7zyzz7
Eradicate Humanity 2024
- Joined
- Sep 1, 2021
- Posts
- 5,218
- Reputation
- 7,367
People Can Die As A Result Of Giving Up (a State Caused By Low Dopamine)
Ask any doctor if loss of hope can kill and he/she will laugh in your face. Even if you use the more scientific term "learned helplessness" you will still be laughed out of the room. Well, the study below shows that "give-up-itis" (GUI) is quite real and can reliably kill a person if it takes a...
"the study claims that the direct cause of giving up is dramatically lowered dopamine levels as a result of the inescapable stress/trauma. "
"the study shows that it is events of chronic stress/defeat/inescapability that lead to the dopamine exhaustion and giving up. As such, initial mild apathy and withdrawal seen in people in early stages of learned helplessness is adaptive and beneficial, in an attempt to avoid the "defeating" event and thus replenish dopamine levels. Interestingly enough, the term "chronic social defeat" is extremely well-known in animal research of any kind (rodents, reptiles, amphibians, apes, etc) and is known as a reliable way to quickly induce chronic disease in ANY animal, including conditions such as diabetes, cancer, Alzheimer, Parkinson, CVD, etc. An example of such events would be public verbal, physical or emotional abuse by an individual with higher social status. Unsuccessful competition for job promotion, romantic partner, major sport event, or even being stuck in traffic while late for a VERY important meeting are other common examples of such social defeat events."
"An even more pernicious and sinister approach is known as "chronic unpredictable mild stress" (CUMS) as animals subjected to it develop subtle metabolic changes over a long period of time that eventually lead to the same devastating diseases. Yet on paper, the animal is mostly healthy and the eventual disease cannot really be traced to any single event in the animal's life. An example of such events would be your bank charging you overdraft fees, pesky emails from your boss while on vacation, marketing calls at the least appropriate times, persistent "multitasking" leading to feelings of being overwhelmed with work, etc."
https://www.sciencedirect.com/science/article/pii/S0306987718306145?via=ihub
"...People with reduced dopamine levels tend towards apathy, lack a zest for life and often have an impairment in routine actions such as walking which is normally slowed and observed as a shuffling gait [50]. This slow shuffling movement has been observed in PoWs and camp prisoners during stage II GUI and is a mark of defeat.
"...In certain clinical conditions differences in the severity of apathy is considered to be at least partly a dopamine-dependent syndrome [51]; aboulia is suggested to be a dopamine-related dysfunction [46], and DA agents are used successfully to counter apathy and treat psychic akinesia [47]. DA depletion is also associated with anhedonia that also presents in GUI and general anhedonia is associated with stress that is uncontrollable and unpredictable "
"...GUI commonly occurs in a traumatic situation from which there is, or is perceived to be, no escape and over which a person has little or no influence. Essentially, the GUI victim sees him or herself as being defeated. Cruickshank [58] thought that many of the behavioural symptoms exhibited by his patients in the Japanese PoW camp at Changi were as much, ‘…the result of fighting a losing battle’ as of the disease.
"If active coping is not possible then sustained activation of cortical DA production leads to a profound inhibition of NAc DA release resulting in behavioural impairments and abnormalities in mechanisms of motivation, including withdrawal and apathy [60,62] that are comparable to those observed in GUI victims.
"in both human and animal studies, passive coping is associated with blunting stress-induced emotional arousal [64] which is consistent with field observations that passive behaviours were seen as a form of protection and as a necessary mechanism of self-defence [20,22]."
"...A common observation was that people died between three days to three weeks from the onset of a ‘fatal withdrawal’ or GUI if the person was not forced to respond to his environment [1]. It is possible to recover from even extreme stages of GUI as it is to recover from comparable clinical conditions of apathy, aboulia and psychic akinesia, although in the latter cases usually through administering DA agonists such as bromocriptine, ropinirole, etc."
People can die from giving up the fight
"...People can die simply because they've given up, life has beaten them and they feel defeat is inescapable, according to new research. The study, by Dr John Leach, a senior research fellow at the University of Portsmouth, is the first to describe the clinical markers for 'give-up-itis', a term used to describe what is known medically as psychogenic death. It usually follows a trauma from which a person thinks there is no escape, making death seem like the only rational outcome. If not arrested, death usually occurs three weeks after the first stage of withdrawal.
He said: "Severe trauma might trigger some people's anterior cingulate circuit to malfunction. Motivation is essential for coping with life and if that fails, apathy is almost inevitable." Death isn't inevitable in someone suffering from give-up-itis and can be reversed by different things at each stage. The most common interventions are physical activity and/or a person being able to see a situation is at least partially within their control, both of which trigger the release of the feel-good chemical dopamine. "Reversing the give-up-itis slide towards death tends to come when a survivor finds or recovers a sense of choice, of having some control, and tends to be accompanied by that person licking their wounds and taking a renewed interest in life," he said."
TLDR: LDAR is literally killing you from the inside, you need to remain hopeful of making it at all costs.
