Everything you need to know about Enclomiphene.

[Coffeebackwards]

What is Enclomiphene?

Enclomiphene is an SERM (selective estragon receptor modulator)
Unlike tamoxifen ( another SERM), Enclomiphene is designed to specifically raise testosterone without as many estrogen related side effects.
If you're wondering, no it's not exogenous testosterone. Meaning it doesn't replace your natural T. It stimulates your body to make more naturally.

How does it work?

1. Hypothalamus interaction

Enclomiphene blocks estrogen receptors in the hypothalamus.
Normally, estrogen feeds back to the hypothalamus to signal that there is enough testosterone already.

2. Pituary activation

By blocking this signal, the hypothalamus thinks testosterone is low. Then the hypothalamus releases GnRH ( gonadotropin-releasing hormone).
GnRH stimulates the pituitary gland to release LH and FSH.

3. Testicular response

LH signals leydig cells in the testes to produce more testosterone
FSH supports spermatogenesis, maintaining fertility
Results: Higher endogenous testosterone without shutting down the testes ( unlike TRT)

How does it affect the body?

1. Muscle mass: more androgen = better protein synthesis


2. Fat distribution: Testosterone favors lean mass and reduces visceral fat.


3. Libido/mood:
Testosterone elevation improved energy, confidence and sex drive ( you'll basically become a walking sex machine )



KEY POINT:

unlike exogenous T, enclomiphene preserves HPTA function, so testes don't shrink and fertility is maintained.

How is it different from clomiphene citrate?

Clomiphene is a mixture of two isomers:

Enclomiphene - pure activating isomer, meaning: faster testosterone increase, less risk of estrogen related side effects, more predictable lab outcomes.

zuclomiphene ( can cause estrogenic side effects ) - you don't have to worry about it since you'd only be taking Enclomiphene.

Studies in men with secondary hypogonadism have shown that testosterone levels rise within 2-4 weeks, fertility is maintained, estradiol may rise but it's usually within normal range.

Here are 2 Prime examples before and after using Enclomiphene:

Key takeaways:

Enclomiphene is not a steroid, it's a hormone modulator.
Works by tricking your brain into making more testosterone naturally.

Effects:
better muscle to fat ratio, slight facial improvements, more energy.


Requires proper dosage to avoid estrogen rebound or other side effects. ( Sadly I'm not knowledgeable enough to give you a full dosage breakdown )


Disclaimer:

I am not promoting Enclomiphene or encouraging anyone to use it.
This post is purely for research and educational purposes.
If you are planning to use Enclomiphene, please do your own research.
( This is my first proper post so if you have any tips on how to improve my threads please tell me )
Sources:

https://go.drugbank.com/drugs/DB067...01&phase=3&purpose=treatment&status=completed

https://www.news-medical.net/life-s...hanism-efficacy-and-safety-consideration.aspx

https://pubmed.ncbi.nlm.nih.gov/25044085

https://en.wikipedia.org/wiki/Enclomifene

https://pmc.ncbi.nlm.nih.gov/articles/PMC5009465

https://pmc.ncbi.nlm.nih.gov/articles/PMC4155868

https://pmc.ncbi.nlm.nih.gov/articles/PMC11491226

https://academic.oup.com/jsm/article/21/Supplement_1/qdae001.090/7600907

https://www.hims.com/blog/what-is-enclomiphene

 

[nunotherone]

dnr

 

[llane9]

dnr enclo is shit and shouldn't be touched by anyone.

 

[Chad]

What I know is enclo is complete and utter dogshit.

DNR a molecule.

 

[Laqi]

What I know is enclo is complete and utter dogshit.

DNR a molecule.

based

 

[Deleted member 59162]

What I know is enclo is complete and utter dogshit.

DNR a molecule.

Mogs clomid to dagestan and back

 

[amiok]

dnr enclo is shit and shouldn't be touched by anyone.

why?

 

[amiok]

i think ts is a great thread lol

 

[hiiwasodie]

Everyone loves to shit on enclo but no one provides any evidence or sources to back their claim.

 

[Coffeebackwards]

Everyone loves to shit on enclo but no one provides any evidence or sources to back their claim.

And pneumo used it, got good results to counter his test lowering cuz of rad 140. Can't lie I'm hopping on that as well so I'll document it on here

 

[O'bhai]

And pneumo used it, got good results to counter his test lowering cuz of rad 140. Can't lie I'm hopping on that as well so I'll document it on here

did you hop on it?

 

[11st.dom11]

care to elaborate nigga?

dnr enclo is shit and shouldn't be touched by anyone.

 

[11st.dom11]

What I know is enclo is complete and utter dogshit.

DNR a molecule.

can you explain why? i really dont see the downside to boosting test without nuking fertility....

 

[tokyo01010]

dnr enclo is shit and shouldn't be touched by anyone.

What I know is enclo is complete and utter dogshit.

DNR a molecule.

care to explain??

 

[Coffeebackwards]

I completely forgot about this forum, I have some threads prepared, I'll post them soon

 

[tokyo01010]

I completely forgot about this forum, I have some threads prepared, I'll post them soon

can you tag me

 

[Coffeebackwards]

did you hop on it?

I'm hopping on test enanthate instead and then doing pct because I don't plan being on it forever, just trying out my first cycle and then I'll see if I want to continue or no.

can you tag me

Yeah sure dude

 

[tokyo01010]

I'm hopping on test enanthate instead and then doing pct because I don't plan being on it forever, just trying out my first cycle and then I'll see if I want to continue or no.

Yeah sure dude

thanks bro, i’m starting enclo soon, any reccomendations what to use with it?

 

[Coffeebackwards]

thanks bro, i’m starting enclo soon, any reccomendations what to use with it?

Defo use tadalafil or cialis for PCT, and I recommend you use pregnenolone along with it for hormonal support. For dosage you should do your own research though, and pinning technique as well I can't help with that

 

[tokyo01010]

Defo use tadalafil or cialis for PCT, and I recommend you use pregnenolone along with it for hormonal support. For dosage you should do your own research though, and pinning technique as well I can't help with that.

I got oral enclo but the plan rn is 25mg eod with hcg but i haven’t bought hcg yet since im still looking at other supports to use with enclo. ill definitely look at pregnenolone

 

[Coffeebackwards]

I got oral enclo but the plan rn is 25mg eod with hcg but i haven’t bought hcg yet since im still looking at other supports to use with enclo. ill definitely look at pregnenolone

I was gonna say it's good to use HCG cuz enclo just completely blocks estrogen receptors. I recommend using both HCG and pregnenolone

 

[tokyo01010]

I was gonna say it's good to use HCG cuz enclo just completely blocks estrogen receptors. I recommend using both HCG and pregnenolone

Thanks for the info brah

 

[ryanlyin]

I’m on enclo rn but only because I’m on Accutane, 25mg eod. My test before was 650 so I’ll update whenever I get my next bloodwork but I’m expecting 1000+

 

[Coffeebackwards]

I’m on enclo rn but only because I’m on Accutane, 25mg eod. My test before was 650 so I’ll update whenever I get my next bloodwork but I’m expecting 1000+

Defo update me, I'd like to see the results as well

 

[tokyo01010]

I’m on enclo rn but only because I’m on Accutane, 25mg eod. My test before was 650 so I’ll update whenever I get my next bloodwork but I’m expecting 1000+

me too brah

 

[SoundnVision]

I’m on enclo rn but only because I’m on Accutane, 25mg eod. My test before was 650 so I’ll update whenever I get my next bloodwork but I’m expecting 1000+

Update

 

[ryanlyin]

Update

In the next month most likely