Scientists found a way to reverse aging (GTFIH)

[ThreadMatters]

Take the glycine pill

Scientists reverse aging in human cell lines and give theory of aging a new lease of life

Can the process of aging be delayed or even reversed? Research has shown that, in human cell lines at least, it can. They also found that the regulation of two genes involved with the production of glycine, the smallest and simplest amino acid, is partly responsible for some of the...

www.sciencedaily.com

Can the process of aging be delayed or even reversed? Research led by specially appointed Professor Jun-Ichi Hayashi from the University of Tsukuba in Japan has shown that, in human cell lines at least, it can. They also found that the regulation of two genes involved with the production of glycine, the smallest and simplest amino acid, is partly responsible for some of the characteristics of aging.

Professor Hayashi and his team made this exciting discovery while in the process of addressing some controversial issues surrounding a popular theory of aging.

This theory, the mitochondrial theory of aging, proposes that age-associated mitochondrial defects are controlled by the accumulation of mutations in the mitochondrial DNA. Abnormal mitochondrial function is one of the hallmarks of aging in many species, including humans. This is mostly due to the fact that the mitochondrion is the so-called powerhouse of the cell as it produces energy in a process called cellular respiration. Damage to the mitochondrial DNA results in changes or mutations in the DNA sequence. Accumulation of these changes is associated with a reduced lifespan and early onset of aging-related characteristics such as weight and hair loss, curvature of the spine and osteoporosis.

There is, however, a growing body of conflicting evidence that has raised doubts about the validity of this theory. The Tsukuba team in particular has performed some compelling research that has led them to propose that age-associated mitochondrial defects are not controlled by the accumulation of mutations in the mitochondrial DNA but by another form of genetic regulation. The research, published this month in the journal Nature's Scientific Reports,looked at the function of the mitochondria in human fibroblast cell lines derived from young people (ranging in age from a fetus to a 12 year old) and elderly people (ranging in age from 80-97 years old). The researchers compared the mitochondrial respiration and the amount of DNA damage in the mitochondria of the two groups, expecting respiration to be reduced and DNA damage to be increased in the cells from the elderly group. While the elderly group had reduced respiration, in accordance with the current theory, there was, however, no difference in the amount of DNA damage between the elderly and young groups of cells. This led the researchers to propose that another form of genetic regulation, epigenetic regulation, may be responsible for the age-associated effects seen in the mitochondria.

Epigenetic regulation refers to changes, such as the addition of chemical structures or proteins, which alter the physical structure of the DNA, resulting in genes turning on or off. Unlike mutations, these changes do not affect the DNA sequence itself. If this theory is correct, then genetically reprogramming the cells to an embryonic stem cell-like state would remove any epigenetic changes associated with the mitochondrial DNA. In order to test this theory, the researchers reprogrammed human fibroblast cell lines derived from young and elderly people to an embryonic stem cell-like state. These cells were then turned back into fibroblasts and their mitochondrial respiratory function examined. Incredibly, the age-associated defects had been reversed -- all of the fibroblasts had respiration rates comparable to those of the fetal fibroblast cell line, irrespective of whether they were derived from young or elderly people. This indicates that the aging process in the mitochondrion is controlled by epigenetic regulation, not by mutations.

The researchers then looked for genes that might be controlled epigenetically resulting in these age-associated mitochondrial defects. Two genes that regulate glycine production in mitochondria, CGAT and SHMT2, were found. The researchers showed that by changing the regulation of these genes, they could induce defects or restore mitochondrial function in the fibroblast cell lines. In a compelling finding, the addition of glycine for 10 days to the culture medium of the 97 year old fibroblast cell line restored its respiratory function. This suggests that glycine treatment can reverse the age-associated respiration defects in the elderly human fibroblasts.

These findings reveal that, contrary to the mitochondrial theory of aging, epigenetic regulation controls age-associated respiration defects in human fibroblast cell lines. Can epigenetic regulation also control aging in humans? That theory remains to be tested, and if proven, could result in glycine supplements giving our older population a new lease of life.

In summary?
U should take 10-20g glycine everyday till gandy heaven

 

[Deleted member 4430]

 

[Deleted member 2634]

@Lifeisgood72

 

[IvanArgentina]

Just don't get old

 

[RoundHouse]

Take the glycine pill

Scientists reverse aging in human cell lines and give theory of aging a new lease of life

Can the process of aging be delayed or even reversed? Research has shown that, in human cell lines at least, it can. They also found that the regulation of two genes involved with the production of glycine, the smallest and simplest amino acid, is partly responsible for some of the...

www.sciencedaily.com

In summary?
U should take 10-20g glycine everyday till gandy heaven

this would be big if proven true

 

[EasternRightWinger15]

just make the suffering longer theory

 

[recessed]

caged

 

[ThreadMatters]

this would be big if proven true

Well the benefits of glycine on regrowing new cells its not new news tbh
Glycine is an actually supplement for increasing collagen production

 

[RoundHouse]

Well the benefits of glycine on regrowing new cells its not new news tbh
Glycine is an actually supplement for increasing collagen production

does it stunt growth or anything?

 

[ThreadMatters]

caged

View attachment 775677

Fucking jews replying gifs instead of giving an actual rep to ur homies

 

[RoundHouse]

does it stunt growth or anything?

i meant in puberty nigga

 

[Baldingman1998]

Write this down before the chosen people will say this was a fraud and use it only on themselves while making it illegal to the public

 

[ThreadMatters]

i meant in puberty nigga

No doesnt have any correlation

 

[RoundHouse]

No doesnt have any correlation

might give it a try then.

 

[ThreadMatters]

might give it a try then.

Do it with 20g a day for life tbh. Its actually cheap and has good benefits

 

[RoundHouse]

Do it with 20g a day for life tbh. Its actually cheap and has good benefits

if i die, my ghost will haunt u nigga.

 

[Baldingman1998]

2015 study

 

[ThreadMatters]

2015 study

Yea glycine benefits were found even later than that

 

[bossman]

metformin dhea and hgh can revise the epigenetic clock

 

[ThreadMatters]

metformin dhea and hgh can revise the epigenetic clock

Fasting sauna cryotherapy hiit nmn are also legit

 

[AscendingHero]

Bone marrow/bone broth has tons of collagen, glycine, plus more. Sad it's not talked about more tbh, a superpower food when it comes to skinmaxxing+beef liver

 

[Lawton88]

It seems to not be that popular at longecity some years after this study. A lot of people taking it for sleep though. Surprised there hasn't been any studies with rodent lifespan and this.

 

[Deleted member 4106]

Lifefuel