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Kraken
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Never really explained what it is so here's a brief explanation of why it's important.
Q:
Few questions. Would appreciate if you could answer
"Achieve Macro Autophagy of the brain"
"Activate Selective Autophagy via ULK1"
How would we benefit from these?
"Activate the NRF2 Pathway"
what does this pathway do?
It's some complicated stuff
A:
Autophagy means "Self Eating". It's basically a process where your body stops focusing on growth and proliferation and instead focuses on "cleaning up". Clearing misfolded proteins, senescent cells, healing wounds. For example, microneedling is a form of autophagy selective to the skin; because you're provoking a response that heals, and fixes small problems.
Caloric restriction is the broad way of entering autophagy. And autophagy can take place in brain cells too, making you think clearer and feel better. That's why a lot of people feel more focused and in a better mood during a fast. With more energy and attention span when working on trivial things.
ULK1 is just 1 of the autophagic pathways which is activated once you starve yourself of amino acids. There's nothing too special about ULK1, but it has benefits like upregulating nutrient sensing etc.
NRF2 is activated during calorie restriction and can be activated in varying degrees; ie: you can get into deeper autophagy and activate NRF2 to a greater or lesser extent, based on how long you fast for.
NRF2 is like one of our survival pathways. When it's activated, your body releases a whole host of anti-inflammatory cytokines. And unlike exogenous anti-oxidants, these endogenous cytokines released via NRF2 are much more potent and practical in terms of cleaning up wounds and corrupted cells; since your body released these specific cytokines itself, to deal with the internal problems at hand. Any normal anti-oxidant pill has a set range of anti-oxidant properties, which won't be totally specific to deal with the oxidative stress that your body needs to handle at any given time.
Q:
Few questions. Would appreciate if you could answer
"Achieve Macro Autophagy of the brain"
"Activate Selective Autophagy via ULK1"
How would we benefit from these?
"Activate the NRF2 Pathway"
what does this pathway do?
It's some complicated stuff
A:
Autophagy means "Self Eating". It's basically a process where your body stops focusing on growth and proliferation and instead focuses on "cleaning up". Clearing misfolded proteins, senescent cells, healing wounds. For example, microneedling is a form of autophagy selective to the skin; because you're provoking a response that heals, and fixes small problems.
Caloric restriction is the broad way of entering autophagy. And autophagy can take place in brain cells too, making you think clearer and feel better. That's why a lot of people feel more focused and in a better mood during a fast. With more energy and attention span when working on trivial things.
ULK1 is just 1 of the autophagic pathways which is activated once you starve yourself of amino acids. There's nothing too special about ULK1, but it has benefits like upregulating nutrient sensing etc.
NRF2 is activated during calorie restriction and can be activated in varying degrees; ie: you can get into deeper autophagy and activate NRF2 to a greater or lesser extent, based on how long you fast for.
NRF2 is like one of our survival pathways. When it's activated, your body releases a whole host of anti-inflammatory cytokines. And unlike exogenous anti-oxidants, these endogenous cytokines released via NRF2 are much more potent and practical in terms of cleaning up wounds and corrupted cells; since your body released these specific cytokines itself, to deal with the internal problems at hand. Any normal anti-oxidant pill has a set range of anti-oxidant properties, which won't be totally specific to deal with the oxidative stress that your body needs to handle at any given time.