Sirtuin 6 intake. Anti-aging maxxing ingredient

[eduardkoopman]

just saying, research looks pretty promising. On Sirtuin 6.

In mice, SIRT6 depletion leads to premature aging, degenerative diseases, and early death.6 Overexpression of SIRT6, in contrast, reduces insulin-like growth factor 1, promoting improved glucose tolerance and increased lifespan in mice.7

Of the natural substances that may influence SIRT activity, resveratrol is certainly the best studied.
In a yeast model utilizing Saccharomyces cerevisiae, application of resveratrol resulted in a 70% increase in lifespan. Among three polyphenols tested (resveratrol, butein, and fisetin), resveratrol produced the greatest degree of SIRT2 activation.

 

[ChristianChad]

I don't see it supporting metabolism in any way

 

[ChristianChad]

God you make me so hard

 

[Seth Walsh]

just saying, research looks pretty promising. On Sirtuin 6.

In mice, SIRT6 depletion leads to premature aging, degenerative diseases, and early death.6 Overexpression of SIRT6, in contrast, reduces insulin-like growth factor 1, promoting improved glucose tolerance and increased lifespan in mice.7

Of the natural substances that may influence SIRT activity, resveratrol is certainly the best studied.
In a yeast model utilizing Saccharomyces cerevisiae, application of resveratrol resulted in a 70% increase in lifespan. Among three polyphenols tested (resveratrol, butein, and fisetin), resveratrol produced the greatest degree of SIRT2 activation.

How does reduced IGF1 increase aging, shouldn't it be the opposite?

 

[eduardkoopman]

How to get this. non-supplement

 

[eduardkoopman]

How does reduced IGF1 increase aging, shouldn't it be the opposite?

no man, high turn-over moggs.

 

[thereallegend]

How much longer till it goes to market?

 

[thereallegend]

How to get this. non-supplement

Ok black elderberry.

Elderberry extract was a supplement I saw before.

 

[eduardkoopman]

How much longer till it goes to market?

it exist naturally in some things we can eat. So, it's already "in market' in that sense.
extra, supplements, probably overpirced, already exist being sold.

Better find other ways though, imo. price efficiency spreaking

 

[CometDragon]

How does reduced IGF1 increase aging, shouldn't it be the opposite?

This is actually a super interesting topic.

There is a type of dwarfism that involves a complete absence of IGF-1 called Laron Syndrome. These people have an extreme resistance to cancer and type 2 diabetes.

Laron syndrome - Wikipedia

en.m.wikipedia.org

I think people see IGF-1 as an anti-aging compound when really it should be seen as a lifestyle enhancing compound. Better sleep and body composition, etc.