The Cure For Hair Loss - The Truth About 5α-Reductase Inhibitors and Topical Anti-Androgens

[ThisCat]

Im not reading all of this can someone explain the drama?

 

[imightbewrong42]

just what i need, you saved my life

 

[Snicket]

That's literally what I mean. You did not do any research, just copied what you saw when you asked Chat GPT and called it a day. There is enough proof that topical dutasteride works, you just didn't dig deep enough:

Microneedling plus topical dutasteride solution for androgenetic alopecia: a randomized placebo-controlled study - PubMed

Microneedling plus topical dutasteride solution for androgenetic alopecia: a randomized placebo-controlled study

pubmed.ncbi.nlm.nih.gov

This is irrelevant. You're taking Dutasteride once a week and the drug has a half life of 4-5 weeks so you're getting systemic absorption anyway.

you also don't need RU58841 if you are on oral dut or fin you retard

They have separate mechanisms of action. One is a 5AR inhibitor the other is a topical anti andorgen that binds with androgen receptors. It's not a question of either or. They work better together.

Also, there is no clinical relevant data on RU58841, it's pure anecdotal, there are no public studies on this stuff, just because you saw Derek recommends it doesn't make it backed by science JFL

There is clinical data on manque monkeys - they have AGA just like humans.
RU58841 at a 5% concentration was found to be more effective than finasteride, leading to a 103% increase in hair growth compared to finasteride's 88%.
I can't link it now because it was taken down annoyingly but I will post when I find it.

I agree that having no human trial data is a sleight against the treatment though.

 

[imightbewrong42]

Recommending a non fda approved medicine is dangerous

you mean not approved by jews? of course it won't

 

[Snicket]

Yeah i already talked about it

If you are thinking about roiding read this thread.

Huh, when did i say this? Are you AGAIN making things up? On god you said this, you know it too. You are buying overpriced online pharmacy isotretinoin STFU. You brain is destroyed by all that steriods, i am not running rad140 > Claims steroids are the key to ascension > Claims they...

looksmax.org

Ru is garbage, dutasteride is 100x much more effective

It's not garbage, there is some compelling that it has even better efficacy than finasteride.
But the whole framing of one vs the other is wrong here.

Recommending a non fda approved medicine is dangerous

I agree that it's troubling we don't have any real long term data on human usage.
The implications of systemic absorption of a topical anti androgen in the long term are troubling.

 

[Graham]

However, Type 1 DHT is actually expressed in bones. This matters because the studies I have shown above, are actually only deficient in the type 2 isoenzyme, which is the one that is not present in bones. This is the reason they present with normal bone mineral density, bone structure etc. If they were also deficient in Type 1 DHT, this would likely not be the case at all.

"5α-Reductase type 1 inactivated male mice have reduced bone mass and forelimb muscle grip strength, which has been proposed to be due to lack of 5α-reductase type 1 expression in bone and muscle.[29] In 5 alpha reductase type 2 deficient males, the type 1 isoenzyme is thought to be responsible for their virilization at puberty.[6]"

This study concluded dutasteride (and finasteride) had no effect on bone health, so hopefully it won't have a negative effect on humans.

https://link.springer.com/content/pdf/10.1186/s12891-018-2076-9.pdf