morticious
Iron
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- Dec 12, 2021
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Alongside its skin-lightening (and somewhat eye-lightening for myself and some others on the internet) properties, MSM is also used as a supplement to help with skin and hair health. It's also good for the joints and can help keep morning height throughout the day. However, I recently saw this post that scared the shit out of me. I'm trying to maximize my puberty, and glucosamine and MSM are commonly used in conjunction with each other. What if MSM had similar IGF-1 blocking effects?
Luckily, I was proven wrong. In this study by some South Korean researchers, "MSM was not toxic to osteoblastic cells and MSCs. MSM increased the expression of GH-related proteins including IGF-1R, p-IGF-1R, STAT5b, p-STAT5b, and Jak2 in osteoblastic cells and MSCs. MSM increased IGF-1R and GHR mRNA expression in osteoblastic cells." They also found that "MSM and GH, separately or in combination, activated GH signaling via the Jak2/STAT5b pathway in UMR-106 cells."
Their conclusion was that "MSM increased ALP activity and the mineralization of MSCs. Taken together, these results indicated that MSM can promote osteogenic differentiation of MSCs through activation of STAT5b." This is important as MSCs are Mesenchymal stem cells, which "are multipotent stem cells found in bone marrow that are important for making and repairing skeletal tissues, such as cartilage, bone and the fat found in bone marrow."
Alongside this, another study by Korean researchers from Konkuk University investigated MSM's effects on how MSM reduces the negative effect of the stress hormone cortisol on muscle cells. The researchers exposed muscle cells to cortisol and 50 millimoles of MSM and looked at the effect on p53, SDHA, and HPRT1.
And yes: MSM blocked the effects of cortisol.
While the results from these studies aren't proven to be drastic, with all of its other benefits, I don't see why more people don't take MSM. Just try it! Personally, I take 5g daily.
Open to any differentiating opinions, we can discuss!
Luckily, I was proven wrong. In this study by some South Korean researchers, "MSM was not toxic to osteoblastic cells and MSCs. MSM increased the expression of GH-related proteins including IGF-1R, p-IGF-1R, STAT5b, p-STAT5b, and Jak2 in osteoblastic cells and MSCs. MSM increased IGF-1R and GHR mRNA expression in osteoblastic cells." They also found that "MSM and GH, separately or in combination, activated GH signaling via the Jak2/STAT5b pathway in UMR-106 cells."
Their conclusion was that "MSM increased ALP activity and the mineralization of MSCs. Taken together, these results indicated that MSM can promote osteogenic differentiation of MSCs through activation of STAT5b." This is important as MSCs are Mesenchymal stem cells, which "are multipotent stem cells found in bone marrow that are important for making and repairing skeletal tissues, such as cartilage, bone and the fat found in bone marrow."
Alongside this, another study by Korean researchers from Konkuk University investigated MSM's effects on how MSM reduces the negative effect of the stress hormone cortisol on muscle cells. The researchers exposed muscle cells to cortisol and 50 millimoles of MSM and looked at the effect on p53, SDHA, and HPRT1.
And yes: MSM blocked the effects of cortisol.
While the results from these studies aren't proven to be drastic, with all of its other benefits, I don't see why more people don't take MSM. Just try it! Personally, I take 5g daily.
Open to any differentiating opinions, we can discuss!
