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Caloric restriction (CR) , as applied in laboratory mice , can extend lifespan by 20 to 40 percent compared to ad libitum (free access to chow) .
Several caveats exist , however .
One caveat is that a major cause of laboratory mouse mortality is cancer . Therefore , reduceing cancer mortality but not ageing would give the illusion of an anti ageing effect .
Another caveat is that CR mice typically eat all of their allotment of food within a few hours , whereas ad lib mice eat throughout the 24 hour period . This increases the efficiency of CR mice , for they get used to only haveing to process food at the specific time of which they are routinely fed . They also are fasted for quite some time each day .
Another caveat is that ad lib mice often become obese , and therefore simply preventing obesity would prevent accelerated ageing and death and doesnt necessarily mean that restricting calories in healthy weight humans would further slow ageing .
Another caveat is that mouse chow contains toxins like AGEs and other contaminants . Therefore it may not be calories per se that is restricted to delay death but the toxins , such as AGEs .
Another caveat is that CR mice are often given extra vitamin and mineral mix so that their micronutrient intake is similar to ad lib mice depsite reduced chow consumption . This means their micronutrient density is increased , yet in humans , reduceing food intake generally will reduce micronutrients as well as calories .
And the last caveat I will mention is one that Aubrey de Grey mentions in the linked article , that mice simply have shorter lifespans than humans , and that humans presumeably would gain a smaller degree of life extension from CR , perhaps only 2-3 years at most .
karger.com
I will mention my idea on the mechanistic theory of CR . Based on the assumption that CR per se slows ageing , my perspective is that the primary mechanism of this is by decreaseing natural processes such as growth , reproductive capactites , and immune activation . In organic chemistry , all reactions generate byproducts in addition to the main purpose of the reaction . Therefore , by reduceing growth and reprodcutive and immune processes , CR can decrease the rate at which damage (ageing) accumulates .
This is in theory , but in practice the potential degree of the anti-ageing effect is unknown in ourselves .
Several caveats exist , however .
One caveat is that a major cause of laboratory mouse mortality is cancer . Therefore , reduceing cancer mortality but not ageing would give the illusion of an anti ageing effect .
Another caveat is that CR mice typically eat all of their allotment of food within a few hours , whereas ad lib mice eat throughout the 24 hour period . This increases the efficiency of CR mice , for they get used to only haveing to process food at the specific time of which they are routinely fed . They also are fasted for quite some time each day .
Another caveat is that ad lib mice often become obese , and therefore simply preventing obesity would prevent accelerated ageing and death and doesnt necessarily mean that restricting calories in healthy weight humans would further slow ageing .
Another caveat is that mouse chow contains toxins like AGEs and other contaminants . Therefore it may not be calories per se that is restricted to delay death but the toxins , such as AGEs .
Another caveat is that CR mice are often given extra vitamin and mineral mix so that their micronutrient intake is similar to ad lib mice depsite reduced chow consumption . This means their micronutrient density is increased , yet in humans , reduceing food intake generally will reduce micronutrients as well as calories .
And the last caveat I will mention is one that Aubrey de Grey mentions in the linked article , that mice simply have shorter lifespans than humans , and that humans presumeably would gain a smaller degree of life extension from CR , perhaps only 2-3 years at most .
The Unfortunate Influence of the Weather on the Rate of Ageing: Why Human Caloric Restriction or Its Emulation May Only Extend Life Expectancy by 2–3 Years
Abstract. Much research interest, and recently even commercial interest, has been predicated on the assumption that reasonably closely-related species – humans and mice, for example – should, in principle, respond to ageing-retarding interventions with an increase in maximum lifespan roughly...
karger.com
I will mention my idea on the mechanistic theory of CR . Based on the assumption that CR per se slows ageing , my perspective is that the primary mechanism of this is by decreaseing natural processes such as growth , reproductive capactites , and immune activation . In organic chemistry , all reactions generate byproducts in addition to the main purpose of the reaction . Therefore , by reduceing growth and reprodcutive and immune processes , CR can decrease the rate at which damage (ageing) accumulates .
This is in theory , but in practice the potential degree of the anti-ageing effect is unknown in ourselves .
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