Avoid IGF-1 LR3 for Height?: IGF-1 Variants May NOT Be As Effective For HEIGHTMAXING as they seem!

[enchanted_elixir]

Should k take hgh

if you're actively growing, yes.

 

[Deleted member 77288]

if you're actively growing, yes.

Will it ruin my harmony ? And is it like igf1 and will be in bad receptors

 

[enchanted_elixir]

Will it ruin my harmony ? And is it like igf1 and will be in bad receptors

I don't know.
All I know is that it's more safe doing it during active growth than when you're not growing.
If you don't do it during your active growth phase, the excess HGH will go to your face.

Active growth: Got taller in the past 6 months.

 

[Deleted member 77288]

I don't know.
All I know is that it's more safe doing it during active growth than when you're not growing.
If you don't do it during your active growth phase, the excess HGH will go to your face.

Active growth: Got taller in the past 6 months.

Is 2/ 3 cm enough ?

 

[enchanted_elixir]

Is 2/ 3 cm enough ?

Yes.

 

[Deleted member 77288]

Yes.

Will it ruin my face

 

[enchanted_elixir]

Will it ruin my face

If you're not actively growing, it will if you use it too long.

 

[jxcob.79]

Here's what I'll say, after researching this.

IGF-1 DES barely binds to all IGFBPs (these proteins tell IGF-1 in the blood where to go, regulate bioavailability and half life), so it'll just immediately attach to IGF-1 receptors near the injection site and not really go anywhere else.

IGF-1 LR3 doesn't really bind well to certain IGFBPs like IGFBP-3, so it basically won't really be transported to growth plates or other sources of long bone cartilage.

Receptor Grade IGF-1 LR3 is basically a more pure and slightly enhanced IGF-1 LR3, but since it's LR3, it can't really bind to certain IGFBPs like IGFBP-3.

My verdict, as far as my current knowledge goes:

• DES is only good if you can actually inject it directly on your growth plates in each leg. Good luck at not causing uneven growth or injecting in sore spots everyday.
• LR3 is not as effective because it won't really be transported to growth plates. The IGFBPs it does respond to makes it more conducive to muscle growth than chondrogenesis it seems.

I think endogenous IGF-1 is for the win here since it's responsive to every IGFBPs.

---

Explained simply: First explanation

Imagine IGF-1 is like a delivery package, and IGFBPs are GPS devices attached to it. These GPS devices tell the package where to go in the body.

• DES is like a faulty GPS: It barely works, so the package just sticks to the first stop (injection site) and doesn't reach other important locations like growth plates. This can lead to uneven or localized growth, like one leg growing faster than the other.
• LR3 is like a GPS with some missing maps: It can't find certain places like growth plates because those maps are missing (weak binding to IGFBP-3). So, it mostly goes to different destinations like muscles, which might make you stronger but not necessarily taller.
• Receptor Grade LR3 is like an upgraded LR3: It's a bit cleaner and faster, but still has the same missing maps problem.
• Endogenous IGF-1 is like a perfect GPS: It has all the maps and can reach all the important places, including growth plates, muscles, and other organs. This is why it's the best natural option for healthy growth.

Remember:

• Messing with these GPS devices (using IGF-1 variants) can be risky and unpredictable. It's like tinkering with your phone's GPS - you might end up lost or in the wrong place!
• The safest and most effective way to grow is to let your body do its own thing naturally, with good exercise, healthy eating, and enough sleep. This helps your body make its own perfect GPS (IGF-1) for optimal growth.

---

Explained simply: Second explanation

Imagine IGF-1 as a delivery truck:

• It carries important molecules (like growth signals) to different parts of the body.
• IGFBPs are like traffic lights: They tell the truck where to go and how long to stay.
• Receptors are like buildings: When the truck reaches the right building, it delivers its cargo (growth signals) to help it grow.

Now, let's compare the different versions of IGF-1:

• DES: This truck has a busted GPS! It can't read the traffic lights (IGFBPs) well, so it just stops at the first building it sees (closest receptor). That's not good for bone growth, because it only delivers signals near the injection site, not to those far-away growth plates in your legs.
• LR3: This truck has a slightly better GPS, but it still can't read some traffic lights (like IGFBP-3). So, it gets stuck in the muscle building area (other receptors) and doesn't reach the growth plate buildings as well as it should.
• Receptor Grade LR3: This is like a fancy upgrade of the LR3 truck. It's cleaner and more efficient, but it still has the same problem with the GPS. It might be a bit better than regular LR3, but it still won't reach the growth plates as effectively as...
• Endogenous IGF-1: This is the original, well-maintained truck! It has a perfect GPS and can read all the traffic lights (IGFBPs) perfectly. It delivers its cargo (growth signals) exactly where they need to go, including those important growth plate buildings in your legs.

The verdict:

• DES: Bad idea. It's like trying to navigate a new city without a map – you'll end up lost and in the wrong place. Only worth it of you can inject directly in your growth plates.
• LR3: Not ideal. It'll prefer to help with other things like muscle growth than height. It will increase IGF-1 in for height, but most of its energy will go to other things like muscle growth, etc.
• Receptor Grade LR3: Slightly better than LR3, but still not the best option. Same problems as LR3.
• Endogenous IGF-1: The clear winner! It's safe, effective, and delivers the growth signals exactly where your body needs them.

---

Explained simply: Third explanation

Imagine your body is a bustling city, and IGF-1 is a delivery driver carrying essential packages for growth and repair.

• IGFBPs are the traffic cops patrolling the city: Their job is to direct IGF-1 drivers to the right destinations, ensuring that growth happens in a controlled and balanced way.
• Regular IGF-1 is a law-abiding driver: It follows the cops' instructions, patiently waiting at red lights and taking the designated routes to reach important growth areas like bones and muscles.

But some IGF-1 variants are a bit rebellious:

• DES is like a reckless driver: It speeds through red lights and ignores traffic cops, causing chaos and delivering all it's packages at the first place (or places) it lands. This can lead to uneven growth and unwanted effects in random areas.
• LR3 is like a driver with a fake GPS: It has a faulty GPS that tends to dislike certain checkpoints (like growth plates) because it evades certain IGFBPs like IGFBP-3. This means it often ends up delivering most of it's packages (IGF-1) to other places instead, focusing more on strength than height. It sometimes delivers IGF-1 to growth plates but much less than the heightmaxer wants.

---

My Final Sayings:

If we could find injectable raw IGF-1 (not the variants) or a variant specifically and/or only responsive to IGFBPs that help with height (ex. IGFBP-3), that'd be great.

Besides that, it's blast HGH (or some other GH agonist), get all of our micronutrients, and consume an insane amount of animal protein (eggs, meat, milk, dairy, etc.) to maximize endogenous IGF-1.

Protip: Vitamin D helps increase IGFBP-3.

What about IGF-1 LR3 for muscle mass?

 

[enchanted_elixir]

What about IGF-1 LR3 for muscle mass?

That's the perfect use case for it.

 

[jxcob.79]

That's the perfect use case for it.

Thanks, im on an aggressive cut rn and ofcourse as a skinny dude sacrificing facial anesthetics for a shitty body isn't fun, so ive just been looking at peptides/steroids/supplements for muscle mass (since then I won't look like a stick at 11% bf).

How much results do you actually get on IGF though, is it like mininal or is it genuinely insane results? Or genuinely amazing, not insane tho.

 

[enchanted_elixir]

Thanks, im on an aggressive cut rn and ofcourse as a skinny dude sacrificing facial anesthetics for a shitty body isn't fun, so ive just been looking at peptides/steroids/supplements for muscle mass (since then I won't look like a stick at 11% bf).

How much results do you actually get on IGF though, is it like mininal or is it genuinely insane results? Or genuinely amazing, not insane tho.

My personal experience: Day 3 of using IGF-1 LR3 nasal sprays, my mother noticed I looked bigger.

 

[jxcob.79]

My personal experience: Day 3 of using IGF-1 LR3 nasal sprays, my mother noticed I looked bigger.

Nicee. I didn't know it came in nasal sprays? Thought it's injection only, but it's good to hear.

 

[enchanted_elixir]

Nicee. I didn't know it came in nasal sprays? Thought it's injection only, but it's good to hear.

Injection has a better bioavailability.

 

[jxcob.79]

Injection has a better bioavailability.

Where'd you get yours from? How expensive was it?

 

[Deleted member 110192]

Here's what I'll say, after researching this.

IGF-1 DES barely binds to all IGFBPs (these proteins tell IGF-1 in the blood where to go, regulate bioavailability and half life), so it'll just immediately attach to IGF-1 receptors near the injection site and not really go anywhere else.

IGF-1 LR3 doesn't really bind well to certain IGFBPs like IGFBP-3, so it basically won't really be transported to growth plates or other sources of long bone cartilage.

Receptor Grade IGF-1 LR3 is basically a more pure and slightly enhanced IGF-1 LR3, but since it's LR3, it can't really bind to certain IGFBPs like IGFBP-3.

My verdict, as far as my current knowledge goes:

• DES is only good if you can actually inject it directly on your growth plates in each leg. Good luck at not causing uneven growth or injecting in sore spots everyday.
• LR3 is not as effective because it won't really be transported to growth plates. The IGFBPs it does respond to makes it more conducive to muscle growth than chondrogenesis it seems.

I think endogenous IGF-1 is for the win here since it's responsive to every IGFBPs.

---

Explained simply: First explanation

Imagine IGF-1 is like a delivery package, and IGFBPs are GPS devices attached to it. These GPS devices tell the package where to go in the body.

• DES is like a faulty GPS: It barely works, so the package just sticks to the first stop (injection site) and doesn't reach other important locations like growth plates. This can lead to uneven or localized growth, like one leg growing faster than the other.
• LR3 is like a GPS with some missing maps: It can't find certain places like growth plates because those maps are missing (weak binding to IGFBP-3). So, it mostly goes to different destinations like muscles, which might make you stronger but not necessarily taller.
• Receptor Grade LR3 is like an upgraded LR3: It's a bit cleaner and faster, but still has the same missing maps problem.
• Endogenous IGF-1 is like a perfect GPS: It has all the maps and can reach all the important places, including growth plates, muscles, and other organs. This is why it's the best natural option for healthy growth.

Remember:

• Messing with these GPS devices (using IGF-1 variants) can be risky and unpredictable. It's like tinkering with your phone's GPS - you might end up lost or in the wrong place!
• The safest and most effective way to grow is to let your body do its own thing naturally, with good exercise, healthy eating, and enough sleep. This helps your body make its own perfect GPS (IGF-1) for optimal growth.

---

Explained simply: Second explanation

Imagine IGF-1 as a delivery truck:

• It carries important molecules (like growth signals) to different parts of the body.
• IGFBPs are like traffic lights: They tell the truck where to go and how long to stay.
• Receptors are like buildings: When the truck reaches the right building, it delivers its cargo (growth signals) to help it grow.

Now, let's compare the different versions of IGF-1:

• DES: This truck has a busted GPS! It can't read the traffic lights (IGFBPs) well, so it just stops at the first building it sees (closest receptor). That's not good for bone growth, because it only delivers signals near the injection site, not to those far-away growth plates in your legs.
• LR3: This truck has a slightly better GPS, but it still can't read some traffic lights (like IGFBP-3). So, it gets stuck in the muscle building area (other receptors) and doesn't reach the growth plate buildings as well as it should.
• Receptor Grade LR3: This is like a fancy upgrade of the LR3 truck. It's cleaner and more efficient, but it still has the same problem with the GPS. It might be a bit better than regular LR3, but it still won't reach the growth plates as effectively as...
• Endogenous IGF-1: This is the original, well-maintained truck! It has a perfect GPS and can read all the traffic lights (IGFBPs) perfectly. It delivers its cargo (growth signals) exactly where they need to go, including those important growth plate buildings in your legs.

The verdict:

• DES: Bad idea. It's like trying to navigate a new city without a map – you'll end up lost and in the wrong place. Only worth it of you can inject directly in your growth plates.
• LR3: Not ideal. It'll prefer to help with other things like muscle growth than height. It will increase IGF-1 in for height, but most of its energy will go to other things like muscle growth, etc.
• Receptor Grade LR3: Slightly better than LR3, but still not the best option. Same problems as LR3.
• Endogenous IGF-1: The clear winner! It's safe, effective, and delivers the growth signals exactly where your body needs them.

---

Explained simply: Third explanation

Imagine your body is a bustling city, and IGF-1 is a delivery driver carrying essential packages for growth and repair.

• IGFBPs are the traffic cops patrolling the city: Their job is to direct IGF-1 drivers to the right destinations, ensuring that growth happens in a controlled and balanced way.
• Regular IGF-1 is a law-abiding driver: It follows the cops' instructions, patiently waiting at red lights and taking the designated routes to reach important growth areas like bones and muscles.

But some IGF-1 variants are a bit rebellious:

• DES is like a reckless driver: It speeds through red lights and ignores traffic cops, causing chaos and delivering all it's packages at the first place (or places) it lands. This can lead to uneven growth and unwanted effects in random areas.
• LR3 is like a driver with a fake GPS: It has a faulty GPS that tends to dislike certain checkpoints (like growth plates) because it evades certain IGFBPs like IGFBP-3. This means it often ends up delivering most of it's packages (IGF-1) to other places instead, focusing more on strength than height. It sometimes delivers IGF-1 to growth plates but much less than the heightmaxer wants.

---

My Final Sayings:

If we could find injectable raw IGF-1 (not the variants) or a variant specifically and/or only responsive to IGFBPs that help with height (ex. IGFBP-3), that'd be great.

Besides that, it's blast HGH (or some other GH agonist), get all of our micronutrients, and consume an insane amount of animal protein (eggs, meat, milk, dairy, etc.) to maximize endogenous IGF-1.

Protip: Vitamin D helps increase IGFBP-3.

WLR (will read later).

 

[JizzFarmer]

Bit of a necropost but IGF-1 LR3's poor affinity for all of the IGFBPs (1-6) is what makes it more anabolically potent than regular IGF-1. The IGF1BPs essentially sequester IGF-1, resulting in IGF-1 not remaining in free circulation as long. The IGF1BPs essentially buffer IGF-1 instead of letting it run rampant throughout circulation for 20+h (which is the case for IGF-1 LR3). The relationship is somewhat similar to SHBG and testosterone (free T is the true measure of biologically active T). Given that IGF-1 LR3 can bypass the binding proteins, it can act on the IGF-1 receptors in tissues relatively unimpeded as opposed to regular IGF-1 which is slowed down by the regulatory IGFBPs. As a result, IGF-1 LR3 has much stronger and longer-lasting anabolic signalling on tissues. This is why most people staunchly warn against its use and recommend it be reserved for pro bodybuilders as the true extent to how extreme the signalling is is yet to be known due to a lack of human data. There is no safe dose of LR3 and anyone who using it is essentially sailing into uncharted territory wearing a blindfold.

 

[Aryan Incel]

High iq

 

[infrainfra]

Here's what I'll say, after researching this.

IGF-1 DES barely binds to all IGFBPs (these proteins tell IGF-1 in the blood where to go, regulate bioavailability and half life), so it'll just immediately attach to IGF-1 receptors near the injection site and not really go anywhere else.

IGF-1 LR3 doesn't really bind well to certain IGFBPs like IGFBP-3, so it basically won't really be transported to growth plates or other sources of long bone cartilage.

Receptor Grade IGF-1 LR3 is basically a more pure and slightly enhanced IGF-1 LR3, but since it's LR3, it can't really bind to certain IGFBPs like IGFBP-3.

My verdict, as far as my current knowledge goes:

• DES is only good if you can actually inject it directly on your growth plates in each leg. Good luck at not causing uneven growth or injecting in sore spots everyday.
• LR3 is not as effective because it won't really be transported to growth plates. The IGFBPs it does respond to makes it more conducive to muscle growth than chondrogenesis it seems.

I think endogenous IGF-1 is for the win here since it's responsive to every IGFBPs.

---

Explained simply: First explanation

Imagine IGF-1 is like a delivery package, and IGFBPs are GPS devices attached to it. These GPS devices tell the package where to go in the body.

• DES is like a faulty GPS: It barely works, so the package just sticks to the first stop (injection site) and doesn't reach other important locations like growth plates. This can lead to uneven or localized growth, like one leg growing faster than the other.
• LR3 is like a GPS with some missing maps: It can't find certain places like growth plates because those maps are missing (weak binding to IGFBP-3). So, it mostly goes to different destinations like muscles, which might make you stronger but not necessarily taller.
• Receptor Grade LR3 is like an upgraded LR3: It's a bit cleaner and faster, but still has the same missing maps problem.
• Endogenous IGF-1 is like a perfect GPS: It has all the maps and can reach all the important places, including growth plates, muscles, and other organs. This is why it's the best natural option for healthy growth.

Remember:

• Messing with these GPS devices (using IGF-1 variants) can be risky and unpredictable. It's like tinkering with your phone's GPS - you might end up lost or in the wrong place!
• The safest and most effective way to grow is to let your body do its own thing naturally, with good exercise, healthy eating, and enough sleep. This helps your body make its own perfect GPS (IGF-1) for optimal growth.

---

Explained simply: Second explanation

Imagine IGF-1 as a delivery truck:

• It carries important molecules (like growth signals) to different parts of the body.
• IGFBPs are like traffic lights: They tell the truck where to go and how long to stay.
• Receptors are like buildings: When the truck reaches the right building, it delivers its cargo (growth signals) to help it grow.

Now, let's compare the different versions of IGF-1:

• DES: This truck has a busted GPS! It can't read the traffic lights (IGFBPs) well, so it just stops at the first building it sees (closest receptor). That's not good for bone growth, because it only delivers signals near the injection site, not to those far-away growth plates in your legs.
• LR3: This truck has a slightly better GPS, but it still can't read some traffic lights (like IGFBP-3). So, it gets stuck in the muscle building area (other receptors) and doesn't reach the growth plate buildings as well as it should.
• Receptor Grade LR3: This is like a fancy upgrade of the LR3 truck. It's cleaner and more efficient, but it still has the same problem with the GPS. It might be a bit better than regular LR3, but it still won't reach the growth plates as effectively as...
• Endogenous IGF-1: This is the original, well-maintained truck! It has a perfect GPS and can read all the traffic lights (IGFBPs) perfectly. It delivers its cargo (growth signals) exactly where they need to go, including those important growth plate buildings in your legs.

The verdict:

• DES: Bad idea. It's like trying to navigate a new city without a map – you'll end up lost and in the wrong place. Only worth it of you can inject directly in your growth plates.
• LR3: Not ideal. It'll prefer to help with other things like muscle growth than height. It will increase IGF-1 in for height, but most of its energy will go to other things like muscle growth, etc.
• Receptor Grade LR3: Slightly better than LR3, but still not the best option. Same problems as LR3.
• Endogenous IGF-1: The clear winner! It's safe, effective, and delivers the growth signals exactly where your body needs them.

---

Explained simply: Third explanation

Imagine your body is a bustling city, and IGF-1 is a delivery driver carrying essential packages for growth and repair.

• IGFBPs are the traffic cops patrolling the city: Their job is to direct IGF-1 drivers to the right destinations, ensuring that growth happens in a controlled and balanced way.
• Regular IGF-1 is a law-abiding driver: It follows the cops' instructions, patiently waiting at red lights and taking the designated routes to reach important growth areas like bones and muscles.

But some IGF-1 variants are a bit rebellious:

• DES is like a reckless driver: It speeds through red lights and ignores traffic cops, causing chaos and delivering all it's packages at the first place (or places) it lands. This can lead to uneven growth and unwanted effects in random areas.
• LR3 is like a driver with a fake GPS: It has a faulty GPS that tends to dislike certain checkpoints (like growth plates) because it evades certain IGFBPs like IGFBP-3. This means it often ends up delivering most of it's packages (IGF-1) to other places instead, focusing more on strength than height. It sometimes delivers IGF-1 to growth plates but much less than the heightmaxer wants.

---

My Final Sayings:

If we could find injectable raw IGF-1 (not the variants) or a variant specifically and/or only responsive to IGFBPs that help with height (ex. IGFBP-3), that'd be great.

Besides that, it's blast HGH (or some other GH agonist), get all of our micronutrients, and consume an insane amount of animal protein (eggs, meat, milk, dairy, etc.) to maximize endogenous IGF-1.

Protip: Vitamin D helps increase IGFBP-3.

what if i pin igf des into my zygos? will i see growth

 

[enchanted_elixir]

what if i pin igf des into my zygos? will i see growth

If you inject very close to your bones, then yes, most likely. But, you’d have to spread it out evenly because if you inject more in one area of your zygos compared to another, you’re going to have uneven zygos lol. I think you would have to do this with surgical precision.

 

[infrainfra]

If you inject very close to your bones, then yes, most likely. But, you’d have to spread it out evenly because if you inject more in one area of your zygos compared to another, you’re going to have uneven zygos lol. I think you would have to do this with surgical precision.

yeah ofc precision is key but if im 16 wont it disrupt my natural growth if im just pinning igfdes into my zygos? same dose on each zygo lets say

 

[enchanted_elixir]

yeah ofc precision is key but if im 16 wont it disrupt my natural growth if im just pinning igfdes into my zygos? same dose on each zygo lets say

It could. Your IGF-1 receptors could become more and more desensitized over time.

 

[infrainfra]

It could. Your IGF-1 receptors could become more and more desensitized over time.

bit since its localized (DES) into my zygos how would it affect my growth plates and lets say frame growth? it attaches to the receptors near injection site.

 

[enchanted_elixir]

bit since its localized (DES) into my zygos how would it affect my growth plates and lets say frame growth? it attaches to the receptors near injection site.

Effects only occur near injection site.
If you inject in your zygomatic bones, it won't affect your growth plates or your frame.

 

[infrainfra]

Effects only occur near injection site.
If you inject in your zygomatic bones, it won't affect your growth plates or your frame.

yeah but you said if i only used igf des into my zygos at 16 it would be bad for my overall growth because of receptor desensitization. but doesnt it desensitize only near injection site? how would rhat slow down my growth

 

[enchanted_elixir]

yeah but you said if i only used igf des into my zygos at 16 it would be bad for my overall growth because of receptor desensitization. but doesnt it desensitize only near injection site? how would rhat slow down my growth

Maybe you misunderstood me or I didn't say it clearly.

If you inject IGF-1 DES into location x, the receptors exclusively in location x will be desensitized over time.
Any IGF-1 that is secreted endogenously that is supposed to contribute to your development won't bind to as many receptors as they should (due to receptor desensitization), and that would mess with your development.

 

[infrainfra]

Maybe you misunderstood me or I didn't say it clearly.

If you inject IGF-1 DES into location x, the receptors exclusively in location x will be desensitized over time.
Any IGF-1 that is secreted endogenously that is supposed to contribute to your development won't bind to as many receptors as they should (due to receptor desensitization), and that would mess with your development.

but if i inject DES into location x
i only desensitize location x right?
so i can still keep on growing while growing my zygos with DES lets say? am i right or no?

 

[enchanted_elixir]

but if i inject DES into location x
i only desensitize location x right?
so i can still keep on growing while growing my zygos with DES lets say? am i right or no?

correct.

 

[infrainfra]

correct.

but you just said using JUST des into my zygos at 16 could mess up my height growth. because of receptor desensitization so im confused now. does it desensitize the whole body?

 

[enchanted_elixir]

Maybe you misunderstood me or I didn't say it clearly.

If you inject IGF-1 DES into location x, the receptors exclusively in location x will be desensitized over time.
Any IGF-1 that is secreted endogenously that is supposed to contribute to your development won't bind to as many receptors as they should (due to receptor desensitization), and that would mess with your development.

So sorry

When I said "development" here, I meant development in the target area (zygos), nothing more, nothing less.

 

[infrainfra]

So sorry

When I said "development" here, I meant development in the target area (zygos), nothing more, nothing less.

but if i blast consistently for like 5 months? (what do you suggest?) and get potentially bone growth in my zygos and stop pinning do i experience anything that can cause problems? like me losing bone in that area or something? can i stop my face from developing in other areas if i pin des into my zygos?

 

[enchanted_elixir]

but if i blast consistently for like 5 months? (what do you suggest?) and get potentially bone growth in my zygos and stop pinning do i experience anything that can cause problems? like me losing bone in that area or something? can i stop my face from developing in other areas if i pin des into my zygos?

Most of the problems that could happen are... weird zygomatic shape (you can't really control how the liquid distributes), damage to veins or nerves (if you're not hyper-precise), having to target all the way down to your bones, and targeting strictly bone (nearly impossible, as the liquid will most certainly touch other things). it won't affect any other arfea besides the areas that come into contact with it.

I would suggest that you get implants unless you are capable of super surgeon precision, and capable of being hyper-consistent and flawless for 5 months straight.

I mean, even then, you could still f up, because you can be precise but it's hard to control how the liquid distributes

 

[infrainfra]

Most of the problems that could happen are... weird zygomatic shape (you can't really control how the liquid distributes), damage to veins or nerves (if you're not hyper-precise), having to target all the way down to your bones, and targeting strictly bone (nearly impossible, as the liquid will most certainly touch other things). it won't affect any other arfea besides the areas that come into contact with it.

I would suggest that you get implants unless you are capable of super surgeon precision, and capable of being hyper-consistent and flawless for 5 months straight.

I mean, even then, you could still f up, because you can be precise but it's hard to control how the liquid distributes

but isnt targetting strictly bone easy? if i just pin subq onto my zygos where else would the igf des bind to igf receptors? can it just make my muscle bigger there probably not

 

[enchanted_elixir]

but isnt targetting strictly bone easy? if i just pin subq onto my zygos where else would the igf des bind to igf receptors? can it just make my muscle bigger there probably not

It would bind to the cells directly above the bone.

 

[infrainfra]

It would bind to the cells directly above the bone.

but what would that do? are there any cells above bone that can actually attach to igf-1? that kinda makes no sense

 

[TheOsei]

sorry for bumping an old thread but isn't this completely wrong
IGFBPs are what inhibits free igf from to binding to receptors like igf-r1, the way lr3 avoids these proteins would actually be a huge benefit sort of like how low SBGH = higher free T as it's free to circulate through the bloodstream, and we know there is nothing that "directs nutrients" to the growth plates as the receptors there just "grab" from the bloodstream.
I don't think this thread was a good argument tbh. Even if you cherrypick the only beneficial igfbp, IGFBP-5, it only works on matrix production and is already secreted locally in the growth plates.

i think the best thing to do overall would be 0.1-0.15iu/kg HGH to keep all the necessary pathways then ramp igf with 20mcg LR3 3x/wk