
ascensionneeeded
Bronze
- Joined
- Oct 3, 2024
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number one beginner stack (no injections, no fridge, no androgens)
read below stack for lots of info
30 days | Β£80-105 a month
optional: d3, k2, calcium, collagen peptides,
βββββββββββββββββββββββ
why choose this stack for a beginner?
ββββββββββββββββββββββ
what does mk677 do? why this dose?
note that mk677 will not result in potent results but is the most beginner friendly substance. donβt expect a substantial change in any factors listed above.
βββββββββββββββββββββββ
What is the DIM and calcium-d-glucarate for?
mk677 >
HGH >
IGF-1
IGF-1 > supports leydig cell function in testes > more testosterone > more substrate for aromatase > more T being converted into estrogen
IGF-1 > stimulates aromatase expression > increased estrogen production
DIM
Calcium-D-glucarate
βββββββββββββββββββββββ
will DIM and CDG actually reduce my estrogen? is this the right dose? why do i need less estrogen?
calculations
skip if needed.
βββββββββββββββββββββββ
mk677 gh and igf-1 average increase:
gh pulse amplitude: +75%
igf-1: from 200 ng/mL > 320β400 ng/mL in 30 days β nass et al., 2008 (annals of internal medicine)
baseline igf-1: 250 ng/mL (average uk male 16β18yo)
post-mk677 igf-1: 375 ng/mL (+50%)
igf-1 and gh enhance p450 aromatase expression via pi3k/akt and camp pathways β simpson et al., 1999 (endocrine reviews)
estimated increase in aromatase activity is 25β50% under gh/igf-1 upregulation
a 50% increase in igf-1 can realistically cause a 20β35% increase in estradiol (e2) in a young male, if aromatization is active β auclair et al., 1991 (journal of steroid biochemistry)
baseline estradiol (e2): 25 pg/mL (average uk 16yo male)
could expect e2 to rise to:
32.5 pg/mL (25 Γ 1.3)
clinical trials and estrogen metabolism models show:
200mg dim > 20β25% improvement in estrogen metabolite ratio (2-oh/16Ξ±-oh) β bradlow et al., 1991 (journal of the national cancer institute)
1000mg calcium-d-glucarate > 20β25% reduction in estrogen reabsorption by inhibiting Ξ²-glucuronidase β walaszek et al., 1990 (cancer letters)
combined effect (dim + cdg): 30β35% total estrogen modulation
estimated e2 with stack: 24β25 pg/mL (reduced from 32.5)
back to safe levels
(based on avg hormones 16-18 year old)
βββββββββββββββββββββββ
why do i need berberine?
mk677 results in poor insulin sensitivty which is an extremely important bio marker for health. poor insulin sensitivty can lead to diabetes. i wont explain how berberine works but it helps to counter the affects of worsened insulin sensitivity and 500mg 2x a day is a standard dose. there are no risks with berberine at this dose and it has shown to be effective.
βββββββββββββββββββββββ
final message:
i hope you found this useful. if you follow this stack it will definitely benefit you. itβs a safe and easy stack to use (especially with strict parents) - to all the edgy ppl saying dnr and telling kids to blast tren, you arenβt funny. this is a good, safe start point and while it wont be very effective, itβs better than nothing.
also, please monitor your symptoms and dm me if you need to. enjoy!
read below stack for lots of info

- mk677 - 25mg a day
- DIM - 200mg a day
- calcium-D-glucarate - 1000mg a day
- berberine - 500mg 2x a day
30 days | Β£80-105 a month
optional: d3, k2, calcium, collagen peptides,
βββββββββββββββββββββββ
why choose this stack for a beginner?
- requires no injections
- requires no fridge
- no interference with androgens
- everything is taken orally
- very cheap
- will result in increased HGH / IGF-1
- not risky, dangerous, detrimental
- no quality issues
- no post-stack attention required
- can easily be stopped and started
ββββββββββββββββββββββ
what does mk677 do? why this dose?
- 25mg a day will yield far greater HGH increases than 12.5mg. the relationship between mk677 and HGH is not linear and there are diminishing returns after around 22-25mg of mk677. going over 25mg a day is not worth it as the HGH drops off and the side effects increase.
- 25mg a day of mk677 = 1.5-2IU HGH give or take, although they are very different. just for reference.
- HGH is responsible for: bone growth, increased hypertrophy, fat loss, skin elasticity, recovery, etc.
note that mk677 will not result in potent results but is the most beginner friendly substance. donβt expect a substantial change in any factors listed above.
βββββββββββββββββββββββ
What is the DIM and calcium-d-glucarate for?
mk677 >




- since mk677 will result in increased estrogen, we must supplement to decrease the estrogen back to baseline (or near). as this is a beginner stack, we cannot use an AI. instead we will use DIM and calcium-D-glucarate
DIM
- shifts estrogen metabolism, increases the 2-OH pathways, thus reducing the more potent & harmful forms.
- supports phase I liver detox enzymes. makes estrogen metabolites easier to flush out. effectively gets excess estrogen out of your system.
- slightly suppresses aromatase - is a very weak/mild aromatase inhibitor
Calcium-D-glucarate
- CDG blocks Ξ²-glucuronidase which is responsible for removing estrogen from the gut and sending it back into circulation. CDG results in less estrogen recycling > lower total circulation estrogen
- enhances phase II liver detox > makes your estrogen clearance faster and more efficient.
βββββββββββββββββββββββ
will DIM and CDG actually reduce my estrogen? is this the right dose? why do i need less estrogen?
- too much estrogen has a variety of side effects such as gyno, sore joints and most importantly, prolonged high estrogen encourages premature growth plate closure. to maximise growth and our general health, we must reduce our estrogen. however, rescuing estrogen too much also results in side effects like less libido and decreased bone health. we must find the proper dose.
calculations

skip if needed.
βββββββββββββββββββββββ
mk677 gh and igf-1 average increase:
gh pulse amplitude: +75%
igf-1: from 200 ng/mL > 320β400 ng/mL in 30 days β nass et al., 2008 (annals of internal medicine)
baseline igf-1: 250 ng/mL (average uk male 16β18yo)
post-mk677 igf-1: 375 ng/mL (+50%)
igf-1 and gh enhance p450 aromatase expression via pi3k/akt and camp pathways β simpson et al., 1999 (endocrine reviews)
estimated increase in aromatase activity is 25β50% under gh/igf-1 upregulation
a 50% increase in igf-1 can realistically cause a 20β35% increase in estradiol (e2) in a young male, if aromatization is active β auclair et al., 1991 (journal of steroid biochemistry)
baseline estradiol (e2): 25 pg/mL (average uk 16yo male)
could expect e2 to rise to:
32.5 pg/mL (25 Γ 1.3)
clinical trials and estrogen metabolism models show:
200mg dim > 20β25% improvement in estrogen metabolite ratio (2-oh/16Ξ±-oh) β bradlow et al., 1991 (journal of the national cancer institute)
1000mg calcium-d-glucarate > 20β25% reduction in estrogen reabsorption by inhibiting Ξ²-glucuronidase β walaszek et al., 1990 (cancer letters)
combined effect (dim + cdg): 30β35% total estrogen modulation
estimated e2 with stack: 24β25 pg/mL (reduced from 32.5)
back to safe levels
(based on avg hormones 16-18 year old)
- 200mg DIM, 1000mg CDG
βββββββββββββββββββββββ
why do i need berberine?
mk677 results in poor insulin sensitivty which is an extremely important bio marker for health. poor insulin sensitivty can lead to diabetes. i wont explain how berberine works but it helps to counter the affects of worsened insulin sensitivity and 500mg 2x a day is a standard dose. there are no risks with berberine at this dose and it has shown to be effective.
βββββββββββββββββββββββ
final message:
i hope you found this useful. if you follow this stack it will definitely benefit you. itβs a safe and easy stack to use (especially with strict parents) - to all the edgy ppl saying dnr and telling kids to blast tren, you arenβt funny. this is a good, safe start point and while it wont be very effective, itβs better than nothing.
also, please monitor your symptoms and dm me if you need to. enjoy!