Esoteric framecel/heightcel drug thread

[Sachlichkeit]

Im on phone so post quality will be low

I’ve already discussed CNP analogues in other thread. Drug that directly impacts growth plates by inhibiting FGF growth factor.

Vosoritide therapy is $100,000/year.

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram. That is enough for 5-6 people to run a 6 month cycle. Combining this synergistically with something like HGH for growth & Anavar for height velocity seems really promising.

Height is partially genetic, this we already know. So we need to find some way to modulate our genes to allow for growth.

HDAC inhibitors, namely vorinostat in low and sparse doses (50mg 5 days on 4-6weeks off) tells your genes to “relax,” and allow for growth. (Both vertical and horizontal.) cheapest I’ve found it is ~$100 for a 3 month cycle.

YAMANAKA PEPTIDES

Oct4 and sox2 are peptides that tell your cells to, “be young again.” Not only do these peptides make cells young (which we don’t care about,) but they regenerate tissues in particular chondrocytes and stem cells. But most importantly, they REVERSE GROWTH PLATE SENESCENCE.

What’s plate senescence? It’s slow loss of growth potential in plates. Your body gets old, growth shuts down because of biomarkers telling your body it’s getting old. Oct4 + sox2 can reverse these biomarkers. Yes I know gross oversimplification of why plates close but who cares.

Anyways dosage is 250-750mcg of both sox2 and oct4 every 2-4 weeks probably subq injection for systemic effect

I haven’t found source for these yet but they seem pretty cheap compared to CNP analogs

Senolytics

Dasatinib quercetin. Senolytics kill old useless cells. These old useless cells also tell other young cells to become old and useless. This makes your body old. They tell your body to stop growing, increase inflammation, and make other healthy cells “work slower.”

Dasat dose is 2mg/kg ED for 2 days. Querc is 1000mg ED 2 days. cycle every 4-8weeks

Thoughts?

 

[RODEBLUR]

esoteric is such a funny word haha

 

[RODEBLUR]

esoteric is such a funny word haha

like

𝓮𝓼𝓸𝓽𝓮𝓻𝓲𝓬

 

[subvitobasso]

can I dm you?

 

[iblamex]

Im on phone so post quality will be low

I’ve already discussed CNP analogues in other thread. Drug that directly impacts growth plates by inhibiting FGF growth factor.

Vosoritide therapy is $100,000/year.

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram. That is enough for 5-6 people to run a 6 month cycle. Combining this synergistically with something like HGH for growth & Anavar for height velocity seems really promising.

Height is partially genetic, this we already know. So we need to find some way to modulate our genes to allow for growth.

HDAC inhibitors, namely vorinostat in low and sparse doses (50mg 5 days on 4-6weeks off) tells your genes to “relax,” and allow for growth. (Both vertical and horizontal.) cheapest I’ve found it is ~$100 for a 3 month cycle.

YAMANAKA PEPTIDES

Oct4 and sox2 are peptides that tell your cells to, “be young again.” Not only do these peptides make cells young (which we don’t care about,) but they regenerate tissues in particular chondrocytes and stem cells. But most importantly, they REVERSE GROWTH PLATE SENESCENCE.

What’s plate senescence? It’s slow loss of growth potential in plates. Your body gets old, growth shuts down because of biomarkers telling your body it’s getting old. Oct4 + sox2 can reverse these biomarkers. Yes I know gross oversimplification of why plates close but who cares.

Anyways dosage is 250-750mcg of both sox2 and oct4 every 2-4 weeks probably subq injection for systemic effect

I haven’t found source for these yet but they seem pretty cheap compared to CNP analogs

Senolytics

Dasatinib quercetin. Senolytics kill old useless cells. These old useless cells also tell other young cells to become old and useless. This makes your body old. They tell your body to stop growing, increase inflammation, and make other healthy cells “work slower.”

Dasat dose is 2mg/kg ED for 2 days. Querc is 1000mg ED 2 days. cycle every 4-8weeks

Thoughts?

bump

 

[medialcanthus]

Im on phone so post quality will be low

I’ve already discussed CNP analogues in other thread. Drug that directly impacts growth plates by inhibiting FGF growth factor.

Vosoritide therapy is $100,000/year.

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram. That is enough for 5-6 people to run a 6 month cycle. Combining this synergistically with something like HGH for growth & Anavar for height velocity seems really promising.

Height is partially genetic, this we already know. So we need to find some way to modulate our genes to allow for growth.

HDAC inhibitors, namely vorinostat in low and sparse doses (50mg 5 days on 4-6weeks off) tells your genes to “relax,” and allow for growth. (Both vertical and horizontal.) cheapest I’ve found it is ~$100 for a 3 month cycle.

YAMANAKA PEPTIDES

Oct4 and sox2 are peptides that tell your cells to, “be young again.” Not only do these peptides make cells young (which we don’t care about,) but they regenerate tissues in particular chondrocytes and stem cells. But most importantly, they REVERSE GROWTH PLATE SENESCENCE.

What’s plate senescence? It’s slow loss of growth potential in plates. Your body gets old, growth shuts down because of biomarkers telling your body it’s getting old. Oct4 + sox2 can reverse these biomarkers. Yes I know gross oversimplification of why plates close but who cares.

Anyways dosage is 250-750mcg of both sox2 and oct4 every 2-4 weeks probably subq injection for systemic effect

I haven’t found source for these yet but they seem pretty cheap compared to CNP analogs

Senolytics

Dasatinib quercetin. Senolytics kill old useless cells. These old useless cells also tell other young cells to become old and useless. This makes your body old. They tell your body to stop growing, increase inflammation, and make other healthy cells “work slower.”

Dasat dose is 2mg/kg ED for 2 days. Querc is 1000mg ED 2 days. cycle every 4-8weeks

Thoughts?

ngl what you're talking about seems SS+ tier but the potential repercussions also seem SS+ tier. Imma have to check out your other threads

 

[iblamex]

Im on phone so post quality will be low

I’ve already discussed CNP analogues in other thread. Drug that directly impacts growth plates by inhibiting FGF growth factor.

Vosoritide therapy is $100,000/year.

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram. That is enough for 5-6 people to run a 6 month cycle. Combining this synergistically with something like HGH for growth & Anavar for height velocity seems really promising.

Height is partially genetic, this we already know. So we need to find some way to modulate our genes to allow for growth.

HDAC inhibitors, namely vorinostat in low and sparse doses (50mg 5 days on 4-6weeks off) tells your genes to “relax,” and allow for growth. (Both vertical and horizontal.) cheapest I’ve found it is ~$100 for a 3 month cycle.

YAMANAKA PEPTIDES

Oct4 and sox2 are peptides that tell your cells to, “be young again.” Not only do these peptides make cells young (which we don’t care about,) but they regenerate tissues in particular chondrocytes and stem cells. But most importantly, they REVERSE GROWTH PLATE SENESCENCE.

What’s plate senescence? It’s slow loss of growth potential in plates. Your body gets old, growth shuts down because of biomarkers telling your body it’s getting old. Oct4 + sox2 can reverse these biomarkers. Yes I know gross oversimplification of why plates close but who cares.

Anyways dosage is 250-750mcg of both sox2 and oct4 every 2-4 weeks probably subq injection for systemic effect

I haven’t found source for these yet but they seem pretty cheap compared to CNP analogs

Senolytics

Dasatinib quercetin. Senolytics kill old useless cells. These old useless cells also tell other young cells to become old and useless. This makes your body old. They tell your body to stop growing, increase inflammation, and make other healthy cells “work slower.”

Dasat dose is 2mg/kg ED for 2 days. Querc is 1000mg ED 2 days. cycle every 4-8weeks

Thoughts?

crazy high iq. u got any sources for oct4 and sox2?

 

[LiamV]

Im on phone so post quality will be low

I’ve already discussed CNP analogues in other thread. Drug that directly impacts growth plates by inhibiting FGF growth factor.

Vosoritide therapy is $100,000/year.

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram. That is enough for 5-6 people to run a 6 month cycle. Combining this synergistically with something like HGH for growth & Anavar for height velocity seems really promising.

Height is partially genetic, this we already know. So we need to find some way to modulate our genes to allow for growth.

HDAC inhibitors, namely vorinostat in low and sparse doses (50mg 5 days on 4-6weeks off) tells your genes to “relax,” and allow for growth. (Both vertical and horizontal.) cheapest I’ve found it is ~$100 for a 3 month cycle.

YAMANAKA PEPTIDES

Oct4 and sox2 are peptides that tell your cells to, “be young again.” Not only do these peptides make cells young (which we don’t care about,) but they regenerate tissues in particular chondrocytes and stem cells. But most importantly, they REVERSE GROWTH PLATE SENESCENCE.

What’s plate senescence? It’s slow loss of growth potential in plates. Your body gets old, growth shuts down because of biomarkers telling your body it’s getting old. Oct4 + sox2 can reverse these biomarkers. Yes I know gross oversimplification of why plates close but who cares.

Anyways dosage is 250-750mcg of both sox2 and oct4 every 2-4 weeks probably subq injection for systemic effect

I haven’t found source for these yet but they seem pretty cheap compared to CNP analogs

Senolytics

Dasatinib quercetin. Senolytics kill old useless cells. These old useless cells also tell other young cells to become old and useless. This makes your body old. They tell your body to stop growing, increase inflammation, and make other healthy cells “work slower.”

Dasat dose is 2mg/kg ED for 2 days. Querc is 1000mg ED 2 days. cycle every 4-8weeks

Thoughts?

Had to read this twice just to understand Anyway does this make you age slower considering you said "that tells your cells to,"be young again."" ?

 

[Sachlichkeit]

Had to read this twice just to understand Anyway does this make you age slower considering you said "that tells your cells to,"be young again."" ?

Yeah that’s because it’s poorly written

Yeah probably but I’m not an age biohacker. We are only really concerned with keeping the cells responsible for bone growth young. If they get old, ur plates close.

 

[Sachlichkeit]

Y

can I dm you?

Ya when I figure out how

 

[Sachlichkeit]

Bump. Edit: The CNP analogue Vosoritide is non-attainable. Even in powder form it decays quickly at room temperature. So you would need to cold chain ship it which is not an option.

Infigratinib, which has shown to have a larger height increase than vosoritide is a more risky, but suitable alternative.

dose would be 50mg/day. After 50mg the risk of ocular side effects drastically increase. Ocular meaning EYES, so blindness typically temporary or other changes in the eyes which went unnoticed by patients but noticed by doctors.

For context, in cancer treatment it’s administered orally ED at 125mg. 15-20% of patients at this dose experienced retinal changes.

I am scrapping CNP analogs altogether because there is zero anecdotal accounts of people using them for height increase and the only clinical examples are for dwarf children. So the risk is too high and the reward is too low

 

[Sachlichkeit]

TGF beta ANTAGONISTS

TGF beta is a protein that regulates bone and muscle growth. Mice with overactive TGF were found to have 30-40% shorter limbs. So TGF plays a VERY significant role in the length of bones.

Tgf antagonists antagonize TGF.

Losartan is a well established blood pressure medication that moderately antagonizes TGF Beta. It has a half life of 3-6 hours. Dosage is 25mg AM & PM. I’ve hypothesized megadosing /cycling to increase the effect on TGF but I simply don’t know enough about the drug yet. So 50mg/day is a safe bet.

Fresolimumab is a cancer medication that completely blocks TGF beta. It’s riskier, harder to get access to, and more effective. Dose is 1mg per lb every 4 weeks. The problem is, administration has to be intravenous. Meaning you need an IV drip. So not an option.

 

[kiidz24]

TGF beta ANTAGONISTS

TGF beta is a protein that regulates bone and muscle growth. Mice with overactive TGF were found to have 30-40% shorter limbs. So TGF plays a VERY significant role in the length of bones.

Tgf antagonists antagonize TGF.

Losartan is a well established blood pressure medication that moderately antagonizes TGF Beta. It has a half life of 3-6 hours. Dosage is 25mg AM & PM. I’ve hypothesized megadosing /cycling to increase the effect on TGF but I simply don’t know enough about the drug yet. So 50mg/day is a safe bet.

Fresolimumab is a cancer medication that completely blocks TGF beta. It’s riskier, harder to get access to, and more effective. Dose is 1mg per lb every 4 weeks. The problem is, administration has to be intravenous. Meaning you need an IV drip. So not an option.

Holy researching

 

[Sachlichkeit]

Oct and Sox2 alternatives for cell longevity in order to impede growth plate senescence

Too expensive.

Androgens not only close plates through estrogen rebound, but by aging the entire body. Including the cells located in epiphyseal plates.

So some sort of anti aging protocol will help us extend the growth benefits of steroids by mitigating cell aging

Epitalon keeps cells younger, longer.

It rebuilds the tips of telomeres. Every time a cell divides, the telomeres get shorter until the cell is too old and weak to work. So the life of your cells are epigenetically prolonged.

Dose is subq 10mg/day. Safety profile is good. Low risk decent reward

Rapamycin pulse

stimulate mTOR > cells grow.

Press it too much, cells age prematurely. Gear will do this.

Rapamycin impedes mTOR stimulation, giving your body time to recover and extend cell longevity.

Rapamycin PCT in between cycles. 5mg oral, 5 weeks apart or however long your cycle is.

Side effects for 1 day of 5mg a month apart aren’t even worth mentioning.

Lithium orotate ancillary supplement

Modulates Wnt/b cantenin pathway, good for bone growth.
Blocks gsk-3 protein which accelerates aging, protects stem cells from stress and age. 5mg/day

NMN epigenetic enhancement

protects DNA and telomeres
Improves DNA repair
Boosts cell energy by producing NAD+. More cell energy, more resources for repair and growth.
1000mg/day either sublingual or oral

 

[Gaygymmaxx]

Im on phone so post quality will be low

I’ve already discussed CNP analogues in other thread. Drug that directly impacts growth plates by inhibiting FGF growth factor.

Vosoritide therapy is $100,000/year.

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram. That is enough for 5-6 people to run a 6 month cycle. Combining this synergistically with something like HGH for growth & Anavar for height velocity seems really promising.

Height is partially genetic, this we already know. So we need to find some way to modulate our genes to allow for growth.

HDAC inhibitors, namely vorinostat in low and sparse doses (50mg 5 days on 4-6weeks off) tells your genes to “relax,” and allow for growth. (Both vertical and horizontal.) cheapest I’ve found it is ~$100 for a 3 month cycle.

YAMANAKA PEPTIDES

Oct4 and sox2 are peptides that tell your cells to, “be young again.” Not only do these peptides make cells young (which we don’t care about,) but they regenerate tissues in particular chondrocytes and stem cells. But most importantly, they REVERSE GROWTH PLATE SENESCENCE.

What’s plate senescence? It’s slow loss of growth potential in plates. Your body gets old, growth shuts down because of biomarkers telling your body it’s getting old. Oct4 + sox2 can reverse these biomarkers. Yes I know gross oversimplification of why plates close but who cares.

Anyways dosage is 250-750mcg of both sox2 and oct4 every 2-4 weeks probably subq injection for systemic effect

I haven’t found source for these yet but they seem pretty cheap compared to CNP analogs

Senolytics

Dasatinib quercetin. Senolytics kill old useless cells. These old useless cells also tell other young cells to become old and useless. This makes your body old. They tell your body to stop growing, increase inflammation, and make other healthy cells “work slower.”

Dasat dose is 2mg/kg ED for 2 days. Querc is 1000mg ED 2 days. cycle every 4-8weeks

Thoughts?

Nigga where the esoteric part? This is drugs

 

[Sadist]

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram.

sauce?

 

[Sachlichkeit]

sauce?

Scroll down it’s basically impossible to get and ineffective

 

[Seong Gi-Hun]

can I rape you?

What's up with that

 

[Sachlichkeit]

Im on phone so post quality will be low

I’ve already discussed CNP analogues in other thread. Drug that directly impacts growth plates by inhibiting FGF growth factor.

Vosoritide therapy is $100,000/year.

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram. That is enough for 5-6 people to run a 6 month cycle. Combining this synergistically with something like HGH for growth & Anavar for height velocity seems really promising.

Height is partially genetic, this we already know. So we need to find some way to modulate our genes to allow for growth.

HDAC inhibitors, namely vorinostat in low and sparse doses (50mg 5 days on 4-6weeks off) tells your genes to “relax,” and allow for growth. (Both vertical and horizontal.) cheapest I’ve found it is ~$100 for a 3 month cycle.

YAMANAKA PEPTIDES

Oct4 and sox2 are peptides that tell your cells to, “be young again.” Not only do these peptides make cells young (which we don’t care about,) but they regenerate tissues in particular chondrocytes and stem cells. But most importantly, they REVERSE GROWTH PLATE SENESCENCE.

What’s plate senescence? It’s slow loss of growth potential in plates. Your body gets old, growth shuts down because of biomarkers telling your body it’s getting old. Oct4 + sox2 can reverse these biomarkers. Yes I know gross oversimplification of why plates close but who cares.

Anyways dosage is 250-750mcg of both sox2 and oct4 every 2-4 weeks probably subq injection for systemic effect

I haven’t found source for these yet but they seem pretty cheap compared to CNP analogs

Senolytics

Dasatinib quercetin. Senolytics kill old useless cells. These old useless cells also tell other young cells to become old and useless. This makes your body old. They tell your body to stop growing, increase inflammation, and make other healthy cells “work slower.”

Dasat dose is 2mg/kg ED for 2 days. Querc is 1000mg ED 2 days. cycle every 4-8weeks

Thoughts?

Androgenic genetic upregulator VESANOID

Oral form of tretinoin

In rat studies longterm use closed growth plates and shortened limbs.

Short term pulses, it activates genes related to facial shape, bone development, and increased androgen sensitivity.

This is a drug to genetically masculinize the bones in your face

10mgs ED 2 weeks on 4-6 off. Pair with other cyclicals like vorinostat. DO NOT run it for long cycles it will impede bone growth

 

[BWC]

Im on phone so post quality will be low

I’ve already discussed CNP analogues in other thread. Drug that directly impacts growth plates by inhibiting FGF growth factor.

Vosoritide therapy is $100,000/year.

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram. That is enough for 5-6 people to run a 6 month cycle. Combining this synergistically with something like HGH for growth & Anavar for height velocity seems really promising.

Height is partially genetic, this we already know. So we need to find some way to modulate our genes to allow for growth.

HDAC inhibitors, namely vorinostat in low and sparse doses (50mg 5 days on 4-6weeks off) tells your genes to “relax,” and allow for growth. (Both vertical and horizontal.) cheapest I’ve found it is ~$100 for a 3 month cycle.

YAMANAKA PEPTIDES

Oct4 and sox2 are peptides that tell your cells to, “be young again.” Not only do these peptides make cells young (which we don’t care about,) but they regenerate tissues in particular chondrocytes and stem cells. But most importantly, they REVERSE GROWTH PLATE SENESCENCE.

What’s plate senescence? It’s slow loss of growth potential in plates. Your body gets old, growth shuts down because of biomarkers telling your body it’s getting old. Oct4 + sox2 can reverse these biomarkers. Yes I know gross oversimplification of why plates close but who cares.

Anyways dosage is 250-750mcg of both sox2 and oct4 every 2-4 weeks probably subq injection for systemic effect

I haven’t found source for these yet but they seem pretty cheap compared to CNP analogs

Senolytics

Dasatinib quercetin. Senolytics kill old useless cells. These old useless cells also tell other young cells to become old and useless. This makes your body old. They tell your body to stop growing, increase inflammation, and make other healthy cells “work slower.”

Dasat dose is 2mg/kg ED for 2 days. Querc is 1000mg ED 2 days. cycle every 4-8weeks

Thoughts?

High iq post

 

[Sachlichkeit]

Androgenic genetic upregulator VESANOID

Oral form of tretinoin

In rat studies longterm use closed growth plates and shortened limbs.

Short term pulses, it activates genes related to facial shape, bone development, and increased androgen sensitivity.

This is a drug to genetically masculinize the bones in your face

10mgs ED 2 weeks on 4-6 off. Pair with other cyclicals like vorinostat. DO NOT run it for long cycles it will impede bone growth

METFORMIN

ANOTHER anti-aging drug to offset androgens

will mitigate aging by 10-20% roughly

1. Shifts metabolism away from growth and towards cellular repair
2. Slows aging and lowers the risk of cancer through indirectly inhibiting mTOR.
3. Dulls IGF-1 signaling reducing growth and aging effects
4. Suppresses SASP system which ages tissue

But if we run this while using GH and androgens, it will dampen their effects.

We pair it with other cyclical drugs or pct, running it in between cycles or on down days

dose is 500-1000mg

common side effects are Nausea, Bloating, Diarrhea, Metallic taste

rare and longterm use is B12 deficiency and hypoglycemia (low blood sugar.)

 

[segmt]

You found a lot of the compounds I found, following thread, good research

sourcing is hard, don't know legit places, I can't trust indiamart jfl

 

[Sachlichkeit]

You found a lot of the compounds I found, following thread, good research

sourcing is hard, don't know legit places, I can't trust indiamart jfl

Dm me what you want I’ll provide my sources. You can trust IndiaMART it’s just basic 3rd world medication. Would actually take more work to lace something & companies that have been selling for 4 years aren’t going to risk losing their reputation on you.

 

[segmt]

Dm me what you want I’ll provide my sources. You can trust IndiaMART it’s just basic 3rd world

Yeah but it's abroad man
they won't put any stealth

Easy seizure by customs, love letter to your mail and it's done for your address

 

[Sachlichkeit]

Yeah but it's abroad man
they won't put any stealth

Easy seizure by customs, love letter to your mail and it's done for your address

So far so good personally

Use a fake name, ship to a different address. You can probably rent a shipping locker for more anonymity

Cops aren’t looking to seize personal use prescription medication that isn’t classified as schedule 1. If you were shipping something like Xanax it would be different.

Ask the dealer if they can package it confidently if you are worried. When I ordered my orals they sent them in Vit C bottles

 

[segmt]

So far so good personally

Use a fake name, ship to a different address. You can probably rent a shipping locker for more anonymity

Cops aren’t looking to seize personal use prescription medication that isn’t classified as schedule 1. If you were shipping something like Xanax it would be different.

Ask the dealer if they can package it confidently if you are worried. When I ordered my orals they sent them in Vit C bottles

I thought you were still researching more. actually mirin

 

[Sachlichkeit]

MENT Pulse.

Ment is comparable to Tren in its effectiveness for skeleton, facial bones, and voice deepening. It’s actually more effective than tren but a worse compound because of intense aromatization.

The difference between ment and tren is that ment is significantly better than tren when it comes to genetic signaling.

Pulse for 5 days - 2 weeks with harsh AI then never use again basically.

Pair with hdac inhibitor like vorinostat, -> unlock genes -> hit them with aggressive masculine growth signal -> sustain growth with longer term androgens. It’s like flipping a genetic switch.

Rad140 also looks promising but is only really half as effective as MENT or TREN if not less. Payoff is that it is more fit for longer term use (which is what we want.) blasting gear for short term is worse for dimorphism than low dose long duration cycles.

DNMT inhibitor DECITABINE

DNA is turned off by methyltransferase. Dec is a methyltransferase inhibitor. It blocks the enzyme and re activates silenced genes. Dec is special in that it activates PRENATAL growth genes. Meaning the genes that regulated growth in utero.

It turns on prenatal genes that regulate the growth of limbs, jaw and torso. It boosts osteoblast activity and skull remodeling, increases androgen receptor count AND sensitivity, re-activates the fetal variant of IGF-1 (the primary mechanism of growth,) known as IGF-2. A bunch of other stuff but really too much to write down

Dec will turn the genes on, using androgens will stimulate the use of them.

Should be pulsed like Vorinostat

This is soft eugenics. Effects can be long lasting if not permanent but that is not guaranteed because these genes are only temporarily turned on/off. When you stop using dec the methyl tags re-activate and the genes shut off again.

Dec doesn’t indiscriminately turn on genes but it turns on a lot of them, some of which we don’t want.

Methylated B12 + Folate and SAMe

These drugs are the dec cleanup crew and prolongers of desired gene activation. SAMe reinforces the newly established genetic pattern, creating a “new normal” genetic code if that makes sense. It also donates methyl to DNA which helps close genes we might not want activated. B12 and folate basically do the same thing on a lower scale. The issue is, SAMe is dependent on b12 and folate for effectiveness.

Because it’s DNA related you pulse it. Anything DNA related is typically short term and low dose.

SO, we turn on a bunch of growth genes, Activate them using androgens, and turn off the rest.

 

[Epochs]

Im on phone so post quality will be low

I’ve already discussed CNP analogues in other thread. Drug that directly impacts growth plates by inhibiting FGF growth factor.

Vosoritide therapy is $100,000/year.

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram. That is enough for 5-6 people to run a 6 month cycle. Combining this synergistically with something like HGH for growth & Anavar for height velocity seems really promising.

Height is partially genetic, this we already know. So we need to find some way to modulate our genes to allow for growth.

HDAC inhibitors, namely vorinostat in low and sparse doses (50mg 5 days on 4-6weeks off) tells your genes to “relax,” and allow for growth. (Both vertical and horizontal.) cheapest I’ve found it is ~$100 for a 3 month cycle.

YAMANAKA PEPTIDES

Oct4 and sox2 are peptides that tell your cells to, “be young again.” Not only do these peptides make cells young (which we don’t care about,) but they regenerate tissues in particular chondrocytes and stem cells. But most importantly, they REVERSE GROWTH PLATE SENESCENCE.

What’s plate senescence? It’s slow loss of growth potential in plates. Your body gets old, growth shuts down because of biomarkers telling your body it’s getting old. Oct4 + sox2 can reverse these biomarkers. Yes I know gross oversimplification of why plates close but who cares.

Anyways dosage is 250-750mcg of both sox2 and oct4 every 2-4 weeks probably subq injection for systemic effect

I haven’t found source for these yet but they seem pretty cheap compared to CNP analogs

Senolytics

Dasatinib quercetin. Senolytics kill old useless cells. These old useless cells also tell other young cells to become old and useless. This makes your body old. They tell your body to stop growing, increase inflammation, and make other healthy cells “work slower.”

Dasat dose is 2mg/kg ED for 2 days. Querc is 1000mg ED 2 days. cycle every 4-8weeks

Thoughts?

Ur from .com

 

[Sachlichkeit]

MENT Pulse.

Ment is comparable to Tren in its effectiveness for skeleton, facial bones, and voice deepening. It’s actually more effective than tren but a worse compound because of intense aromatization.

The difference between ment and tren is that ment is significantly better than tren when it comes to genetic signaling.

Pulse for 5 days - 2 weeks with harsh AI then never use again basically.

Pair with hdac inhibitor like vorinostat, -> unlock genes -> hit them with aggressive masculine growth signal -> sustain growth with longer term androgens. It’s like flipping a genetic switch.

Rad140 also looks promising but is only really half as effective as MENT or TREN if not less. Payoff is that it is more fit for longer term use (which is what we want.) blasting gear for short term is worse for dimorphism than low dose long duration cycles.

DNMT inhibitor DECITABINE

DNA is turned off by methyltransferase. Dec is a methyltransferase inhibitor. It blocks the enzyme and re activates silenced genes. Dec is special in that it activates PRENATAL growth genes. Meaning the genes that regulated growth in utero.

It turns on prenatal genes that regulate the growth of limbs, jaw and torso. It boosts osteoblast activity and skull remodeling, increases androgen receptor count AND sensitivity, re-activates the fetal variant of IGF-1 (the primary mechanism of growth,) known as IGF-2. A bunch of other stuff but really too much to write down

Dec will turn the genes on, using androgens will stimulate the use of them.

Should be pulsed like Vorinostat

This is soft eugenics. Effects can be long lasting if not permanent but that is not guaranteed because these genes are only temporarily turned on/off. When you stop using dec the methyl tags re-activate and the genes shut off again.

Dec doesn’t indiscriminately turn on genes but it turns on a lot of them, some of which we don’t want.

Methylated B12 + Folate and SAMe

These drugs are the dec cleanup crew and prolongers of desired gene activation. SAMe reinforces the newly established genetic pattern, creating a “new normal” genetic code if that makes sense. It also donates methyl to DNA which helps close genes we might not want activated. B12 and folate basically do the same thing on a lower scale. The issue is, SAMe is dependent on b12 and folate for effectiveness.

Because it’s DNA related you pulse it. Anything DNA related is typically short term and low dose.

SO, we turn on a bunch of growth genes, Activate them using androgens, and turn off the rest.

Bump

I was wrong ment is Retarded. It converts to estrogen without aromatase so using AIs won’t do anything. You need to pair it with a serm which is too much work. Pulsing tren for a worse yet still significant genetic effect is preferable. Ment is genuinely just a horribly designed androgen.

 

[Sachlichkeit]

Bump

I was wrong ment is Retarded. It converts to estrogen without aromatase so using AIs won’t do anything. You need to pair it with a serm which is too much work. Pulsing tren for a worse yet still significant genetic effect is preferable. Ment is genuinely just a horribly designed androgen.

Real. I wrote half of this at 3am last night so just revising for accuracy sake

The difference between ment and tren is that ment is significantly better than tren when it comes to genetic signaling.

This is true but not worth it.

Rad140 also looks promising but is only really half as effective as MENT or TREN if not less. Payoff is that it is more fit for longer term use (which is what we want.) blasting gear for short term is worse for dimorphism than low dose long duration cycles.

this is retarded. test base and DHT conversion mogs

It turns on prenatal genes that regulate the growth of limbs, jaw and torso. It boosts osteoblast activity and skull remodeling, increases androgen receptor count AND sensitivity, re-activates the fetal variant of IGF-1 (the primary mechanism of growth,) known as IGF-2.

Theoretically, yes, but exaggerated.

what it has been scientifically proven to impact is,

Androgen receptor sensitivity. (Theoretical marginal increase of 5-10% in normal people.)

PMEPA1, gene for androgenic expression. Like a volume knob for androgens. (Theoretical 40-60% upregulation.)

HOXA11 / HOXA5 which regulates limb and body growth. Theoretical upregulation of 40-60%. This and HGH /PTH could *re awaken* the body's capacity for frame growth

IGFBP3. IGF1 gene. can enhance and prolong IGF-1 signaling. So your body gets more use out of IGF-1 than somebody who has the gene downregulated. Theoretical 30-50% upregulation

AXL. Vorinostat + DEC = 10-18x upregulation. Responsible for cell health under pressure. By pressure I mean stress from things like elevated IGF-1, supraphysiological doses of androgens, bone growers like Teriparatide, AND most importantly, intense physical exericse. Has significant impact on cell migration. Which means it allows for more cells to flood into areas of the body where growth is being stimulated. Also prevents aptosis, which is the programmed death of cells. Aptosis is good but becomes upregulated when blasting gear. AXL is conditional and only activates under physical stress and GEAR.

PMEPA, HOXA, and IGFBP3 gene activation makes DEC very promising drug, not including the insane upregulation of cell longevity

This is soft eugenics.

No its not

Also upregulating genes relies partially on stimulating the pathways for growth. If you take vorinostat and don't use any androgens it will just exaggerate the effects of your already existing hormonal balance. SO, if you wanted something besides bone or muscle growth, like more hair, you would demethylate the DNA and stimulate the pathway primarily responsible for hair growth which is Wnt/B catenin.

 

[Oreone]

Real. I wrote half of this at 3am last night so just revising for accuracy sake


This is true but not worth it.


this is retarded. test base and DHT conversion mogs


Theoretically, yes, but exaggerated.

what it has been scientifically proven to impact is,

Androgen receptor sensitivity. (Theoretical marginal increase of 5-10% in normal people.)

PMEPA1, gene for androgenic expression. Like a volume knob for androgens. (Theoretical 40-60% upregulation.)

HOXA11 / HOXA5 which regulates limb and body growth. Theoretical upregulation of 40-60%. This and HGH /PTH could *re awaken* the body's capacity for frame growth

IGFBP3. IGF1 gene. can enhance and prolong IGF-1 signaling. So your body gets more use out of IGF-1 than somebody who has the gene downregulated. Theoretical 30-50% upregulation

AXL. Vorinostat + DEC = 10-18x upregulation. Responsible for cell health under pressure. By pressure I mean stress from things like elevated IGF-1, supraphysiological doses of androgens, bone growers like Teriparatide, AND most importantly, intense physical exericse. Has significant impact on cell migration. Which means it allows for more cells to flood into areas of the body where growth is being stimulated. Also prevents aptosis, which is the programmed death of cells. Aptosis is good but becomes upregulated when blasting gear. AXL is conditional and only activates under physical stress and GEAR.

PMEPA, HOXA, and IGFBP3 gene activation makes DEC very promising drug, not including the insane upregulation of cell longevity


No its not

Also upregulating genes relies partially on stimulating the pathways for growth. If you take vorinostat and don't use any androgens it will just exaggerate the effects of your already existing hormonal balance. SO, if you wanted something besides bone or muscle growth, like more hair, you would demethylate the DNA and stimulate the pathway primarily responsible for hair growth which is Wnt/B catenin.

mirin
check dm

 

[Sachlichkeit]

PMEPA, HOXA, and IGFBP3 gene activation makes DEC very promising drug, not including the insane upregulation of cell longevity
.

Lyophilized pharmaceutical grade decitabine is so cytotoxic that you would need to rotate 8 injection sites a day. Its only approved for IV use and reconstituting + injecting UGL raw powder risks insane things like sepsis (worst case scenario) and horrible injection site reactions.

INQOVI, is the brand name for orally bioavailable decitabine, intended for cancer. It is paired with carrier drug Cedazuridine and ingested in pill form. There is no generic version so its like $1800 a bottle (lol.) You would need to source both powders separately, and combine them at the proper ratio in pill form.

ZEBULARINE + RG108. Weaker, safer, more moderate, less permanent. Both ingested orally at 5 day cycles 6-8 weeks apart. Zeb 800 ED 400MG AM PM SPLIT. RG108 300MG ED.

RG108 can also be injected SubQ. The dose is lower because of increased bio-availability. 250mg ED.
for Oral, 15% DMSO, 30% PEG 400/ethanol, remainder olive oil.
for subq, 10% DMSO 30% PEG 400, 50% bacteriostatic water

More budget friendly (if you can source them) is RG108 and SGI-1027.
150mg oral, for Oral, 15% DMSO, 30% PEG 400/ethanol, remainder olive oil, empty stomach.

Avoid methly donors (Folate, Methyl B12, SAMe, during pulses.) Methyl donors are for prolonging the temporary genetic effects, not reprogramming.

Dec and Cez are the most effective. I would only use minimum 7 weeks apart with growth factors for safety reasons. Growth factors enhance genetic expression, Abolapartide, Romosumazab, PTH-134, Ky19382 (for bones, sorted best to worst.) GH + Gear 4 everything else.

Loading Gear

MENT, TREN and extreme dose testosterone for androgenic genetic expression during genetic priming phase.

I have already mentioned that MENT is better than tren for genetic programming but is generally just a worse compound with more side effects so tren is preferable. Also MENT is slower than tren. 2 week cycle would be needed for maximum effects whereas tren 5 days.

T is a slower burn, we need an immediate burst of androgenic expression during the priming phase. Dose would also be literally around 1 GRAM for 5 days. While I prefer test over other steroids because its the most researched (and naturally found in the body,) The returns on 1 gram a week compared to side effects will be drastically worse.

TREN. Fits with 5 day cycle, genetically comparable to MENT, needs a test base. 50mg ED 5 days intramuscular injection. If you nick a vein the oil will get into your bloodstream and give you tren cough (temporary.)

So a cycle should have 2-3 distinct periods. Genetic priming, growth, and and repair. You shouldn't run 40 different compounds at the same time. death stack

 

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TETRA-ANALOGS.

Doxycycline and Minocycline inhibit MMP's. They do a few other things but primary use is MMP inhibition. There are other tetra analogs but they are not worth mentioning. Both of these are cheap, well established, orals.

MMPS. Matrix Metalloproteinases. Bone growth requires collagen scaffolding. MMPs cut down this scaffolding. MMP's remodel tissue, remove old/damaged bone matrix, activate during and respond to inflammation. Gear upregulates MMP's through inflammation leading to decreased bone gains.

Doxycycline is the weaker of the two and suitable for longterm use. 20-40MG ED for like 6 months with minimal side effects
Minocycline 50mg ED. Needs to be cycled 2-4 weeks at a time. Because these drugs inhibit MMP's they don't stimulate growth they enhance it through scaffolding preservation. So you need an inflammatory base for growth like gear or bone drugs. (Romo, Abola, Teripara.)

For whatever reason Minocycline likes to collect in facial tissue. This is an oral drug that locally addresses facial bones specifically. Doxy is weaker, systematic.

Estimated gains paired with a standard supraphysiological dose of test E (500mg/wk,) is 10-14% cortical thickening (frame widening,) for Doxy and 9-13% for Mino. Facial bone remodeling 6-12% Doxy 10-18% Mino compared to 8-12% frame and 5-10% face on 500mg test without tetra analogs.

 

[segmt]

TETRA-ANALOGS.

Doxycycline and Minocycline inhibit MMP's. They do a few other things but primary use is MMP inhibition. There are other tetra analogs but they are not worth mentioning. Both of these are cheap, well established, orals.

MMPS. Matrix Metalloproteinases. Bone growth requires collagen scaffolding. MMPs cut down this scaffolding. MMP's remodel tissue, remove old/damaged bone matrix, activate during and respond to inflammation. Gear upregulates MMP's through inflammation leading to decreased bone gains.

Doxycycline is the weaker of the two and suitable for longterm use. 20-40MG ED for like 6 months with minimal side effects
Minocycline 50mg ED. Needs to be cycled 2-4 weeks at a time. Because these drugs inhibit MMP's they don't stimulate growth they enhance it through scaffolding preservation. So you need an inflammatory base for growth like gear or bone drugs. (Romo, Abola, Teripara.)

For whatever reason Minocycline likes to collect in facial tissue. This is an oral drug that locally addresses facial bones specifically. Doxy is weaker, systematic.

Estimated gains paired with a standard supraphysiological dose of test E (500mg/wk,) is 10-14% cortical thickening (frame widening,) for Doxy and 9-13% for Mino. Facial bone remodeling 6-12% Doxy 10-18% Mino compared to 8-12% frame and 5-10% face on 500mg test without tetra analogs.

which are you currently using? out of all the compounds you researched

 

[chipcrip]

Im on phone so post quality will be low

I’ve already discussed CNP analogues in other thread. Drug that directly impacts growth plates by inhibiting FGF growth factor.

Vosoritide therapy is $100,000/year.

The cheapest (with certificate of authenticity) I have found is ~$1400 for 1 gram. That is enough for 5-6 people to run a 6 month cycle. Combining this synergistically with something like HGH for growth & Anavar for height velocity seems really promising.

Height is partially genetic, this we already know. So we need to find some way to modulate our genes to allow for growth.

HDAC inhibitors, namely vorinostat in low and sparse doses (50mg 5 days on 4-6weeks off) tells your genes to “relax,” and allow for growth. (Both vertical and horizontal.) cheapest I’ve found it is ~$100 for a 3 month cycle.

YAMANAKA PEPTIDES

Oct4 and sox2 are peptides that tell your cells to, “be young again.” Not only do these peptides make cells young (which we don’t care about,) but they regenerate tissues in particular chondrocytes and stem cells. But most importantly, they REVERSE GROWTH PLATE SENESCENCE.

What’s plate senescence? It’s slow loss of growth potential in plates. Your body gets old, growth shuts down because of biomarkers telling your body it’s getting old. Oct4 + sox2 can reverse these biomarkers. Yes I know gross oversimplification of why plates close but who cares.

Anyways dosage is 250-750mcg of both sox2 and oct4 every 2-4 weeks probably subq injection for systemic effect

I haven’t found source for these yet but they seem pretty cheap compared to CNP analogs

Senolytics

Dasatinib quercetin. Senolytics kill old useless cells. These old useless cells also tell other young cells to become old and useless. This makes your body old. They tell your body to stop growing, increase inflammation, and make other healthy cells “work slower.”

Dasat dose is 2mg/kg ED for 2 days. Querc is 1000mg ED 2 days. cycle every 4-8weeks

Thoughts?

what is the source for vorinostat

 

[stufftodo]

Oct and Sox2 alternatives for cell longevity in order to impede growth plate senescence

Too expensive.

Androgens not only close plates through estrogen rebound, but by aging the entire body. Including the cells located in epiphyseal plates.

So some sort of anti aging protocol will help us extend the growth benefits of steroids by mitigating cell aging

Epitalon keeps cells younger, longer.

It rebuilds the tips of telomeres. Every time a cell divides, the telomeres get shorter until the cell is too old and weak to work. So the life of your cells are epigenetically prolonged.

Dose is subq 10mg/day. Safety profile is good. Low risk decent reward

Rapamycin pulse

stimulate mTOR > cells grow.

Press it too much, cells age prematurely. Gear will do this.

Rapamycin impedes mTOR stimulation, giving your body time to recover and extend cell longevity.

Rapamycin PCT in between cycles. 5mg oral, 5 weeks apart or however long your cycle is.

Side effects for 1 day of 5mg a month apart aren’t even worth mentioning.

Lithium orotate ancillary supplement

Modulates Wnt/b cantenin pathway, good for bone growth.
Blocks gsk-3 protein which accelerates aging, protects stem cells from stress and age. 5mg/day

NMN epigenetic enhancement

protects DNA and telomeres
Improves DNA repair
Boosts cell energy by producing NAD+. More cell energy, more resources for repair and growth.
1000mg/day either sublingual or oral

i thought telomere length doesn't shorten until 18-20, if you take epitalon at 13-17 wouldn't you be at risk of cancer development?

 

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i thought telomere length doesn't shorten until 18-20, if you take epitalon at 13-17 wouldn't you be at risk of cancer development?

theres a cancer risk for both. If you upregulate the longevity of damaged DNA you run the risk of preventing death in pre-cancerous cells. Telomere shortening comes from age, lifestyle, inflammation, stress. Gear = inflammation and stress on body. Effect on telomeres is probably marginal in adulthood but we are trying to keep our growth plates young. Senolytics PCT to kill damaged calls