The truth about Minoxidil - The holy grail or overhyped Looksmin?

[chadisbeingmade]

they look like my arm's hair

Then they can be brought back. If I was you I would apply RU to just those areas. They are androgen sensitive areas. You still have some DHT left as 0.5mg twice a week since it’s not as nuclear as 2.5mg dut ED for example and you also have scalp testosterone slowly minaturising the follicles. RU will take care of the residual DHT as well as the scalp Testosterone leaving you androgen free in the area so the follicles can unminaturise.

Even if you just add minox alone, eventually it will fall since the follicles are still slowly being raped unless you apply RU, so your minox gains wouldn’t last.

 

[RecessedCel5]

Then they can be brought back. If I was you I would apply RU to just those areas. They are androgen sensitive areas. You still have some DHT left as 0.5mg twice a week since it’s not as nuclear as 2.5mg dut ED for example and you also have scalp testosterone slowly minaturising the follicles. RU will take care of the residual DHT as well as the scalp Testosterone leaving you androgen free in the area so the follicles can unminaturise.

Even if you just add minox alone, eventually it will fall since the follicles are still slowly being raped unless you apply RU, so your minox gains wouldn’t last.

i thought you couldn't buy RU, and wouldn't ketoconazole be good enough as a replacement ?. if i notice more recession i will probably increase the dose.

 

[chadisbeingmade]

i thought you couldn't buy RU, and wouldn't ketoconazole be good enough as a replacement ?. if i notice more recession i will probably increase the dose.

You can buy RU, I use it myself.
Many people here use it, have seen people restore NW 3 with it on here. It is stronger than Fin for sure.

Keto wouldn’t be enough, it would provide barely any benefit in comparison to RU.

 

[LTN psl god]

how and how much should i use to grow facial hair

 

[SoNotFunny]

Does topical minoxidil cause your skin to age due to decreasing collagen?

topical usually has alcohol which is what would cause the skin to age. as long as you don’t let it drip down your face, you should be fine

 

[itsoverarthu]

shit, great effort. But I'll read it carefully, I ended up crying in the middle of this Jfl either I live extremely bloat or I acquire it uee, fuck this made me feel worse knowing that Im not 6'3 there are no solutions not even for my eyebrows

The eyelid thing is bullshit imo. Just use it your

 

[itsoverarthu]

Good thread man, detailed explanation ngl

Is topical safe for eyebrows?( for eyes fat) Does topical also cause bloating?

 

[Zagro]

Is topical safe for eyebrows?( for eyes fat) Does topical also cause bloating?

Yeah, and it doesn’t cause bloating if it doesn’t go systemic i think @Jonas2k7

 

[Jonasㅤㅤ⠀]

Yeah, and it doesn’t cause bloating if it doesn’t go systemic i think @Jonas2k7

It causes some bloating unfortunately. @chadisbeingmade can tell more about that.

 

[chadisbeingmade]

Yeah, and it doesn’t cause bloating if it doesn’t go systemic i think @Jonas2k7

It's going to go systematic no matter what you do, even topical to an extent will go systematic. All will bloat you.

 

[itsoverarthu]

Yeah, and it doesn’t cause bloating if it doesn’t go systemic i think @Jonas2k7

What if some min gets on my orbital fat @Jonas2k7? Does min on hairline have any risk whatsoever to orbital fat? Thanks

 

[Jonasㅤㅤ⠀]

It's going to go systematic no matter what you do, even topical to an extent will go systematic. All will bloat you.

100%. That's one of the mechanisms how Minoxidil works in the first place.

What if some min gets on my orbital fat @Jonas2k7? Does min on hairline have any risk whatsoever to orbital fat? Thanks

There is some anecdotal evidence that Minoxidil can cause "collagen-loss". But no, the Minoxidil on the hairline won't affect your periorbital fat.

how and how much should i use to grow facial hair

Facial hair is a looksmin.

The eyelid thing is bullshit imo. Just use it your

Is topical safe for eyebrows?( for eyes fat) Does topical also cause bloating?

>Claims its bullshit
>Asks if it's true

Alright.

 

[itsoverarthu]

100%. That's one of the mechanisms how Minoxidil works in the first place.

There is some anecdotal evidence that Minoxidil can cause "collagen-loss". But no, the Minoxidil on the hairline won't affect your periorbital fat.

Facial hair is a looksmin.


>Claims its bullshit
>Asks if it's true

Alright.

Yeah you are completely right to point it , i did some research and saw there is some truth to it because i was completely unaware so thanks you for making me aware. are eyebrow safe or nah? Especially low set like mine

 

[itsoverarthu]

It's going to go systematic no matter what you do, even topical to an extent will go systematic. All will bloat you.

Topical only gets absorbed like2%. How is that going to make a difference

 

[TitusA]

Yeah, and it doesn’t cause bloating if it doesn’t go systemic i think @Jonas2k7

2.5mg oral caused me minimal bloating but im lean and the gains I got weren't crazy. Defo not like the oral min transformations you see pics of. Hair got a bit thicker and body hair got slightly thicker but no body hair in new places.

The body literally adapts to the RAAS activation and downregulates aldosterone secretion over time. Same applies with TRT which activates RAAS the same way. You may get bloat initially but most of these people talking about long term bloat are just fat or eating shit/a ton of sodium, or taking high doses.

RAAS activation on the oral min doses recommended for hair loss (2.5mg- max 5mg) is mild and nobody should have a problem long term with bloat. but you should still get checked for more serious side effects

Great thread brother read every molecule. Been wondering why my face has been so bloated despite being very lean, now i see it’s the 20mg of oral minoxidil ive been running for a year. Switching to topical minox + dut asap

why tf would you even take 20mg?
Fr

 

[ryk1r]

been taking topical minoxidil orally, any difference from traditional oral minox? apart from the tiny amount of alcohol

 

[slaters]

View attachment 3682319
The truth about Minoxidil - Part 1​

Spoiler: Previous Part

The truth about ... - The new thread series, AMA

The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...

looksmax.org

Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.

View attachment 3682324View attachment 3682326
​

This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.

---

History

Spoiler: History

Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.

Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC

Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...

pmc.ncbi.nlm.nih.gov

And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.

Appeal in PSL-Spaces

Spoiler: Appeal in PSL-Spaces

The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.

Topical

Spoiler: Topical

Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).

HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC

Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...

pmc.ncbi.nlm.nih.gov

Oral

Spoiler: Oral

Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh ]
View attachment 3682288

Biology

Spoiler: Biology

The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

1. Minoxidil vasodilates blood vessels
2. Activation of RAAS
3. Aldosterone increase
4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?

View attachment 3682392

Conclusion

Spoiler: Conclusion

The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

• Topical Minoxidil on eyebrows, which also affects your lashes.
• Oral Minoxidil only in combination with an aldosterone-antagonist.

---

I hope you learned something new today.

Feel free to AMA.

Spoiler: Tags

@halloweed @menas @Zagro @Drugsmaxxer

I’m hyperresponder to minoxidil
Insane gains with insane bloat
About to get some Eplerenone so I’ll hop back on minoxidil and update

 

[zaideas]

how do you apply minoxydil on eyelashes

 

[3pider]

View attachment 3682319
The truth about Minoxidil - Part 1​

Spoiler: Previous Part

The truth about ... - The new thread series, AMA

The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...

looksmax.org

Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.

View attachment 3682324View attachment 3682326
​

This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.

---

History

Spoiler: History

Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.

Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC

Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...

pmc.ncbi.nlm.nih.gov

And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.

Appeal in PSL-Spaces

Spoiler: Appeal in PSL-Spaces

The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.

Topical

Spoiler: Topical

Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).

HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC

Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...

pmc.ncbi.nlm.nih.gov

Oral

Spoiler: Oral

Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh ]
View attachment 3682288

Biology

Spoiler: Biology

The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

1. Minoxidil vasodilates blood vessels
2. Activation of RAAS
3. Aldosterone increase
4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?

View attachment 3682392

Conclusion

Spoiler: Conclusion

The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

• Topical Minoxidil on eyebrows, which also affects your lashes.
• Oral Minoxidil only in combination with an aldosterone-antagonist.

---

I hope you learned something new today.

Feel free to AMA.

Spoiler: Tags

@halloweed @menas @Zagro @Drugsmaxxer

Make a YouTube man mirin effort

 

[SoNotFunny]

I’m hyperresponder to minoxidil
Insane gains with insane bloat
About to get some Eplerenone so I’ll hop back on minoxidil and update

topical or oral?

 

[grungymallard97]

View attachment 3682319
The truth about Minoxidil - Part 1​

Spoiler: Previous Part

The truth about ... - The new thread series, AMA

The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...

looksmax.org

Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.

View attachment 3682324View attachment 3682326
​

This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.

---

History

Spoiler: History

Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.

Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC

Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...

pmc.ncbi.nlm.nih.gov

And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.

Appeal in PSL-Spaces

Spoiler: Appeal in PSL-Spaces

The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.

Topical

Spoiler: Topical

Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).

HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC

Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...

pmc.ncbi.nlm.nih.gov

Oral

Spoiler: Oral

Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh ]
View attachment 3682288

Biology

Spoiler: Biology

The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

1. Minoxidil vasodilates blood vessels
2. Activation of RAAS
3. Aldosterone increase
4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?

View attachment 3682392

Conclusion

Spoiler: Conclusion

The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

• Topical Minoxidil on eyebrows, which also affects your lashes.
• Oral Minoxidil only in combination with an aldosterone-antagonist.

---

I hope you learned something new today.

Feel free to AMA.

Spoiler: Tags

@halloweed @menas @Zagro @Drugsmaxxer

I haven’t read YET
But minoxidil has done fuck all for me 7 months on. maybe I’m just a retard and don’t apply properly

 

[Jonasㅤㅤ⠀]

I haven’t read YET
But minoxidil has done fuck all for me 7 months on. maybe I’m just a retard and don’t apply properly

Read the other thread too, I liked the second one more personally.

Also read da threads by @chadisbeingmade and (optional ) by @menas

@Zagro's was good too

 

[grungymallard97]

Read the other thread too, I liked the second one more personally.

Also read da threads by @chadisbeingmade and (optional ) by @menas

@Zagro's was good too

ur right abt the upper eyelid fat loss I feel like I actually have some UEE now whereas nefore I had legit none. Minoxidil is kinda wank Ibr yeah lemme read the others

 

[fazehamster]

View attachment 3682319
The truth about Minoxidil - Part 1​

Spoiler: Previous Part

The truth about ... - The new thread series, AMA

The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...

looksmax.org

Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.

View attachment 3682324View attachment 3682326
​

This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.

---

History

Spoiler: History

Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.

Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC

Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...

pmc.ncbi.nlm.nih.gov

And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.

Appeal in PSL-Spaces

Spoiler: Appeal in PSL-Spaces

The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.

Topical

Spoiler: Topical

Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).

HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC

Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...

pmc.ncbi.nlm.nih.gov

Oral

Spoiler: Oral

Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh ]
View attachment 3682288

Biology

Spoiler: Biology

The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

1. Minoxidil vasodilates blood vessels
2. Activation of RAAS
3. Aldosterone increase
4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?

View attachment 3682392

Conclusion

Spoiler: Conclusion

The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

• Topical Minoxidil on eyebrows, which also affects your lashes.
• Oral Minoxidil only in combination with an aldosterone-antagonist.

---

I hope you learned something new today.

Feel free to AMA.

Spoiler: Tags

@halloweed @menas @Zagro @Drugsmaxxer

Such a good thread

 

[lostdrifter]

View attachment 3682319
The truth about Minoxidil - Part 1​

Spoiler: Previous Part

The truth about ... - The new thread series, AMA

The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...

looksmax.org

Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.

View attachment 3682324View attachment 3682326
​

This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.

---

History

Spoiler: History

Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.

Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC

Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...

pmc.ncbi.nlm.nih.gov

And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.

Appeal in PSL-Spaces

Spoiler: Appeal in PSL-Spaces

The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.

Topical

Spoiler: Topical

Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).

HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC

Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...

pmc.ncbi.nlm.nih.gov

Oral

Spoiler: Oral

Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh ]
View attachment 3682288

Biology

Spoiler: Biology

The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

1. Minoxidil vasodilates blood vessels
2. Activation of RAAS
3. Aldosterone increase
4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?

View attachment 3682392

Conclusion

Spoiler: Conclusion

The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

• Topical Minoxidil on eyebrows, which also affects your lashes.
• Oral Minoxidil only in combination with an aldosterone-antagonist.

---

I hope you learned something new today.

Feel free to AMA.

Spoiler: Tags

@halloweed @menas @Zagro @Drugsmaxxer

Would applying topical Minoxidil (only on eyebrows) cause bloat on entire face?

 

[PompastyMogs]

BS LOL, been using minox for many years on eyes, brows, still have the leanest face out here jfl

 

[iblameCopecels]

Do you think taking 2.5 mg of oral minoxidil for a year could lead to permanent eyebrow and eyelash gains?

I spoke with imonthelose yesterday, and he believes terminal results are possible after a year. Is this True ?

 

[CopeTilliRope]

BS LOL, been using minox for many years on eyes, brows, still have the leanest face out here jfl

topical or oral? thx

 

[TitusA]

Ive been using oral minox for a couple of months now and I have noticed 0 side effects and have had very mogger results so far

You read into long term use and when peaks are achieved? Im 7 months in wondering if these are max results or i might get some more.

 

[killyourselfASAP]

Oral

Spoiler: Oral

Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh ]

this bhai used topical on his lashes not oral