BrahminBoss
I drink YOUR milkshake 🥤
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After reading about folate receptor autoantibodies I won't ever consume cow's milk again, but the goat sequence has less homology and doesn't bind to the human autoantibodies. Besides the reduced potency of goat casomorphins, this represents another reason to consume goat dairy (if you can find it). Although milk is indisputably the 'perfect food' for mammals, it cannot be argued that the cow is a different species and milk is purposefully resistant to digestion—two considerations prerequisite for autoantibody formation.
Folate receptor autoantibodies will make you forget all about the casomorphins, literally. The choroid plexus is where all brain folate is absorbed, and the obligatory receptors are ~88% similar to proteins found in bovine milk. This occurs because membrane folate receptors are often cleaved-off, making for a slightly-shorter yet otherwise identical version in the plasma. These are also found in milk in high concentrations, and represent the autoantigen for folate receptor autoantibodies.
These autoantibodies bind the brain folate receptor, making the primary transporter reduced in function. Brain folate is necessary for dNA synthesis, myelination, and some neurotransmitters (i.e. norepinephrine; melatonin).The antidote for these autoantibodies is simply tetrahydrofolate, 5-methylated or otherwise, and the far more common folic acid will not do. This oxidized form normally goes through the folate receptor now blocked by the autoantibody. The electronically-reduced folates are needed to counteract this by bypassing the folate receptor (FR1) though the reduced folate carrier (RFC1), also found on the choroid plexus.
Folate receptor autoantibodies will make you forget all about the casomorphins, literally. The choroid plexus is where all brain folate is absorbed, and the obligatory receptors are ~88% similar to proteins found in bovine milk. This occurs because membrane folate receptors are often cleaved-off, making for a slightly-shorter yet otherwise identical version in the plasma. These are also found in milk in high concentrations, and represent the autoantigen for folate receptor autoantibodies.
These autoantibodies bind the brain folate receptor, making the primary transporter reduced in function. Brain folate is necessary for dNA synthesis, myelination, and some neurotransmitters (i.e. norepinephrine; melatonin).The antidote for these autoantibodies is simply tetrahydrofolate, 5-methylated or otherwise, and the far more common folic acid will not do. This oxidized form normally goes through the folate receptor now blocked by the autoantibody. The electronically-reduced folates are needed to counteract this by bypassing the folate receptor (FR1) though the reduced folate carrier (RFC1), also found on the choroid plexus.