Why DHT is important and should NOT be nuked to the ground

[4lt.Real]

Also ever wondered why most of the Finasteride users like Orc and Clavicular here never experience that many side effects from the 5ARI use? It's because they blast exogenous hormones to the point where the accumulated testosterone compensates for most of the side effects of the lacking DHT.

you're getting banned buddy

 

[4lt.Real]

repped, DHT

 

[Sonny Black]

Noooo, Tranny Mann said all side effects are heckin nocebo

 

[Jonas2k7]

@Underdog9494 please saar

 

[Underdog9494]

@Underdog9494 please saar

Im nusy nigger

 

[Underdog9494]

Tag me in an hour or 2

 

[Underdog9494]

Im baking something

 

[Jonas2k7]

Tag me in an hour or 2

Okay my nigga

 

[DR. NICKGA]

Androgen receptor sensitivity
Even jeffreey could achieve Chad levels but he would need to compensate with enough androgens

Genetics, for sure not androgen receptor sensivity, thats nonense

They cause epigenetic changes, that's why many people experience PFS in the first place.

No proof, you are again just saying bullshit

 

[DR. NICKGA]

.
I think a better thread would be to compile all the ways to prevent/delay hairloss "naturally" aka not using DHT blockers/tranny drugs. I was going to make a big thread but i don't have the motivation as the forum is dead. It's just 15 year old kids shitposting and it's just not worth posting here anymore.

Go make you shitty thread, i love to destroy you completely with science

Go do it

 

[DR. NICKGA]

Body should be viewed holistically (meaning: as a whole)

That is some spiritual shit
Balding is all GENETICS

And once you suffer from balding you will immediately hop on fin like a good dog

 

[DR. NICKGA]

Noooo, Tranny Mann said all side effects are heckin nocebo

No scientific argument

Just a straight up insult

#retard

 

[DNRDniggerking]

just use RU58841

 

[Deleted member 116922]

 

[DR. NICKGA]

No matter how many study i post everyone gonna think dht ks a useless hormone

Good

Its a usseless hormone

Balding is caused by DHT

BALDING (ANDROGENETIC ALOPECIA) IS CAUSED BY DHT the strongest evidence I can think of right now.. If it's not enough to convince someone of the causal role of androgens in baldness then that person is brain dead or willfully ignorant. Common male pattern baldness is a highly heritable trait...

looksmax.org

 

[DR. NICKGA]

View attachment 3400638View attachment 3400639View attachment 3400640View attachment 3400641

Gonna reply to this later but it rlly dont matter for most people

Most people have no metabolic or pcos, and even if you dont have it, genetics gonna still get you

 

[Jonas2k7]

Good

Its a usseless hormone

Balding is caused by DHT

BALDING (ANDROGENETIC ALOPECIA) IS CAUSED BY DHT the strongest evidence I can think of right now.. If it's not enough to convince someone of the causal role of androgens in baldness then that person is brain dead or willfully ignorant. Common male pattern baldness is a highly heritable trait...

looksmax.org

Stop linking that thread all the time, can't you use your "knowledge" and write your own sentences now?

 

[DR. NICKGA]

Stop linking that thread all the time, can't you use your "knowledge" and write your own sentences now?

Nope

 

[mvp2v1]

Anecdotally I know people who are on Fin for their hair. and they report changes in their aggressiveness nothing else. that alone is predictable and unappealing to me and it clearly shows that dht matters. You dont want to be an unassertive man.

 

[AlphaLooksmaxxer666]

 

[AlphaLooksmaxxer666]

agree dht is important hormone

 

[wishIwasSalludon]

Cope

 

[bimaxmaxxer]

Anecdotally I know people who are on Fin for their hair. and they report changes in their aggressiveness nothing else. that alone is predictable and unappealing to me and it clearly shows that dht matters. You dont want to be an unassertive man.

Who wants to be a balding aggressive man? We wanna looksmaxx not prisonmaxx

 

[repszon]

I'm tired of trannies here trying to convince people that DHT is useless. This thread will cover the importance of DHT and why you should not block it by the use of 5ARIs.

My friend @20/04/2008 made a really good thread on it, so I will just TLDR it:

DHT is not only the stronger version of Testosterone (2-4 times higher affinity to the androgen receptor), but also binds differently to the AR because of its unique structure.

This means each androgen exerts unique effects, including DHT. So only using Testosterone is not the right solution.

---

Now to the other uses of the enzyme 5α-reductase: It doesn't only affect the conversion of T to DHT, here are some other reactions:

Cholestenone → 5α-Cholestanone
Progesterone → 5α-Dihydroprogesterone
3α-Dihydroprogesterone → Allopregnanolone
3β-Dihydroprogesterone → Isopregnanolone
Deoxycorticosterone → 5α-Dihydrodeoxycorticosterone
Corticosterone → 5α-Dihydrocorticosterone
Aldosterone → 5α-Dihydroaldosterone
Androstenedione → 5α-Androstanedione
Nandrolone → 5α-Dihydronandrolone

The functions of some of the 5α-reduced steroids are unknown, that's why it isn't a good idea to "just use fin bro because you'll be fine."

Allopregnanolone is an important neurosteroid made from 3α-dihydroprogesterone. Without 5α-reductase on the other hand, this important neurosteroid can't be synthesized.

Progesterone → DHP via 5α-reductase
DHP → Allopregnanolone via 3α-HSD
Allopregnanolone → Positive allosteric modulator of GABA-A receptors

TLDR: No allopregnanolone -> More Anxiety, brain fog, stress, etc.

View attachment 3391024

Not forgetting the sexual dysfunction aspect of inhibiting 5AR.

The cells of the corpus cavernosum have androgen receptors, when you agonize these receptors they produce endothelial nitric oxide. NO triggers the relaxation of smooth muscle cells, leading to vasodilation and increased blood flow, which is needed for achieving and maintaining an erection. This can't be replaced with cialis, you need the local AR activation.

The only solution to solve this, is to have high levels of testosterone especially locally in the area of the penis or to use topical DHT/testosterone gels, just to maintain the normal function of the penis.

There is also the mental aspect of the erectile dysfunction. The main role of the sex drive of males consists of the dopamine/oxytocin signalling, which is inhibited by the use of 5ARIs. So in short, 5ARIs result in a reduction of libido.

View attachment 3391036

DHT is important for bone mass, which in the cited study even resulted in an increase of bone mass. DHT is also important for muscle strength.

"We have previously reported that DHT treatment increases bone mass in orchidectomized mice and that this effect is independent of estrogen receptors."

5AR is important for the metabolism of cortisol in the liver according to this study.

Persistent sexual side effects by the way... "Subjects reported new-onset persistent sexual dysfunction associated with the use of finasteride: 94% developed low libido, 92% developed erectile dysfunction, 92% developed decreased arousal, and 69% developed problems with orgasm."

Also ever wondered why most of the Finasteride users like Orc and Clavicular here never experience that many side effects from the 5ARI use? It's because they blast exogenous hormones to the point where the accumulated testosterone compensates for most of the side effects of the lacking DHT.

---

See? DHT is a vital male hormone, blocking it completely is harmful and has many other harms like discussed in this thread.

View attachment 3391173

Tag list: @halloweed @JohnDoe @Always Stay You @ConfusedBolivian

Retard nigger study, castrated nigger mice studies that apparently extrapolates onto humans, whilst DHT in mice basically has the same physiological function as testosterone in humans, so total retard bone mass study. Then 94% side effect study based on study with pfs goons who already have “side effects” before the study, and also are funded by the pfs foundation.

 

[DR. NICKGA]

Who wants to be a balding aggressive man? We wanna looksmaxx not prisonmaxx

Retard nigger study, castrated nigger mice studies that apparently extrapolates onto humans, whilst DHT in mice basically has the same physiological function as testosterone in humans, so total retard bone mass study. Then 94% side effect study based on study with pfs goons who already have “side effects” before the study, and also are funded by the pfs foundation.

Balding is caused by DHT

BALDING (ANDROGENETIC ALOPECIA) IS CAUSED BY DHT the strongest evidence I can think of right now.. If it's not enough to convince someone of the causal role of androgens in baldness then that person is brain dead or willfully ignorant. Common male pattern baldness is a highly heritable trait...

looksmax.org

Learn the truth

 

[mvp2v1]

Who wants to be a balding aggressive man? We wanna looksmaxx not prisonmaxx

thats an opinion sure. but this is also you admitting that dht is not a useless hormone. That it has some consequential effect in the brain.

 

[DR. NICKGA]

thats an opinion sure. but this is also you admitting that dht is not a useless hormone. That it has some consequential effect in the brain.

Dht is usseles

 

[bimaxmaxxer]

thats an opinion sure. but this is also you admitting that dht is not a useless hormone. That it has some consequential effect in the brain.

bruh, I count myself as very aggressive/impulsive. I can't even go to work and/or talk to normies without training or smoking weed before (Ideally both). Being angry for no reason, specially in higher age is just cringe. And if you are a trained fighter, having a thin skin means you are with one foot in prison or grave, specially if you don't look like a model. It's a different nightmare mode.

This actually makes me look forward into taking fin/dut

 

[movrax]

I'm tired of trannies here trying to convince people that DHT is useless. This thread will cover the importance of DHT and why you should not block it by the use of 5ARIs.

My friend @20/04/2008 made a really good thread on it, so I will just TLDR it:

DHT is not only the stronger version of Testosterone (2-4 times higher affinity to the androgen receptor), but also binds differently to the AR because of its unique structure.

This means each androgen exerts unique effects, including DHT. So only using Testosterone is not the right solution.

---

Now to the other uses of the enzyme 5α-reductase: It doesn't only affect the conversion of T to DHT, here are some other reactions:

Cholestenone → 5α-Cholestanone
Progesterone → 5α-Dihydroprogesterone
3α-Dihydroprogesterone → Allopregnanolone
3β-Dihydroprogesterone → Isopregnanolone
Deoxycorticosterone → 5α-Dihydrodeoxycorticosterone
Corticosterone → 5α-Dihydrocorticosterone
Aldosterone → 5α-Dihydroaldosterone
Androstenedione → 5α-Androstanedione
Nandrolone → 5α-Dihydronandrolone

The functions of some of the 5α-reduced steroids are unknown, that's why it isn't a good idea to "just use fin bro because you'll be fine."

Allopregnanolone is an important neurosteroid made from 3α-dihydroprogesterone. Without 5α-reductase on the other hand, this important neurosteroid can't be synthesized.

Progesterone → DHP via 5α-reductase
DHP → Allopregnanolone via 3α-HSD
Allopregnanolone → Positive allosteric modulator of GABA-A receptors

TLDR: No allopregnanolone -> More Anxiety, brain fog, stress, etc.

View attachment 3391024

Not forgetting the sexual dysfunction aspect of inhibiting 5AR.

The cells of the corpus cavernosum have androgen receptors, when you agonize these receptors they produce endothelial nitric oxide. NO triggers the relaxation of smooth muscle cells, leading to vasodilation and increased blood flow, which is needed for achieving and maintaining an erection. This can't be replaced with cialis, you need the local AR activation.

The only solution to solve this, is to have high levels of testosterone especially locally in the area of the penis or to use topical DHT/testosterone gels, just to maintain the normal function of the penis.

There is also the mental aspect of the erectile dysfunction. The main role of the sex drive of males consists of the dopamine/oxytocin signalling, which is inhibited by the use of 5ARIs. So in short, 5ARIs result in a reduction of libido.

View attachment 3391036

DHT is important for bone mass, which in the cited study even resulted in an increase of bone mass. DHT is also important for muscle strength.

"We have previously reported that DHT treatment increases bone mass in orchidectomized mice and that this effect is independent of estrogen receptors."

5AR is important for the metabolism of cortisol in the liver according to this study.

Persistent sexual side effects by the way... "Subjects reported new-onset persistent sexual dysfunction associated with the use of finasteride: 94% developed low libido, 92% developed erectile dysfunction, 92% developed decreased arousal, and 69% developed problems with orgasm."

Also ever wondered why most of the Finasteride users like Orc and Clavicular here never experience that many side effects from the 5ARI use? It's because they blast exogenous hormones to the point where the accumulated testosterone compensates for most of the side effects of the lacking DHT.

---

See? DHT is a vital male hormone, blocking it completely is harmful and has many other harms like discussed in this thread.

View attachment 3391173

Tag list: @halloweed @JohnDoe @Always Stay You @ConfusedBolivian

But you should obviously not have too much DHT in your system because although it is very androgen alongside with that there come the undesired masculizing properties.