VPA Hair-Growth Experiment

Problem is, most DIY attempts to extract VPA from extended-release tablets (like Amvalor Chrono) turn into a headache: lumps, partial dissolutions, leftover binders, and no guarantee of a proper solution. On the flip side, sourcing “pure” VPA powder from random IndiaMart vendors is risky, there’s no telling if it’s legit.
as you know, the guy in the linked thread said this:
Valproic acid is soluble in organic solvents such as ethanol. Sodium Valproate is soluble in water. I have a problem, I can't dissolve the tablet in water or oil. The tablet only dissolves in alcohol but a small suspension forms. When water / oil / hyaluronic acid / aloe vera etc. is added to alcohol, slurry/clumps of valproic acid are formed.
i think if you dissolve the whole thing in alcohol, then just filter the rest of the stuff out with something like a sieve, it could probably work
 
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There needs to be an update
 
This thread is insane man, I wanna know more about this and what % should valproate solution be?I ingested valproate pills, no side effects, but to my knowledge it can cause hair loss orally, but minoxidil didn't gave me the results I want!Btw are valproate gains permanent?
did you gain bone mass from the valproate
 
Thoughts on @Old Bvll ?
 
I've devised the most elaborate hair-growth routine known to man, which should seriously boost my eyebrow and eyelash growth (in density, thickness, length, you name it). Valproic acid (VPA) keeps coming up because it can push follicles into a stronger growth phase by inhibiting GSK3β. Here's a user attempting to use it:

For most people, minoxidil or a prostaglandin analog (PGA) alone, or in combination, is enough for impressive brow and lash growth. But after trying oral minoxidil and seeing solid gains that still weren’t quite satisfactory, I’ve decided to jump the gun and go all-in. My goal: super dense, thick eyebrows and eyelashes.

Examples:
View attachment 3399131View attachment 3399130View attachment 3399138

If VPA works as well as hoped, maybe I could even artificially lower my hairline. Theoretically, if it works effectively to activate dormant or miniaturized hair follicles in areas just above my existing hairline, it could. Here's someone who seemingly tried, and it kinda worked:
View attachment 3399135

Problem is, most DIY attempts to extract VPA from extended-release tablets (like Amvalor Chrono) turn into a headache: lumps, partial dissolutions, leftover binders, and no guarantee of a proper solution. On the flip side, sourcing “pure” VPA powder from random IndiaMart vendors is risky, there’s no telling if it’s legit.

Meanwhile, there’s also the synergy angle: combining VPA, which activates Wnt/β-catenin for growth, with minoxidil to boost blood flow, PGA2 to extend growth phases, and peptides to strengthen hair and enhance follicle health. Throw in micro-needling to improve absorption, and this stack could hit every pathway for maximizing growth and density. TLDR: If this shit doesn't work, nothing will.

Here’s the cocktail I’m planning:
  • VPA: Dissolved in a mild solvent mix (e.g., water + ethanol + PG) at ~1–2% concentration.
  • PGA (e.g., Bimatoprost): Extends the growth phase and may enhance pigmentation and thickness, complementing the effects of VPA.
  • Peptides: Reinforce hair shafts and pair well with VPA’s growth-pushing effects.
  • Topical Minoxidil: Adds synergy with enhanced blood flow.
  • Micro-Needling (brows only): Helps the solution penetrate deeper into follicles.
Now, I need to decide whether to:
  1. Brave the extended-release tablets (crush, dissolve, filter, hope for the best).
  2. Roll the dice on a reasonably credible “pure VPA” supplier.
If I get a stable, decently pure solution, I’ll carefully apply it to my brows and, maybe cautiously, near the lash line (Latisse-style dabs). Brow and lash cycles are shorter than scalp hair, so I should see changes within a couple of months.

If it flops? It's all over.... At least I’ll know I tried the nuclear approach.
Great thread. Just great.
 
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Great thread. Just great.
Been bumping and messaging this guy asking for results :feelswah::feelswah::feelswah:


But might be time to test it out myself
IMG 1969
 
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This solution is premixed with dmso and pepermint oil
I won’t personally use DMSO in diy products tbh, too risky and it’s better to use pg
 
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.

Meanwhile, there’s also the synergy angle: combining VPA, which activates Wnt/β-catenin for growth, with minoxidil to boost blood flow, PGA2 to extend growth phases, and peptides to strengthen hair and enhance follicle health. Throw in micro-needling to improve absorption, and this stack could hit every pathway for maximizing growth and density. TLDR: If this shit doesn't work, nothing will.
Why not use pgf2a or pge2 instead of pga2 ? It is known that pgf2a and pge2 is more effective than pga2
 
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