VPA Hair-Growth Experiment

Problem is, most DIY attempts to extract VPA from extended-release tablets (like Amvalor Chrono) turn into a headache: lumps, partial dissolutions, leftover binders, and no guarantee of a proper solution. On the flip side, sourcing “pure” VPA powder from random IndiaMart vendors is risky, there’s no telling if it’s legit.
as you know, the guy in the linked thread said this:
Valproic acid is soluble in organic solvents such as ethanol. Sodium Valproate is soluble in water. I have a problem, I can't dissolve the tablet in water or oil. The tablet only dissolves in alcohol but a small suspension forms. When water / oil / hyaluronic acid / aloe vera etc. is added to alcohol, slurry/clumps of valproic acid are formed.
i think if you dissolve the whole thing in alcohol, then just filter the rest of the stuff out with something like a sieve, it could probably work
 
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There needs to be an update
 
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This thread is insane man, I wanna know more about this and what % should valproate solution be?I ingested valproate pills, no side effects, but to my knowledge it can cause hair loss orally, but minoxidil didn't gave me the results I want!Btw are valproate gains permanent?
did you gain bone mass from the valproate
 
Thoughts on @Old Bvll ?
 
I've devised the most elaborate hair-growth routine known to man, which should seriously boost my eyebrow and eyelash growth (in density, thickness, length, you name it). Valproic acid (VPA) keeps coming up because it can push follicles into a stronger growth phase by inhibiting GSK3β. Here's a user attempting to use it:

For most people, minoxidil or a prostaglandin analog (PGA) alone, or in combination, is enough for impressive brow and lash growth. But after trying oral minoxidil and seeing solid gains that still weren’t quite satisfactory, I’ve decided to jump the gun and go all-in. My goal: super dense, thick eyebrows and eyelashes.

Examples:
View attachment 3399131View attachment 3399130View attachment 3399138

If VPA works as well as hoped, maybe I could even artificially lower my hairline. Theoretically, if it works effectively to activate dormant or miniaturized hair follicles in areas just above my existing hairline, it could. Here's someone who seemingly tried, and it kinda worked:
View attachment 3399135

Problem is, most DIY attempts to extract VPA from extended-release tablets (like Amvalor Chrono) turn into a headache: lumps, partial dissolutions, leftover binders, and no guarantee of a proper solution. On the flip side, sourcing “pure” VPA powder from random IndiaMart vendors is risky, there’s no telling if it’s legit.

Meanwhile, there’s also the synergy angle: combining VPA, which activates Wnt/β-catenin for growth, with minoxidil to boost blood flow, PGA2 to extend growth phases, and peptides to strengthen hair and enhance follicle health. Throw in micro-needling to improve absorption, and this stack could hit every pathway for maximizing growth and density. TLDR: If this shit doesn't work, nothing will.

Here’s the cocktail I’m planning:
  • VPA: Dissolved in a mild solvent mix (e.g., water + ethanol + PG) at ~1–2% concentration.
  • PGA (e.g., Bimatoprost): Extends the growth phase and may enhance pigmentation and thickness, complementing the effects of VPA.
  • Peptides: Reinforce hair shafts and pair well with VPA’s growth-pushing effects.
  • Topical Minoxidil: Adds synergy with enhanced blood flow.
  • Micro-Needling (brows only): Helps the solution penetrate deeper into follicles.
Now, I need to decide whether to:
  1. Brave the extended-release tablets (crush, dissolve, filter, hope for the best).
  2. Roll the dice on a reasonably credible “pure VPA” supplier.
If I get a stable, decently pure solution, I’ll carefully apply it to my brows and, maybe cautiously, near the lash line (Latisse-style dabs). Brow and lash cycles are shorter than scalp hair, so I should see changes within a couple of months.

If it flops? It's all over.... At least I’ll know I tried the nuclear approach.
Great thread. Just great.
 
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Great thread. Just great.
Been bumping and messaging this guy asking for results :feelswah::feelswah::feelswah:


But might be time to test it out myself
IMG 1969
 
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This solution is premixed with dmso and pepermint oil
I won’t personally use DMSO in diy products tbh, too risky and it’s better to use pg
 
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.

Meanwhile, there’s also the synergy angle: combining VPA, which activates Wnt/β-catenin for growth, with minoxidil to boost blood flow, PGA2 to extend growth phases, and peptides to strengthen hair and enhance follicle health. Throw in micro-needling to improve absorption, and this stack could hit every pathway for maximizing growth and density. TLDR: If this shit doesn't work, nothing will.
Why not use pgf2a or pge2 instead of pga2 ? It is known that pgf2a and pge2 is more effective than pga2
 
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I've devised the most elaborate hair-growth routine known to man, which should seriously boost my eyebrow and eyelash growth (in density, thickness, length, you name it). Valproic acid (VPA) keeps coming up because it can push follicles into a stronger growth phase by inhibiting GSK3β. Here's a user attempting to use it:

For most people, minoxidil or a prostaglandin analog (PGA) alone, or in combination, is enough for impressive brow and lash growth. But after trying oral minoxidil and seeing solid gains that still weren’t quite satisfactory, I’ve decided to jump the gun and go all-in. My goal: super dense, thick eyebrows and eyelashes.

Examples:
View attachment 3399131View attachment 3399130View attachment 3399138

If VPA works as well as hoped, maybe I could even artificially lower my hairline. Theoretically, if it works effectively to activate dormant or miniaturized hair follicles in areas just above my existing hairline, it could. Here's someone who seemingly tried, and it kinda worked:
View attachment 3399135

Problem is, most DIY attempts to extract VPA from extended-release tablets (like Amvalor Chrono) turn into a headache: lumps, partial dissolutions, leftover binders, and no guarantee of a proper solution. On the flip side, sourcing “pure” VPA powder from random IndiaMart vendors is risky, there’s no telling if it’s legit.

Meanwhile, there’s also the synergy angle: combining VPA, which activates Wnt/β-catenin for growth, with minoxidil to boost blood flow, PGA2 to extend growth phases, and peptides to strengthen hair and enhance follicle health. Throw in micro-needling to improve absorption, and this stack could hit every pathway for maximizing growth and density. TLDR: If this shit doesn't work, nothing will.

Here’s the cocktail I’m planning:
  • VPA: Dissolved in a mild solvent mix (e.g., water + ethanol + PG) at ~1–2% concentration.
  • PGA (e.g., Bimatoprost): Extends the growth phase and may enhance pigmentation and thickness, complementing the effects of VPA.
  • Peptides: Reinforce hair shafts and pair well with VPA’s growth-pushing effects.
  • Topical Minoxidil: Adds synergy with enhanced blood flow.
  • Micro-Needling (brows only): Helps the solution penetrate deeper into follicles.
Now, I need to decide whether to:
  1. Brave the extended-release tablets (crush, dissolve, filter, hope for the best).
  2. Roll the dice on a reasonably credible “pure VPA” supplier.
If I get a stable, decently pure solution, I’ll carefully apply it to my brows and, maybe cautiously, near the lash line (Latisse-style dabs). Brow and lash cycles are shorter than scalp hair, so I should see changes within a couple of months.

If it flops? It's all over.... At least I’ll know I tried the nuclear approach.
It’s been half a year bro, any updates?
 
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Update pookie
 
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@Alexanderr
 
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In the process of ordering the injectable sodium valproate (from Indiamart) that should bypass the entire filtration business. Basically, this is the plan as of now:

Target Concentration: Most studies on VPA for hair use significantly higher concentrations than minoxidil, often 5% to 8.3%. Since you are combining it with microneedling, 5% is a safe, potent starting point.

Step 1: Sourcing

  • Source: IndiaMart or local gray market.
  • Search Term: "Sodium Valproate Injection" or "Valproate Sodium 100mg/ml".
  • Goal: Get vials/ampoules. Do not get tablets.

Step 2: The "Clean" Formulation (5% Solution)

  • Assumption: You buy vials that are 100mg/ml (10%).
  • The Vehicle:
    • Ethanol (Everclear or high-proof vodka if desperate, lab ethanol is best): 30%
    • Propylene Glycol (or Stemoxydine as a carrier): 20%
    • Distilled Water: 0% (Your injectable is already water).
  • The Mix:
    • Take 2mL of Sodium Valproate Injection (10%).
    • Add 1mL of Ethanol (penetration).
    • Add 1mL of Propylene Glycol (humectant/absorption).
  • Result: You now have 4mL of liquid containing 200mg of VPA.

    • 200mg/4ml=50mg/ml=5%200mg/4ml=50mg/ml=5%
      Solution.

Step 3: Storage

  • Store in an amber glass dropper bottle.
  • Keep refrigerated. Sodium Valproate is stable, but DIY mixes without preservatives can grow bacteria if left out too long. Make small batches (1-2 weeks worth).

I'll update you guys as I receive it, thanks for the patience, I'd forgotten about this thing but I'm motivated to see it trough since problem remains; eyebrows not as thick/dense as I'd like them.
 
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In the process of ordering the injectable sodium valproate (from Indiamart) that should bypass the entire filtration business. Basically, this is the plan as of now:



I'll update you guys as I receive it, thanks for the patience, I'd forgotten about this thing but I'm motivated to see it trough since problem remains; eyebrows not as thick/dense as I'd like them.
@imontheloose @chadisbeingmade u guys think DMSO might be ideal for this ? A UK company for topical VPA uses that over propylene gylcole
 
I don’t want to resort to surgery but damn if this don’t work then fuck it I have no choice. I want to see my full potential as I already pull girls now with my cuck tier translucent brows, imagine if I get Chad eyebrows those same bitches might collapse in my presence

So far I’ve tried: Oral minoxidil (2.5, 5, and 10 mg) daily for months on each dose, topical minoxidil twice with dermapen once a week initially then twice a week out of desperation, castor oil twice daily a couple years back and bima twice daily couple years back. Yes I was taking oral and topical minoxidil daily for about a year.
Maybe I got a 30% increases but that not satisfying considering they were nearly non existent depending on the lighting. And yes I’ve tried dying it dark, not much improvement. Currently I do minox with castor and rosemary oil 2x daily with tretinoin on and off and dermapen twice weekly. I added rosemary a couple weeks ago. No significant changes it’s just habit at this point. I want to see if I can still get real results without a transplant I have yet to try Valproic acid and GHK-cu

Edit: I forgot to add I had to stop taking oral cuz I was growing hair all over my cheek and close to my lower eye area. Wasn’t worth continuing since I barely notice any hair density increase in my brows
 
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