An Introduction to Androgens/Growth factors - The Ultimate Guide to PUBERTYMAXXING **WITH STUDIES**

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An Introduction to Androgens/Growth factors - The Ultimate Guide to PUBERTYMAXXING **WITH STUDIES**


Preface:


This thread is made under the presumption you are still undergoing puberty which usually ranges from ages 11-17 but can start earlier/end later depending on genetics. You can check if you are still in puberty by getting an X-ray scan on your left hand/wrist to see if growth plates are still open.

Introduction:

I will be explaining growth-inducing lifestyle habits (diet and sleep) and how to utilise Growth factors/ androgens to get the most facial development, increased sexual dimorphism and vertical growth out of puberty.

Lifestyle habits:

Habits during adolescence are underrated when it comes to development. Although they may not be as effective as other methods mentioned, it is
still necessary.

The ideal habits include:

8 Hours + sleep
Adequate hydration (<3L water)
Daily exercise (gym or martial art + some cardio)
Maintain proper posture

Diet:

The optimal diet won’t yield crazy results but is a staple to your protocol as a whole

The optimal diet consists of:

Wholefoods only - greater nutrient density to support hormonal function + skeletal development
300-500 calorie surplus - high energy availability for thyroid function and growth
Protein 1.2-2.2 g/kg bodyweight - supplements muscle/bone growth
Carbohydrates 3-6k/kg/day - provides energy for growth, performance and maintain glycogen stores
Red meat 3-7 times per week - most nutrient dense food for male development
Dairy - Increases IGF-1 and supports bone mineralization
Vitamin D - allows efficient calcium absorption
Healthy fats - supports hormone production (NOT NECESSARY ON AAS)
Zinc -Supports hormone function

Make a diet following these principles - use ChatGPT for this if you are struggling

Testosterone:

Disclaimer: if not managed properly, this can accelerate the fusion of growth plates


Testosterone is the primary androgen driving male puberty. It fuels muscle growth, bone density and width, voice deepening, facial masculinization, body hair, libido, and overall sexual dimorphism. Levels rise sharply from Tanner 2 onward and peak in late puberty.

The best way to increase test is to pick up the needle: Test E 350mg/week

Side effects:

Bloating
Gyno
Higher libido
Increased aggression
Hair loss
Increased blood pressure

Note: These sides are less likely on a dose of 350mg

I will make a thread simplifying every from sourcing to injecting and managing sides soon, but do you own research before proceeding.

Study on effect of low dose test on boys with delayed puberty https://www.researchgate.net/publication/12970434_Effect_of_low-dose_testosterone_treatment_on_craniofacial_growth_in_boys_with_delayed_puberty


Craniofacial growth was investigated in boys treated with low-dose testosterone for delayed puberty (> 14 years old; testicular volume < 4 ml; n = 7) and compared with controls (12-14 years; n = 37). Cephalometric radiographs, statural height and pubertal stage were recorded at the start of the study and after 1 year. Craniofacial growth was assessed by nine linear measurements. At the beginning of the study, statural height, mandibular ramus length, upper anterior face height, and total cranial base length were significantly shorter in the delayed puberty boys than in the controls. After 1 year, the growth rate of the statural height, total mandibular length, ramus length, and upper and total anterior face height was significantly higher in the treated boys than in the untreated height-matched controls (n = 7). The craniofacial measurements were similar in the treated boys as compared with the controls. These results show that statural height and craniofacial dimensions are low in boys with delayed puberty. Low doses of testosterone accelerate statural and craniofacial growth, particularly in the delayed components, thus leading towards a normalization of facial dimensions.

Trenbolone:

Disclaimer: if not managed properly, this can accelerate the fusion of growth plates and can negatively impact your health.

Trenbolone is a highly potent synthetic anabolic-androgenic steroid (AAS) originally developed for veterinary use. It is not approved for medical use in humans. It binds strongly to the androgen receptor and has powerful anabolic and androgenic effects.

I would strongly advise staying on low dose as anything more is a looksmin in my opinion:: Trenbolone Acetate 25mg.

Side effects:

Night sweats
Insomnia
Increased heart rate
Appetite suppression
Cough (AKA tren cough)
Increased prolactin
Kidney stress
Tren rage

Note: only use this compound towards the very end or a little bit after puberty.

As previously mentioned, A thread on this is due but also do your own research on these compounds.

Study on impact of trenbolone: https://journals.viamedica.pl/endokrynologia_polska/article/view/99130

DHT pre-treatment, however, caused a significant decrease in 3H-E2 retention by gonadotrophs in both males and females. The treatment also caused a decrease in binding by lactotrophs and somatotrophs, but only in the females. No other cell types were altered. Thus, androgen appears to modulate E2 binding and retention by pituitary cells in both a cell-type and sex-dependent manner. Our results also indicate that the inhibitory effects of androgens on E2 binding by the pituitary gland is more complex than can be explained by simple competition for the oestrogen receptor.

Dihydrotestosterone (DHT):

Dihydrotestosterone (DHT) is a potent androgen produced from testosterone by the enzyme 5α-reductase in specific tissues (skin, hair follicles, prostate, genitals). It binds the androgen receptor more strongly than testosterone and does not aromatize into estrogen. It plays a smaller role in muscle growth compared to testosterone but is highly important for sexual dimorphism in hair and genital tissues.

Effective ways to increase DHT (listed from most direct to least):

Direct DHT or strong DHT-derivatives (e.g. topical DHT, Masteron/drostanolone, Proviron/mesterolone)
Higher testosterone base (more substrate for conversion via 5α-reductase)
Supporting 5α-reductase activity: adequate zinc, boron, and overall androgen status

Side effects:

Accelerated male-pattern hair loss (if genetically prone)
Increased body/facial hair
Acne / oily skin
Prostate stimulation (possible enlargement or higher PSA in susceptible individuals)
Potential negative impact on cholesterol with stronger DHT compounds
Suppression of natural hormone production when using exogenous DHT derivatives

Study of Dihydrotestosterone induces a sexual dimorphism in oestrogen uptake by specific anterior pituitary cell types in vivo: https://pubmed.ncbi.nlm.nih.gov/3621311/

DHT pre-treatment, however, caused a significant decrease in 3H-E2 retention by gonadotrophs in both males and females. The treatment also caused a decrease in binding by lactotrophs and somatotrophs, but only in the females. No other cell types were altered. Thus, androgen appears to modulate E2 binding and retention by pituitary cells in both a cell-type and sex-dependent manner. Our results also indicate that the inhibitory effects of androgens on E2 binding by the pituitary gland is more complex than can be explained by simple competition for the oestrogen receptor.

HGH/IGF-1:

Human Growth Hormone (HGH) or somatotropin, is a peptide hormone produced by the anterior pituitary gland. It plays a crucial role in growth, tissue repair, metabolism, and body composition by directly affecting tissues and stimulating the production of insulin-like growth factor-1 (IGF-1), primarily in the liver. Insulin-Like Growth Factor 1 is an anabolic peptide hormone acts as the primary downstream mediator of many of HGH's growth-promoting effects and is also essential for normal skeletal growth, tissue repair, and muscle development.

Effective ways to increase HGH/IGF-1 (listed from most effective to least effective)

HGH - 6-8 IUs ED
GHRP2/6 - 100mcg each 3x a day
IGFLR3 40-50mcg twice a day
Mk677 (cheapest + oral) - 15mg ED

Side effects:

Water retention
Insulin retention
Carpal tunnel symptoms
acceleration of moles
Joint pain

Note: some of these sides are only common with HGH, the other options are less risky.

Study of regulation of muscle mass by growth hormone and IGF-1: https://pmc.ncbi.nlm.nih.gov/articles/PMC2439518/?utm_source
concluded that the GH/IGF-1 axis is a central regulator of muscle growth and that IGF-1 exerts direct anabolic effects through satellite cell activation and protein synthesis pathways.

Study of Craniofacial Changes Among Children and Adolescents Submitted to Growth Hormone Therapy: A Systematic Review: https://pmc.ncbi.nlm.nih.gov/articles/PMC12418064/
Regarding the maxillary and cranial base differences, one study investigated and observed that maxillary height was 2 mm higher when compared to an untreated control group, whereas one study observed an increase of 1 mm in the posterior cranial base after GH therapy.

Conclusion:

Puberty is a limited time window, you only go through it once. Ensuring a mix of androgens like Test/DHT and growth factors like HGH all while maintaining good habits and diet will maximise your potential height and dimorphism obtained through puberty.
 
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An Introduction to Androgens/Growth factors - The Ultimate Guide to PUBERTYMAXXING **WITH STUDIES**


Preface:


This thread is made under the presumption you are still undergoing puberty which usually ranges from ages 11-17 but can start earlier/end later depending on genetics. You can check if you are still in puberty by getting an X-ray scan on your left hand/wrist to see if growth plates are still open.

Introduction:

I will be explaining growth-inducing lifestyle habits (diet and sleep) and how to utilise Growth factors/ androgens to get the most facial development, increased sexual dimorphism and vertical growth out of puberty.

Lifestyle habits:

Habits during adolescence are underrated when it comes to development. Although they may not be as effective as other methods mentioned, it is
still necessary.

The ideal habits include:

8 Hours + sleep
Adequate hydration (<3L water)
Daily exercise (gym or martial art + some cardio)
Maintain proper posture


Diet:

The optimal diet won’t yield crazy results but is a staple to your protocol as a whole

The optimal diet consists of:

Wholefoods only - greater nutrient density to support hormonal function + skeletal development
300-500 calorie surplus - high energy availability for thyroid function and growth
Protein 1.2-2.2 g/kg bodyweight - supplements muscle/bone growth
Carbohydrates 3-6k/kg/day - provides energy for growth, performance and maintain glycogen stores
Red meat 3-7 times per week - most nutrient dense food for male development
Dairy - Increases IGF-1 and supports bone mineralization
Vitamin D - allows efficient calcium absorption
Healthy fats - supports hormone production (NOT NECESSARY ON AAS)
Zinc -Supports hormone function

Make a diet following these principles - use ChatGPT for this if you are struggling


Testosterone:

Disclaimer: if not managed properly, this can accelerate the fusion of growth plates

Testosterone is the primary androgen driving male puberty. It fuels muscle growth, bone density and width, voice deepening, facial masculinization, body hair, libido, and overall sexual dimorphism. Levels rise sharply from Tanner 2 onward and peak in late puberty.

The best way to increase test is to pick up the needle: Test E 350mg/week

Side effects:

Bloating
Gyno
Higher libido
Increased aggression
Hair loss
Increased blood pressure

Note: These sides are less likely on a dose of 350mg

I will make a thread simplifying every from sourcing to injecting and managing sides soon, but do you own research before proceeding.

Study on effect of low dose test on boys with delayed puberty https://www.researchgate.net/publication/12970434_Effect_of_low-dose_testosterone_treatment_on_craniofacial_growth_in_boys_with_delayed_puberty




Trenbolone:

Disclaimer: if not managed properly, this can accelerate the fusion of growth plates and can negatively impact your health.

Trenbolone is a highly potent synthetic anabolic-androgenic steroid (AAS) originally developed for veterinary use. It is not approved for medical use in humans. It binds strongly to the androgen receptor and has powerful anabolic and androgenic effects.

I would strongly advise staying on low dose as anything more is a looksmin in my opinion:: Trenbolone Acetate 25mg.

Side effects:

Night sweats
Insomnia
Increased heart rate
Appetite suppression
Cough (AKA tren cough)
Increased prolactin
Kidney stress
Tren rage

Note: only use this compound towards the very end or a little bit after puberty.

As previously mentioned, A thread on this is due but also do your own research on these compounds.

Study on impact of trenbolone: https://journals.viamedica.pl/endokrynologia_polska/article/view/99130

DHT pre-treatment, however, caused a significant decrease in 3H-E2 retention by gonadotrophs in both males and females. The treatment also caused a decrease in binding by lactotrophs and somatotrophs, but only in the females. No other cell types were altered. Thus, androgen appears to modulate E2 binding and retention by pituitary cells in both a cell-type and sex-dependent manner. Our results also indicate that the inhibitory effects of androgens on E2 binding by the pituitary gland is more complex than can be explained by simple competition for the oestrogen receptor.


Dihydrotestosterone (DHT):

Dihydrotestosterone (DHT) is a potent androgen produced from testosterone by the enzyme 5α-reductase in specific tissues (skin, hair follicles, prostate, genitals). It binds the androgen receptor more strongly than testosterone and does not aromatize into estrogen. It plays a smaller role in muscle growth compared to testosterone but is highly important for sexual dimorphism in hair and genital tissues.

Effective ways to increase DHT (listed from most direct to least):

Direct DHT or strong DHT-derivatives (e.g. topical DHT, Masteron/drostanolone, Proviron/mesterolone)
Higher testosterone base (more substrate for conversion via 5α-reductase)
Supporting 5α-reductase activity: adequate zinc, boron, and overall androgen status

Side effects:

Accelerated male-pattern hair loss (if genetically prone)
Increased body/facial hair
Acne / oily skin
Prostate stimulation (possible enlargement or higher PSA in susceptible individuals)
Potential negative impact on cholesterol with stronger DHT compounds
Suppression of natural hormone production when using exogenous DHT derivatives

Study of Dihydrotestosterone induces a sexual dimorphism in oestrogen uptake by specific anterior pituitary cell types in vivo: https://pubmed.ncbi.nlm.nih.gov/3621311/




HGH/IGF-1:

Human Growth Hormone (HGH) or somatotropin, is a peptide hormone produced by the anterior pituitary gland. It plays a crucial role in growth, tissue repair, metabolism, and body composition by directly affecting tissues and stimulating the production of insulin-like growth factor-1 (IGF-1), primarily in the liver. Insulin-Like Growth Factor 1 is an anabolic peptide hormone acts as the primary downstream mediator of many of HGH's growth-promoting effects and is also essential for normal skeletal growth, tissue repair, and muscle development.

Effective ways to increase HGH/IGF-1 (listed from most effective to least effective)

HGH - 6-8 IUs ED
GHRP2/6 - 100mcg each 3x a day
IGFLR3 40-50mcg twice a day
Mk677 (cheapest + oral) - 15mg ED

Side effects:

Water retention
Insulin retention
Carpal tunnel symptoms
acceleration of moles
Joint pain

Note: some of these sides are only common with HGH, the other options are less risky.

Study of regulation of muscle mass by growth hormone and IGF-1: https://pmc.ncbi.nlm.nih.gov/articles/PMC2439518/?utm_source


Study of Craniofacial Changes Among Children and Adolescents Submitted to Growth Hormone Therapy: A Systematic Review: https://pmc.ncbi.nlm.nih.gov/articles/PMC12418064/



Conclusion:

Puberty is a limited time window, you only go through it once. Ensuring a mix of androgens like Test/DHT and growth factors like HGH all while maintaining good habits and diet will maximise your potential height and dimorphism obtained through puberty.
Saved to read later😊
 
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