GH secretagogues CAN cause negative feedback loop

cumbutamoren

cumbutamoren

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“GHSs promote pulsatile release of GH that is subject to negative feedback and can prevent supra-therapeutic levels of GH and their sequelae.”
https://pubmed.ncbi.nlm.nih.gov/28400207/

thoughts on this? My understanding before was that most people recovered from ghs and even gh injections within a few days. This paper didn’t really specify the degree of the negative feedback effect. For all we know, it could be referring to the diminishing returns which is already well known, or it means to say that it could cause actual shutdown even after cycling off
 
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