Esoteric framecel/heightcel drug thread

[Sachlichkeit]

Im on phone so post quality will be low

I’ve already discussed CNP analogues in other thread. Drug that directly impacts growth plates by inhibiting FGF growth factor.

Vosoritide therapy is $100,000/year.

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram. That is enough for 5-6 people to run a 6 month cycle. Combining this synergistically with something like HGH for growth & Anavar for height velocity seems really promising.

Height is partially genetic, this we already know. So we need to find some way to modulate our genes to allow for growth.

HDAC inhibitors, namely vorinostat in low and sparse doses (50mg 5 days on 4-6weeks off) tells your genes to “relax,” and allow for growth. (Both vertical and horizontal.) cheapest I’ve found it is ~$100 for a 3 month cycle.

YAMANAKA PEPTIDES

Oct4 and sox2 are peptides that tell your cells to, “be young again.” Not only do these peptides make cells young (which we don’t care about,) but they regenerate tissues in particular chondrocytes and stem cells. But most importantly, they REVERSE GROWTH PLATE SENESCENCE.

What’s plate senescence? It’s slow loss of growth potential in plates. Your body gets old, growth shuts down because of biomarkers telling your body it’s getting old. Oct4 + sox2 can reverse these biomarkers. Yes I know gross oversimplification of why plates close but who cares.

Anyways dosage is 250-750mcg of both sox2 and oct4 every 2-4 weeks probably subq injection for systemic effect

I haven’t found source for these yet but they seem pretty cheap compared to CNP analogs

Senolytics

Dasatinib quercetin. Senolytics kill old useless cells. These old useless cells also tell other young cells to become old and useless. This makes your body old. They tell your body to stop growing, increase inflammation, and make other healthy cells “work slower.”

Dasat dose is 2mg/kg ED for 2 days. Querc is 1000mg ED 2 days. cycle every 4-8weeks

Thoughts?

 

[RODEBLUR]

esoteric is such a funny word haha

 

[RODEBLUR]

esoteric is such a funny word haha

like

𝓮𝓼𝓸𝓽𝓮𝓻𝓲𝓬

 

[subvitobasso]

can I dm you?

 

[iblamex]

Im on phone so post quality will be low

I’ve already discussed CNP analogues in other thread. Drug that directly impacts growth plates by inhibiting FGF growth factor.

Vosoritide therapy is $100,000/year.

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram. That is enough for 5-6 people to run a 6 month cycle. Combining this synergistically with something like HGH for growth & Anavar for height velocity seems really promising.

Height is partially genetic, this we already know. So we need to find some way to modulate our genes to allow for growth.

HDAC inhibitors, namely vorinostat in low and sparse doses (50mg 5 days on 4-6weeks off) tells your genes to “relax,” and allow for growth. (Both vertical and horizontal.) cheapest I’ve found it is ~$100 for a 3 month cycle.

YAMANAKA PEPTIDES

Oct4 and sox2 are peptides that tell your cells to, “be young again.” Not only do these peptides make cells young (which we don’t care about,) but they regenerate tissues in particular chondrocytes and stem cells. But most importantly, they REVERSE GROWTH PLATE SENESCENCE.

What’s plate senescence? It’s slow loss of growth potential in plates. Your body gets old, growth shuts down because of biomarkers telling your body it’s getting old. Oct4 + sox2 can reverse these biomarkers. Yes I know gross oversimplification of why plates close but who cares.

Anyways dosage is 250-750mcg of both sox2 and oct4 every 2-4 weeks probably subq injection for systemic effect

I haven’t found source for these yet but they seem pretty cheap compared to CNP analogs

Senolytics

Dasatinib quercetin. Senolytics kill old useless cells. These old useless cells also tell other young cells to become old and useless. This makes your body old. They tell your body to stop growing, increase inflammation, and make other healthy cells “work slower.”

Dasat dose is 2mg/kg ED for 2 days. Querc is 1000mg ED 2 days. cycle every 4-8weeks

Thoughts?

bump

 

[medialcanthus]

Im on phone so post quality will be low

I’ve already discussed CNP analogues in other thread. Drug that directly impacts growth plates by inhibiting FGF growth factor.

Vosoritide therapy is $100,000/year.

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram. That is enough for 5-6 people to run a 6 month cycle. Combining this synergistically with something like HGH for growth & Anavar for height velocity seems really promising.

Height is partially genetic, this we already know. So we need to find some way to modulate our genes to allow for growth.

HDAC inhibitors, namely vorinostat in low and sparse doses (50mg 5 days on 4-6weeks off) tells your genes to “relax,” and allow for growth. (Both vertical and horizontal.) cheapest I’ve found it is ~$100 for a 3 month cycle.

YAMANAKA PEPTIDES

Oct4 and sox2 are peptides that tell your cells to, “be young again.” Not only do these peptides make cells young (which we don’t care about,) but they regenerate tissues in particular chondrocytes and stem cells. But most importantly, they REVERSE GROWTH PLATE SENESCENCE.

What’s plate senescence? It’s slow loss of growth potential in plates. Your body gets old, growth shuts down because of biomarkers telling your body it’s getting old. Oct4 + sox2 can reverse these biomarkers. Yes I know gross oversimplification of why plates close but who cares.

Anyways dosage is 250-750mcg of both sox2 and oct4 every 2-4 weeks probably subq injection for systemic effect

I haven’t found source for these yet but they seem pretty cheap compared to CNP analogs

Senolytics

Dasatinib quercetin. Senolytics kill old useless cells. These old useless cells also tell other young cells to become old and useless. This makes your body old. They tell your body to stop growing, increase inflammation, and make other healthy cells “work slower.”

Dasat dose is 2mg/kg ED for 2 days. Querc is 1000mg ED 2 days. cycle every 4-8weeks

Thoughts?

ngl what you're talking about seems SS+ tier but the potential repercussions also seem SS+ tier. Imma have to check out your other threads

 

[iblamex]

Im on phone so post quality will be low

I’ve already discussed CNP analogues in other thread. Drug that directly impacts growth plates by inhibiting FGF growth factor.

Vosoritide therapy is $100,000/year.

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram. That is enough for 5-6 people to run a 6 month cycle. Combining this synergistically with something like HGH for growth & Anavar for height velocity seems really promising.

Height is partially genetic, this we already know. So we need to find some way to modulate our genes to allow for growth.

HDAC inhibitors, namely vorinostat in low and sparse doses (50mg 5 days on 4-6weeks off) tells your genes to “relax,” and allow for growth. (Both vertical and horizontal.) cheapest I’ve found it is ~$100 for a 3 month cycle.

YAMANAKA PEPTIDES

Oct4 and sox2 are peptides that tell your cells to, “be young again.” Not only do these peptides make cells young (which we don’t care about,) but they regenerate tissues in particular chondrocytes and stem cells. But most importantly, they REVERSE GROWTH PLATE SENESCENCE.

What’s plate senescence? It’s slow loss of growth potential in plates. Your body gets old, growth shuts down because of biomarkers telling your body it’s getting old. Oct4 + sox2 can reverse these biomarkers. Yes I know gross oversimplification of why plates close but who cares.

Anyways dosage is 250-750mcg of both sox2 and oct4 every 2-4 weeks probably subq injection for systemic effect

I haven’t found source for these yet but they seem pretty cheap compared to CNP analogs

Senolytics

Dasatinib quercetin. Senolytics kill old useless cells. These old useless cells also tell other young cells to become old and useless. This makes your body old. They tell your body to stop growing, increase inflammation, and make other healthy cells “work slower.”

Dasat dose is 2mg/kg ED for 2 days. Querc is 1000mg ED 2 days. cycle every 4-8weeks

Thoughts?

crazy high iq. u got any sources for oct4 and sox2?

 

[LiamV]

Im on phone so post quality will be low

I’ve already discussed CNP analogues in other thread. Drug that directly impacts growth plates by inhibiting FGF growth factor.

Vosoritide therapy is $100,000/year.

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram. That is enough for 5-6 people to run a 6 month cycle. Combining this synergistically with something like HGH for growth & Anavar for height velocity seems really promising.

Height is partially genetic, this we already know. So we need to find some way to modulate our genes to allow for growth.

HDAC inhibitors, namely vorinostat in low and sparse doses (50mg 5 days on 4-6weeks off) tells your genes to “relax,” and allow for growth. (Both vertical and horizontal.) cheapest I’ve found it is ~$100 for a 3 month cycle.

YAMANAKA PEPTIDES

Oct4 and sox2 are peptides that tell your cells to, “be young again.” Not only do these peptides make cells young (which we don’t care about,) but they regenerate tissues in particular chondrocytes and stem cells. But most importantly, they REVERSE GROWTH PLATE SENESCENCE.

What’s plate senescence? It’s slow loss of growth potential in plates. Your body gets old, growth shuts down because of biomarkers telling your body it’s getting old. Oct4 + sox2 can reverse these biomarkers. Yes I know gross oversimplification of why plates close but who cares.

Anyways dosage is 250-750mcg of both sox2 and oct4 every 2-4 weeks probably subq injection for systemic effect

I haven’t found source for these yet but they seem pretty cheap compared to CNP analogs

Senolytics

Dasatinib quercetin. Senolytics kill old useless cells. These old useless cells also tell other young cells to become old and useless. This makes your body old. They tell your body to stop growing, increase inflammation, and make other healthy cells “work slower.”

Dasat dose is 2mg/kg ED for 2 days. Querc is 1000mg ED 2 days. cycle every 4-8weeks

Thoughts?

Had to read this twice just to understand Anyway does this make you age slower considering you said "that tells your cells to,"be young again."" ?

 

[Sachlichkeit]

Had to read this twice just to understand Anyway does this make you age slower considering you said "that tells your cells to,"be young again."" ?

Yeah that’s because it’s poorly written

Yeah probably but I’m not an age biohacker. We are only really concerned with keeping the cells responsible for bone growth young. If they get old, ur plates close.

 

[Sachlichkeit]

Y

can I dm you?

Ya when I figure out how

 

[Sachlichkeit]

Bump. Edit: The CNP analogue Vosoritide is non-attainable. Even in powder form it decays quickly at room temperature. So you would need to cold chain ship it which is not an option.

Infigratinib, which has shown to have a larger height increase than vosoritide is a more risky, but suitable alternative.

dose would be 50mg/day. After 50mg the risk of ocular side effects drastically increase. Ocular meaning EYES, so blindness typically temporary or other changes in the eyes which went unnoticed by patients but noticed by doctors.

For context, in cancer treatment it’s administered orally ED at 125mg. 15-20% of patients at this dose experienced retinal changes.

I am scrapping CNP analogs altogether because there is zero anecdotal accounts of people using them for height increase and the only clinical examples are for dwarf children. So the risk is too high and the reward is too low

 

[Sachlichkeit]

TGF beta ANTAGONISTS

TGF beta is a protein that regulates bone and muscle growth. Mice with overactive TGF were found to have 30-40% shorter limbs. So TGF plays a VERY significant role in the length of bones.

Tgf antagonists antagonize TGF.

Losartan is a well established blood pressure medication that moderately antagonizes TGF Beta. It has a half life of 3-6 hours. Dosage is 25mg AM & PM. I’ve hypothesized megadosing /cycling to increase the effect on TGF but I simply don’t know enough about the drug yet. So 50mg/day is a safe bet.

Fresolimumab is a cancer medication that completely blocks TGF beta. It’s riskier, harder to get access to, and more effective. Dose is 1mg per lb every 4 weeks. The problem is, administration has to be intravenous. Meaning you need an IV drip. So not an option.

 

[kiidz24]

TGF beta ANTAGONISTS

TGF beta is a protein that regulates bone and muscle growth. Mice with overactive TGF were found to have 30-40% shorter limbs. So TGF plays a VERY significant role in the length of bones.

Tgf antagonists antagonize TGF.

Losartan is a well established blood pressure medication that moderately antagonizes TGF Beta. It has a half life of 3-6 hours. Dosage is 25mg AM & PM. I’ve hypothesized megadosing /cycling to increase the effect on TGF but I simply don’t know enough about the drug yet. So 50mg/day is a safe bet.

Fresolimumab is a cancer medication that completely blocks TGF beta. It’s riskier, harder to get access to, and more effective. Dose is 1mg per lb every 4 weeks. The problem is, administration has to be intravenous. Meaning you need an IV drip. So not an option.

Holy researching

 

[Sachlichkeit]

Oct and Sox2 alternatives for cell longevity in order to impede growth plate senescence

Too expensive.

Androgens not only close plates through estrogen rebound, but by aging the entire body. Including the cells located in epiphyseal plates.

So some sort of anti aging protocol will help us extend the growth benefits of steroids by mitigating cell aging

Epitalon keeps cells younger, longer.

It rebuilds the tips of telomeres. Every time a cell divides, the telomeres get shorter until the cell is too old and weak to work. So the life of your cells are epigenetically prolonged.

Dose is subq 10mg/day. Safety profile is good. Low risk decent reward

Rapamycin pulse

stimulate mTOR > cells grow.

Press it too much, cells age prematurely. Gear will do this.

Rapamycin impedes mTOR stimulation, giving your body time to recover and extend cell longevity.

Rapamycin PCT in between cycles. 5mg oral, 5 weeks apart or however long your cycle is.

Side effects for 1 day of 5mg a month apart aren’t even worth mentioning.

Lithium orotate ancillary supplement

Modulates Wnt/b cantenin pathway, good for bone growth.
Blocks gsk-3 protein which accelerates aging, protects stem cells from stress and age. 5mg/day

NMN epigenetic enhancement

protects DNA and telomeres
Improves DNA repair
Boosts cell energy by producing NAD+. More cell energy, more resources for repair and growth.
1000mg/day either sublingual or oral

 

[Gaygymmaxx]

Im on phone so post quality will be low

I’ve already discussed CNP analogues in other thread. Drug that directly impacts growth plates by inhibiting FGF growth factor.

Vosoritide therapy is $100,000/year.

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram. That is enough for 5-6 people to run a 6 month cycle. Combining this synergistically with something like HGH for growth & Anavar for height velocity seems really promising.

Height is partially genetic, this we already know. So we need to find some way to modulate our genes to allow for growth.

HDAC inhibitors, namely vorinostat in low and sparse doses (50mg 5 days on 4-6weeks off) tells your genes to “relax,” and allow for growth. (Both vertical and horizontal.) cheapest I’ve found it is ~$100 for a 3 month cycle.

YAMANAKA PEPTIDES

Oct4 and sox2 are peptides that tell your cells to, “be young again.” Not only do these peptides make cells young (which we don’t care about,) but they regenerate tissues in particular chondrocytes and stem cells. But most importantly, they REVERSE GROWTH PLATE SENESCENCE.

What’s plate senescence? It’s slow loss of growth potential in plates. Your body gets old, growth shuts down because of biomarkers telling your body it’s getting old. Oct4 + sox2 can reverse these biomarkers. Yes I know gross oversimplification of why plates close but who cares.

Anyways dosage is 250-750mcg of both sox2 and oct4 every 2-4 weeks probably subq injection for systemic effect

I haven’t found source for these yet but they seem pretty cheap compared to CNP analogs

Senolytics

Dasatinib quercetin. Senolytics kill old useless cells. These old useless cells also tell other young cells to become old and useless. This makes your body old. They tell your body to stop growing, increase inflammation, and make other healthy cells “work slower.”

Dasat dose is 2mg/kg ED for 2 days. Querc is 1000mg ED 2 days. cycle every 4-8weeks

Thoughts?

Nigga where the esoteric part? This is drugs

 

[Sadist]

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram.

sauce?

 

[Sachlichkeit]

sauce?

Scroll down it’s basically impossible to get and ineffective

 

[Seong Gi-Hun]

can I rape you?

What's up with that