Tretinoin made my nose smaller

[goat2x]

shotout to the user who found these studies

i used accutane/tretinoin and now my nose is smaller + shiny as fuck

i already noticed but my mom commented "what happened to your nose? i remember you having a bigger nose" ( i only meet with her every 2 months)

Effects of retinoic acid on cartilage differentiation in a chondrogenic cell line - PubMed

Previously we have isolated the monopotential chondrogenic cell line RCJ 3.1 C5.18 from the multipotential mesenchymal cell line RCJ 3.1 [Grigoriadis et al.: Endocrinology, 125:2103-2110, 1989]. When cultured for approximately 20 days under appropriate conditions, these cells from cartilage...

pubmed.ncbi.nlm.nih.gov

Retinoic acid rapidly reduces cartilage matrix synthesis by altering gene transcription in chondrocytes - PubMed

Retinoic acid can alter the differentiation of a variety of cell types, including chondrocytes. This action may explain the high incidence of craniofacial and limb defects resulting from exposure to retinoic acid during development, and may be the basis for the compound's inhibition of a...

pubmed.ncbi.nlm.nih.gov

 

[goat2x]

tagging shotgun nose cels


@PYT

 

[Deleted member 11748]

maby

 

[goat2x]

View attachment 1021645

maby

@ProAcktiv suck my cock little autist

 

[goat2x]

@ProAcktiv suck my cock little autist

@ProAcktiv bet you would like that you little slut
you like to be degraded dont u

 

[hairyballscel]

i already noticed but my mom commented "what happened to your nose? i remember you having a bigger nose" ( i only meet with her every 2 months)

she's mirin you tbh

fuck her ngl

 

[goat2x]

she's mirin you tbh

fuck her ngl

crawl back to your bunker cuck

 

[SkinjobCatastrophe]

This is interesting, I have seen a bunch of studies showing the cartilage and joints and ligaments and shit like that can be shrunk with use of tretinoin, maybe the nose is even more subject to it than other cartilage in the body

 

[AlwaysHaveQuestions]

i already noticed but my mom commented "what happened to your nose? i remember you having a bigger nose" ( i only meet with her every 2 months)

that's how often you leave your basement?

 

[goat2x]

that's how often you leave your basement?

no i live alone like giga slayr

 

[Deleted member 1680]

lifefuel for bro @SubhumanCurrycel

 

[goat2x]

lifefuel for bro @SubhumanCurrycel

he is shotgunnosed vacumcleaner cel
it wont help him

 

[ProAcktiv]

@ProAcktiv bet you would like that you little slut
you like to be degraded dont u

 

[everythingisacope]

shotout to the user who found these studies

i used accutane/tretinoin and now my nose is smaller + shiny as fuck

i already noticed but my mom commented "what happened to your nose? i remember you having a bigger nose" ( i only meet with her every 2 months)

Effects of retinoic acid on cartilage differentiation in a chondrogenic cell line - PubMed

Previously we have isolated the monopotential chondrogenic cell line RCJ 3.1 C5.18 from the multipotential mesenchymal cell line RCJ 3.1 [Grigoriadis et al.: Endocrinology, 125:2103-2110, 1989]. When cultured for approximately 20 days under appropriate conditions, these cells from cartilage...

pubmed.ncbi.nlm.nih.gov

Retinoic acid rapidly reduces cartilage matrix synthesis by altering gene transcription in chondrocytes - PubMed

Retinoic acid can alter the differentiation of a variety of cell types, including chondrocytes. This action may explain the high incidence of craniofacial and limb defects resulting from exposure to retinoic acid during development, and may be the basis for the compound's inhibition of a...

pubmed.ncbi.nlm.nih.gov

lifefuel since that shit does get bigger with age

 

[Deleted member 439]

Im going to rub tretinoin on my hips everyday

 

[goat2x]

lifefuel since that shit does get bigger with age

no, the cartilige in your nose droops more and more down with age

but ye its lifefuel it can help

 

[goat2x]

Im going to rub tretinoin on my hips everyday

if your hips is built from cartilige then its fuckng over for you

 

[goat2x]

wtf ordering asap
View attachment 1021693

you dont have meaty ethnic nose

its only big from the side

 

[everythingisacope]

Im going to rub tretinoin on my hips everyday

greencel moment

 

[AlwaysHaveQuestions]

shit like this is why i glance at this section every day even though im a rotter

adding to list of things i will never do

 

[goat2x]

so it won't affect the projection of the cartilage?
View attachment 1021697

i dont notice any big difference from the side tbh

i had the same or even more results from 3/4

 

[SubhumanCurrycel]

i dont notice any big difference from the side tbh
View attachment 1021701

i had the same or even more results from 3/4

Is that your nose?
fuck that could help lessen the droopy cartilage at the bottom fuark

 

[goat2x]

Is that your nose?
fuck that could help lessen the droopy cartilage at the bottom fuark

nah its from reddit

there are results like that on reddit

 

[goat2x]

Is that your nose?
fuck that could help lessen the droopy cartilage at the bottom fuark

try it tbh
i think it would work best for droopy nose

 

[Deleted member 439]

anecodotally this did nothing for me. Ive been using .05% 2x a day for almost a 3years.

 

[goat2x]

anecodotally this did nothing for me. Ive been using .05% 2x a day for almost a 3years.

you have pretty small nose in the first place ngl

 

[ilyess]

Pics bro

 

[RecessedPrettyboy]

Yea this works
Might have something to do with sebaceous glands or whatever its called too

 

[MoroccanGoku]

shotout to the user who found these studies

i used accutane/tretinoin and now my nose is smaller + shiny as fuck

i already noticed but my mom commented "what happened to your nose? i remember you having a bigger nose" ( i only meet with her every 2 months)

Effects of retinoic acid on cartilage differentiation in a chondrogenic cell line - PubMed

Previously we have isolated the monopotential chondrogenic cell line RCJ 3.1 C5.18 from the multipotential mesenchymal cell line RCJ 3.1 [Grigoriadis et al.: Endocrinology, 125:2103-2110, 1989]. When cultured for approximately 20 days under appropriate conditions, these cells from cartilage...

pubmed.ncbi.nlm.nih.gov

Retinoic acid rapidly reduces cartilage matrix synthesis by altering gene transcription in chondrocytes - PubMed

Retinoic acid can alter the differentiation of a variety of cell types, including chondrocytes. This action may explain the high incidence of craniofacial and limb defects resulting from exposure to retinoic acid during development, and may be the basis for the compound's inhibition of a...

pubmed.ncbi.nlm.nih.gov

I also notice my nose getting smaller within 5 months of use.
But how is tretinoin making your nose shinier it's the opposite your skin and nose will be drier while on tretinoin that's why you should moisturize.

 

[goat2x]

I also notice my nose getting smaller within 5 months of use.
But how is tretinoin making your nose shinier it's the opposite your skin and nose will be drier while on tretinoin that's why you should moisturize.

its probably cuz cleaner skin

 

[TheEndHasNoEnd]

my nigga why didnt u say in my server

 

[datboijj]

cool
don't need it tho

 

[Deleted member 10987]

shotout to the user who found these studies

i used accutane/tretinoin and now my nose is smaller + shiny as fuck

i already noticed but my mom commented "what happened to your nose? i remember you having a bigger nose" ( i only meet with her every 2 months)

Effects of retinoic acid on cartilage differentiation in a chondrogenic cell line - PubMed

Previously we have isolated the monopotential chondrogenic cell line RCJ 3.1 C5.18 from the multipotential mesenchymal cell line RCJ 3.1 [Grigoriadis et al.: Endocrinology, 125:2103-2110, 1989]. When cultured for approximately 20 days under appropriate conditions, these cells from cartilage...

pubmed.ncbi.nlm.nih.gov

Retinoic acid rapidly reduces cartilage matrix synthesis by altering gene transcription in chondrocytes - PubMed

Retinoic acid can alter the differentiation of a variety of cell types, including chondrocytes. This action may explain the high incidence of craniofacial and limb defects resulting from exposure to retinoic acid during development, and may be the basis for the compound's inhibition of a...

pubmed.ncbi.nlm.nih.gov

Lifefuel for me

 

[PYT]

I read its a common side affect still not taking it though

I'm still worried about Retin a so imagine tret

 

[Deleted member 12071]

Maybe your nose got smaller because all the gunk inside got pushed out

 

[goat2x]

I read its a common side affect still not taking it though

I'm still worried about Retin a so imagine tret

tret and retina is same

flawda education smh..

 

[Deleted member 9511]

my nose is massive - been applying .05 tret to my face since november and have had pretty minimal results. Acne scars faded a tiny bit.

 

[Deleted member 5061]

prolly just placebo.

Afaik our noses are more swollen in the morning and leaner in the evening or after workout etc.

At least for me this is the case. Somethings it swells up like crazy though and it looks ridiculous.

 

[RAITEIII]

If this were to be true it's only with accutane. It's not happening with tretinoin dont waste ur mental energy.

@goat2x what dose did u take?

 

[goat2x]

If this were to be true it's only with accutane. It's not happening with tretinoin dont waste ur mental energy.

@goat2x what dose did u take?

10mg everyday

60 days

after tretinoin

 

[RAITEIII]

10mg everyday

60 days

after tretinoin

Only 10? What ur collagen.

Accutane can have very crazy effects so I dont really put in doubt this could happen. Depending on ur sensitivity.

I took 60 mg for 2 days and that shit was insane even my dick skin was shedding and 20% of those llittle white points in the dick disappears. Now it looks better ngl.

I'm gonna rin again this shit for 2 months but I need to buy stuff to protect my hair first

 

[goat2x]

Only 10? What ur collagen.

Accutane can have very crazy effects so I dont really put in doubt this could happen. Depending on ur sensitivity.

I took 60 mg for 2 days and that shit was insane even my dick skin was shedding and 20% of those llittle white points in the dick disappears. Now it looks better ngl.

I'm gonna rin again this shit for 2 months but I need to buy stuff to protect my hair first

yes accutane is crazy i shedded hair too

60mg is too much

 

[RAITEIII]

yes accutane is crazy i shedded hair too

60mg is too much

ResultS or death.

But did u see collagen increase with 10 mg?

 

[newperson]

i read somewhere thats its only temporary

 

[Deleted member 439]

I just looked into this study and its weird as fuck

In in vitro studies, RA has been shown to inhibit cartilage differentiation in chick limb bud mesenchymal cells (Lewis et al., '78; Hassell et al., '78; Paulsen and Solursh, '88; Moon et al., '86; Zimmermann and Received September 15, 1992; ncrrptrd llecrmber 23, 1992 Q 1993 WILEY-LISS, INC. 556 W.F. LAU ET AL. Tsambaos, '85) and chick facial primordia (Wedden et al., '87) and to stimulate cartilage matrix degradation (Horton et al., '87). However, under some conditions RA also appears to stimulate differentiation of chondroprogenitors: it mimics the action of the zone of polarizing activity (ZPA) in inducing a duplicate set of digits in limb buds of chick embryos

Retinoic acid can alter the differentiation of a variety of cell types, including chondrocytes. This action may explain the high incidence of craniofacial and limb defects resulting from exposure to retinoic acid during development

I havent gone into much depth because I am going to use tretinoin regardless, but If im not mistaken it looks like they are investigating this with the context of birth defects cause with exposure to RA

"Retinoic acid (RA), a biologically active derivative of retinol (vitamin A), regulates cell proliferation and differentiation in many cell types (Roberts and Sporn, '84). In mammals, administration of retinoids during early pregnancy causes defects in central nervous system and cardiovascular system development" - this study also discusses this in the introduction

 

[everythingisacope]

I read its a common side affect still not taking it though

I'm still worried about Retin a so imagine tret

high inhib low education ngl

 

[PYT]

This forum is shit, I keep asking for questions about Retin A and it's alleged side effects but everyone would rather read about autism

high inhib low education ngl

 

[everythingisacope]

This forum is shit, I keep asking for questions about Retin A and it's alleged side effects but everyone would rather read about autism

elab or link thread

 

[Deleted member 1862]

tret side effects are so good jfl

 

[Looks234]

Lifefuel for blackcels