Deleted member 5187
Kraken
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Melanotan 1. When it comes to effects, Melanotan 1 primarily increases melanogenesis by binding to the melanocortin 1 receptor (MC1). MT1 is currently approved by FDA and other regulating bodies for treatment of different skin related illnesses.
It was approved by the Italian Medicines Agency [(AIFA) Agenzia Italiana del Farmaco] for the treatment of Erythropoietic Protoporphyria (EPP) in 2010. It was also approved by the European Medicines Agency (EMA) for treating phototoxicity in people with EPP in 2015.
As of 2019, the US FDA approved MT1 for reducing pain caused by sun exposure in people with EPP.
Melanotan2. Similar to MT1, MT2 also increases melanogenesis by stimulating the melanocortin 1 receptor. However, unlike MT1, MT2 has the ability to stimulate other melanocortin receptors, specifically MC1, MC3, MC4, MC5.
This stimulation of other MC receptors results to other effects including penile erection, sexual arousal, and appetite suppression.
What most seek is the binding of MC1-R so why is mt2 more popular?
It's cheaper and easier to find but mt1 isn't difficult at all to find.
The actions on mc3, mc4 and mc5 isn't really that well known at all.
Yes increased erections and suppressed appetite can be a plus.
But these could be gained by using more studied drugs that don't cause nausea in the process.
Meanwhile there might be actions of mc3-mc5 that isn't know yet.
So why not just use melanotan 1 that's been approved for human consumption in both Europe and US?
It was approved by the Italian Medicines Agency [(AIFA) Agenzia Italiana del Farmaco] for the treatment of Erythropoietic Protoporphyria (EPP) in 2010. It was also approved by the European Medicines Agency (EMA) for treating phototoxicity in people with EPP in 2015.
As of 2019, the US FDA approved MT1 for reducing pain caused by sun exposure in people with EPP.
Melanotan2. Similar to MT1, MT2 also increases melanogenesis by stimulating the melanocortin 1 receptor. However, unlike MT1, MT2 has the ability to stimulate other melanocortin receptors, specifically MC1, MC3, MC4, MC5.
This stimulation of other MC receptors results to other effects including penile erection, sexual arousal, and appetite suppression.
What most seek is the binding of MC1-R so why is mt2 more popular?
It's cheaper and easier to find but mt1 isn't difficult at all to find.
The actions on mc3, mc4 and mc5 isn't really that well known at all.
Yes increased erections and suppressed appetite can be a plus.
But these could be gained by using more studied drugs that don't cause nausea in the process.
Meanwhile there might be actions of mc3-mc5 that isn't know yet.
So why not just use melanotan 1 that's been approved for human consumption in both Europe and US?
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