How to properly use GHK-Cu

NZb6Air

NZb6Air

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GHK-Cu, on paper, seems to be the single best looksmaxxing compound there is (perfect skin, anti-aging, surgery recovery, neurogenesis,¹¹ etc)¹, yet no one seems to be reaping any of its benefits. What’s even more bizarre is that injection-related pain is massively reported, more consistently so than its supposed benefits².

a white cat is sitting on a box with the words `` why '' written on it .




Quickly, Glycyl-L-histidyl-L-lysine (GHK) is a tripeptide isolated from human plasma³, which possesses a high affinity for copper (II) ions, with which it spontaneously forms a complex (GHK-Cu). GHK alone has been shown to be responsible for the collagen boost⁴ and no injection-related pain has been reported with it⁵, so go for it if you want but it's the added copper that is responsible for this myriad of blessings;

EXAMPLES :
The complex, unlike GHK alone, helps activate matrix metalloproteinases, which break down damaged tissue so it can be replaced with healthy tissue⁶.


1730643345817


OR

Compositions of copper (II) containing compounds have been show to accelerate the healing of wounds in warm-blooded animals, and more specifically the systemic loading of copper (II) compounds to accelerate the rate of wound healing following injury or surgery to warm-blooded animals.⁷


1730643739905



; ...and consequently what seems to cause tissue damage during injection.


If we look at the cayman chemicals reviews of the molecules in question :



1730641809887
1730641818165



The main differences are the addition of a copper atom and a significantly worse solubility profile, which suggests a causal relationship between these two differences (meaning that the added copper induces the worse solubility).

In fact, we know that metals are gay

Gay meaning they have different bonding properties vs carbon, oxygen, etc (this whole field of gay metals is “inorganic chemistry”) The reason for this is that metals basically have up to ten relevant electrons , which have comically complex geometries, are much larger (radius) and less bound to the nucelus

1730644086285


Simply, they like to move a lot, they're playful building blocks that like to change and mix :heart:, while other atoms are stronger and stick together better, 🥺 other atoms, like those in water or air, are like super strong blocks that hold together really well🍆. They don’t like to change as much, so they are usually more stable. :eek:




Seriously, metals require ions to stabilize in various contexts, primarily due to their tendency to lose electrons and form positive charges, the ions in PBS can neutralize the positive charge of the copper ions, reducing the likelihood of oxidation or other reactions that would destabilize the copper. PBS also maintains a stable pH, which is important for keeping copper in its soluble form. In bac water or regular saline, changes in pH can lead to precipitation or oxidation of copper ions. (5 to 7 for bac and reg saline vs 7.2 to 7.4 for Phosphate Buffered Saline)

Hence why GHK-Cu needs PBS (again because the ionic solution (has a lot of ions) stabilizes the added copper), otherwise the copper-nitrogen bonds are likely to break.
1730648117086



The common folk seems to be dissolving GHK-Cu in Bac Water since that is the usual commercially available and promoted solvent for peptides².
However, Bac Water has a lower ion concentration than PBS (which makes the copper less likely to be stable), I hypothesize that the pain comes from the free copper atoms raping your tissues (not fully understood).


1730643919153


Injection solutions :

Phosphate Buffered Saline :


1730645494661



1730645635971



1730646202461



i.e. what is mostly used in studies and what is recommended by CaymanChem

Making PBS at home looks annoying af so just fucking buy it : https://www.sigmaaldrich.com/US/en/product/sigma/d8537

WORKS AND STABLE




Normale saline (0.9% saline) :


Direct on-site injection tho

1730646319107



1730645909676
1730645963206


WORKS BUT THEORETICALLY NOT STABLE, since the PH will be too low

You'd need to adjsut it yourself⁷


1730647548421


BAC WATER :

DOESN'T WORK (YOU ONLY GET GHK AND INJECTION SITE DAMAGE)²





Topical :

Topical formulations of GHKcu have been developed and are effective

BetTar:

The best one (both low-cost, most effective and most stable) being Bet Tar which is a recent (2023) chinese developped ionic-liquid-based delivery vehicle composed of betaine and tartaric acid
https://external-content.duckduckgo.com/iu/?u=https%3A%2F%2Fmedia1.tenor.com%2Fm%2F_ylM1V0OJlIAAAAC%2Fdonald-trump-talking.gif&f=1&nofb=1&ipt=7ecca7ab4663a5d1e0dd8f1ccd4a7e406e04e4a17d62f94524b064be533188e0&ipo=images


1730648346326


1730648357463

1730648479367


Stable as fuck :
1730648381525


PDI is dispersity

I will be attaching the papers⁸ in case President Xi takes them down


Hyaluronic acid-based hydrogel embedded with GHK peptide nanofibers : ( :lul: )

Works af for direct wound healing


1730649079289


YES BRO I WILL TOTALLY MAKE THIS jfl

1730649114484



THERE ARE 8 BILLION GOOD TOPICAL ways but WE CAN NOT MAKE/BUY any of these

This was good for wound closure but go figure how they made it

1730647390510
1730649221776


Concering DMSO :

IT DOESN'T WORK (IT'S EVEN LESS STABLE THAN BAC WATER since it has less ions (water (bac water) has H+ and OH- (water)))

These niggas tried to study its structure while dissolving it in DMSO¹⁰ : https://sci-hub.ru/10.1016/0162-0134(89)84011-5, which gave them completly retarded results "under their conditions"

Metals in general seem to be struggling in DMSO

1730650540628


Goodluck rabbitholemaxxing this :lul:








TLDR :



- RECONSTITUTE GHK-Cu IN PBS or DPBS (which you can buy) and inject it daily

- BUY and RECONSTITUTE GHK IN BAC WATER IF YOU ONLY WANT COLLAGEN BOOST AND EASE OF USE and inject it daily

- TRY TO MAKE a [Bet] [Tar] GHK-Cu Topical Liquid Solution, if you want, for when you can't inject or as first-aid





@Hexmask @N1666 @Clavicular @NorwoodAscender @meathead



¹Pickart, L., & Margolina, A. (2018). Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International Journal of Molecular Sciences, 19(7), https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/pdf/ijms-19-01987.pdf
²
³Pickart L, Thaler MM. Tripeptide in human serum which prolongs survival of normal liver cells and stimulates growth in neoplastic liver. Nat New Biol. 1973 May 16;243(124):85-7. PMID: 4349963.
⁴Maquart, F.-X., Pickart, L., Laurent, M., Gillery, P., Monboisse, J.-C., & Borel, J.-P. (1988). Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu²⁺. Biochemical and Biophysical Research Communications, 238(2), 343-346. https://sci-hub.ru/10.1016/0014-5793(88)80509-X
⁵ Google it and add Reddit and various forums to the key-words
⁶Siméon, A., Emonard, H., Hornebeck, W., & Maquart, F.-X. (2000). The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu²⁺ stimulates matrix metalloproteinase-2 expression by fibroblast cultures. Life Sciences, 67(20), 2257-2265. https://sci-hub.ru/10.1016/S0024-3205(00)00803-1
⁷ Pickart, L. R. (1992). Method of using copper(II) containing compounds to accelerate wound healing (U.S. Patent No. 5164367). U.S. Patent and Trademark Office. https://patentimages.storage.googleapis.com/28/c1/c7/6fb3bbcf61becb/US5164367.pdf
⁸Liu, T., Hu, L., Lu, B., Bo, Y., Liao, Y., Zhan, J., Pei, Y., Sun, H., Wang, Z., Guo, C., & Zhang, J. (2023). A novel delivery vehicle for copper peptides. New Journal of Chemistry https://pubs.rsc.org/en/content/articlelanding/2023/nj/d2nj04282g#fn1
⁹L. Pickart, in BioIogy of Copper Complexes, J. R. C. Sorenson, Ed., Human Press, Clifton, NJ, 1987, pp. 273-285 (https://library.lol/main/04A4B0236383B58B30E1AF569542355F), neurogenesis also mentionned here¹⁰
¹⁰Antholine, W. E., Petering, D. H., & Pickart, L. (1989). ESR studies of the interaction of copper(II) GHK, histidine, and Ehrlich cells. Journal of Inorganic Biochemistry, 35(2), U-224
¹¹Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2012). The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: Implications for cognitive health. Oxidative Medicine and Cellular Longevity, 2012, Article ID 324832. https://doi.org/10.1155/2012/324832
 

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@N1666
 
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reading all molecules rn
 
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GHK-Cu, on paper, seems to be the single best looksmaxxing compound there is (perfect skin, anti-aging, surgery recovery, neurogenesis,¹¹ etc)¹, yet no one seems to be reaping any of its benefits. What’s even more bizarre is that injection-related pain is massively reported, more consistently so than its supposed benefits².

a white cat is sitting on a box with the words `` why '' written on it .'' written on it .




Quickly, Glycyl-L-histidyl-L-lysine (GHK) is a tripeptide isolated from human plasma³, which possesses a high affinity for copper (II) ions, with which it spontaneously forms a complex (GHK-Cu). GHK alone has been shown to be responsible for the collagen boost⁴ and no injection-related pain has been reported with it⁵, so go for it if you want but it's the added copper that is responsible for this myriad of blessings;

EXAMPLES :
The complex, unlike GHK alone, helps activate matrix metalloproteinases, which break down damaged tissue so it can be replaced with healthy tissue⁶.


View attachment 3275853

OR

Compositions of copper (II) containing compounds have been show to accelerate the healing of wounds in warm-blooded animals, and more specifically the systemic loading of copper (II) compounds to accelerate the rate of wound healing following injury or surgery to warm-blooded animals.⁷


View attachment 3275859


; ...and consequently what seems to cause tissue damage during injection.


If we look at the cayman chemicals reviews of the molecules in question :



View attachment 3275820View attachment 3275821


The main differences are the addition of a copper atom and a significantly worse solubility profile, which suggests a causal relationship between these two differences (meaning that the added copper induces the worse solubility).

In fact, we know that metals are gay

Gay meaning they have different bonding properties vs carbon, oxygen, etc (this whole field of gay metals is “inorganic chemistry”) The reason for this is that metals basically have up to ten relevant electrons , which have comically complex geometries, are much larger (radius) and less bound to the nucelus

View attachment 3275870

Simply, they like to move a lot, they're playful building blocks that like to change and mix :heart:, while other atoms are stronger and stick together better, 🥺 other atoms, like those in water or air, are like super strong blocks that hold together really well🍆. They don’t like to change as much, so they are usually more stable. :eek:




Seriously, metals require ions to stabilize in various contexts, primarily due to their tendency to lose electrons and form positive charges, the ions in PBS can neutralize the positive charge of the copper ions, reducing the likelihood of oxidation or other reactions that would destabilize the copper. PBS also maintains a stable pH, which is important for keeping copper in its soluble form. In bac water or regular saline, changes in pH can lead to precipitation or oxidation of copper ions. (5 to 7 for bac and reg saline vs 7.2 to 7.4 for Phosphate Buffered Saline)

Hence why GHK-Cu needs PBS (again because the ionic solution (has a lot of ions) stabilizes the added copper), otherwise the copper-nitrogen bonds are likely to break.
View attachment 3276079


The common folk seems to be dissolving GHK-Cu in Bac Water since that is the usual commercially available and promoted solvent for peptides².
However, Bac Water has a lower ion concentration than PBS (which makes the copper less likely to be stable), I hypothesize that the pain comes from the free copper atoms raping your tissues (not fully understood).


View attachment 3275864

Injection solutions :

Phosphate Buffered Saline :


View attachment 3275998


View attachment 3276003


View attachment 3276026


i.e. what is mostly used in studies and what is recommended by CaymanChem

Making PBS at home looks annoying af so just fucking buy it : https://www.sigmaaldrich.com/US/en/product/sigma/d8537

WORKS AND STABLE




Normale saline (0.9% saline) :


Direct on-site injection tho

View attachment 3276031


View attachment 3276018View attachment 3276019

WORKS BUT THEORETICALLY NOT STABLE, since the PH will be too low

You'd need to adjsut it yourself⁷


View attachment 3276064

BAC WATER :

DOESN'T WORK (YOU ONLY GET GHK AND INJECTION SITE DAMAGE)²





Topical :

Topical formulations of GHKcu have been developed and are effective

BetTar:

The best one (both low-cost, most effective and most stable) being Bet Tar which is a recent (2023) chinese developped ionic-liquid-based delivery vehicle composed of betaine and tartaric acid
https://external-content.duckduckgo.com/iu/?u=https%3A%2F%2Fmedia1.tenor.com%2Fm%2F_ylM1V0OJlIAAAAC%2Fdonald-trump-talking.gif&f=1&nofb=1&ipt=7ecca7ab4663a5d1e0dd8f1ccd4a7e406e04e4a17d62f94524b064be533188e0&ipo=images


View attachment 3276085

View attachment 3276086
View attachment 3276090

Stable as fuck :
View attachment 3276087

PDI is dispersity

I will be attaching the papers⁸ in case President Xi takes them down


Hyaluronic acid-based hydrogel embedded with GHK peptide nanofibers : ( :lul: )

Works af for direct wound healing


View attachment 3276113

YES BRO I WILL TOTALLY MAKE THIS jfl

View attachment 3276114


THERE ARE 8 BILLION GOOD TOPICAL ways but WE CAN NOT MAKE/BUY any of these

This was good for wound closure but go figure how they made it

View attachment 3276058View attachment 3276117

Concering DMSO :

IT DOESN'T WORK (IT'S EVEN LESS STABLE THAN BAC WATER since it has less ions (water (bac water) has H+ and OH- (water)))

These niggas tried to study its structure while dissolving it in DMSO¹⁰ : https://sci-hub.ru/10.1016/0162-0134(89)84011-5, which gave them completly retarded results "under their conditions"

Metals in general seem to be struggling in DMSO

View attachment 3276159

Goodluck rabbitholemaxxing this :lul:








TLDR :



- RECONSTITUTE GHK-Cu IN PBS or DPBS (which you can buy) and inject it daily

- BUY and RECONSTITUTE GHK IN BAC WATER IF YOU ONLY WANT COLLAGEN BOOST AND EASE OF USE and inject it daily

- TRY TO MAKE a [Bet] [Tar] GHK-Cu Topical Liquid Solution, if you want, for when you can't inject or as first-aid





@Hexmask @N1666 @Clavicular @NorwoodAscender @meathead



¹Pickart, L., & Margolina, A. (2018). Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International Journal of Molecular Sciences, 19(7), https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/pdf/ijms-19-01987.pdf
²
³Pickart L, Thaler MM. Tripeptide in human serum which prolongs survival of normal liver cells and stimulates growth in neoplastic liver. Nat New Biol. 1973 May 16;243(124):85-7. PMID: 4349963.
⁴Maquart, F.-X., Pickart, L., Laurent, M., Gillery, P., Monboisse, J.-C., & Borel, J.-P. (1988). Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu²⁺. Biochemical and Biophysical Research Communications, 238(2), 343-346. https://sci-hub.ru/10.1016/0014-5793(88)80509-X
⁵ Google it and add Reddit and various forums to the key-words
⁶Siméon, A., Emonard, H., Hornebeck, W., & Maquart, F.-X. (2000). The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu²⁺ stimulates matrix metalloproteinase-2 expression by fibroblast cultures. Life Sciences, 67(20), 2257-2265. https://sci-hub.ru/10.1016/S0024-3205(00)00803-1
⁷ Pickart, L. R. (1992). Method of using copper(II) containing compounds to accelerate wound healing (U.S. Patent No. 5164367). U.S. Patent and Trademark Office. https://patentimages.storage.googleapis.com/28/c1/c7/6fb3bbcf61becb/US5164367.pdf
⁸Liu, T., Hu, L., Lu, B., Bo, Y., Liao, Y., Zhan, J., Pei, Y., Sun, H., Wang, Z., Guo, C., & Zhang, J. (2023). A novel delivery vehicle for copper peptides. New Journal of Chemistry https://pubs.rsc.org/en/content/articlelanding/2023/nj/d2nj04282g#fn1
⁹L. Pickart, in BioIogy of Copper Complexes, J. R. C. Sorenson, Ed., Human Press, Clifton, NJ, 1987, pp. 273-285 (https://library.lol/main/04A4B0236383B58B30E1AF569542355F), neurogenesis also mentionned here¹⁰
¹⁰Antholine, W. E., Petering, D. H., & Pickart, L. (1989). ESR studies of the interaction of copper(II) GHK, histidine, and Ehrlich cells. Journal of Inorganic Biochemistry, 35(2), U-224
¹¹Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2012). The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: Implications for cognitive health. Oxidative Medicine and Cellular Longevity, 2012, Article ID 324832. https://doi.org/10.1155/2012/324832

Why is this thread so high and low effort at the same time :forcedsmile:

Subway surfers caught me off guard :lul:
 
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bookmarked, will read later
already know that its a good thread
make looksmax section great again
 
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This forum is eventually gonna make me eat uranium if the thread sounds smart enough
 
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@CoreSchizo how is ur injectable ghk cu
 
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well, if it was any good, it would have been more monetized and marketed
 
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Stickied, gonna jab roasties with this so they get hot again
 
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I HAVE OBSERVED YOU FOR A WHILE…





I MUST SAY YOU ARE VERY INTELLIGENT…





FROM THE WAY YOU PRESENT YOURSELF TO HOW YOU FORMULATE YOU’RE WORDS…





YOU ARE THE DEFINITION OF CHAD AND AN INSPIRATION TO US ALL…





THANK YOU ❤️
 
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another banger, will read every molecule :feelsmage:
 
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High quality. I personally never experienced any injection pain with mine.
 
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Literally just before I opened .org I was watching this video. Idk how people still just mindlessly inject it when you get this bad of a reaction:



With the two vials I had I thought I’d try bac water in the first one and leave the second one until your thread came out (coincidentally I only reconstituted an hour before you made this thread) and see if I’d reap any benefits.

I’ll order PBS and use it for the second vial though.

What do you think about buying topical creams/serums from a website like this?



Is it just overpriced rubbish?
 
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High IQ thread, read every word.
Screenshot 2024 11 03 at 102701PM
 
Last edited:
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I HAVE OBSERVED YOU FOR A WHILE…





I MUST SAY YOU ARE VERY INTELLIGENT…





FROM THE WAY YOU PRESENT YOURSELF TO HOW YOU FORMULATE YOU’RE WORDS…





YOU ARE THE DEFINITION OF CHAD AND AN INSPIRATION TO US ALL…






THANK YOU ❤️
yeah take the cock out your mouth
 
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This shit sounds like too much work just for a faster recovery ngl prob not gonna do it
 
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Mirin bhai , will read later . Bookmarked though
 
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GHK-Cu, on paper, seems to be the single best looksmaxxing compound there is (perfect skin, anti-aging, surgery recovery, neurogenesis,¹¹ etc)¹, yet no one seems to be reaping any of its benefits. What’s even more bizarre is that injection-related pain is massively reported, more consistently so than its supposed benefits².

a white cat is sitting on a box with the words `` why '' written on it .'' written on it .




Quickly, Glycyl-L-histidyl-L-lysine (GHK) is a tripeptide isolated from human plasma³, which possesses a high affinity for copper (II) ions, with which it spontaneously forms a complex (GHK-Cu). GHK alone has been shown to be responsible for the collagen boost⁴ and no injection-related pain has been reported with it⁵, so go for it if you want but it's the added copper that is responsible for this myriad of blessings;

EXAMPLES :
The complex, unlike GHK alone, helps activate matrix metalloproteinases, which break down damaged tissue so it can be replaced with healthy tissue⁶.


View attachment 3275853

OR

Compositions of copper (II) containing compounds have been show to accelerate the healing of wounds in warm-blooded animals, and more specifically the systemic loading of copper (II) compounds to accelerate the rate of wound healing following injury or surgery to warm-blooded animals.⁷


View attachment 3275859


; ...and consequently what seems to cause tissue damage during injection.


If we look at the cayman chemicals reviews of the molecules in question :



View attachment 3275820View attachment 3275821


The main differences are the addition of a copper atom and a significantly worse solubility profile, which suggests a causal relationship between these two differences (meaning that the added copper induces the worse solubility).

In fact, we know that metals are gay

Gay meaning they have different bonding properties vs carbon, oxygen, etc (this whole field of gay metals is “inorganic chemistry”) The reason for this is that metals basically have up to ten relevant electrons , which have comically complex geometries, are much larger (radius) and less bound to the nucelus

View attachment 3275870

Simply, they like to move a lot, they're playful building blocks that like to change and mix :heart:, while other atoms are stronger and stick together better, 🥺 other atoms, like those in water or air, are like super strong blocks that hold together really well🍆. They don’t like to change as much, so they are usually more stable. :eek:




Seriously, metals require ions to stabilize in various contexts, primarily due to their tendency to lose electrons and form positive charges, the ions in PBS can neutralize the positive charge of the copper ions, reducing the likelihood of oxidation or other reactions that would destabilize the copper. PBS also maintains a stable pH, which is important for keeping copper in its soluble form. In bac water or regular saline, changes in pH can lead to precipitation or oxidation of copper ions. (5 to 7 for bac and reg saline vs 7.2 to 7.4 for Phosphate Buffered Saline)

Hence why GHK-Cu needs PBS (again because the ionic solution (has a lot of ions) stabilizes the added copper), otherwise the copper-nitrogen bonds are likely to break.
View attachment 3276079


The common folk seems to be dissolving GHK-Cu in Bac Water since that is the usual commercially available and promoted solvent for peptides².
However, Bac Water has a lower ion concentration than PBS (which makes the copper less likely to be stable), I hypothesize that the pain comes from the free copper atoms raping your tissues (not fully understood).


View attachment 3275864

Injection solutions :

Phosphate Buffered Saline :


View attachment 3275998


View attachment 3276003


View attachment 3276026


i.e. what is mostly used in studies and what is recommended by CaymanChem

Making PBS at home looks annoying af so just fucking buy it : https://www.sigmaaldrich.com/US/en/product/sigma/d8537

WORKS AND STABLE




Normale saline (0.9% saline) :


Direct on-site injection tho

View attachment 3276031


View attachment 3276018View attachment 3276019

WORKS BUT THEORETICALLY NOT STABLE, since the PH will be too low

You'd need to adjsut it yourself⁷


View attachment 3276064

BAC WATER :

DOESN'T WORK (YOU ONLY GET GHK AND INJECTION SITE DAMAGE)²





Topical :

Topical formulations of GHKcu have been developed and are effective

BetTar:

The best one (both low-cost, most effective and most stable) being Bet Tar which is a recent (2023) chinese developped ionic-liquid-based delivery vehicle composed of betaine and tartaric acid
https://external-content.duckduckgo.com/iu/?u=https%3A%2F%2Fmedia1.tenor.com%2Fm%2F_ylM1V0OJlIAAAAC%2Fdonald-trump-talking.gif&f=1&nofb=1&ipt=7ecca7ab4663a5d1e0dd8f1ccd4a7e406e04e4a17d62f94524b064be533188e0&ipo=images


View attachment 3276085

View attachment 3276086
View attachment 3276090

Stable as fuck :
View attachment 3276087

PDI is dispersity

I will be attaching the papers⁸ in case President Xi takes them down


Hyaluronic acid-based hydrogel embedded with GHK peptide nanofibers : ( :lul: )

Works af for direct wound healing


View attachment 3276113

YES BRO I WILL TOTALLY MAKE THIS jfl

View attachment 3276114


THERE ARE 8 BILLION GOOD TOPICAL ways but WE CAN NOT MAKE/BUY any of these

This was good for wound closure but go figure how they made it

View attachment 3276058View attachment 3276117

Concering DMSO :

IT DOESN'T WORK (IT'S EVEN LESS STABLE THAN BAC WATER since it has less ions (water (bac water) has H+ and OH- (water)))

These niggas tried to study its structure while dissolving it in DMSO¹⁰ : https://sci-hub.ru/10.1016/0162-0134(89)84011-5, which gave them completly retarded results "under their conditions"

Metals in general seem to be struggling in DMSO

View attachment 3276159

Goodluck rabbitholemaxxing this :lul:








TLDR :



- RECONSTITUTE GHK-Cu IN PBS or DPBS (which you can buy) and inject it daily

- BUY and RECONSTITUTE GHK IN BAC WATER IF YOU ONLY WANT COLLAGEN BOOST AND EASE OF USE and inject it daily

- TRY TO MAKE a [Bet] [Tar] GHK-Cu Topical Liquid Solution, if you want, for when you can't inject or as first-aid





@Hexmask @N1666 @Clavicular @NorwoodAscender @meathead



¹Pickart, L., & Margolina, A. (2018). Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International Journal of Molecular Sciences, 19(7), https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/pdf/ijms-19-01987.pdf
²
³Pickart L, Thaler MM. Tripeptide in human serum which prolongs survival of normal liver cells and stimulates growth in neoplastic liver. Nat New Biol. 1973 May 16;243(124):85-7. PMID: 4349963.
⁴Maquart, F.-X., Pickart, L., Laurent, M., Gillery, P., Monboisse, J.-C., & Borel, J.-P. (1988). Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu²⁺. Biochemical and Biophysical Research Communications, 238(2), 343-346. https://sci-hub.ru/10.1016/0014-5793(88)80509-X
⁵ Google it and add Reddit and various forums to the key-words
⁶Siméon, A., Emonard, H., Hornebeck, W., & Maquart, F.-X. (2000). The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu²⁺ stimulates matrix metalloproteinase-2 expression by fibroblast cultures. Life Sciences, 67(20), 2257-2265. https://sci-hub.ru/10.1016/S0024-3205(00)00803-1
⁷ Pickart, L. R. (1992). Method of using copper(II) containing compounds to accelerate wound healing (U.S. Patent No. 5164367). U.S. Patent and Trademark Office. https://patentimages.storage.googleapis.com/28/c1/c7/6fb3bbcf61becb/US5164367.pdf
⁸Liu, T., Hu, L., Lu, B., Bo, Y., Liao, Y., Zhan, J., Pei, Y., Sun, H., Wang, Z., Guo, C., & Zhang, J. (2023). A novel delivery vehicle for copper peptides. New Journal of Chemistry https://pubs.rsc.org/en/content/articlelanding/2023/nj/d2nj04282g#fn1
⁹L. Pickart, in BioIogy of Copper Complexes, J. R. C. Sorenson, Ed., Human Press, Clifton, NJ, 1987, pp. 273-285 (https://library.lol/main/04A4B0236383B58B30E1AF569542355F), neurogenesis also mentionned here¹⁰
¹⁰Antholine, W. E., Petering, D. H., & Pickart, L. (1989). ESR studies of the interaction of copper(II) GHK, histidine, and Ehrlich cells. Journal of Inorganic Biochemistry, 35(2), U-224
¹¹Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2012). The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: Implications for cognitive health. Oxidative Medicine and Cellular Longevity, 2012, Article ID 324832. https://doi.org/10.1155/2012/324832

Interesting. There's far more potent compounds as EGF thought
 
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love u

smartest user by far
 
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the goat has posted
reading every element
 
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Btw you should take zinc alongside copper peptides

And ghkcu totally kills your IGF1 which is unfortunate
 
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Btw you should take zinc alongside copper peptides

And ghkcu totally kills your IGF1 which is unfortunate
Topical is potentially an option but efficacy may be less
 
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I also advocate for 0.75mm+ depth microneedling with topicals for greater dermal absorption, I saw in one study on novel hair loss preventative agents that when small holes are made into the epidermis/dermis it increases the absorption of topicals, this should apply for peptides as well (also helps because peptides have larger molweights so the skin is harder to penetrate for them)
 
this stuff gives you cancer
 
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bookmarked. will read every molecule.
 
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G
GHK-Cu, on paper, seems to be the single best looksmaxxing compound there is (perfect skin, anti-aging, surgery recovery, neurogenesis,¹¹ etc)¹, yet no one seems to be reaping any of its benefits. What’s even more bizarre is that injection-related pain is massively reported, more consistently so than its supposed benefits².

a white cat is sitting on a box with the words `` why '' written on it .'' written on it .




Quickly, Glycyl-L-histidyl-L-lysine (GHK) is a tripeptide isolated from human plasma³, which possesses a high affinity for copper (II) ions, with which it spontaneously forms a complex (GHK-Cu). GHK alone has been shown to be responsible for the collagen boost⁴ and no injection-related pain has been reported with it⁵, so go for it if you want but it's the added copper that is responsible for this myriad of blessings;

EXAMPLES :
The complex, unlike GHK alone, helps activate matrix metalloproteinases, which break down damaged tissue so it can be replaced with healthy tissue⁶.


View attachment 3275853

OR

Compositions of copper (II) containing compounds have been show to accelerate the healing of wounds in warm-blooded animals, and more specifically the systemic loading of copper (II) compounds to accelerate the rate of wound healing following injury or surgery to warm-blooded animals.⁷


View attachment 3275859


; ...and consequently what seems to cause tissue damage during injection.


If we look at the cayman chemicals reviews of the molecules in question :



View attachment 3275820View attachment 3275821


The main differences are the addition of a copper atom and a significantly worse solubility profile, which suggests a causal relationship between these two differences (meaning that the added copper induces the worse solubility).

In fact, we know that metals are gay

Gay meaning they have different bonding properties vs carbon, oxygen, etc (this whole field of gay metals is “inorganic chemistry”) The reason for this is that metals basically have up to ten relevant electrons , which have comically complex geometries, are much larger (radius) and less bound to the nucelus

View attachment 3275870

Simply, they like to move a lot, they're playful building blocks that like to change and mix :heart:, while other atoms are stronger and stick together better, 🥺 other atoms, like those in water or air, are like super strong blocks that hold together really well🍆. They don’t like to change as much, so they are usually more stable. :eek:




Seriously, metals require ions to stabilize in various contexts, primarily due to their tendency to lose electrons and form positive charges, the ions in PBS can neutralize the positive charge of the copper ions, reducing the likelihood of oxidation or other reactions that would destabilize the copper. PBS also maintains a stable pH, which is important for keeping copper in its soluble form. In bac water or regular saline, changes in pH can lead to precipitation or oxidation of copper ions. (5 to 7 for bac and reg saline vs 7.2 to 7.4 for Phosphate Buffered Saline)

Hence why GHK-Cu needs PBS (again because the ionic solution (has a lot of ions) stabilizes the added copper), otherwise the copper-nitrogen bonds are likely to break.
View attachment 3276079


The common folk seems to be dissolving GHK-Cu in Bac Water since that is the usual commercially available and promoted solvent for peptides².
However, Bac Water has a lower ion concentration than PBS (which makes the copper less likely to be stable), I hypothesize that the pain comes from the free copper atoms raping your tissues (not fully understood).


View attachment 3275864

Injection solutions :

Phosphate Buffered Saline :


View attachment 3275998


View attachment 3276003


View attachment 3276026


i.e. what is mostly used in studies and what is recommended by CaymanChem

Making PBS at home looks annoying af so just fucking buy it : https://www.sigmaaldrich.com/US/en/product/sigma/d8537

WORKS AND STABLE




Normale saline (0.9% saline) :


Direct on-site injection tho

View attachment 3276031


View attachment 3276018View attachment 3276019

WORKS BUT THEORETICALLY NOT STABLE, since the PH will be too low

You'd need to adjsut it yourself⁷


View attachment 3276064

BAC WATER :

DOESN'T WORK (YOU ONLY GET GHK AND INJECTION SITE DAMAGE)²





Topical :

Topical formulations of GHKcu have been developed and are effective

BetTar:

The best one (both low-cost, most effective and most stable) being Bet Tar which is a recent (2023) chinese developped ionic-liquid-based delivery vehicle composed of betaine and tartaric acid
https://external-content.duckduckgo.com/iu/?u=https%3A%2F%2Fmedia1.tenor.com%2Fm%2F_ylM1V0OJlIAAAAC%2Fdonald-trump-talking.gif&f=1&nofb=1&ipt=7ecca7ab4663a5d1e0dd8f1ccd4a7e406e04e4a17d62f94524b064be533188e0&ipo=images


View attachment 3276085

View attachment 3276086
View attachment 3276090

Stable as fuck :
View attachment 3276087

PDI is dispersity

I will be attaching the papers⁸ in case President Xi takes them down


Hyaluronic acid-based hydrogel embedded with GHK peptide nanofibers : ( :lul: )

Works af for direct wound healing


View attachment 3276113

YES BRO I WILL TOTALLY MAKE THIS jfl

View attachment 3276114


THERE ARE 8 BILLION GOOD TOPICAL ways but WE CAN NOT MAKE/BUY any of these

This was good for wound closure but go figure how they made it

View attachment 3276058View attachment 3276117

Concering DMSO :

IT DOESN'T WORK (IT'S EVEN LESS STABLE THAN BAC WATER since it has less ions (water (bac water) has H+ and OH- (water)))

These niggas tried to study its structure while dissolving it in DMSO¹⁰ : https://sci-hub.ru/10.1016/0162-0134(89)84011-5, which gave them completly retarded results "under their conditions"

Metals in general seem to be struggling in DMSO

View attachment 3276159

Goodluck rabbitholemaxxing this :lul:








TLDR :



- RECONSTITUTE GHK-Cu IN PBS or DPBS (which you can buy) and inject it daily

- BUY and RECONSTITUTE GHK IN BAC WATER IF YOU ONLY WANT COLLAGEN BOOST AND EASE OF USE and inject it daily

- TRY TO MAKE a [Bet] [Tar] GHK-Cu Topical Liquid Solution, if you want, for when you can't inject or as first-aid





@Hexmask @N1666 @Clavicular @NorwoodAscender @meathead



¹Pickart, L., & Margolina, A. (2018). Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International Journal of Molecular Sciences, 19(7), https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/pdf/ijms-19-01987.pdf
²
³Pickart L, Thaler MM. Tripeptide in human serum which prolongs survival of normal liver cells and stimulates growth in neoplastic liver. Nat New Biol. 1973 May 16;243(124):85-7. PMID: 4349963.
⁴Maquart, F.-X., Pickart, L., Laurent, M., Gillery, P., Monboisse, J.-C., & Borel, J.-P. (1988). Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu²⁺. Biochemical and Biophysical Research Communications, 238(2), 343-346. https://sci-hub.ru/10.1016/0014-5793(88)80509-X
⁵ Google it and add Reddit and various forums to the key-words
⁶Siméon, A., Emonard, H., Hornebeck, W., & Maquart, F.-X. (2000). The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu²⁺ stimulates matrix metalloproteinase-2 expression by fibroblast cultures. Life Sciences, 67(20), 2257-2265. https://sci-hub.ru/10.1016/S0024-3205(00)00803-1
⁷ Pickart, L. R. (1992). Method of using copper(II) containing compounds to accelerate wound healing (U.S. Patent No. 5164367). U.S. Patent and Trademark Office. https://patentimages.storage.googleapis.com/28/c1/c7/6fb3bbcf61becb/US5164367.pdf
⁸Liu, T., Hu, L., Lu, B., Bo, Y., Liao, Y., Zhan, J., Pei, Y., Sun, H., Wang, Z., Guo, C., & Zhang, J. (2023). A novel delivery vehicle for copper peptides. New Journal of Chemistry https://pubs.rsc.org/en/content/articlelanding/2023/nj/d2nj04282g#fn1
⁹L. Pickart, in BioIogy of Copper Complexes, J. R. C. Sorenson, Ed., Human Press, Clifton, NJ, 1987, pp. 273-285 (https://library.lol/main/04A4B0236383B58B30E1AF569542355F), neurogenesis also mentionned here¹⁰
¹⁰Antholine, W. E., Petering, D. H., & Pickart, L. (1989). ESR studies of the interaction of copper(II) GHK, histidine, and Ehrlich cells. Journal of Inorganic Biochemistry, 35(2), U-224
¹¹Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2012). The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: Implications for cognitive health. Oxidative Medicine and Cellular Longevity, 2012, Article ID 324832. https://doi.org/10.1155/2012/324832

Good thread
 
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thanks for the write-up, mirin the knowledge & effort :Comfy:
 
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yes, way too expensive for prolly 0 effects or like 0.1%




bump @TechnoBoss @edodalic29 @DORIAN @MA_ascender @Magnum Opus
How do you tell if something you haven't tried is too expensive? Be it skincare or an education course.

Interesting thread, bit too complex in terms of it being productive, I would be lying if I understood anything I skimmed past on what you are explaining. However that's an issue I find with most looksmaxxing on a-certain-topic thread, it's why @enchanted_elixir is seen as an autistic mong to most. Or that scene when seeing @pneumocystosis's draw be more stacked than the local pharmacy and Patrick Bateman combined. Just jfl and not the way to live.

I wonder if users who write topics like these come from a dermatology or chemistry (at the very least) background?..

If so, all my credit where credits due. Nice try mate.

[edit]
Only had few hours sleep so I'll bookmark and try again.
 
Last edited:
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GHK-Cu, on paper, seems to be the single best looksmaxxing compound there is (perfect skin, anti-aging, surgery recovery, neurogenesis,¹¹ etc)¹, yet no one seems to be reaping any of its benefits. What’s even more bizarre is that injection-related pain is massively reported, more consistently so than its supposed benefits².

a white cat is sitting on a box with the words `` why '' written on it .'' written on it .




Quickly, Glycyl-L-histidyl-L-lysine (GHK) is a tripeptide isolated from human plasma³, which possesses a high affinity for copper (II) ions, with which it spontaneously forms a complex (GHK-Cu). GHK alone has been shown to be responsible for the collagen boost⁴ and no injection-related pain has been reported with it⁵, so go for it if you want but it's the added copper that is responsible for this myriad of blessings;

EXAMPLES :
The complex, unlike GHK alone, helps activate matrix metalloproteinases, which break down damaged tissue so it can be replaced with healthy tissue⁶.


View attachment 3275853

OR

Compositions of copper (II) containing compounds have been show to accelerate the healing of wounds in warm-blooded animals, and more specifically the systemic loading of copper (II) compounds to accelerate the rate of wound healing following injury or surgery to warm-blooded animals.⁷


View attachment 3275859


; ...and consequently what seems to cause tissue damage during injection.


If we look at the cayman chemicals reviews of the molecules in question :



View attachment 3275820View attachment 3275821


The main differences are the addition of a copper atom and a significantly worse solubility profile, which suggests a causal relationship between these two differences (meaning that the added copper induces the worse solubility).

In fact, we know that metals are gay

Gay meaning they have different bonding properties vs carbon, oxygen, etc (this whole field of gay metals is “inorganic chemistry”) The reason for this is that metals basically have up to ten relevant electrons , which have comically complex geometries, are much larger (radius) and less bound to the nucelus

View attachment 3275870

Simply, they like to move a lot, they're playful building blocks that like to change and mix :heart:, while other atoms are stronger and stick together better, 🥺 other atoms, like those in water or air, are like super strong blocks that hold together really well🍆. They don’t like to change as much, so they are usually more stable. :eek:




Seriously, metals require ions to stabilize in various contexts, primarily due to their tendency to lose electrons and form positive charges, the ions in PBS can neutralize the positive charge of the copper ions, reducing the likelihood of oxidation or other reactions that would destabilize the copper. PBS also maintains a stable pH, which is important for keeping copper in its soluble form. In bac water or regular saline, changes in pH can lead to precipitation or oxidation of copper ions. (5 to 7 for bac and reg saline vs 7.2 to 7.4 for Phosphate Buffered Saline)

Hence why GHK-Cu needs PBS (again because the ionic solution (has a lot of ions) stabilizes the added copper), otherwise the copper-nitrogen bonds are likely to break.
View attachment 3276079


The common folk seems to be dissolving GHK-Cu in Bac Water since that is the usual commercially available and promoted solvent for peptides².
However, Bac Water has a lower ion concentration than PBS (which makes the copper less likely to be stable), I hypothesize that the pain comes from the free copper atoms raping your tissues (not fully understood).


View attachment 3275864

Injection solutions :

Phosphate Buffered Saline :


View attachment 3275998


View attachment 3276003


View attachment 3276026


i.e. what is mostly used in studies and what is recommended by CaymanChem

Making PBS at home looks annoying af so just fucking buy it : https://www.sigmaaldrich.com/US/en/product/sigma/d8537

WORKS AND STABLE




Normale saline (0.9% saline) :


Direct on-site injection tho

View attachment 3276031


View attachment 3276018View attachment 3276019

WORKS BUT THEORETICALLY NOT STABLE, since the PH will be too low

You'd need to adjsut it yourself⁷


View attachment 3276064

BAC WATER :

DOESN'T WORK (YOU ONLY GET GHK AND INJECTION SITE DAMAGE)²





Topical :

Topical formulations of GHKcu have been developed and are effective

BetTar:

The best one (both low-cost, most effective and most stable) being Bet Tar which is a recent (2023) chinese developped ionic-liquid-based delivery vehicle composed of betaine and tartaric acid
https://external-content.duckduckgo.com/iu/?u=https%3A%2F%2Fmedia1.tenor.com%2Fm%2F_ylM1V0OJlIAAAAC%2Fdonald-trump-talking.gif&f=1&nofb=1&ipt=7ecca7ab4663a5d1e0dd8f1ccd4a7e406e04e4a17d62f94524b064be533188e0&ipo=images


View attachment 3276085

View attachment 3276086
View attachment 3276090

Stable as fuck :
View attachment 3276087

PDI is dispersity

I will be attaching the papers⁸ in case President Xi takes them down


Hyaluronic acid-based hydrogel embedded with GHK peptide nanofibers : ( :lul: )

Works af for direct wound healing


View attachment 3276113

YES BRO I WILL TOTALLY MAKE THIS jfl

View attachment 3276114


THERE ARE 8 BILLION GOOD TOPICAL ways but WE CAN NOT MAKE/BUY any of these

This was good for wound closure but go figure how they made it

View attachment 3276058View attachment 3276117

Concering DMSO :

IT DOESN'T WORK (IT'S EVEN LESS STABLE THAN BAC WATER since it has less ions (water (bac water) has H+ and OH- (water)))

These niggas tried to study its structure while dissolving it in DMSO¹⁰ : https://sci-hub.ru/10.1016/0162-0134(89)84011-5, which gave them completly retarded results "under their conditions"

Metals in general seem to be struggling in DMSO

View attachment 3276159

Goodluck rabbitholemaxxing this :lul:








TLDR :



- RECONSTITUTE GHK-Cu IN PBS or DPBS (which you can buy) and inject it daily

- BUY and RECONSTITUTE GHK IN BAC WATER IF YOU ONLY WANT COLLAGEN BOOST AND EASE OF USE and inject it daily

- TRY TO MAKE a [Bet] [Tar] GHK-Cu Topical Liquid Solution, if you want, for when you can't inject or as first-aid





@Hexmask @N1666 @Clavicular @NorwoodAscender @meathead



¹Pickart, L., & Margolina, A. (2018). Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International Journal of Molecular Sciences, 19(7), https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/pdf/ijms-19-01987.pdf
²
³Pickart L, Thaler MM. Tripeptide in human serum which prolongs survival of normal liver cells and stimulates growth in neoplastic liver. Nat New Biol. 1973 May 16;243(124):85-7. PMID: 4349963.
⁴Maquart, F.-X., Pickart, L., Laurent, M., Gillery, P., Monboisse, J.-C., & Borel, J.-P. (1988). Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu²⁺. Biochemical and Biophysical Research Communications, 238(2), 343-346. https://sci-hub.ru/10.1016/0014-5793(88)80509-X
⁵ Google it and add Reddit and various forums to the key-words
⁶Siméon, A., Emonard, H., Hornebeck, W., & Maquart, F.-X. (2000). The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu²⁺ stimulates matrix metalloproteinase-2 expression by fibroblast cultures. Life Sciences, 67(20), 2257-2265. https://sci-hub.ru/10.1016/S0024-3205(00)00803-1
⁷ Pickart, L. R. (1992). Method of using copper(II) containing compounds to accelerate wound healing (U.S. Patent No. 5164367). U.S. Patent and Trademark Office. https://patentimages.storage.googleapis.com/28/c1/c7/6fb3bbcf61becb/US5164367.pdf
⁸Liu, T., Hu, L., Lu, B., Bo, Y., Liao, Y., Zhan, J., Pei, Y., Sun, H., Wang, Z., Guo, C., & Zhang, J. (2023). A novel delivery vehicle for copper peptides. New Journal of Chemistry https://pubs.rsc.org/en/content/articlelanding/2023/nj/d2nj04282g#fn1
⁹L. Pickart, in BioIogy of Copper Complexes, J. R. C. Sorenson, Ed., Human Press, Clifton, NJ, 1987, pp. 273-285 (https://library.lol/main/04A4B0236383B58B30E1AF569542355F), neurogenesis also mentionned here¹⁰
¹⁰Antholine, W. E., Petering, D. H., & Pickart, L. (1989). ESR studies of the interaction of copper(II) GHK, histidine, and Ehrlich cells. Journal of Inorganic Biochemistry, 35(2), U-224
¹¹Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2012). The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: Implications for cognitive health. Oxidative Medicine and Cellular Longevity, 2012, Article ID 324832. https://doi.org/10.1155/2012/324832

Will be reading after my appointment but already seems like a mirin thread:love:
 
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Read every single molecule , good thread bhai:love:
 
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blah blah blah where do I buy the damn thing ffs
 
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yall niggas dumb if you can’t understand this.

thank fuck ghk-cu injectable will never be widely used. improved my skin quality within days of using and got comments on it having improved so ik it’s not placebo. the other benefits are nice too
 
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yall niggas dumb if you can’t understand this.

thank fuck ghk-cu injectable will never be widely used. improved my skin quality within days of using and got comments on it having improved so ik it’s not placebo. the other benefits are nice too
Whats your source? I am looking for one in EU that is lab tested...
 
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