(Study) Vit C increases collagen but DECREASES skin elasticity! Everyone GTFIH

[Deleted member 534]

Opposing effects of ascorbate on collagen and elastin deposition in the neonatal rat aorta - PubMed

Ascorbic acid plays an important role in connective tissue metabolism, where, among other effects, it acts as a reducing factor in the reactions catalyzed by prolyl and lysyl hydroxylases. In vitro, ascorbic acid has been shown to have a positive influence on collagen synthesis at pre- and/or...

pubmed.ncbi.nlm.nih.gov

“the effects of vitamin C on extracellular matrix deposition have been studied in vivo. Stereological analysis on electron micrographs showed, compared to age-matched controls, a 50 to 60% increase of collagen deposition in the media and in the adventitia of the aorta of rats treated for 30 days from the 18th day of life with 10% ascorbate in their drinking water. By contrast, elastin volume density was significantly reduced by the treatment at all ages examined. These morphological data were supported by in situ hybridization observations showing enhanced collagen type I mRNA and reduced elastin mRNA expression upon treatment. Although vitamin C did not inhibit lysyl oxidase activity in vivo, being only slightly higher than in controls, enzyme activity was significantly reduced, when high doses of ascorbate were added in vitro. Lysyl oxidase activity may be a function of enhanced collagen metabolism rather than a direct effect of the vitamin on the enzyme activity. These data indicate that ascorbate exerts opposite effects on the deposition of two major components of the extracellular matrix in vivo, at least during periods of rapid growth.”

it’s over for you guys VIT c reduces elastin,retin A kills fat pads, microneedling cause damage in the skin in the long run

What gay earth ngl

 

[Julian]

Just have a good personality bro

 

[Deleted member 534]

Just have a good personality bro

Fuuuurk we can’t ascend

god made us subhumans on purpose

 

[goat2x]

With supplementation or if u aplly it

 

[ezio6]

over

 

[RandomGuy]

In 3 months : oops I'm loosing my teeth is that scurvy

 

[Deleted member 7651]

bitch vitamin c is exactly what i need

 

[Atem Rah]

 

[Deleted member 2634]

@Seth Walsh
@Lifeisgood72

 

[hairyballscel]

@Cope

 

[Deleted member 534]

With supplementation or if u aplly it

Not sure man

probably oral ngl

 

[Deleted member 4310]

Skincare is cope, you should only treat acne and scars if you suffer from it but using 17 different products to get "glowing skin" is pointless. No skincare ingredient has actually been proven to make a significant difference.

Just use retin a and sunscreen to at least keep your skin from aging like shit.

 

[Deleted member 534]

Skincare is cope, you should only treat acne and scars if you suffer from it but using 17 different products to get "glowing skin" is pointless. No skincare ingredient has actually been proven to make a significant difference.

Just use retin a and sunscreen to at least keep your skin from aging like shit.

Bit C is not cope

but this study is weird

I mean if you use retin A you need to use cleanser and mostrizer

 

[Good_Little_Goy]

stop with this

first it's in rats for fucks sake
second they're talking about elastin in their aorta's specifically so we don't even know how much, if at all it applies to the rat's skin let alone our skin
Third, the researchers themselves say this may only apply during periods of rapid growth.

Maybe it does decrease elastin but lets not be so hasty, this is not sufficient evidence

same goes for retin a and fat pads

@Cope what's your thoughts?

 

[Good_Little_Goy]

tbf they seem to be treating the extracellular matrix as a whole regardless of tissue type so I assume they have reason to do so.
but you really can't apply this directly to cosmetic use of vit c serum in humans

 

[lifestyle21873]

its over i just bought vitamin c serum

 

[Atem Rah]

tbf they seem to be treating the extracellular matrix as a whole regardless of tissue type so I assume they have reason to do so.
but you really can't apply this directly to cosmetic use of vit c serum in humans

Fuck it
I'll just cope with aloe vera.

 

[Good_Little_Goy]

Fuck it
I'll just cope with aloe vera.

If you want I guess

im sure you can find some human controlled study where they measure elastin volume in skin and how vit c serums affect it

 

[Cope]

stop with this

first it's in rats for fucks sake
second they're talking about elastin in their aorta's specifically so we don't even know how much, if at all it applies to the rat's skin let alone our skin
Third, the researchers themselves say this may only apply during periods of rapid growth.

Maybe it does decrease elastin but lets not be so hasty, this is not sufficient evidence

same goes for retin a and fat pads

@Cope what's your thoughts?

In vitro studies have shown the same result so this is not a good sign lol

But unless we see something similar in a human in vivo study then I wouldn't conclude anything yet.

 

[goat2x]

In vitro studies have shown the same result so this is not a good sign lol
View attachment 596319

But unless we see something similar in a human in vivo study then I wouldn't conclude anything yet.

Is this w supplementation or while applying it

 

[audimax]

Opposing effects of ascorbate on collagen and elastin deposition in the neonatal rat aorta - PubMed

Ascorbic acid plays an important role in connective tissue metabolism, where, among other effects, it acts as a reducing factor in the reactions catalyzed by prolyl and lysyl hydroxylases. In vitro, ascorbic acid has been shown to have a positive influence on collagen synthesis at pre- and/or...

pubmed.ncbi.nlm.nih.gov

“the effects of vitamin C on extracellular matrix deposition have been studied in vivo. Stereological analysis on electron micrographs showed, compared to age-matched controls, a 50 to 60% increase of collagen deposition in the media and in the adventitia of the aorta of rats treated for 30 days from the 18th day of life with 10% ascorbate in their drinking water. By contrast, elastin volume density was significantly reduced by the treatment at all ages examined. These morphological data were supported by in situ hybridization observations showing enhanced collagen type I mRNA and reduced elastin mRNA expression upon treatment. Although vitamin C did not inhibit lysyl oxidase activity in vivo, being only slightly higher than in controls, enzyme activity was significantly reduced, when high doses of ascorbate were added in vitro. Lysyl oxidase activity may be a function of enhanced collagen metabolism rather than a direct effect of the vitamin on the enzyme activity. These data indicate that ascorbate exerts opposite effects on the deposition of two major components of the extracellular matrix in vivo, at least during periods of rapid growth.”

it’s over for you guys VIT c reduces elastin,retin A kills fat pads, microneedling cause damage in the skin in the long run

What gay earth ngl

So what the fuck can we even do anymore
Just moisturize after shower?

 

[Andros]

It's over, we can't defeat the agepill unless we have great genetics

 

[Good_Little_Goy]

In vitro studies have shown the same result so this is not a good sign lol
View attachment 596319

But unless we see something similar in a human in vivo study then I wouldn't conclude anything yet.

It seems like it reduces elastin transcription heavily and that's why we see the volume significantly decreased in the matrix.

different doses may inhibit or increase production.

I'm not sure why he used this study when there are much more relevant human ones that look at the skin fibroblasts.

Is this w supplementation or while applying it

supplementation, that's why I'm cautious about applying it to vit c serum, but it doesn't look good tbh

So what the fuck can we even do anymore
Just moisturize after shower?

don't make any judgement calls yet

 

[Deleted member 534]

So what the fuck can we even do anymore
Just moisturize after shower?

Rope

that’s what we should all do

it make sense we incels trying to cheat Mother Nature to fit into the servival and reproduce with female, however due to our genetic crisis

we try ways to cheat Mother Nature by vitC retin A,ect

in other word YEAH apply moisturizer but you can't win regardless because moisturizer won't do anythingbeside hydration

 

[Lev Peshkov]

Bro tbh

Collagen over everything

 

[Deleted member 534]

Bro tbh

Collagen over everything

Elasticity is what makes out skin firm bro

we need both elasticity and collagen

fuck we literally can’t win

 

[Cope]

Is this w supplementation or while applying it

I'm pretty sure it's referring to topical

 

[goat2x]

I'm pretty sure it's referring to topical

@Good_Little_Goy

 

[Good_Little_Goy]

@Good_Little_Goy

I mean OPs study

"10% ascorbate in their drinking water."

the ones he posted would be topical most likely

 

[goat2x]

I mean OPs study

the ones he posted would be topical most likely

Ive seen studies that oral supplementation increaaed it lol

 

[Good_Little_Goy]

Ive seen studies that oral supplementation increaaed it lol

link? weird as fuck

 

[Cope]

@Good_Little_Goy

My reasoning for this is because oral vitamin C does very little for overall synthesis, its main purpose is to help change polypeptide chains into procollagen.

 

[Deleted member 6217]

@Copemaxxing every looksmax has a side effect.

 

[goat2x]

link? weird as fuck

It was with other supplements but it still improvednskin elasticy

 

[goat2x]

link? weird as fuck

Improvement of dermal parameters in aged skin after oral use of a nutrient supplement

Skin aging is a progressive and degenerative process caused by a decrease in the physiological functions of the skin tissue. In addition, environmental factors as well as concomitant diseases and lifestyle (nutrition, sedentary lifestyle, smoking, etc) ...

www.ncbi.nlm.nih.gov

@Cope

 

[Copemaxxing]

@Copemaxxing every looksmax has a side effect.

Check my appointment with my local surgeon thread nibba

 

[Deleted member 6217]

tag me nigha im working i dont have time to search for it

 

[Cope]

Improvement of dermal parameters in aged skin after oral use of a nutrient supplement

Skin aging is a progressive and degenerative process caused by a decrease in the physiological functions of the skin tissue. In addition, environmental factors as well as concomitant diseases and lifestyle (nutrition, sedentary lifestyle, smoking, etc) ...

www.ncbi.nlm.nih.gov

@Cope

It just goes show that even if vitamin C does decrease elastin synthesis, there are other supplements and skincare products that will just increase it anyways.

 

[Deleted member 534]

My reasoning for this is because oral vitamin C does very little for overall synthesis, its main purpose is to help change polypeptide chains into procollagen.

Improvement of dermal parameters in aged skin after oral use of a nutrient supplement

Skin aging is a progressive and degenerative process caused by a decrease in the physiological functions of the skin tissue. In addition, environmental factors as well as concomitant diseases and lifestyle (nutrition, sedentary lifestyle, smoking, etc) ...

www.ncbi.nlm.nih.gov

@Cope

@Copemaxxing every looksmax has a side effect.

The Low-Down on Vitamin C for Skincare — The Eco Well

Vitamin C is a pretty trendy ingredient right now for cosmetics, but what should you know when your purchasing or formulating products with it? Notoriously unstable in formulation, what steps can you take to ensure you’ve got a good product with functional vitamin C? How does vitamin C impact the he

www.theecowell.com

It’s increases skin elastin GTFIH guys
“

1. In a recent systematic review of studies, they found that intervention with vitamin C intake was associated with improvements in skin elasticity, facial wrinkling, roughness, and color. These interventions where either via vitamin C from supplements or from the diet, fruits, and veggies.”

 

[Good_Little_Goy]

Improvement of dermal parameters in aged skin after oral use of a nutrient supplement

Skin aging is a progressive and degenerative process caused by a decrease in the physiological functions of the skin tissue. In addition, environmental factors as well as concomitant diseases and lifestyle (nutrition, sedentary lifestyle, smoking, etc) ...

www.ncbi.nlm.nih.gov

@Cope

probably best to try and offset any loss in elastin with another product tbh even if it's not confirmed.

It just goes show that even if vitamin C does decrease elastin synthesis, there are other supplements and skincare products that will just increase it anyways.

exactly. No reason to stop using vit c serums just yet.

 

[Cope]

lmao my man @mido the slayer had us on a rollercoaster for a sec, I'm in class rn jfl

 

[Deleted member 534]

lmao my man @mido the slayer had us on a rollercoaster for a sec, I'm in class rn jfl

Hahahah

weird man every study says something else but even if Vit Cdecrease elasticity, we have retin A and sunscreen and collagen supplements to build it back from what I read

 

[Deleted member 4310]

Rope

that’s what we should all do

it make sense we incels trying to cheat Mother Nature to fit into the servival and reproduce with female, however due to our genetic crisis

we try ways to cheat Mother Nature by vitC retin A,ect

in other word YEAH apply moisturizer but you can't win regardless because moisturizer won't do anythingbeside hydration

Anything that isn't an expensive procedure isn't a looksmax, jfl at users here thinking applying some $10 cream on their face every day will make a difference.

There's no other way around it, if you are ugly then you need invasie surgeries to change your features.

 

[benignice]

Fucking hell, the people responsible for the science education of the users of this site have a lot to answer for.
Can you please all stop finding a single fucking study that you think changes science as we know it and proceeding to draw a boatload of false conclusions from it?

- The abstract of a study isn't enough to draw any kind of conclusions from it.
- This study is from 1991 and isn't being held up as a huge development in the field- in fact, one of the few articles that use this as a citation is in direct conflict with the conclusion drawn here.
- I'm not even going to get into how this study has nothing to do with skin or hum
- Did you miss the part in the abstract where the researchers themselves offer an alternative explanation and say "Lysyl oxidase activity may be a function of enhanced collagen metabolism rather than a direct effect of the vitamin on the enzyme activity."
- Lets not forget the function of collagen versus elastin in the skin, collagen is what maintains structure as you age, not the elastin. Also;

View attachment 596245
bitch vitamin c is exactly what i need

this photo is of Gary Turner, he has Ehlers Danlos Syndrome and its his collagen that is faulty, not his elastin.

 

[Deleted member 534]

Fucking hell, the people responsible for the science education of the users of this site have a lot to answer for.
Can you please all stop finding a single fucking study that you think changes science as we know it and proceeding to draw a boatload of false conclusions from it?

- The abstract of a study isn't enough to draw any kind of conclusions from it.
- This study is from 1991 and isn't being held up as a huge development in the field- in fact, one of the few articles that use this as a citation is in direct conflict with the conclusion drawn here.
- I'm not even going to get into how this study has nothing to do with skin or hum
- Did you miss the part in the abstract where the researchers themselves offer an alternative explanation and say "Lysyl oxidase activity may be a function of enhanced collagen metabolism rather than a direct effect of the vitamin on the enzyme activity."
- Lets not forget the function of collagen versus elastin in the skin, collagen is what maintains structure as you age, not the elastin. Also;

this photo is of Gary Turner, he has Ehlers Danlos Syndrome and its his collagen that is faulty, not his elastin.

 

[Germania]

Opposing effects of ascorbate on collagen and elastin deposition in the neonatal rat aorta - PubMed

Ascorbic acid plays an important role in connective tissue metabolism, where, among other effects, it acts as a reducing factor in the reactions catalyzed by prolyl and lysyl hydroxylases. In vitro, ascorbic acid has been shown to have a positive influence on collagen synthesis at pre- and/or...

pubmed.ncbi.nlm.nih.gov

“the effects of vitamin C on extracellular matrix deposition have been studied in vivo. Stereological analysis on electron micrographs showed, compared to age-matched controls, a 50 to 60% increase of collagen deposition in the media and in the adventitia of the aorta of rats treated for 30 days from the 18th day of life with 10% ascorbate in their drinking water. By contrast, elastin volume density was significantly reduced by the treatment at all ages examined. These morphological data were supported by in situ hybridization observations showing enhanced collagen type I mRNA and reduced elastin mRNA expression upon treatment. Although vitamin C did not inhibit lysyl oxidase activity in vivo, being only slightly higher than in controls, enzyme activity was significantly reduced, when high doses of ascorbate were added in vitro. Lysyl oxidase activity may be a function of enhanced collagen metabolism rather than a direct effect of the vitamin on the enzyme activity. These data indicate that ascorbate exerts opposite effects on the deposition of two major components of the extracellular matrix in vivo, at least during periods of rapid growth.”

it’s over for you guys VIT c reduces elastin,retin A kills fat pads, microneedling cause damage in the skin in the long run

What gay earth ngl

It's always the same here on the forum, to everything you can find pros and cons on this page, and in the end everyone is LDARing

 

[Good_Little_Goy]

Fucking hell, the people responsible for the science education of the users of this site have a lot to answer for.
Can you please all stop finding a single fucking study that you think changes science as we know it and proceeding to draw a boatload of false conclusions from it?

- The abstract of a study isn't enough to draw any kind of conclusions from it.
- This study is from 1991 and isn't being held up as a huge development in the field- in fact, one of the few articles that use this as a citation is in direct conflict with the conclusion drawn here.
- I'm not even going to get into how this study has nothing to do with skin or hum
- Did you miss the part in the abstract where the researchers themselves offer an alternative explanation and say "Lysyl oxidase activity may be a function of enhanced collagen metabolism rather than a direct effect of the vitamin on the enzyme activity."
- Lets not forget the function of collagen versus elastin in the skin, collagen is what maintains structure as you age, not the elastin. Also;

this photo is of Gary Turner, he has Ehlers Danlos Syndrome and its his collagen that is faulty, not his elastin.

can you read my posts in this thread and tell me if i'm high iq or not?

this photo is of Gary Turner, he has Ehlers Danlos Syndrome and its his collagen that is faulty, not his elastin.

yeah that shit was pretty funny tbh, nothing to do with this.

btw, on this subject, I have hyper-mobility and always have had stretchy skin, as I understand it my collagen is weaker than other people's:

Is there anything I can be doing to help my collagen and try to 'make my skin more normal'?
or just general collagenmaxxing?

 

[Deleted member 534]

can you read my posts in this thread and tell me if i'm high iq or not?


yeah that shit was pretty funny tbh, nothing to do with this.

btw, on this subject, I have hyper-mobility and always have had stretchy skin, as I understand it my collagen is weaker than other people's:

Is there anything I can be doing to help my collagen and try to 'make my skin more normal'?
or just general collagenmaxxing?

Check collagen maxing guides on the best of the bests section

 

[Good_Little_Goy]

Check collagen maxing guides on the best of the bests section

I'm doing a lot of the stuff mentioned now, tretinoin, niacinamide, astaxanthin, spf etc
vit c serum was too irritating

but I meant more some treatment specific to my condition, I doubt there is anything but worth a shot.

 

[JustAFewMM]

Im gonna rope with these threads? Wtf is this shit