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Kraken
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The video above already covers this topic, but for a more detailed approach to the topic you can read it here:
https://medium.com/attractiontheory/minoxidil-and-the-collagen-synthesis
Over the internet there are a few people who claim that after using minoxidil, be it on their face or scalp to regrow the hair and slow down male pattern baldness, they noticed that their skin started to look bad as if they got much older since they started using minoxidil.
All this becomes reinforced when they talk to other people who also claim the same effect and use the 1996 article by Lachgar S., et al., as proof that minoxidil indeed reduces the collagen synthesis in the human skin.
Usually, these people will quote the following from the article as evidence that they are correct:
There are several misinterpretations about this article though.
First, the article did not investigate the inhibitory effects of minoxidil and other substances in the human skin, but in cultured hair dermal papilla cells (DPC).
The dermal papilla is located in the base of the hair follicle and contains tiny blood vessels called capillaries that nourish the cells in this area.
The study investigated the collagen synthesis in the DPCin monolayer cultures and embedded in three-dimensional collagen gel, that is, in vitro.
It’s important to mention that the morphology of the DPC in monolayer culture differed clearly from that of DPC cultured in collagen lattices. In the lattices, DPC was larger and tended morphologically to resemble cells observed in vivo.
In monolayer cultures, DPC displayed an elongated bipolar shape.
In the lattices, DPC was larger and tended morphologically to resemble cells observed in vivo.
This point is important because the DPC cultured in lattices had a reduction of collagen synthesis 50% less than that recorded on the monolayer culture.
The differentiation of the morphology and the environment of the DPC were enough to significantly change the results between the experiments.
Furthermore, this possible reduction of collagen synthesis on the DPC may be one of the reasons for the growth effect of these substances, since these compounds directly inhibit collagen synthesis, the connective tissue surrounding the dermal papilla may become less dense and compact. Which would theoretically favor a greater extent of vascularization for the purely physical reason that the new blood vessels meet less resistance in penetrating the collagen mass.
Therefore there is no proof that minoxidil decreases the collagen synthesis on the human skin, especially to a noticeable point.
The real cause of the age effect that some people claim, could be actually caused by the fact that minoxidil contains ethanol/propylene glycol on its composition to help the drug penetrate the skin.
Unfortunately, these substances are known to decrease significantly skin hydration. This skin dehydration, in turn, may cause wrinkles and peeling of the skin.
Therefore, when using minoxidil it’s important to also use throughout the treatment a ceramic hydration cream which has the highest rates of skin hydration to counter the effects of the ethanol in the minoxidil composition.
If you want to support the channel you can buy minoxidil and the ceramide cream using these links (You won't be charged more nor will I be able to know your personal info):
Buy Minoxidil Here: https://amzn.to/2nfFjpn
Buy Ceramide Hydration Cream Here: https://amzn.to/2nZsQ9o
Ref.:
https://www.ncbi.nlm.nih.gov/pubmed/8844127
https://www.ncbi.nlm.nih.gov/pubmed/7562405
https://www.ncbi.nlm.nih.gov/pubmed/17578437
https://www.ncbi.nlm.nih.gov/pubmed/22672420
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197824/
