SAYORI’S WHITENING GUIDE - [Full guide from overall skin lightening to treating melasma] no need to think just read-Part 1

[Navity]

I don't dnr anyone on purpose

 

[Sayori]

View attachment 4980158

oh lol I was prob sleepy asf

 

[Genio]

Yes I would like that, anecdotes are always welcome

Took my first dose of Tranexamic Acid, 500mg all in a dose, can't be asked to take it bi-daily.

 

[SteveRogers]

Unreal thread for curries.
Wondering your thoughts on using this for lips?

 

[Sayori]

Unreal thread for curries.
Wondering your thoughts on using this for lips?

I'm going to be honest here, I haven't looked into it for lips, but ill have u know if by some reason my package didn't get seized, I will try it in ur honor

Just from theory, I am 80 percent confident that it will lighten lips

If i fucks up my lips or whether it works

 

[BronzeageMaxxing]

SAYORI’S WHITENING GUIDE - [ Full guide from overall skin lightening to treating melasma] no need to think just read


Table of contents​

Must know vocab before starting thread

General deep dive about products for whitening

Whitening routine

---

edit Note:
If its to complex, just skip to the conclusions and notes I left, you can also just skip to the routine

Must know vocab before starting thread
MASI:
It stands for melasma area severity index; it's used to indicate how bad melasma is and its used to check if a treatment is working. The higher the number for this index the worse and the smaller the number the better.

Mean:
In statistics, the mean is a measure of central tendency that summarizes a dataset with a single number reflecting its center or typical value.

SD:
This stands for standard deviation in statistics, standard deviation in statistics is a measure of how much the values in a dataset deviate from the mean, indicating the spread of variability of the data set. The data I will be presenting you with only shows you one standard deviation which means 68% percent of all data fits within the number if you were to take the mean and +/- from it once.
View attachment 4976445
View attachment 4976444

T test and CL:
“A t-test is a statistical test used to compare the means of two groups, while a confidence interval (CI) is a range of values that is likely to include the true population mean with a certain degree of confidence. The 95% CI is a specific type of confidence interval that provides a 95% probability that the true population mean lies within the specified range. This means that if you were to conduct the experiment multiple times and calculate the CI each time, approximately 95% of the intervals would contain the true population mean. The CI is calculated using the sample mean, standard deviation, and degrees of freedom to estimate the variability of the population mean.”

Central limit theorem for means:
One of the most basic principles in statistics, the Central Limit Theorem (CLT) describes how the sample mean distribution changes with increasing sample size. If the sample is sufficiently large (usually n > 30), then the sample means' distribution will be normally distributed regardless of the underlying population distribution, whether it is normal, skewed, or otherwise.
View attachment 4976446

P56 gene:
Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.[5] RELA, also known as p65, is a REL-associated protein involved in NF-κB heterodimer formation, nuclear translocation and activation.[6] NF-κB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc. Phosphorylation and acetylation of RELA are crucial post-translational modifications required for NF-κB activation. RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer. (for our needs it causes inflammation and tissue damage lol)

---

General deep dive about products for whitening
Azelaic acid 20 % vs Hydroquinone 4% In people with melasma:

Method:
29 women with melasma were recruited and treated, 15 were with hydroquinone 4% for 2 months and 14 were treated with azelaic acid 4% for 2 months, the cream was applied twice daily and a broad spectrum sunscreen was used concomitantly by both groups.

Hydroquinone 4%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.2
• SD=3.2
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.7
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.2
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Azelaic acid 20%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.6
• SD=3.5
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.3
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=3.8
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Conclusion:
The study suggest that 20% azelaic acid cream applied twice daily may be more effective than hydroquinone 4%

Note:
The study sample size is below 30 and “central limit theorem for means” tells us that if a sample is below 30 we can't trust it. However, if the population= Normal distribution there is no need for a minimum of a sample size of 30. So our statistics qualify for “the central limit theorem for means”.

Note:
Keep in mind this is for individuals with melasma. If this were to be put against normal skin the hydroquinone would win at lightening as it is a non selective tyrosinase inhibitor as compared to azelaic acid which only targets over active cells.

Study used for this:

https://www.researchgate.net/publication/51862186_Comparative_study_of_therapeutic_effects_of_20_azelaic_acid_and_hydroquinone_4_cream_in_the_treatment_of_melasma

Hydroquinone combined with aloe vera in order to reduce side effects:
So combining hydroquinone with aloe vera in rats aided in reducing side effects of hydroquinone. So it can hypothetically do the same to us humans. In the words of the researchers “The application of aloe vera gel to the already treated skin had observable effects as Aloe vera gel application showed potentials to ameliorate hydroquinone deleterious effects by persevering the stratum corneum which were generally disrupted in other groups that were administered hydroquinone [to the skin]” this just means that it makes potential side effects of hydroquinone better. Further more “ the expression of p56 in these groups was relatively reduced [Figure 3]. Thus, aloe-vera gel as used had protective effects and by extension might be protecting the skin from the potential consequences associated with the effects of hydroquinone.” This is just telling us that inflammation is being reduced as P56 causes that.

In conclusion:
Without over complicating the data shows that aloe vera on your skin can reduce a lot of the hydroquinone side effects on rats. Which will be important if you choose to run this compound. I don't want to over complicate this section since its pretty water aloe vera is good for you.

The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7147621/

What to cycle Hydroquinone and what to maintenance results with:
TCC better than Hyrdoquino 4% & general info:
The study talks about combining “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ ; it also mentions that they are “ frequently employed” for whitening purposes. In the literature it also talks about “ limited-duration hydroquinone courses, and transition to non-hydroquinone maintenance to minimize adverse effects that can exacerbate pigmentation, such as irritant dermatitis.” This is just telling you to cycle this shii nga. This is from the study directly “77% of TCC-treated participants reached complete or near complete clearing, in contrast only 47% of dual-combination group achieved the very endpoints. Ferreira Cestari et al. also displayed its superiority to 4% hydroquinone in the view of efficacy41. Clearance of melasma, meaning lesions nearly equivalent to perilesional skin, was observed in 35% of subjects using TCC versus 5% using HQ alone.” What this tells us is that the combination “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ mogged the fuck out of dual combination and just hyrdoquinone 4%. Which means we should be combining it for my effectiveness.

The combination of these products are better as shown here “the higher efficacy of this product based on the synergistic effects of its ingredients. Specifically, the topical steroid is thought to ameliorate irritation caused by the other two ingredients and inhibit melanin synthesis, while the retinoid is believed to interrupt the oxidation of hydroquinone and facilitate its trans-epidermal penetration42. “ as you can see its saying they work with each other to counter each other's negatives and make each other more effectively absorbed.

Don't cycle longer then 3 months is the norm but here “Given that hydroquinone in concentrations above 4% and in treatment courses longer than 3 months may be associated with new onset ochronosis43, the combination formula limiting the concentration of hydroquinone as 4% thanks to combined effects with other constituents may account for the lower risk of ochronosis4 “ We can cycle for longer or just cycle the same time with less possible side effects while it being more effective yay.

Oral tranexamic acid (TXA)
Oral tranexamic acid stops melanocyte communication "TXA affects the communication between keratinocytes and melanocytes.", Its effects on your vascular tissue and uv “TXA hinders the plasmin activity induced by UV light exposure, leading to a reduction in mast cell activity and the inhibition of fibroblast growth factor50. This, in turn, results in a decrease in the number of mast cells in the dermis and a reduction in the formation of new blood vessels13,50 “ this just means you will get less ugly redness that people get from sun exposure helps people that suffer from PIE. IT also regulates the degradation of melanosomes “TXA can activate the autophagy system by increasing the expression of autophagy-related proteins51. Earlier research indicates that the autophagy system plays a crucial role in determining skin color by regulating the degradation of melanosomes in keratinocytes, which is enhanced by activators of autophagy52 “ This will keep your skin lighter and for longer. The results are the same between dosages but if you want faster results take higher doses “although faster results were achieved with higher doses.".

Conclusion:
TCC is way more effective than solo hydroquinone 4% or just a dual combination. The effects all work to help each other. Oral TXA is effective to take if you want your skin to reduce in redness and want easier maintenance of your whitening. It also mentioned that you shouldn't run these products for longer than 3 months at a time.

Glutathione needed for the natural whitening look:

This will be finished in part 2
I will not be putting in more effort on this topic if its not liked


The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3848650/

Conclusion:
TCC which is ““ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ is more effective at skin whitening and has less side effects as they work together, one works to absorb better and another mechanism to reduce side effects. The research also tells us the cycling for more than 3 months is bad.

---

Whitening routine

1. TCC ( fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% ) applied twice daily for 3 months
2. Oral tranexamic acid in order to reduce redness and maintain the whitening effects
3. After 3 months switch to TCC monthly and azelaic acid 20 percent two times daily repeat for a month
4. Remove TCC and run azelaic acid 20% twice and Oral tranexamic acid any dose you like for 3 more months
5. Lastly repeat this cycle over and over and don't forget sunscreen ever 2 hours non negotiable

---

Tags:
@illusion @Hernan @goku21 @Randomized @Jason Voorhees

DNRD this is very good if ur brown otherwise whiteboys tanmaxx

 

[Sayori]

DNRD this is very good if ur brown otherwise whiteboys tanmaxx

Or if u have melesma or are a brown eyed white boy

 

[BronzeageMaxxing]

green eyed whiteboy

 

[saumya_19]

"Keep running forever"

Some serious kidney or liver damage

 

[Sayori]

"Keep running forever"

Some serious kidney or liver damage

where did I saw that nga tard

 

[hexumsforgotten]

D you

SAYORI’S WHITENING GUIDE - [ Full guide from overall skin lightening to treating melasma] no need to think just read


Table of contents​

Must know vocab before starting thread

General deep dive about products for whitening

Whitening routine

---

edit Note:
If its to complex, just skip to the conclusions and notes I left, you can also just skip to the routine

Must know vocab before starting thread
MASI:
It stands for melasma area severity index; it's used to indicate how bad melasma is and its used to check if a treatment is working. The higher the number for this index the worse and the smaller the number the better.

Mean:
In statistics, the mean is a measure of central tendency that summarizes a dataset with a single number reflecting its center or typical value.

SD:
This stands for standard deviation in statistics, standard deviation in statistics is a measure of how much the values in a dataset deviate from the mean, indicating the spread of variability of the data set. The data I will be presenting you with only shows you one standard deviation which means 68% percent of all data fits within the number if you were to take the mean and +/- from it once.
View attachment 4976445
View attachment 4976444

T test and CL:
“A t-test is a statistical test used to compare the means of two groups, while a confidence interval (CI) is a range of values that is likely to include the true population mean with a certain degree of confidence. The 95% CI is a specific type of confidence interval that provides a 95% probability that the true population mean lies within the specified range. This means that if you were to conduct the experiment multiple times and calculate the CI each time, approximately 95% of the intervals would contain the true population mean. The CI is calculated using the sample mean, standard deviation, and degrees of freedom to estimate the variability of the population mean.”

Central limit theorem for means:
One of the most basic principles in statistics, the Central Limit Theorem (CLT) describes how the sample mean distribution changes with increasing sample size. If the sample is sufficiently large (usually n > 30), then the sample means' distribution will be normally distributed regardless of the underlying population distribution, whether it is normal, skewed, or otherwise.
View attachment 4976446

P56 gene:
Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.[5] RELA, also known as p65, is a REL-associated protein involved in NF-κB heterodimer formation, nuclear translocation and activation.[6] NF-κB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc. Phosphorylation and acetylation of RELA are crucial post-translational modifications required for NF-κB activation. RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer. (for our needs it causes inflammation and tissue damage lol)

---

General deep dive about products for whitening
Azelaic acid 20 % vs Hydroquinone 4% In people with melasma:

Method:
29 women with melasma were recruited and treated, 15 were with hydroquinone 4% for 2 months and 14 were treated with azelaic acid 4% for 2 months, the cream was applied twice daily and a broad spectrum sunscreen was used concomitantly by both groups.

Hydroquinone 4%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.2
• SD=3.2
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.7
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.2
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Azelaic acid 20%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.6
• SD=3.5
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.3
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=3.8
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Conclusion:
The study suggest that 20% azelaic acid cream applied twice daily may be more effective than hydroquinone 4%

Note:
The study sample size is below 30 and “central limit theorem for means” tells us that if a sample is below 30 we can't trust it. However, if the population= Normal distribution there is no need for a minimum of a sample size of 30. So our statistics qualify for “the central limit theorem for means”.

Note:
Keep in mind this is for individuals with melasma. If this were to be put against normal skin the hydroquinone would win at lightening as it is a non selective tyrosinase inhibitor as compared to azelaic acid which only targets over active cells.

Study used for this:

https://www.researchgate.net/publication/51862186_Comparative_study_of_therapeutic_effects_of_20_azelaic_acid_and_hydroquinone_4_cream_in_the_treatment_of_melasma

Hydroquinone combined with aloe vera in order to reduce side effects:
So combining hydroquinone with aloe vera in rats aided in reducing side effects of hydroquinone. So it can hypothetically do the same to us humans. In the words of the researchers “The application of aloe vera gel to the already treated skin had observable effects as Aloe vera gel application showed potentials to ameliorate hydroquinone deleterious effects by persevering the stratum corneum which were generally disrupted in other groups that were administered hydroquinone [to the skin]” this just means that it makes potential side effects of hydroquinone better. Further more “ the expression of p56 in these groups was relatively reduced [Figure 3]. Thus, aloe-vera gel as used had protective effects and by extension might be protecting the skin from the potential consequences associated with the effects of hydroquinone.” This is just telling us that inflammation is being reduced as P56 causes that.

In conclusion:
Without over complicating the data shows that aloe vera on your skin can reduce a lot of the hydroquinone side effects on rats. Which will be important if you choose to run this compound. I don't want to over complicate this section since its pretty water aloe vera is good for you.

The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7147621/

What to cycle Hydroquinone and what to maintenance results with:
TCC better than Hyrdoquino 4% & general info:
The study talks about combining “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ ; it also mentions that they are “ frequently employed” for whitening purposes. In the literature it also talks about “ limited-duration hydroquinone courses, and transition to non-hydroquinone maintenance to minimize adverse effects that can exacerbate pigmentation, such as irritant dermatitis.” This is just telling you to cycle this shii nga. This is from the study directly “77% of TCC-treated participants reached complete or near complete clearing, in contrast only 47% of dual-combination group achieved the very endpoints. Ferreira Cestari et al. also displayed its superiority to 4% hydroquinone in the view of efficacy41. Clearance of melasma, meaning lesions nearly equivalent to perilesional skin, was observed in 35% of subjects using TCC versus 5% using HQ alone.” What this tells us is that the combination “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ mogged the fuck out of dual combination and just hyrdoquinone 4%. Which means we should be combining it for my effectiveness.

The combination of these products are better as shown here “the higher efficacy of this product based on the synergistic effects of its ingredients. Specifically, the topical steroid is thought to ameliorate irritation caused by the other two ingredients and inhibit melanin synthesis, while the retinoid is believed to interrupt the oxidation of hydroquinone and facilitate its trans-epidermal penetration42. “ as you can see its saying they work with each other to counter each other's negatives and make each other more effectively absorbed.

Don't cycle longer then 3 months is the norm but here “Given that hydroquinone in concentrations above 4% and in treatment courses longer than 3 months may be associated with new onset ochronosis43, the combination formula limiting the concentration of hydroquinone as 4% thanks to combined effects with other constituents may account for the lower risk of ochronosis4 “ We can cycle for longer or just cycle the same time with less possible side effects while it being more effective yay.

Oral tranexamic acid (TXA)
Oral tranexamic acid stops melanocyte communication "TXA affects the communication between keratinocytes and melanocytes.", Its effects on your vascular tissue and uv “TXA hinders the plasmin activity induced by UV light exposure, leading to a reduction in mast cell activity and the inhibition of fibroblast growth factor50. This, in turn, results in a decrease in the number of mast cells in the dermis and a reduction in the formation of new blood vessels13,50 “ this just means you will get less ugly redness that people get from sun exposure helps people that suffer from PIE. IT also regulates the degradation of melanosomes “TXA can activate the autophagy system by increasing the expression of autophagy-related proteins51. Earlier research indicates that the autophagy system plays a crucial role in determining skin color by regulating the degradation of melanosomes in keratinocytes, which is enhanced by activators of autophagy52 “ This will keep your skin lighter and for longer. The results are the same between dosages but if you want faster results take higher doses “although faster results were achieved with higher doses.".

Conclusion:
TCC is way more effective than solo hydroquinone 4% or just a dual combination. The effects all work to help each other. Oral TXA is effective to take if you want your skin to reduce in redness and want easier maintenance of your whitening. It also mentioned that you shouldn't run these products for longer than 3 months at a time.

Glutathione needed for the natural whitening look:

This will be finished in part 2
I will not be putting in more effort on this topic if its not liked


The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3848650/

Conclusion:
TCC which is ““ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ is more effective at skin whitening and has less side effects as they work together, one works to absorb better and another mechanism to reduce side effects. The research also tells us the cycling for more than 3 months is bad.

---

Whitening routine

1. TCC ( fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% ) applied twice daily for 3 months
2. Oral tranexamic acid in order to reduce redness and maintain the whitening effects
3. After 3 months switch to TCC monthly and azelaic acid 20 percent two times daily repeat for a month
4. Remove TCC and run azelaic acid 20% twice and Oral tranexamic acid any dose you like for 3 more months
5. Lastly repeat this cycle over and over and don't forget sunscreen ever 2 hours non negotiable

---

Tags:
@illusion @Hernan @goku21 @Randomized @Jason Voorhees[/USe
[/QUOTE]

 

[hexumsforgotten]

SAYORI’S WHITENING GUIDE - [ Full guide from overall skin lightening to treating melasma] no need to think just read


Table of contents​

Must know vocab before starting thread

General deep dive about products for whitening

Whitening routine

---

edit Note:
If its to complex, just skip to the conclusions and notes I left, you can also just skip to the routine

Must know vocab before starting thread
MASI:
It stands for melasma area severity index; it's used to indicate how bad melasma is and its used to check if a treatment is working. The higher the number for this index the worse and the smaller the number the better.

Mean:
In statistics, the mean is a measure of central tendency that summarizes a dataset with a single number reflecting its center or typical value.

SD:
This stands for standard deviation in statistics, standard deviation in statistics is a measure of how much the values in a dataset deviate from the mean, indicating the spread of variability of the data set. The data I will be presenting you with only shows you one standard deviation which means 68% percent of all data fits within the number if you were to take the mean and +/- from it once.
View attachment 4976445
View attachment 4976444

T test and CL:
“A t-test is a statistical test used to compare the means of two groups, while a confidence interval (CI) is a range of values that is likely to include the true population mean with a certain degree of confidence. The 95% CI is a specific type of confidence interval that provides a 95% probability that the true population mean lies within the specified range. This means that if you were to conduct the experiment multiple times and calculate the CI each time, approximately 95% of the intervals would contain the true population mean. The CI is calculated using the sample mean, standard deviation, and degrees of freedom to estimate the variability of the population mean.”

Central limit theorem for means:
One of the most basic principles in statistics, the Central Limit Theorem (CLT) describes how the sample mean distribution changes with increasing sample size. If the sample is sufficiently large (usually n > 30), then the sample means' distribution will be normally distributed regardless of the underlying population distribution, whether it is normal, skewed, or otherwise.
View attachment 4976446

P56 gene:
Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.[5] RELA, also known as p65, is a REL-associated protein involved in NF-κB heterodimer formation, nuclear translocation and activation.[6] NF-κB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc. Phosphorylation and acetylation of RELA are crucial post-translational modifications required for NF-κB activation. RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer. (for our needs it causes inflammation and tissue damage lol)

---

General deep dive about products for whitening
Azelaic acid 20 % vs Hydroquinone 4% In people with melasma:

Method:
29 women with melasma were recruited and treated, 15 were with hydroquinone 4% for 2 months and 14 were treated with azelaic acid 4% for 2 months, the cream was applied twice daily and a broad spectrum sunscreen was used concomitantly by both groups.

Hydroquinone 4%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.2
• SD=3.2
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.7
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.2
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Azelaic acid 20%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.6
• SD=3.5
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.3
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=3.8
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Conclusion:
The study suggest that 20% azelaic acid cream applied twice daily may be more effective than hydroquinone 4%

Note:
The study sample size is below 30 and “central limit theorem for means” tells us that if a sample is below 30 we can't trust it. However, if the population= Normal distribution there is no need for a minimum of a sample size of 30. So our statistics qualify for “the central limit theorem for means”.

Note:
Keep in mind this is for individuals with melasma. If this were to be put against normal skin the hydroquinone would win at lightening as it is a non selective tyrosinase inhibitor as compared to azelaic acid which only targets over active cells.

Study used for this:

https://www.researchgate.net/publication/51862186_Comparative_study_of_therapeutic_effects_of_20_azelaic_acid_and_hydroquinone_4_cream_in_the_treatment_of_melasma

Hydroquinone combined with aloe vera in order to reduce side effects:
So combining hydroquinone with aloe vera in rats aided in reducing side effects of hydroquinone. So it can hypothetically do the same to us humans. In the words of the researchers “The application of aloe vera gel to the already treated skin had observable effects as Aloe vera gel application showed potentials to ameliorate hydroquinone deleterious effects by persevering the stratum corneum which were generally disrupted in other groups that were administered hydroquinone [to the skin]” this just means that it makes potential side effects of hydroquinone better. Further more “ the expression of p56 in these groups was relatively reduced [Figure 3]. Thus, aloe-vera gel as used had protective effects and by extension might be protecting the skin from the potential consequences associated with the effects of hydroquinone.” This is just telling us that inflammation is being reduced as P56 causes that.

In conclusion:
Without over complicating the data shows that aloe vera on your skin can reduce a lot of the hydroquinone side effects on rats. Which will be important if you choose to run this compound. I don't want to over complicate this section since its pretty water aloe vera is good for you.

The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7147621/

What to cycle Hydroquinone and what to maintenance results with:
TCC better than Hyrdoquino 4% & general info:
The study talks about combining “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ ; it also mentions that they are “ frequently employed” for whitening purposes. In the literature it also talks about “ limited-duration hydroquinone courses, and transition to non-hydroquinone maintenance to minimize adverse effects that can exacerbate pigmentation, such as irritant dermatitis.” This is just telling you to cycle this shii nga. This is from the study directly “77% of TCC-treated participants reached complete or near complete clearing, in contrast only 47% of dual-combination group achieved the very endpoints. Ferreira Cestari et al. also displayed its superiority to 4% hydroquinone in the view of efficacy41. Clearance of melasma, meaning lesions nearly equivalent to perilesional skin, was observed in 35% of subjects using TCC versus 5% using HQ alone.” What this tells us is that the combination “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ mogged the fuck out of dual combination and just hyrdoquinone 4%. Which means we should be combining it for my effectiveness.

The combination of these products are better as shown here “the higher efficacy of this product based on the synergistic effects of its ingredients. Specifically, the topical steroid is thought to ameliorate irritation caused by the other two ingredients and inhibit melanin synthesis, while the retinoid is believed to interrupt the oxidation of hydroquinone and facilitate its trans-epidermal penetration42. “ as you can see its saying they work with each other to counter each other's negatives and make each other more effectively absorbed.

Don't cycle longer then 3 months is the norm but here “Given that hydroquinone in concentrations above 4% and in treatment courses longer than 3 months may be associated with new onset ochronosis43, the combination formula limiting the concentration of hydroquinone as 4% thanks to combined effects with other constituents may account for the lower risk of ochronosis4 “ We can cycle for longer or just cycle the same time with less possible side effects while it being more effective yay.

Oral tranexamic acid (TXA)
Oral tranexamic acid stops melanocyte communication "TXA affects the communication between keratinocytes and melanocytes.", Its effects on your vascular tissue and uv “TXA hinders the plasmin activity induced by UV light exposure, leading to a reduction in mast cell activity and the inhibition of fibroblast growth factor50. This, in turn, results in a decrease in the number of mast cells in the dermis and a reduction in the formation of new blood vessels13,50 “ this just means you will get less ugly redness that people get from sun exposure helps people that suffer from PIE. IT also regulates the degradation of melanosomes “TXA can activate the autophagy system by increasing the expression of autophagy-related proteins51. Earlier research indicates that the autophagy system plays a crucial role in determining skin color by regulating the degradation of melanosomes in keratinocytes, which is enhanced by activators of autophagy52 “ This will keep your skin lighter and for longer. The results are the same between dosages but if you want faster results take higher doses “although faster results were achieved with higher doses.".

Conclusion:
TCC is way more effective than solo hydroquinone 4% or just a dual combination. The effects all work to help each other. Oral TXA is effective to take if you want your skin to reduce in redness and want easier maintenance of your whitening. It also mentioned that you shouldn't run these products for longer than 3 months at a time.

Glutathione needed for the natural whitening look:

This will be finished in part 2
I will not be putting in more effort on this topic if its not liked


The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3848650/

Conclusion:
TCC which is ““ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ is more effective at skin whitening and has less side effects as they work together, one works to absorb better and another mechanism to reduce side effects. The research also tells us the cycling for more than 3 months is bad.

---

Whitening routine

1. TCC ( fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% ) applied twice daily for 3 months
2. Oral tranexamic acid in order to reduce redness and maintain the whitening effects
3. After 3 months switch to TCC monthly and azelaic acid 20 percent two times daily repeat for a month
4. Remove TCC and run azelaic acid 20% twice and Oral tranexamic acid any dose you like for 3 more months
5. Lastly repeat this cycle over and over and don't forget sunscreen ever 2 hours non negotiable

---

Tags:
@illusion @Hernan @goku21 @Randomized @Jason Voorhees

When do you apply the aloe Vera gel before the routine or right after?

 

[s1xnan]

SAYORI’S WHITENING GUIDE - [ Full guide from overall skin lightening to treating melasma] no need to think just read


Table of contents​

Must know vocab before starting thread

General deep dive about products for whitening

Whitening routine

---

edit Note:
If its to complex, just skip to the conclusions and notes I left, you can also just skip to the routine

Must know vocab before starting thread
MASI:
It stands for melasma area severity index; it's used to indicate how bad melasma is and its used to check if a treatment is working. The higher the number for this index the worse and the smaller the number the better.

Mean:
In statistics, the mean is a measure of central tendency that summarizes a dataset with a single number reflecting its center or typical value.

SD:
This stands for standard deviation in statistics, standard deviation in statistics is a measure of how much the values in a dataset deviate from the mean, indicating the spread of variability of the data set. The data I will be presenting you with only shows you one standard deviation which means 68% percent of all data fits within the number if you were to take the mean and +/- from it once.
View attachment 4976445
View attachment 4976444

T test and CL:
“A t-test is a statistical test used to compare the means of two groups, while a confidence interval (CI) is a range of values that is likely to include the true population mean with a certain degree of confidence. The 95% CI is a specific type of confidence interval that provides a 95% probability that the true population mean lies within the specified range. This means that if you were to conduct the experiment multiple times and calculate the CI each time, approximately 95% of the intervals would contain the true population mean. The CI is calculated using the sample mean, standard deviation, and degrees of freedom to estimate the variability of the population mean.”

Central limit theorem for means:
One of the most basic principles in statistics, the Central Limit Theorem (CLT) describes how the sample mean distribution changes with increasing sample size. If the sample is sufficiently large (usually n > 30), then the sample means' distribution will be normally distributed regardless of the underlying population distribution, whether it is normal, skewed, or otherwise.
View attachment 4976446

P56 gene:
Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.[5] RELA, also known as p65, is a REL-associated protein involved in NF-κB heterodimer formation, nuclear translocation and activation.[6] NF-κB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc. Phosphorylation and acetylation of RELA are crucial post-translational modifications required for NF-κB activation. RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer. (for our needs it causes inflammation and tissue damage lol)

---

General deep dive about products for whitening
Azelaic acid 20 % vs Hydroquinone 4% In people with melasma:

Method:
29 women with melasma were recruited and treated, 15 were with hydroquinone 4% for 2 months and 14 were treated with azelaic acid 4% for 2 months, the cream was applied twice daily and a broad spectrum sunscreen was used concomitantly by both groups.

Hydroquinone 4%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.2
• SD=3.2
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.7
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.2
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Azelaic acid 20%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.6
• SD=3.5
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.3
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=3.8
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Conclusion:
The study suggest that 20% azelaic acid cream applied twice daily may be more effective than hydroquinone 4%

Note:
The study sample size is below 30 and “central limit theorem for means” tells us that if a sample is below 30 we can't trust it. However, if the population= Normal distribution there is no need for a minimum of a sample size of 30. So our statistics qualify for “the central limit theorem for means”.

Note:
Keep in mind this is for individuals with melasma. If this were to be put against normal skin the hydroquinone would win at lightening as it is a non selective tyrosinase inhibitor as compared to azelaic acid which only targets over active cells.

Study used for this:

https://www.researchgate.net/publication/51862186_Comparative_study_of_therapeutic_effects_of_20_azelaic_acid_and_hydroquinone_4_cream_in_the_treatment_of_melasma

Hydroquinone combined with aloe vera in order to reduce side effects:
So combining hydroquinone with aloe vera in rats aided in reducing side effects of hydroquinone. So it can hypothetically do the same to us humans. In the words of the researchers “The application of aloe vera gel to the already treated skin had observable effects as Aloe vera gel application showed potentials to ameliorate hydroquinone deleterious effects by persevering the stratum corneum which were generally disrupted in other groups that were administered hydroquinone [to the skin]” this just means that it makes potential side effects of hydroquinone better. Further more “ the expression of p56 in these groups was relatively reduced [Figure 3]. Thus, aloe-vera gel as used had protective effects and by extension might be protecting the skin from the potential consequences associated with the effects of hydroquinone.” This is just telling us that inflammation is being reduced as P56 causes that.

In conclusion:
Without over complicating the data shows that aloe vera on your skin can reduce a lot of the hydroquinone side effects on rats. Which will be important if you choose to run this compound. I don't want to over complicate this section since its pretty water aloe vera is good for you.

The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7147621/

What to cycle Hydroquinone and what to maintenance results with:
TCC better than Hyrdoquino 4% & general info:
The study talks about combining “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ ; it also mentions that they are “ frequently employed” for whitening purposes. In the literature it also talks about “ limited-duration hydroquinone courses, and transition to non-hydroquinone maintenance to minimize adverse effects that can exacerbate pigmentation, such as irritant dermatitis.” This is just telling you to cycle this shii nga. This is from the study directly “77% of TCC-treated participants reached complete or near complete clearing, in contrast only 47% of dual-combination group achieved the very endpoints. Ferreira Cestari et al. also displayed its superiority to 4% hydroquinone in the view of efficacy41. Clearance of melasma, meaning lesions nearly equivalent to perilesional skin, was observed in 35% of subjects using TCC versus 5% using HQ alone.” What this tells us is that the combination “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ mogged the fuck out of dual combination and just hyrdoquinone 4%. Which means we should be combining it for my effectiveness.

The combination of these products are better as shown here “the higher efficacy of this product based on the synergistic effects of its ingredients. Specifically, the topical steroid is thought to ameliorate irritation caused by the other two ingredients and inhibit melanin synthesis, while the retinoid is believed to interrupt the oxidation of hydroquinone and facilitate its trans-epidermal penetration42. “ as you can see its saying they work with each other to counter each other's negatives and make each other more effectively absorbed.

Don't cycle longer then 3 months is the norm but here “Given that hydroquinone in concentrations above 4% and in treatment courses longer than 3 months may be associated with new onset ochronosis43, the combination formula limiting the concentration of hydroquinone as 4% thanks to combined effects with other constituents may account for the lower risk of ochronosis4 “ We can cycle for longer or just cycle the same time with less possible side effects while it being more effective yay.

Oral tranexamic acid (TXA)
Oral tranexamic acid stops melanocyte communication "TXA affects the communication between keratinocytes and melanocytes.", Its effects on your vascular tissue and uv “TXA hinders the plasmin activity induced by UV light exposure, leading to a reduction in mast cell activity and the inhibition of fibroblast growth factor50. This, in turn, results in a decrease in the number of mast cells in the dermis and a reduction in the formation of new blood vessels13,50 “ this just means you will get less ugly redness that people get from sun exposure helps people that suffer from PIE. IT also regulates the degradation of melanosomes “TXA can activate the autophagy system by increasing the expression of autophagy-related proteins51. Earlier research indicates that the autophagy system plays a crucial role in determining skin color by regulating the degradation of melanosomes in keratinocytes, which is enhanced by activators of autophagy52 “ This will keep your skin lighter and for longer. The results are the same between dosages but if you want faster results take higher doses “although faster results were achieved with higher doses.".

Conclusion:
TCC is way more effective than solo hydroquinone 4% or just a dual combination. The effects all work to help each other. Oral TXA is effective to take if you want your skin to reduce in redness and want easier maintenance of your whitening. It also mentioned that you shouldn't run these products for longer than 3 months at a time.

Glutathione needed for the natural whitening look:

This will be finished in part 2
I will not be putting in more effort on this topic if its not liked


The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3848650/

Conclusion:
TCC which is ““ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ is more effective at skin whitening and has less side effects as they work together, one works to absorb better and another mechanism to reduce side effects. The research also tells us the cycling for more than 3 months is bad.

---

Whitening routine

1. TCC ( fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% ) applied twice daily for 3 months
2. Oral tranexamic acid in order to reduce redness and maintain the whitening effects
3. After 3 months switch to TCC monthly and azelaic acid 20 percent two times daily repeat for a month
4. Remove TCC and run azelaic acid 20% twice and Oral tranexamic acid any dose you like for 3 more months
5. Lastly repeat this cycle over and over and don't forget sunscreen ever 2 hours non negotiable

---

Tags:
@illusion @Hernan @goku21 @Randomized @Jason Voorhees

dude (Fluocinolone) handles the irritation but it is litr a steriod if we use it for more than 2 3 weeks its gonna create bad acne marks and also leads to extreme peeling and redness

 

[Abusive]

DNR thread for shitskins

 

[saumya_19]

where did I saw that nga tard

 

[childishkillah]

SAYORI’S WHITENING GUIDE - [ Full guide from overall skin lightening to treating melasma] no need to think just read


Table of contents​

Must know vocab before starting thread

General deep dive about products for whitening

Whitening routine

---

edit Note:
If its to complex, just skip to the conclusions and notes I left, you can also just skip to the routine

Must know vocab before starting thread
MASI:
It stands for melasma area severity index; it's used to indicate how bad melasma is and its used to check if a treatment is working. The higher the number for this index the worse and the smaller the number the better.

Mean:
In statistics, the mean is a measure of central tendency that summarizes a dataset with a single number reflecting its center or typical value.

SD:
This stands for standard deviation in statistics, standard deviation in statistics is a measure of how much the values in a dataset deviate from the mean, indicating the spread of variability of the data set. The data I will be presenting you with only shows you one standard deviation which means 68% percent of all data fits within the number if you were to take the mean and +/- from it once.
View attachment 4976445
View attachment 4976444

T test and CL:
“A t-test is a statistical test used to compare the means of two groups, while a confidence interval (CI) is a range of values that is likely to include the true population mean with a certain degree of confidence. The 95% CI is a specific type of confidence interval that provides a 95% probability that the true population mean lies within the specified range. This means that if you were to conduct the experiment multiple times and calculate the CI each time, approximately 95% of the intervals would contain the true population mean. The CI is calculated using the sample mean, standard deviation, and degrees of freedom to estimate the variability of the population mean.”

Central limit theorem for means:
One of the most basic principles in statistics, the Central Limit Theorem (CLT) describes how the sample mean distribution changes with increasing sample size. If the sample is sufficiently large (usually n > 30), then the sample means' distribution will be normally distributed regardless of the underlying population distribution, whether it is normal, skewed, or otherwise.
View attachment 4976446

P56 gene:
Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.[5] RELA, also known as p65, is a REL-associated protein involved in NF-κB heterodimer formation, nuclear translocation and activation.[6] NF-κB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc. Phosphorylation and acetylation of RELA are crucial post-translational modifications required for NF-κB activation. RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer. (for our needs it causes inflammation and tissue damage lol)

---

General deep dive about products for whitening
Azelaic acid 20 % vs Hydroquinone 4% In people with melasma:

Method:
29 women with melasma were recruited and treated, 15 were with hydroquinone 4% for 2 months and 14 were treated with azelaic acid 4% for 2 months, the cream was applied twice daily and a broad spectrum sunscreen was used concomitantly by both groups.

Hydroquinone 4%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.2
• SD=3.2
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.7
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.2
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Azelaic acid 20%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.6
• SD=3.5
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.3
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=3.8
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Conclusion:
The study suggest that 20% azelaic acid cream applied twice daily may be more effective than hydroquinone 4%

Note:
The study sample size is below 30 and “central limit theorem for means” tells us that if a sample is below 30 we can't trust it. However, if the population= Normal distribution there is no need for a minimum of a sample size of 30. So our statistics qualify for “the central limit theorem for means”.

Note:
Keep in mind this is for individuals with melasma. If this were to be put against normal skin the hydroquinone would win at lightening as it is a non selective tyrosinase inhibitor as compared to azelaic acid which only targets over active cells.

Study used for this:

https://www.researchgate.net/publication/51862186_Comparative_study_of_therapeutic_effects_of_20_azelaic_acid_and_hydroquinone_4_cream_in_the_treatment_of_melasma

Hydroquinone combined with aloe vera in order to reduce side effects:
So combining hydroquinone with aloe vera in rats aided in reducing side effects of hydroquinone. So it can hypothetically do the same to us humans. In the words of the researchers “The application of aloe vera gel to the already treated skin had observable effects as Aloe vera gel application showed potentials to ameliorate hydroquinone deleterious effects by persevering the stratum corneum which were generally disrupted in other groups that were administered hydroquinone [to the skin]” this just means that it makes potential side effects of hydroquinone better. Further more “ the expression of p56 in these groups was relatively reduced [Figure 3]. Thus, aloe-vera gel as used had protective effects and by extension might be protecting the skin from the potential consequences associated with the effects of hydroquinone.” This is just telling us that inflammation is being reduced as P56 causes that.

In conclusion:
Without over complicating the data shows that aloe vera on your skin can reduce a lot of the hydroquinone side effects on rats. Which will be important if you choose to run this compound. I don't want to over complicate this section since its pretty water aloe vera is good for you.

The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7147621/

What to cycle Hydroquinone and what to maintenance results with:
TCC better than Hyrdoquino 4% & general info:
The study talks about combining “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ ; it also mentions that they are “ frequently employed” for whitening purposes. In the literature it also talks about “ limited-duration hydroquinone courses, and transition to non-hydroquinone maintenance to minimize adverse effects that can exacerbate pigmentation, such as irritant dermatitis.” This is just telling you to cycle this shii nga. This is from the study directly “77% of TCC-treated participants reached complete or near complete clearing, in contrast only 47% of dual-combination group achieved the very endpoints. Ferreira Cestari et al. also displayed its superiority to 4% hydroquinone in the view of efficacy41. Clearance of melasma, meaning lesions nearly equivalent to perilesional skin, was observed in 35% of subjects using TCC versus 5% using HQ alone.” What this tells us is that the combination “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ mogged the fuck out of dual combination and just hyrdoquinone 4%. Which means we should be combining it for my effectiveness.

The combination of these products are better as shown here “the higher efficacy of this product based on the synergistic effects of its ingredients. Specifically, the topical steroid is thought to ameliorate irritation caused by the other two ingredients and inhibit melanin synthesis, while the retinoid is believed to interrupt the oxidation of hydroquinone and facilitate its trans-epidermal penetration42. “ as you can see its saying they work with each other to counter each other's negatives and make each other more effectively absorbed.

Don't cycle longer then 3 months is the norm but here “Given that hydroquinone in concentrations above 4% and in treatment courses longer than 3 months may be associated with new onset ochronosis43, the combination formula limiting the concentration of hydroquinone as 4% thanks to combined effects with other constituents may account for the lower risk of ochronosis4 “ We can cycle for longer or just cycle the same time with less possible side effects while it being more effective yay.

Oral tranexamic acid (TXA)
Oral tranexamic acid stops melanocyte communication "TXA affects the communication between keratinocytes and melanocytes.", Its effects on your vascular tissue and uv “TXA hinders the plasmin activity induced by UV light exposure, leading to a reduction in mast cell activity and the inhibition of fibroblast growth factor50. This, in turn, results in a decrease in the number of mast cells in the dermis and a reduction in the formation of new blood vessels13,50 “ this just means you will get less ugly redness that people get from sun exposure helps people that suffer from PIE. IT also regulates the degradation of melanosomes “TXA can activate the autophagy system by increasing the expression of autophagy-related proteins51. Earlier research indicates that the autophagy system plays a crucial role in determining skin color by regulating the degradation of melanosomes in keratinocytes, which is enhanced by activators of autophagy52 “ This will keep your skin lighter and for longer. The results are the same between dosages but if you want faster results take higher doses “although faster results were achieved with higher doses.".

Conclusion:
TCC is way more effective than solo hydroquinone 4% or just a dual combination. The effects all work to help each other. Oral TXA is effective to take if you want your skin to reduce in redness and want easier maintenance of your whitening. It also mentioned that you shouldn't run these products for longer than 3 months at a time.

Glutathione needed for the natural whitening look:

This will be finished in part 2
I will not be putting in more effort on this topic if its not liked


The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3848650/

Conclusion:
TCC which is ““ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ is more effective at skin whitening and has less side effects as they work together, one works to absorb better and another mechanism to reduce side effects. The research also tells us the cycling for more than 3 months is bad.

---

Whitening routine

1. TCC ( fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% ) applied twice daily for 3 months
2. Oral tranexamic acid in order to reduce redness and maintain the whitening effects
3. After 3 months switch to TCC monthly and azelaic acid 20 percent two times daily repeat for a month
4. Remove TCC and run azelaic acid 20% twice and Oral tranexamic acid any dose you like for 3 more months
5. Lastly repeat this cycle over and over and don't forget sunscreen ever 2 hours non negotiable

---

Tags:
@illusion @Hernan @goku21 @Randomized @Jason Voorhees

Dnr drop da coloring guide

 

[bmdoc]

If this gets over 50 reps ill make part 2 since idk if people want this type of thread

please do

 

[reborn_white_falcon]

SAYORI’S WHITENING GUIDE - [ Full guide from overall skin lightening to treating melasma] no need to think just read


Table of contents​

Must know vocab before starting thread

General deep dive about products for whitening

Whitening routine

---

edit Note:
If its to complex, just skip to the conclusions and notes I left, you can also just skip to the routine

Must know vocab before starting thread
MASI:
It stands for melasma area severity index; it's used to indicate how bad melasma is and its used to check if a treatment is working. The higher the number for this index the worse and the smaller the number the better.

Mean:
In statistics, the mean is a measure of central tendency that summarizes a dataset with a single number reflecting its center or typical value.

SD:
This stands for standard deviation in statistics, standard deviation in statistics is a measure of how much the values in a dataset deviate from the mean, indicating the spread of variability of the data set. The data I will be presenting you with only shows you one standard deviation which means 68% percent of all data fits within the number if you were to take the mean and +/- from it once.
View attachment 4976445
View attachment 4976444

T test and CL:
“A t-test is a statistical test used to compare the means of two groups, while a confidence interval (CI) is a range of values that is likely to include the true population mean with a certain degree of confidence. The 95% CI is a specific type of confidence interval that provides a 95% probability that the true population mean lies within the specified range. This means that if you were to conduct the experiment multiple times and calculate the CI each time, approximately 95% of the intervals would contain the true population mean. The CI is calculated using the sample mean, standard deviation, and degrees of freedom to estimate the variability of the population mean.”

Central limit theorem for means:
One of the most basic principles in statistics, the Central Limit Theorem (CLT) describes how the sample mean distribution changes with increasing sample size. If the sample is sufficiently large (usually n > 30), then the sample means' distribution will be normally distributed regardless of the underlying population distribution, whether it is normal, skewed, or otherwise.
View attachment 4976446

P56 gene:
Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.[5] RELA, also known as p65, is a REL-associated protein involved in NF-κB heterodimer formation, nuclear translocation and activation.[6] NF-κB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc. Phosphorylation and acetylation of RELA are crucial post-translational modifications required for NF-κB activation. RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer. (for our needs it causes inflammation and tissue damage lol)

---

General deep dive about products for whitening
Azelaic acid 20 % vs Hydroquinone 4% In people with melasma:

Method:
29 women with melasma were recruited and treated, 15 were with hydroquinone 4% for 2 months and 14 were treated with azelaic acid 4% for 2 months, the cream was applied twice daily and a broad spectrum sunscreen was used concomitantly by both groups.

Hydroquinone 4%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.2
• SD=3.2
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.7
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.2
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Azelaic acid 20%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.6
• SD=3.5
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.3
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=3.8
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Conclusion:
The study suggest that 20% azelaic acid cream applied twice daily may be more effective than hydroquinone 4%

Note:
The study sample size is below 30 and “central limit theorem for means” tells us that if a sample is below 30 we can't trust it. However, if the population= Normal distribution there is no need for a minimum of a sample size of 30. So our statistics qualify for “the central limit theorem for means”.

Note:
Keep in mind this is for individuals with melasma. If this were to be put against normal skin the hydroquinone would win at lightening as it is a non selective tyrosinase inhibitor as compared to azelaic acid which only targets over active cells.

Study used for this:

https://www.researchgate.net/publication/51862186_Comparative_study_of_therapeutic_effects_of_20_azelaic_acid_and_hydroquinone_4_cream_in_the_treatment_of_melasma

Hydroquinone combined with aloe vera in order to reduce side effects:
So combining hydroquinone with aloe vera in rats aided in reducing side effects of hydroquinone. So it can hypothetically do the same to us humans. In the words of the researchers “The application of aloe vera gel to the already treated skin had observable effects as Aloe vera gel application showed potentials to ameliorate hydroquinone deleterious effects by persevering the stratum corneum which were generally disrupted in other groups that were administered hydroquinone [to the skin]” this just means that it makes potential side effects of hydroquinone better. Further more “ the expression of p56 in these groups was relatively reduced [Figure 3]. Thus, aloe-vera gel as used had protective effects and by extension might be protecting the skin from the potential consequences associated with the effects of hydroquinone.” This is just telling us that inflammation is being reduced as P56 causes that.

In conclusion:
Without over complicating the data shows that aloe vera on your skin can reduce a lot of the hydroquinone side effects on rats. Which will be important if you choose to run this compound. I don't want to over complicate this section since its pretty water aloe vera is good for you.

The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7147621/

What to cycle Hydroquinone and what to maintenance results with:
TCC better than Hyrdoquino 4% & general info:
The study talks about combining “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ ; it also mentions that they are “ frequently employed” for whitening purposes. In the literature it also talks about “ limited-duration hydroquinone courses, and transition to non-hydroquinone maintenance to minimize adverse effects that can exacerbate pigmentation, such as irritant dermatitis.” This is just telling you to cycle this shii nga. This is from the study directly “77% of TCC-treated participants reached complete or near complete clearing, in contrast only 47% of dual-combination group achieved the very endpoints. Ferreira Cestari et al. also displayed its superiority to 4% hydroquinone in the view of efficacy41. Clearance of melasma, meaning lesions nearly equivalent to perilesional skin, was observed in 35% of subjects using TCC versus 5% using HQ alone.” What this tells us is that the combination “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ mogged the fuck out of dual combination and just hyrdoquinone 4%. Which means we should be combining it for my effectiveness.

The combination of these products are better as shown here “the higher efficacy of this product based on the synergistic effects of its ingredients. Specifically, the topical steroid is thought to ameliorate irritation caused by the other two ingredients and inhibit melanin synthesis, while the retinoid is believed to interrupt the oxidation of hydroquinone and facilitate its trans-epidermal penetration42. “ as you can see its saying they work with each other to counter each other's negatives and make each other more effectively absorbed.

Don't cycle longer then 3 months is the norm but here “Given that hydroquinone in concentrations above 4% and in treatment courses longer than 3 months may be associated with new onset ochronosis43, the combination formula limiting the concentration of hydroquinone as 4% thanks to combined effects with other constituents may account for the lower risk of ochronosis4 “ We can cycle for longer or just cycle the same time with less possible side effects while it being more effective yay.

Oral tranexamic acid (TXA)
Oral tranexamic acid stops melanocyte communication "TXA affects the communication between keratinocytes and melanocytes.", Its effects on your vascular tissue and uv “TXA hinders the plasmin activity induced by UV light exposure, leading to a reduction in mast cell activity and the inhibition of fibroblast growth factor50. This, in turn, results in a decrease in the number of mast cells in the dermis and a reduction in the formation of new blood vessels13,50 “ this just means you will get less ugly redness that people get from sun exposure helps people that suffer from PIE. IT also regulates the degradation of melanosomes “TXA can activate the autophagy system by increasing the expression of autophagy-related proteins51. Earlier research indicates that the autophagy system plays a crucial role in determining skin color by regulating the degradation of melanosomes in keratinocytes, which is enhanced by activators of autophagy52 “ This will keep your skin lighter and for longer. The results are the same between dosages but if you want faster results take higher doses “although faster results were achieved with higher doses.".

Conclusion:
TCC is way more effective than solo hydroquinone 4% or just a dual combination. The effects all work to help each other. Oral TXA is effective to take if you want your skin to reduce in redness and want easier maintenance of your whitening. It also mentioned that you shouldn't run these products for longer than 3 months at a time.

Glutathione needed for the natural whitening look:

This will be finished in part 2
I will not be putting in more effort on this topic if its not liked


The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3848650/

Conclusion:
TCC which is ““ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ is more effective at skin whitening and has less side effects as they work together, one works to absorb better and another mechanism to reduce side effects. The research also tells us the cycling for more than 3 months is bad.

---

Whitening routine

1. TCC ( fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% ) applied twice daily for 3 months
2. Oral tranexamic acid in order to reduce redness and maintain the whitening effects
3. After 3 months switch to TCC monthly and azelaic acid 20 percent two times daily repeat for a month
4. Remove TCC and run azelaic acid 20% twice and Oral tranexamic acid any dose you like for 3 more months
5. Lastly repeat this cycle over and over and don't forget sunscreen ever 2 hours non negotiable

---

Tags:
@illusion @Hernan @goku21 @Randomized @Jason Voorhees

such a good thread. How do you make such masterpieces?

 

[6”3neartyronelite]

SAYORI’S WHITENING GUIDE - [ Full guide from overall skin lightening to treating melasma] no need to think just read


Table of contents​

Must know vocab before starting thread

General deep dive about products for whitening

Whitening routine

---

edit Note:
If its to complex, just skip to the conclusions and notes I left, you can also just skip to the routine

Must know vocab before starting thread
MASI:
It stands for melasma area severity index; it's used to indicate how bad melasma is and its used to check if a treatment is working. The higher the number for this index the worse and the smaller the number the better.

Mean:
In statistics, the mean is a measure of central tendency that summarizes a dataset with a single number reflecting its center or typical value.

SD:
This stands for standard deviation in statistics, standard deviation in statistics is a measure of how much the values in a dataset deviate from the mean, indicating the spread of variability of the data set. The data I will be presenting you with only shows you one standard deviation which means 68% percent of all data fits within the number if you were to take the mean and +/- from it once.
View attachment 4976445
View attachment 4976444

T test and CL:
“A t-test is a statistical test used to compare the means of two groups, while a confidence interval (CI) is a range of values that is likely to include the true population mean with a certain degree of confidence. The 95% CI is a specific type of confidence interval that provides a 95% probability that the true population mean lies within the specified range. This means that if you were to conduct the experiment multiple times and calculate the CI each time, approximately 95% of the intervals would contain the true population mean. The CI is calculated using the sample mean, standard deviation, and degrees of freedom to estimate the variability of the population mean.”

Central limit theorem for means:
One of the most basic principles in statistics, the Central Limit Theorem (CLT) describes how the sample mean distribution changes with increasing sample size. If the sample is sufficiently large (usually n > 30), then the sample means' distribution will be normally distributed regardless of the underlying population distribution, whether it is normal, skewed, or otherwise.
View attachment 4976446

P56 gene:
Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.[5] RELA, also known as p65, is a REL-associated protein involved in NF-κB heterodimer formation, nuclear translocation and activation.[6] NF-κB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc. Phosphorylation and acetylation of RELA are crucial post-translational modifications required for NF-κB activation. RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer. (for our needs it causes inflammation and tissue damage lol)

---

General deep dive about products for whitening
Azelaic acid 20 % vs Hydroquinone 4% In people with melasma:

Method:
29 women with melasma were recruited and treated, 15 were with hydroquinone 4% for 2 months and 14 were treated with azelaic acid 4% for 2 months, the cream was applied twice daily and a broad spectrum sunscreen was used concomitantly by both groups.

Hydroquinone 4%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.2
• SD=3.2
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.7
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.2
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Azelaic acid 20%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.6
• SD=3.5
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.3
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=3.8
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Conclusion:
The study suggest that 20% azelaic acid cream applied twice daily may be more effective than hydroquinone 4%

Note:
The study sample size is below 30 and “central limit theorem for means” tells us that if a sample is below 30 we can't trust it. However, if the population= Normal distribution there is no need for a minimum of a sample size of 30. So our statistics qualify for “the central limit theorem for means”.

Note:
Keep in mind this is for individuals with melasma. If this were to be put against normal skin the hydroquinone would win at lightening as it is a non selective tyrosinase inhibitor as compared to azelaic acid which only targets over active cells.

Study used for this:

https://www.researchgate.net/publication/51862186_Comparative_study_of_therapeutic_effects_of_20_azelaic_acid_and_hydroquinone_4_cream_in_the_treatment_of_melasma

Hydroquinone combined with aloe vera in order to reduce side effects:
So combining hydroquinone with aloe vera in rats aided in reducing side effects of hydroquinone. So it can hypothetically do the same to us humans. In the words of the researchers “The application of aloe vera gel to the already treated skin had observable effects as Aloe vera gel application showed potentials to ameliorate hydroquinone deleterious effects by persevering the stratum corneum which were generally disrupted in other groups that were administered hydroquinone [to the skin]” this just means that it makes potential side effects of hydroquinone better. Further more “ the expression of p56 in these groups was relatively reduced [Figure 3]. Thus, aloe-vera gel as used had protective effects and by extension might be protecting the skin from the potential consequences associated with the effects of hydroquinone.” This is just telling us that inflammation is being reduced as P56 causes that.

In conclusion:
Without over complicating the data shows that aloe vera on your skin can reduce a lot of the hydroquinone side effects on rats. Which will be important if you choose to run this compound. I don't want to over complicate this section since its pretty water aloe vera is good for you.

The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7147621/

What to cycle Hydroquinone and what to maintenance results with:
TCC better than Hyrdoquino 4% & general info:
The study talks about combining “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ ; it also mentions that they are “ frequently employed” for whitening purposes. In the literature it also talks about “ limited-duration hydroquinone courses, and transition to non-hydroquinone maintenance to minimize adverse effects that can exacerbate pigmentation, such as irritant dermatitis.” This is just telling you to cycle this shii nga. This is from the study directly “77% of TCC-treated participants reached complete or near complete clearing, in contrast only 47% of dual-combination group achieved the very endpoints. Ferreira Cestari et al. also displayed its superiority to 4% hydroquinone in the view of efficacy41. Clearance of melasma, meaning lesions nearly equivalent to perilesional skin, was observed in 35% of subjects using TCC versus 5% using HQ alone.” What this tells us is that the combination “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ mogged the fuck out of dual combination and just hyrdoquinone 4%. Which means we should be combining it for my effectiveness.

The combination of these products are better as shown here “the higher efficacy of this product based on the synergistic effects of its ingredients. Specifically, the topical steroid is thought to ameliorate irritation caused by the other two ingredients and inhibit melanin synthesis, while the retinoid is believed to interrupt the oxidation of hydroquinone and facilitate its trans-epidermal penetration42. “ as you can see its saying they work with each other to counter each other's negatives and make each other more effectively absorbed.

Don't cycle longer then 3 months is the norm but here “Given that hydroquinone in concentrations above 4% and in treatment courses longer than 3 months may be associated with new onset ochronosis43, the combination formula limiting the concentration of hydroquinone as 4% thanks to combined effects with other constituents may account for the lower risk of ochronosis4 “ We can cycle for longer or just cycle the same time with less possible side effects while it being more effective yay.

Oral tranexamic acid (TXA)
Oral tranexamic acid stops melanocyte communication "TXA affects the communication between keratinocytes and melanocytes.", Its effects on your vascular tissue and uv “TXA hinders the plasmin activity induced by UV light exposure, leading to a reduction in mast cell activity and the inhibition of fibroblast growth factor50. This, in turn, results in a decrease in the number of mast cells in the dermis and a reduction in the formation of new blood vessels13,50 “ this just means you will get less ugly redness that people get from sun exposure helps people that suffer from PIE. IT also regulates the degradation of melanosomes “TXA can activate the autophagy system by increasing the expression of autophagy-related proteins51. Earlier research indicates that the autophagy system plays a crucial role in determining skin color by regulating the degradation of melanosomes in keratinocytes, which is enhanced by activators of autophagy52 “ This will keep your skin lighter and for longer. The results are the same between dosages but if you want faster results take higher doses “although faster results were achieved with higher doses.".

Conclusion:
TCC is way more effective than solo hydroquinone 4% or just a dual combination. The effects all work to help each other. Oral TXA is effective to take if you want your skin to reduce in redness and want easier maintenance of your whitening. It also mentioned that you shouldn't run these products for longer than 3 months at a time.

Glutathione needed for the natural whitening look:

This will be finished in part 2
I will not be putting in more effort on this topic if its not liked


The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3848650/

Conclusion:
TCC which is ““ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ is more effective at skin whitening and has less side effects as they work together, one works to absorb better and another mechanism to reduce side effects. The research also tells us the cycling for more than 3 months is bad.

---

Whitening routine

1. TCC ( fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% ) applied twice daily for 3 months
2. Oral tranexamic acid in order to reduce redness and maintain the whitening effects
3. After 3 months switch to TCC monthly and azelaic acid 20 percent two times daily repeat for a month
4. Remove TCC and run azelaic acid 20% twice and Oral tranexamic acid any dose you like for 3 more months
5. Lastly repeat this cycle over and over and don't forget sunscreen ever 2 hours non negotiable

---

Tags:
@illusion @Hernan @goku21 @Randomized @Jason Voorhees

thoughts on cysteamine dream I’m gna use it + tretinoin 0.025% for some undereye darkness

 

[Sayori]

View attachment 4983052

Holy shii ur retarded than, you will experience shii for kidney or liver damage, especially from topics

@Starborn did u hear this nga cycling azeliac acid 20% for 3 to 4 months and TCC ( fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%) cycled for 3 moths which are all topical is going to cause kidney and liver damage

 

[Starborn]

Holy shii ur retarded than, you will experience shii for kidney or liver damage, especially from topics

@Starborn did u hear this nga cycling azeliac acid 20% for 3 to 4 months and TCC ( fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%) cycled for 3 moths which are all topical is going to cause kidney and liver damage

nigga what the fuck are these chemicals

Im broke asf and havent been able to buy anything im months behind

only thing i recognize is tret

i gotta tap back in fuck bro

 

[saumya_19]

Holy shii ur retarded than, you will experience shii for kidney or liver damage, especially from topics

@Starborn did u hear this nga cycling azeliac acid 20% for 3 to 4 months and TCC ( fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%) cycled for 3 moths which are all topical is going to cause kidney and liver damage

But you cannot actually lighten your whole body through this. Full body Skin lightening mainly consists of a oral stack so you should have kept your Post title to just face Skin lightening instead

 

[Sayori]

But you cannot actually lighten your whole body through this. Full body Skin lightening mainly consists of a oral stack so you should have kept your Post title to just face Skin lightening instead

When did I say lightening ur whole body? Also, part two does lighten ur full body

Also, you really can lighten ur full body, it's just a hassle, when you can just lighten visible areas

 

[saumya_19]

View attachment 4984817

nigga what the fuck are these chemicals

Im broke asf and havent been able to buy anything im months behind

only thing i recognize is tret

i gotta tap back in fuck bro

Hydroquinone+Tret is actually enough rest doesn't have much roi. You can get hydroquinone for about 4$ peice in Indian Mart

 

[Sayori]

View attachment 4984817

nigga what the fuck are these chemicals

Im broke asf and havent been able to buy anything im months behind

only thing i recognize is tret

i gotta tap back in fuck bro

These chemicals are cents cheap

 

[Sayori]

Hydroquinone+Tret is actually enough rest doesn't have much roi. You can get hydroquinone for about 4$ peice in Indian Mart

read the study retard before speaking

 

[Starborn]

Hydroquinone+Tret is actually enough rest doesn't have much roi. You can get hydroquinone for about 4$ peice in Indian Mart

why buy from india mart when i live in india??? i can just go find it

 

[saumya_19]

why buy from india mart when i live in india??? i can just go find it

Am also from India in that case no need for Indian Mart just go Amazon

It's chepaer then tretinoin but if you are still broke just go to jan asudhi Kendra and get 2% hydroquinone for 56 rupees

 

[Starborn]

Am also from India in that case no need for Indian Mart just go Amazon
View attachment 4984869
It's chepaer then tretinoin but if you are still broke just go to jan asudhi Kendra and get 2% hydroquinone for 56 rupees

im joking im not even indian
can americans buy from india mart I thought your not able to?

 

[saumya_19]

im joking im not even indian
can americans buy from india mart I thought your not able to?

You can ig maybe they will charge you more just a bit. If you can get some Indian guy to ship you that would be even much cheaper dirt cheap rates

 

[DownwardGrowthCel]

looks like a superthred. but i didn't read because i just pinned mt2 i admire the effort on this thread tho

 

[Sayori]

looks like a superthred. but i didn't read because i just pinned mt2 i admire the effort on this thread tho

Mt2 nice, I pinned over an mg of it and fell asleep in the sun, this is why I started this research it raped and damaged my skin

Keep in mind in cali the sun is crazy here and I was on over 120mg of Accutane daily

 

[DownwardGrowthCel]

Mt2 nice, I pinned over an mg of it and fell asleep in the sun, this is why I started this research it raped and damaged my skin

Keep in mind in cali the sun is crazy here and I was on over 120mg of Accutane daily

sounds crazy. i take 0.5mg every day untill i get the tan i want. after that im switching to 0.5mg a week.

the sun in sweden isn't as strong. so i dont think i will have to worry as much jfl

UV4 this weekend. sungazing is about to go crazyyy

 

[ltn-potential]

Mt2 nice, I pinned over an mg of it and fell asleep in the sun, this is why I started this research it raped and damaged my skin

Keep in mind in cali the sun is crazy here and I was on over 120mg of Accutane daily

hey, could i please request the deletion of my two threads on rating please?

 

[Sayori]

hey, could i please request the deletion of my two threads on rating please?

You need a global moderator or a moderator who doesn't mod off topic unfortunately, I only mod offtopic

I believe these two can do it:
@Randomized @Clavicular

 

[ltn-potential]

You need a global moderator or a moderator who doesn't mod off topic unfortunately, I only mod offtopic

I believe these two can do it:
@Randomized @Clavicular

Clavicular is crazy also im a petit grey but is this the real Clavicular?

 

[nathan V]

How nice of you

 

[Deleted member 268817]

yo sayori thanks bro but we still have pneumo’s thread

 

[Deleted member 268817]

Clavicular is crazy also im a petit grey but is this the real Clavicular?

no, theres this one user @blackgymmaxx he basically has two accounts and poses as clav

 

[whiteTeeth]

SAYORI’S WHITENING GUIDE - [ Full guide from overall skin lightening to treating melasma] no need to think just read


Table of contents​

Must know vocab before starting thread

General deep dive about products for whitening

Whitening routine

---

edit Note:
If its to complex, just skip to the conclusions and notes I left, you can also just skip to the routine

Must know vocab before starting thread
MASI:
It stands for melasma area severity index; it's used to indicate how bad melasma is and its used to check if a treatment is working. The higher the number for this index the worse and the smaller the number the better.

Mean:
In statistics, the mean is a measure of central tendency that summarizes a dataset with a single number reflecting its center or typical value.

SD:
This stands for standard deviation in statistics, standard deviation in statistics is a measure of how much the values in a dataset deviate from the mean, indicating the spread of variability of the data set. The data I will be presenting you with only shows you one standard deviation which means 68% percent of all data fits within the number if you were to take the mean and +/- from it once.
View attachment 4976445
View attachment 4976444

T test and CL:
“A t-test is a statistical test used to compare the means of two groups, while a confidence interval (CI) is a range of values that is likely to include the true population mean with a certain degree of confidence. The 95% CI is a specific type of confidence interval that provides a 95% probability that the true population mean lies within the specified range. This means that if you were to conduct the experiment multiple times and calculate the CI each time, approximately 95% of the intervals would contain the true population mean. The CI is calculated using the sample mean, standard deviation, and degrees of freedom to estimate the variability of the population mean.”

Central limit theorem for means:
One of the most basic principles in statistics, the Central Limit Theorem (CLT) describes how the sample mean distribution changes with increasing sample size. If the sample is sufficiently large (usually n > 30), then the sample means' distribution will be normally distributed regardless of the underlying population distribution, whether it is normal, skewed, or otherwise.
View attachment 4976446

P56 gene:
Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.[5] RELA, also known as p65, is a REL-associated protein involved in NF-κB heterodimer formation, nuclear translocation and activation.[6] NF-κB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc. Phosphorylation and acetylation of RELA are crucial post-translational modifications required for NF-κB activation. RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer. (for our needs it causes inflammation and tissue damage lol)

---

General deep dive about products for whitening
Azelaic acid 20 % vs Hydroquinone 4% In people with melasma:

Method:
29 women with melasma were recruited and treated, 15 were with hydroquinone 4% for 2 months and 14 were treated with azelaic acid 4% for 2 months, the cream was applied twice daily and a broad spectrum sunscreen was used concomitantly by both groups.

Hydroquinone 4%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.2
• SD=3.2
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.7
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.2
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Azelaic acid 20%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.6
• SD=3.5
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.3
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=3.8
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Conclusion:
The study suggest that 20% azelaic acid cream applied twice daily may be more effective than hydroquinone 4%

Note:
The study sample size is below 30 and “central limit theorem for means” tells us that if a sample is below 30 we can't trust it. However, if the population= Normal distribution there is no need for a minimum of a sample size of 30. So our statistics qualify for “the central limit theorem for means”.

Note:
Keep in mind this is for individuals with melasma. If this were to be put against normal skin the hydroquinone would win at lightening as it is a non selective tyrosinase inhibitor as compared to azelaic acid which only targets over active cells.

Study used for this:

https://www.researchgate.net/publication/51862186_Comparative_study_of_therapeutic_effects_of_20_azelaic_acid_and_hydroquinone_4_cream_in_the_treatment_of_melasma

Hydroquinone combined with aloe vera in order to reduce side effects:
So combining hydroquinone with aloe vera in rats aided in reducing side effects of hydroquinone. So it can hypothetically do the same to us humans. In the words of the researchers “The application of aloe vera gel to the already treated skin had observable effects as Aloe vera gel application showed potentials to ameliorate hydroquinone deleterious effects by persevering the stratum corneum which were generally disrupted in other groups that were administered hydroquinone [to the skin]” this just means that it makes potential side effects of hydroquinone better. Further more “ the expression of p56 in these groups was relatively reduced [Figure 3]. Thus, aloe-vera gel as used had protective effects and by extension might be protecting the skin from the potential consequences associated with the effects of hydroquinone.” This is just telling us that inflammation is being reduced as P56 causes that.

In conclusion:
Without over complicating the data shows that aloe vera on your skin can reduce a lot of the hydroquinone side effects on rats. Which will be important if you choose to run this compound. I don't want to over complicate this section since its pretty water aloe vera is good for you.

The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7147621/

What to cycle Hydroquinone and what to maintenance results with:
TCC better than Hyrdoquino 4% & general info:
The study talks about combining “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ ; it also mentions that they are “ frequently employed” for whitening purposes. In the literature it also talks about “ limited-duration hydroquinone courses, and transition to non-hydroquinone maintenance to minimize adverse effects that can exacerbate pigmentation, such as irritant dermatitis.” This is just telling you to cycle this shii nga. This is from the study directly “77% of TCC-treated participants reached complete or near complete clearing, in contrast only 47% of dual-combination group achieved the very endpoints. Ferreira Cestari et al. also displayed its superiority to 4% hydroquinone in the view of efficacy41. Clearance of melasma, meaning lesions nearly equivalent to perilesional skin, was observed in 35% of subjects using TCC versus 5% using HQ alone.” What this tells us is that the combination “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ mogged the fuck out of dual combination and just hyrdoquinone 4%. Which means we should be combining it for my effectiveness.

The combination of these products are better as shown here “the higher efficacy of this product based on the synergistic effects of its ingredients. Specifically, the topical steroid is thought to ameliorate irritation caused by the other two ingredients and inhibit melanin synthesis, while the retinoid is believed to interrupt the oxidation of hydroquinone and facilitate its trans-epidermal penetration42. “ as you can see its saying they work with each other to counter each other's negatives and make each other more effectively absorbed.

Don't cycle longer then 3 months is the norm but here “Given that hydroquinone in concentrations above 4% and in treatment courses longer than 3 months may be associated with new onset ochronosis43, the combination formula limiting the concentration of hydroquinone as 4% thanks to combined effects with other constituents may account for the lower risk of ochronosis4 “ We can cycle for longer or just cycle the same time with less possible side effects while it being more effective yay.

Oral tranexamic acid (TXA)
Oral tranexamic acid stops melanocyte communication "TXA affects the communication between keratinocytes and melanocytes.", Its effects on your vascular tissue and uv “TXA hinders the plasmin activity induced by UV light exposure, leading to a reduction in mast cell activity and the inhibition of fibroblast growth factor50. This, in turn, results in a decrease in the number of mast cells in the dermis and a reduction in the formation of new blood vessels13,50 “ this just means you will get less ugly redness that people get from sun exposure helps people that suffer from PIE. IT also regulates the degradation of melanosomes “TXA can activate the autophagy system by increasing the expression of autophagy-related proteins51. Earlier research indicates that the autophagy system plays a crucial role in determining skin color by regulating the degradation of melanosomes in keratinocytes, which is enhanced by activators of autophagy52 “ This will keep your skin lighter and for longer. The results are the same between dosages but if you want faster results take higher doses “although faster results were achieved with higher doses.".

Conclusion:
TCC is way more effective than solo hydroquinone 4% or just a dual combination. The effects all work to help each other. Oral TXA is effective to take if you want your skin to reduce in redness and want easier maintenance of your whitening. It also mentioned that you shouldn't run these products for longer than 3 months at a time.

Glutathione needed for the natural whitening look:

This will be finished in part 2
I will not be putting in more effort on this topic if its not liked


The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3848650/

Conclusion:
TCC which is ““ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ is more effective at skin whitening and has less side effects as they work together, one works to absorb better and another mechanism to reduce side effects. The research also tells us the cycling for more than 3 months is bad.

---

Whitening routine

1. TCC ( fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% ) applied twice daily for 3 months
2. Oral tranexamic acid in order to reduce redness and maintain the whitening effects
3. After 3 months switch to TCC monthly and azelaic acid 20 percent two times daily repeat for a month
4. Remove TCC and run azelaic acid 20% twice and Oral tranexamic acid any dose you like for 3 more months
5. Lastly repeat this cycle over and over and don't forget sunscreen ever 2 hours non negotiable

---

Tags:
@illusion @Hernan @goku21 @Randomized @Jason Voorhees

Interested in the glutathione more so than hydroquinone. Good post tho

 

[sixtysevendismembi]

im sleeping rn so dnr

 

[Mr.Blitzkrieg]

bookmarked, I'll read this guide later. Thanks man

 

[HentaiConnoisseur]

High IQ thread

But you need to talk more abt oral tranexamic, blood clot risk is for sure real

 

[Don_and-idk]

SAYORI’S WHITENING GUIDE - [ Full guide from overall skin lightening to treating melasma] no need to think just read


Table of contents​

Must know vocab before starting thread

General deep dive about products for whitening

Whitening routine

---

edit Note:
If its to complex, just skip to the conclusions and notes I left, you can also just skip to the routine

Must know vocab before starting thread
MASI:
It stands for melasma area severity index; it's used to indicate how bad melasma is and its used to check if a treatment is working. The higher the number for this index the worse and the smaller the number the better.

Mean:
In statistics, the mean is a measure of central tendency that summarizes a dataset with a single number reflecting its center or typical value.

SD:
This stands for standard deviation in statistics, standard deviation in statistics is a measure of how much the values in a dataset deviate from the mean, indicating the spread of variability of the data set. The data I will be presenting you with only shows you one standard deviation which means 68% percent of all data fits within the number if you were to take the mean and +/- from it once.
View attachment 4976445
View attachment 4976444

T test and CL:
“A t-test is a statistical test used to compare the means of two groups, while a confidence interval (CI) is a range of values that is likely to include the true population mean with a certain degree of confidence. The 95% CI is a specific type of confidence interval that provides a 95% probability that the true population mean lies within the specified range. This means that if you were to conduct the experiment multiple times and calculate the CI each time, approximately 95% of the intervals would contain the true population mean. The CI is calculated using the sample mean, standard deviation, and degrees of freedom to estimate the variability of the population mean.”

Central limit theorem for means:
One of the most basic principles in statistics, the Central Limit Theorem (CLT) describes how the sample mean distribution changes with increasing sample size. If the sample is sufficiently large (usually n > 30), then the sample means' distribution will be normally distributed regardless of the underlying population distribution, whether it is normal, skewed, or otherwise.
View attachment 4976446

P56 gene:
Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.[5] RELA, also known as p65, is a REL-associated protein involved in NF-κB heterodimer formation, nuclear translocation and activation.[6] NF-κB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc. Phosphorylation and acetylation of RELA are crucial post-translational modifications required for NF-κB activation. RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer. (for our needs it causes inflammation and tissue damage lol)

---

General deep dive about products for whitening
Azelaic acid 20 % vs Hydroquinone 4% In people with melasma:

Method:
29 women with melasma were recruited and treated, 15 were with hydroquinone 4% for 2 months and 14 were treated with azelaic acid 4% for 2 months, the cream was applied twice daily and a broad spectrum sunscreen was used concomitantly by both groups.

Hydroquinone 4%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.2
• SD=3.2
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.7
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.2
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Azelaic acid 20%:
Before treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=7.6
• SD=3.5
• No significant difference between both groups(T level, and CL 95%= 2.9 to 2.2)

One month after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=6.3
• SD=3.4
• No significant difference between both groups(T level, and CL 95%= 2.3 to 3)

Two months after treatment:
MASI Index Mean, SD, T level, and CL 95%:

• Mean=3.8
• SD=2.8
• Azelaic acid significant statistical differenceT level, and CL 95%= .03 to 4.9)

Conclusion:
The study suggest that 20% azelaic acid cream applied twice daily may be more effective than hydroquinone 4%

Note:
The study sample size is below 30 and “central limit theorem for means” tells us that if a sample is below 30 we can't trust it. However, if the population= Normal distribution there is no need for a minimum of a sample size of 30. So our statistics qualify for “the central limit theorem for means”.

Note:
Keep in mind this is for individuals with melasma. If this were to be put against normal skin the hydroquinone would win at lightening as it is a non selective tyrosinase inhibitor as compared to azelaic acid which only targets over active cells.

Study used for this:

https://www.researchgate.net/publication/51862186_Comparative_study_of_therapeutic_effects_of_20_azelaic_acid_and_hydroquinone_4_cream_in_the_treatment_of_melasma

Hydroquinone combined with aloe vera in order to reduce side effects:
So combining hydroquinone with aloe vera in rats aided in reducing side effects of hydroquinone. So it can hypothetically do the same to us humans. In the words of the researchers “The application of aloe vera gel to the already treated skin had observable effects as Aloe vera gel application showed potentials to ameliorate hydroquinone deleterious effects by persevering the stratum corneum which were generally disrupted in other groups that were administered hydroquinone [to the skin]” this just means that it makes potential side effects of hydroquinone better. Further more “ the expression of p56 in these groups was relatively reduced [Figure 3]. Thus, aloe-vera gel as used had protective effects and by extension might be protecting the skin from the potential consequences associated with the effects of hydroquinone.” This is just telling us that inflammation is being reduced as P56 causes that.

In conclusion:
Without over complicating the data shows that aloe vera on your skin can reduce a lot of the hydroquinone side effects on rats. Which will be important if you choose to run this compound. I don't want to over complicate this section since its pretty water aloe vera is good for you.

The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7147621/

What to cycle Hydroquinone and what to maintenance results with:
TCC better than Hyrdoquino 4% & general info:
The study talks about combining “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ ; it also mentions that they are “ frequently employed” for whitening purposes. In the literature it also talks about “ limited-duration hydroquinone courses, and transition to non-hydroquinone maintenance to minimize adverse effects that can exacerbate pigmentation, such as irritant dermatitis.” This is just telling you to cycle this shii nga. This is from the study directly “77% of TCC-treated participants reached complete or near complete clearing, in contrast only 47% of dual-combination group achieved the very endpoints. Ferreira Cestari et al. also displayed its superiority to 4% hydroquinone in the view of efficacy41. Clearance of melasma, meaning lesions nearly equivalent to perilesional skin, was observed in 35% of subjects using TCC versus 5% using HQ alone.” What this tells us is that the combination “ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ mogged the fuck out of dual combination and just hyrdoquinone 4%. Which means we should be combining it for my effectiveness.

The combination of these products are better as shown here “the higher efficacy of this product based on the synergistic effects of its ingredients. Specifically, the topical steroid is thought to ameliorate irritation caused by the other two ingredients and inhibit melanin synthesis, while the retinoid is believed to interrupt the oxidation of hydroquinone and facilitate its trans-epidermal penetration42. “ as you can see its saying they work with each other to counter each other's negatives and make each other more effectively absorbed.

Don't cycle longer then 3 months is the norm but here “Given that hydroquinone in concentrations above 4% and in treatment courses longer than 3 months may be associated with new onset ochronosis43, the combination formula limiting the concentration of hydroquinone as 4% thanks to combined effects with other constituents may account for the lower risk of ochronosis4 “ We can cycle for longer or just cycle the same time with less possible side effects while it being more effective yay.

Oral tranexamic acid (TXA)
Oral tranexamic acid stops melanocyte communication "TXA affects the communication between keratinocytes and melanocytes.", Its effects on your vascular tissue and uv “TXA hinders the plasmin activity induced by UV light exposure, leading to a reduction in mast cell activity and the inhibition of fibroblast growth factor50. This, in turn, results in a decrease in the number of mast cells in the dermis and a reduction in the formation of new blood vessels13,50 “ this just means you will get less ugly redness that people get from sun exposure helps people that suffer from PIE. IT also regulates the degradation of melanosomes “TXA can activate the autophagy system by increasing the expression of autophagy-related proteins51. Earlier research indicates that the autophagy system plays a crucial role in determining skin color by regulating the degradation of melanosomes in keratinocytes, which is enhanced by activators of autophagy52 “ This will keep your skin lighter and for longer. The results are the same between dosages but if you want faster results take higher doses “although faster results were achieved with higher doses.".

Conclusion:
TCC is way more effective than solo hydroquinone 4% or just a dual combination. The effects all work to help each other. Oral TXA is effective to take if you want your skin to reduce in redness and want easier maintenance of your whitening. It also mentioned that you shouldn't run these products for longer than 3 months at a time.

Glutathione needed for the natural whitening look:

This will be finished in part 2
I will not be putting in more effort on this topic if its not liked


The study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3848650/

Conclusion:
TCC which is ““ fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05%’ is more effective at skin whitening and has less side effects as they work together, one works to absorb better and another mechanism to reduce side effects. The research also tells us the cycling for more than 3 months is bad.

---

Whitening routine

1. TCC ( fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% ) applied twice daily for 3 months
2. Oral tranexamic acid in order to reduce redness and maintain the whitening effects
3. After 3 months switch to TCC monthly and azelaic acid 20 percent two times daily repeat for a month
4. Remove TCC and run azelaic acid 20% twice and Oral tranexamic acid any dose you like for 3 more months
5. Lastly repeat this cycle over and over and don't forget sunscreen ever 2 hours non negotiable

---

Tags:
@illusion @Hernan @goku21 @Randomized @Jason Voorhees

very good high iq thread, but what would u recommend for pigmented eyelids? i thougt of only 2% hydrochinone cuz tret could fuck up my eye glands. Also, what do u think of monobenzone?

 

[UrGirlsMcm]

High IQ thread

But you need to talk more abt oral tranexamic, blood clot risk is for sure real

threads like this always downplay the risks to appear high IQ running half the topical shit hes talking about will literally melt your skin off

Also I'm strongly agains writing threads like this if you haven't ran this yourself with proven results

 

[hexumsforgotten]

Can we use you're routine on arms and forearms

 

[selfhatingcurrycel]

@Verdam gtfih

what about rest of your body , if you walk around with a pale asf face and a shitskin body it will be pretty obvious

 

[selfhatingcurrycel]

your're gonna do TCC on your lips aswell wtf

You need a global moderator or a moderator who doesn't mod off topic unfortunately, I only mod offtopic

I believe these two can do it:
@Randomized @Clavicular

 

[Sayori]

your're gonna do TCC on your lips aswell wtf

Yeah its no dif

 

[bones>]

thanks dad
I am currently on hq 4% and taz 0.05% for my PIH what do you think about ts