low dosing aspirin makes 0 sense

[Deleted member 373233]

Okay, Ray Peat has done and said a lot of things right, but his theory about aspirin seems incredibly illogical. All the evidence suggests that the principle “low-dose aspirin activates AMPK → autophagy → longevity” is simply not true. According to the papers, AMPK activation requires ≥1 mmol/L of salicylate in plasma; 75–100 mg of aspirin, for example, achieves 0.03 mmol/L. Low-dose aspirin doubles the risk of upper GI bleeding (from ~0.5–1% to ~1–2% per year), increases hemorrhagic strokes by 30–60%, can cause subclinical anemia, and interacts with numerous medications. For secondary prevention, aspirin makes logical sense, but the need for it simply doesn’t exist in 99% of people at these low doses.

Pretty silly, in my opinion, for longevity—or have I overlooked something here?

 

[fraudster#1]

Okay, Ray Peat has done and said a lot of things right, but his theory about aspirin seems incredibly illogical. All the evidence suggests that the principle “low-dose aspirin activates AMPK → autophagy → longevity” is simply not true. According to the papers, AMPK activation requires ≥1 mmol/L of salicylate in plasma; 75–100 mg of aspirin, for example, achieves 0.03 mmol/L. Low-dose aspirin doubles the risk of upper GI bleeding (from ~0.5–1% to ~1–2% per year), increases hemorrhagic strokes by 30–60%, can cause subclinical anemia, and interacts with numerous medications. For secondary prevention, aspirin makes logical sense, but the need for it simply doesn’t exist in 99% of people at these low doses.

Pretty silly, in my opinion, for longevity—or have I overlooked something here?

DNR+ get mogged by aspirin edit from ttk

 

[Deleted member 373233]

DNR+ get mogged by aspirin edit from ttk