Metformin limits cell survival and shortens lifespan (shocking)

[6ft8InTheNetherlands]

Just came across this shocking study which basically claims that metformin causes non diabetic older metformin users to age much quicker by causing an aging-associated failure of energy metabolism. Although the study says younger users experience benefits.

I really wonder what David Sinclair thinks about this.

Link: https://www.biorxiv.org/content/10.1101/863357v1

Highlights

• Late life metformin treatment limits cell survival and shortens lifespan.
• Metformin exacerbates aging-associated mitochondrial dysfunction causing fatal ATP exhaustion.
• Old cells fail to upregulate glycolysis as a compensatory response to metformin.
• The dietary restriction (DR) mimetic response to metformin is abrogated in old animals.
• PKA and not AMPK pathway instigates the early life DR response to metformin.
• Stabilization of cellular ATP levels alleviates late life metformin toxicity in vitro and in vivo.

 

[Deleted member 2486]

jfl @SirGey cucked

 

[Deleted member 656]

I'm not a sciencecel

Would this not be similar for berberine seeing as they function very similarly?

 

[Deleted member 2933]

Google is useless for everything. Both sides can be found https://www.sciencedirect.com/science/article/abs/pii/S104327601930147X

Real life experience is the only way to know.

 

[6ft8InTheNetherlands]

I am waiting for the replies of Peter Attia and David Sinclair. They have been forwarded this study.

I also think they are talking about really old people in this study.

Google is useless for everything. Both sides can be found https://www.sciencedirect.com/science/article/abs/pii/S104327601930147X

I agree, next week we come across a study claiming the opposite.

 

[OldRooster]

Just petri dish and worm research. No one should draw any conclusions as to humans.