
antiantifa
Fuck you.
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In the dermis, mostly androgens and 5-a reduced estrogens are synthesized, while in the subcutaneous fat layer, mostly estrogens and glucocorticoids(cortisol) are synthesized.
Ever noticed how baldcels often have good beards and lean faces, even thought there's no correlation between systemic DHT/E2 and balding. Well in bald people the scalp skin simply has too much DHT in it relative to the estrogens, often this is caused by poor blood flow between the different skin layers, so the blood in a sense gets "stuck" and the hormones inside this blood keep getting 5-a reduced to provide all kinds of anti-estrogens and androgens. Since the hair on scalp is mostly stimulated by estrogens while the hair in the beard is mostly stimulated by androgens, there is in a way a kind of a shift happening from the estrogenic hair of the scalp to the androgenic hair of the beard/body hair/pubic hair/axilla hair.
In theory increasing blood flow locally in the skin should be the best cure for baldness, indeed minoxidil works by improving skin blood flow, but even the effects of minox are often not sufficient. Also often the skin gets used to minox and doesn't respond anymore, so while a lot of the androgens are cleared, eventually they build up again even with constant minox application.
Here NO, most abundant vasodilator in the body, improved hair growth:
"Preclinical studies showed the Nitric Oxide (NO) gel significantly promoted hair follicle formation and growth in both rat and mouse models. The NO gel induced major physiological, developmental, and structural changes in the skin of mammals to increase the number of hair follicles, follicle stem cell development and regeneration as well as hair shaft elongation, and accelerated hair growth rate. Based on our animal model findings, the investigators hypothesize that the nitric oxide releasing gel could be used as a medical treatment for hair growth in humans. The objective of this trial is to evaluate the safety and efficacy of this NO gel (XN-001), in comparison with a placebo gel in subjects in a 24-week treatment schedule."
Look what I found when looking up vaso-dilation/vasoconstriction:

TL;DR constant vasoconstriction in the lower layers of the skin causes hypo-dermis thinning and lowers local estrogen levels, while constant vasodilation in the upper layers causes excess androgens to be produced locally.
When you use topical vasodilators, they dilate all layers, especially those that were constricted. This creates a higher E2/DHT ratio in the scalp locally, which prevents balding.
Lack of fat on the scalp = balding.
Answer poll for scientific reasons, thnx.

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