among those who took it to treat acne in childhood versus doxycycline” yeah here u go buddy. antibiotics are horrible for u.


and the study is „not LINKED to shorter adult height”


oh yeah and red meat is LINKED to cancer so it must cause cancer

vege diets linked to longer lifespans SO MEAT IS BAD. thats essentially your way of thinking.


read my thread nigga

 

[jubilation]

„Isotretinoin was actually linked to a taller adult height among those who took it to treat acne in childhood versus doxycycline” yeah here u go buddy. antibiotics are horrible for u.


and the study is „not LINKED to shorter adult height”


oh yeah and red meat is LINKED to cancer so it must cause cancer

vege diets linked to longer lifespans SO MEAT IS BAD. thats essentially your way of thinking.


read my thread nigga

okay so accutane is LINKED to shorter height in 9 kids so it must cause shorter height. I've been looking at this for 2 days and ur the only dude on this forum doing all this fearmongering. I also looked at ur studies or whatever and of course its gonna have an effect on rats which weigh only 0.605% of what a human weighs, also another study is on kids with cancer using way high doses at super young ages. accutane is the ONLY known drug to cure all acne

 

[infrainfra]

okay so accutane is LINKED to shorter height in 9 kids so it must cause shorter height. I've been looking at this for 2 days and ur the only dude on this forum doing all this fearmongering. I also looked at ur studies or whatever and of course its gonna have an effect on rats which weigh only 0.605% of what a human weighs, also another study is on kids with cancer using way high doses at super young ages. accutane is the ONLY known drug to cure all acne

wtf is ur point? u essentially said that smaller animals (rats) get smaller doses and stunt growth lmao. the doses used are equivalent to human doses in mg/kg. there are human studies read it all nigga. and accutane isnt the only acne product