The Cure For Hair Loss - The Truth About 5α-Reductase Inhibitors and Topical Anti-Androgens

[Godera]

Do i have to worry about hairloss if i want to become roided superhuman but take fin/dut + min

 

[whitestacyslayer]

View attachment 3683815

The Cure For Hair Loss - The Truth about 5α-Reductase Inhibitors and Topical Anti-Androgens - Part 2
(excuse the shit formatting, I don't normally write threads, so I can't format for shit)

What does this thread include?

Spoiler

In this thread I will be covering the different treatments depending on your age and situation for hair loss, as well as what impact each of these drugs will have on your development.

1) Introduction
2) Why are you balding in the first place?
3) What can we do about DHT at the scalp?
4) Distinguishing between Type 1 isoenzyme and Type 2 isoenzyme
5) Should I be worried about side effects from FInasteride?
6) Hair loss treatment if you are over 18
7) Hair loss treatment if you are under 18
8) What do do if you still experience hair loss on 5α-Reductase inhibitors
9) Is RU58841 safe for use, since it's a research chemical
10) How to make RU58841 solution
11) Drug dosages

Introduction.

Spoiler

We all know, hair is life, if you have no hair, you have no life.

Once you down the rabbit hole of finding a "cure" for hair loss, you will find that you have only 2 real options in term of halting the actual hair loss itself. Those options would be Finasteride/Dutasteride (5α-Reductase inhibitor) or research produces like ru58841. In this thread I will go into depth about these, and which one people should use depending on their situation, or if they should use one at all.

Why are you balding in the first place?

Spoiler

The vast majority of men go bald because of a hereditary condition called Androgenic Alopecia (AGA). Unfortunately, the number of men that do not have condition are in the minority, so do not assume that you are safe from the norwood reaper, ever. Everyone's hair follicles has a different sensitivity to androgens. The androgens binding to the hair follicles will make the Anagen phase shorter and shorter until a permanent state of anagen phase is present and the hair follicle is deactivated. The strongest hormone that shorten the Anagen phase is DHT (dihydrotestosteron) and Testosterone. Some woman are so sensitive to DHT and Testosterone that the small amount they produce is sufficient enough to cause hair loss.

What can we do about DHT at the scalp?

Spoiler

As I mentioned above, there is a very limited number of things we can do to combat this, however using the protocols I will outline in this thread will leave you having you hair for life. First we have to take care of the main androgen in causing hair loss, which already outlined above, is DHT. There is only one safe way to decrease the amount of DHT in your body, and that is taking a 5α-Reductase inhibitor such as Finasteride or Dutasteride. In taking on of these 5α-Reductase inhibitors, we are systematically decreasing the amount of DHT in out body, and subsequently decreasing the amount of scalp DHT we have, which is what we want to reduce as much as possible. I will outline which is best to take for each individual, since it's dependant on your age, if you use certain compounds to "pubertymaxx" etc.

Will 5α-Reductase inhibitors stunt bone development?

Spoiler

Is taking 5α-Reductase inhibitors going to keep you boneless forever? Lets find out.

Study:

Spoiler

Normal bone density in male pseudohermaphroditism due to 5alpha- reductase 2 deficiency - PubMed

Patients with dihydrotestosterone deficiency present normal bone mineral density, suggesting that dihydrotestosterone is not the main androgen acting in bone.

pubmed.ncbi.nlm.nih.gov

Results: Patients with dihydrotestosterone deficiency present normal bone mineral density, suggesting that dihydrotestosterone is not the main androgen acting in bone.

Study:

Spoiler

5α-reductase-2 Deficiency’s Effect on Human Fertility - PMC

A most interesting and intriguing male disorder of sexual differentiation is due to 5α-reductase-2 isoenzyme deficiency. These males are born with ambiguous external genitalia due to a deficiency in their ability to catalyze the conversion of ...

pmc.ncbi.nlm.nih.gov

Results:
View attachment 3683851

The two guys on the left have 0 DHT (literally) and they still have a normal bone structure and an identical height, bone density and skeletal mass to their healthy siblings, it have a higher binding affinity to the androgen receptor but it doesn't cause the same physiological response.
The pubertal growth spurt (for men) is also induced by testosterone and not DHT.

Also 5AR is not very active in bone tissues and DHT is mainly a paracrine hormone (i.e it acts where it's produced while testosterone acts on the whole body despite being produced in the testes).

So, does that mean we should all just take the strongest 5α-Reductase inhibitor (Dutasteride) and call it a day? Well, no. First we have to distinguish between the two forms of DHT, as these studies to not distinguish between them, so it is not the full picture.

Distinguishing between Type 1 isoenzyme and Type 1 isoenzyme.

Both these studies show that DHT doesn't have an effect on bones, right? So, we should all just take Dutasteride? Wrong.

These studies have not differentiated between type 1 isoenzyme, and type 2 isoenzyme.

So, first we have to see where type 1 DHT and type 2 DHT are expressed in the body.

Type 2 DHT is not expressed in bones at all, it's only expressed in the genitals, prostate gland, epididymides, seminal vesicles, genital skin, facial and chest hair follicles, and liver, while lower expression is observed in certain brain areas, non-genital skin/hair follicles, testes, and kidneys.

However, Type 1 DHT is actually expressed in bones. This matters because the studies I have shown above, are actually only deficient in the type 2 isoenzyme, which is the one that is not present in bones. This is the reason they present with normal bone mineral density, bone structure etc. If they were also deficient in Type 1 DHT, this would likely not be the case at all.

"5α-Reductase type 1 inactivated male mice have reduced bone mass and forelimb muscle grip strength, which has been proposed to be due to lack of 5α-reductase type 1 expression in bone and muscle.[29] In 5 alpha reductase type 2 deficient males, the type 1 isoenzyme is thought to be responsible for their virilization at puberty.[6]"

Bone growth and change will be minimal after 18, I definitely agree, but it still does happen. Facial bones are flat bones. They do not fuse, so they will continue to change forever, obviously to a lesser extent the older you get. Bones development/growth “stops” when resorption becomes greater than formation. As you age, this is more likely to happen, and will happen at a certain age most likely. Taking Dut with inhibits type 1, which is active in bones would likely have a negative impact, and speed up this process. You also won't achieve the slight bone changes that maybe desirable. It's true you don't know if you will have any noticeable change. Even in terms of BMD, doesn't effect aesthetics, it is still somewhat important for health. I would feel more comfortable to take Finasteride over Dutasteride if natural, since enhanced individuals would probably be able to compensate with supraphysiological Test levels and compensate for the lack of Type 1 DHT. The only thing I can really think of that have possibly comparable DHT type 1 levels to men on Dutasteride, would be women, who do actually have lower bone mass and lower BMD than men, and are at a greater risk of developing osteoporosis compared to men. That is not me saying if you take Dut your bones are going to melt and dissolve off your face.

Should I be worried about side effects from Finasteride?

Spoiler

I am not going to say that side effects do not exist, there are going to be the very unfortunate minority that may get side effects, but most of the people that are reporting side effects are schizo, especially if you go to places like r/tressless. They are basically all mentally ill. I’m not saying PFS or side effects in general aren't real, but I am saying that side effects, including PFS, are very much exaggerated in 2025.

Even in long-term studies (10 yr +) in Asians, no evidence of PFS symptoms were ever discovered. Only 1-3% get sexual sides, which wasn't even significantly different from the placebo arm in the original trials.

View attachment 3683840


Only after social media started popping off side effect reports started skyrocketing, and no, it’s not because there were fewer users back in the 2000s, millions of men were already on it back then.

There is some evidence for the existence of PFS and I will link a post here:

The obsession about DHT needs to end

what about sun? does it inhibit both collagen or elastin? Yes also do u think mt2 alonne all years with 20m tanning beds 3x per week can replace spf? No absolutely not you can't replace SPF. Melanin won't stop aging and UV damage

looksmax.org

Personally, I would take the chance 10/10 times.

Hair loss treatment if you're over 18.

Spoiler

If you are above the age of 18, and are natural, which means you DO NOT take exogenous hormones, such as Testosterone to achieve supraphysiological Testosterone levels in the body, I would recommend taking Finasteride at 1mg ever day.
If you are above the age of 18, and are enhanced, which means you DO take exogenous hormones, such as Testosterone to achieve supraphysiological Testosterone levels in the body, I would recommend taking Dutasteride at 2.5mg a day.

Hair loss treatment if you're under 18.

Spoiler

If you are younger than, you don't want to reduce your serum DHT levels since you are obliviously still growing, and DHT does play an important role in puberty. This means we are going to have to deal with scalp DH and Testosterone through compounds that will not effect your systematic levels. This can be accomplished through the use to the research chemical RU58841. This is a anti androgen which is applied topically to the scalp. To put it simply, it binds to the androgen receptors instead of DHT and Testosterone. Since hormones like DHT and Testosterone will not be able to bind, your hair will be safe from the norwood reaper, at least until you are old enough to get on approved treatments.

What should I do if you still experience hair loss while taking a 5α-Reductase inhibitor?

Spoiler

So you may have taken a 5α-Reductase inhibitor and are still seeing hair loss after a few months on treatment. You are probably very sensitive to androgens at the scalp, since for a large majority, 5α-Reductase inhibitors will be enough. If you still experience loss, it is because 5α-Reductase inhibitors will not completely remove scalp DHT, there is still some present at the scalp. As well as this, 5α-Reductase inhibitors don't decrease scalp Testosterone. The only way to deal with any residual DHT at the scalp, and the scalp Testosterone is by using ru58841. I already mentioned above that it does. Adding this on top of 5α-Reductase inhibitors will mean that your scalp will have as little androgens present that is currently possible, and will give your hair the best chance of survival.

Is RU58841 safe for use, since it's a research chemical?

Spoiler

This next part is not my words, it's from a post else where.

Spoiler

I found out about a clinical researcher that worked on the compound.
I wrote him two e-mails, but he didn't answer.
Therefore I tried to call him on the phone. It was quite hard to get to him since his secretaries apparently don't speak English. But the third time I was calling, I was lucky enough to get himself on the phone.
When I mentioned PSK-3841 he knew immediately what I was talking about. Apparently he got at least 10 phone calls in the last 3 years about this subject.
I asked him wether he remembers major safety concerns and he said no. He thinks the research was stopped because of financial issues or bad marketability.
He also said he tried to contact Prostrakan about it, but they are not interested in continuing the research.

He said that PSK-3841 was quite effective when he used it in the 6 month trial. He even suggested crowdfunding to make Prostrakan release the data or continue research.
This corresponds with the following statement, that was released by Prostrakan.

Topical anti-androgen
This is an innovative molecule with a unique mechanism of action for the treatment of androgen-dependent conditions, such as alopecia and acne.
In pre-clinical studies, it has shown promising activity in various models of acne, alopecia and hirsutism. The product has good systemic and dermal tolerance.
In human clinical pharmacology, there was no systemic anti-androgenic activity and again good general and dermal tolerance.
The molecule has completed several Phase I studies and a Proof of Concept Phase II study for alopecia.
It has demonstrated similar efficacy after 6 months treatment as that observed with current oral therapy for alopecia after twelve months, based on the increase in net hair count. Again, no systemic anti-androgenic effect was observed (n=90).
This product is available for licensing.

PS: English is not my native language so I may have not understood everything 100% correctly. But I asked him about the safety concerns 2 times, so I'm quite sure about that.

Edit: I don't want the researcher to get into legal trouble. Therefore I have deleted the name from the post. He has not shared confidential Data with me but I want him to be safe.

How to make an RU58841 solution.

Spoiler

You can either use a premade solution or you can home brew your own, which is much cheaper.
I will outline how to make your own now.

You will need: Precisions measuring scale 0.001g, Propylene Glycol, Ethanol 95%, RU58841 raw powder, glass measuring beakers.

I will outline how to make a 5% solution.
This will contain 50mg RU58841 per mL. And it will be a 50mL solution.
70% Ethanol 30% Propylene Glycol is the best ratio for the solution.
You can use DMSO if you wish instead of Propylene Gylycol, with the same 70% 30% ratio.

Steps
1) Get the precision scale and put a measuring beaker on it, and set the weight to 0
2) Put the RU58841 powder into the beaker, measuring out 2.5g
3) Using the measuring beaker, measure out 35mL of ethanol 95%, and add that to the one with the RU58841 powder in it.
4) Using the measuring beaker and measure out 15mL of Propylene Glycol and add that to the beaker with the RU58841 and ethanol.
5) Stir until the RU dissolves.
Store the ready made solution in the fridge. Store the raw RU58841 powder in the freezer.

Here is a video from Reddit if you wish to follow that instead:

Drug Dosages.

Spoiler

Why 1mg of FInasteride and not 0.1mg or 5mg?

Spoiler

Clinical dose ranging studies with finasteride, a type 2 5alpha-reductase inhibitor, in men with male pattern hair loss - PubMed

Finasteride 1 mg/day is the optimal dose for the treatment of men with male pattern hair loss and was subsequently identified for further clinical development.

pubmed.ncbi.nlm.nih.gov

The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia - PubMed

In this study, doses of finasteride as low as 0.2 mg per day maximally decreased both scalp skin and serum DHT levels. These data support the rationale used to conduct clinical trials in men with male pattern hair loss at doses of finasteride between 0.2 and 5 mg.

pubmed.ncbi.nlm.nih.gov

View attachment 3683969

Why 2.5mg Dutasteride and not the standard dosage of 0.5mg?

Spoiler

You are taking supraphysiological amounts of Testosterone, which as a result means you are going to have high DHT levels, and if you are particularly prone to androgens raping your hair follicles, you need to be as nuclear as you can be.
Serum DHT inhibition is not that different (about 4% more with 2.5mg) but the Scalp DHT inhibition is almost 80% at 2.5mg compared to 50% with 0.5mg.

Best RU58841 dosage?

Spoiler

I will clarify, by dosage I mean the amount of ru58841 that is applied to your scalp. You are not drinking it or taking it orally, you will be a Testosteroneless creature.
Apply between 50-100mg of RU58841 to the scalp. I would recommend not exceeding 100mg as it will increase the chances of systematic absorption.

If you still lose hair on the stack mentioned in this thread, you are likely not balding due to AGA.

Also go check out @Jonas2k7 thread about Minoxidil:

Spoiler

The truth about Minoxidil - The holy grail or overhyped Looksmin?

The truth about Minoxidil - Part 1 Growing your eyelashes and eyebrows is one of the best and only true softmaxxes. Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp. This thread will reveal why you should be cautious with...

looksmax.org

TAGS

Spoiler

@Drugsmaxxer @Hexmask @spectrumaesthetics2

@imontheloose (I will respond on dc to you, I just haven't gotten round to it yet)

nice one bhai

 

[chadisbeingmade]

Do i have to worry about hairloss if i want to become roided superhuman but take fin/dut + min

If your on roids skip Finasteride completely and go on Dutasteride. You don't really need Minoxidil unless you have ground to recover, though it can be beneficial for your lashes and brows as well as improve scalp further.

 

[psl8mogger]

read every word

 

[imontheloose]

so low IQ. DHT is essential for many aspects of pubertal and post-pubertal development including penis. You probably created multiple lifelong dickcels with this post. any male intentionally reducing his DHT systemically before like 25 is permanently reducing his dimorphism.

@chadisbeingmade

 

[chadisbeingmade]

View attachment 3708451
@chadisbeingmade

Mirin actively reducing competition tbh.

Can’t believe this mf thinks this dick is going to grow so substantially at 25 years old it’s worth sacrificing you hair (it won’t grow a nanometer).

 

[slaters]

Ab to make my own ru

 

[chadisbeingmade]

Ab to make my own ru

Mirin

 

[slaters]

Mirin

U notice any hair drying or flakes after using it

 

[chadisbeingmade]

U notice any hair drying or flakes after using it

Hair? No.
You apply it to your scalp, PG and ethanol and be quite drying so you may experience some dry scalp.

 

[Snicket]

You don't really need Minoxidil unless you have ground to recover, though it can be beneficial for your lashes and brows as well as improve scalp further.

OP, are there any other growth stimulants that rival the efficacy of minoxidil?
Obviously there are powerful anti androgens, like estradiol, spiro do but they are out of the question for guys.
You see MTF HRT with insane regrowth:

 

[chadisbeingmade]

OP, are there any other growth stimulants that rival the efficacy of minoxidil?
Obviously there are powerful anti androgens, like estradiol, spiro do but they are out of the question for guys.
You see MTF HRT with insane regrowth:
View attachment 3708625View attachment 3708632

You could maybe look into GHK-cu but it definitely will not be as effective as Minoxidil IF it even works.

Seen reports of Nandrolone HRT that shows good regrowth.


that is it for the most part. I remember seeing something else but i’m pretty I dismissed once I looked a bit into it. I wil try see what it was.

 

[slaters]

OP, are there any other growth stimulants that rival the efficacy of minoxidil?
Obviously there are powerful anti androgens, like estradiol, spiro do but they are out of the question for guys.
You see MTF HRT with insane regrowth:
View attachment 3708625View attachment 3708632

I know nonlooksmaxing roiders that just use RU & ghk as their hairloss protocol

 

[Snicket]

You could maybe look into GHK-cu but it definitely will not be as effective as Minoxidil IF it even works.

Seen reports of Nandrolone HRT that shows good regrowth.


that is it for the most part. I remember seeing something else but i’m pretty I dismissed once I looked a bit into it. I wil try see what it was.

Thanks.
I’m more than happy maintaining what I have.
It was more of an academic question.

We know that DHT inhibition will only cause so much regrowth.

Even castrating a balding man wouldn’t bring him back to an NW1.

The stimulant side of the equation is also very important for those who want regrowth.

 

[Snicket]

I know nonlooksmaxing roiders that just use RU & ghk as their hairloss protocol

Does ghk have a different mechanism of action to minox?

If so, I assume they can be used synergistically?

 

[chadisbeingmade]

Thanks.
I’m more than happy maintaining what I have.
It was more of an academic question.

We know that DHT inhibition will only cause so much regrowth.

Even castrating a balding man wouldn’t bring him back to an NW1.

The stimulant side of the equation is also very important for those who want regrowth.

If people are at the point of needing regrowth, they should skip the sugar pill (fin) and go straight for Duta since it shows superior regrowth obviously. Max dosage of 2.5mg. See where that takes them in terms of regrowth. If considerable ground is still lost then they’ve gotta look into growth stimulants, Minoxidil if they want their best chance tbh. However, if the area is slick bald, I wouldn’t even bother with Minoxidil and would fly to Turkey instead, it’s unlikely it will regrow.

I do believe that miniaturised follicles and vellus follicles can be brought back without needing growth stimulants, given enough time on 5ARi, however small they are.

 

[slaters]

Does ghk have a different mechanism of action to minox?

If so, I assume they can be used synergistically?

Minox has smthn to do with potassium channels
GHK stimulates NGF and VEGF
collagen stimulation probably apart of it too?

But yeah they can def be used synergistically

 

[shredded4summer]

@Jonas2k7 a randomized double blinded placebo control study

https://www.auajournals.org/doi/10.1016/j.juro.2008.01.145#:~:text=Significant%20suppression%20of%20circulating%20dihydrotestosterone%20levels%20with,Similarly%20serum%20lipoproteins%20and%20hemoglobin%20were%20unaffected.

shows both fin and dut dont effect BMD or bone metabolism

another randomized control study showing dut does not effect muscle growth in men with low T who are on HRT

https://jamanetwork.com/journals/jama/fullarticle/1105045

what about the people that suffer from loss of all emotion and libidio from fin and dut

 

[chadisbeingmade]

what about the people that suffer from loss of all emotion and libidio from fin and dut

There’s a section on side effects bud.
I wouldn’t be worried bout them.
I experienced none of that shit.

 

[Snicket]

There’s a section on side effects bud.
I wouldn’t be worried bout them.
I experienced none of that shit.

You'd think from this that finasteride is like the pill from the Equilibrium movie that makes everyone emotionless!

 

[william.]

emotionless

 

[shredded4summer]

There’s a section on side effects bud.
I wouldn’t be worried bout them.
I experienced none of that shit.

theres people that have literally lost all sense of love from doing dut lol fuckin brutal and you push it away with an anecdote

 

[shredded4summer]

You'd think from this that finasteride is like the pill from the Equilibrium movie that makes everyone emotionless!

no nigga its rare but it happens

 

[chadisbeingmade]

you push it away with an anecdote

theres people that have literally lost all sense of love from doing dut

Is this not an anecdote? LOL

I provided research bud, you are the one that provided anecdotes from mentally ill schizo r/tressless users.

 

[shredded4summer]

Is this not an anecdote? LOL

I provided research bud, you are the one that provided anecdotes from mentally ill schizo r/tressless users.

an anecdote = one anecdote

people = multiple anecdotes

mirrin ur iq

 

[chadisbeingmade]

an anecdote = one anecdote

people = multiple anecdotes

mirrin ur iq

Yeah, so?

Anecdotes do not mean anything.

 

[Snicket]

no nigga its rare but it happens

Multiple studies comparing placebos with finasteride groups showed no observable difference.
If you have a problem, you can just get off the meds. I don't see the issue here.
I'm pretty sure "no emotion" isn't one of the apparent symptoms though!

 

[shredded4summer]

Yeah, so?

Anecdotes do not mean anything.

studies are a compilation of anecdotes

 

[chadisbeingmade]

studies are a compilation of anecdotes

ok then

Multiple studies comparing placebos with finasteride groups showed no observable difference.

You can't win here.

 

[shredded4summer]

ok then


You can't win here.

1. Systematic Review and Meta-Analysis (2018)​

A comprehensive meta-analysis of 15 randomized, double-blind, placebo-controlled trials involving 4,495 men assessed the risk of sexual dysfunction associated with finasteride and dutasteride. The study found that the use of 5α-reductase inhibitors was associated with a 1.57-fold increased risk of sexual dysfunction. Specifically, finasteride had a relative risk of 1.66, while dutasteride had a relative risk of 1.37, though the latter was not statistically significant. This suggests that both medications may increase the risk of sexual side effects, including decreased libido and erectile dysfunction. PubMed+2PubMed+2PubMed+2

2. Prospective Randomized Study on Dutasteride (2018)​

A study published in the Journal of Dermatology focused on men aged 23–50 treated with dutasteride for androgenetic alopecia. The results indicated that 16% of participants experienced sexual adverse events, such as impotence and decreased libido, during the double-blind period. These adverse events were generally mild to moderate in severity and were reversible upon discontinuation of the medication. PMC+1PubMed+1PubMed+1PMC+1

3. Persistent Sexual Side Effects After Finasteride Use (2011)​

A study involving 71 healthy men aged 21–46 who reported new-onset sexual side effects associated with finasteride use found that 94% developed low libido, 92% experienced erectile dysfunction, and 92% had decreased arousal. The mean duration of persistent sexual side effects was 40 months, even after discontinuation of the medication. This underscores the potential for long-lasting sexual dysfunction following finasteride use. PubMed

4. FDA Warning on Topical Finasteride Formulations (2025)​

In April 2025, the U.S. Food and Drug Administration issued a public alert regarding compounded topical finasteride formulations, which have not undergone FDA approval or safety review. The warning followed reports of 32 adverse events linked to these formulations, including erectile dysfunction, anxiety, depression, brain fog, suicidal thoughts, decreased libido, and testicular pain. These side effects were reported by men who obtained the medication through telehealth platforms without comprehensive risk disclosures. New York Post+2New York Post+2WSJ+2

5. Persistent Sexual Symptoms After Finasteride Use (2017)​

A study published in Andrology reviewed data from 17 randomized controlled trials involving 24,463 subjects treated with finasteride or dutasteride for benign prostatic hyperplasia. The analysis found that the use of 5α-reductase inhibitors significantly increased the risk of erectile dysfunction and hypoactive sexual desire. These findings highlight the potential for persistent sexual side effects even after discontinuation of the medication. Wiley Online LibraryWiley Online Library+6PubMed+6PubMed+6

---

These studies collectively suggest that both finasteride and dutasteride can cause sexual dysfunction, including decreased libido and erectile dysfunction.


just chatgpt'd this cause i dont wanna do research

 

[chadisbeingmade]

These studies collectively suggest that both finasteride and dutasteride can cause sexual dysfunction, including decreased libido and erectile dysfunction.

I didn't argue against that at all. They are known potential side effects of it's usage. It's just unlikely you get them.

 

[Snicket]

I didn't argue against that at all. They are known potential side effects of it's usage. It's just unlikely you get them.

To be fair, I said multiple studies have shown no observable difference, which is true as well, but I don't deny side-effects are possible and do happen either.

Here's a study with sample size 70K+ where no increased sexual side effects from 5AR were found and I could find many more.

https://pubmed.ncbi.nlm.nih.gov/27659058/

Regardless, almost all of the guy's linked studies state that side effects stop after discontinuation of treatment.

 

[wishIwasSalludon]

what about the people that suffer from loss of all emotion and libidio from fin and dut

It’s all in their mind 99% of the time

 

[CEO]

Hi bro, above the age of 18 + natty for life, quick question I had about: Micro-dosing fin... Studies report that even a dosage something as little as 0.25 mg dose is hella effective... I've been taking 0.5mg by splitting them in half with a pill cutter. 1 daily. You mind elaborating real quick your rationale of still sticking to 1mg instead of 0.5mg or 0.25mg? Thanks @chadisbeingmade

Is this study kike propaganda or what? I appreciate you bro.

 

[chadisbeingmade]

Hi bro, above the age of 18 + natty for life, quick question I had about: Micro-dosing fin... Studies report that even a dosage something as little as 0.25 mg dose is hella effective... I've been taking 0.5mg by splitting them in half with a pill cutter. 1 daily. You mind elaborating real quick your rationale of still sticking to 1mg instead of 0.5mg or 0.25mg? Thanks @chadisbeingmade

Is this study kike propaganda or what? I appreciate you bro.

There isn't any logic behind why taking lower doses has lower risks of side effects other than its lower efficacy. Higher doses of finasteride blocks slightly more serum DHT but block more than 5% of scalp DHT. That 5% extra block of scalp DHT is way more important than you think. If it was insignificant there would be any reason to use Dut because 0.5mg Dut only blocks 10% more scalp DHT more than 1mg fin.

We care about scalp DHT. For example 2.5 Dut decreases serum DHT by only 4% more than 0.5mg (96% vs 92%) but it’s scalp reduction is 30% more than 0.5mg

 

[CEO]

There isn't any logic behind why taking lower doses has lower risks of side effects other than its lower efficacy. Higher doses of finasteride blocks slightly more serum DHT but block more than 5% of scalp DHT. That 5% extra block of scalp DHT is way more important than you think. If it was insignificant there would be any reason to use Dut because 0.5mg Dut only blocks 10% more scalp DHT more than 1mg fin.

View attachment 3714135

We care about scalp DHT. For example 2.5 Dut decreases serum DHT by only 4% more than 0.5mg (96% vs 92%) but it’s scalp reduction is 30% more than 0.5mg

Exactly bro scalp DHT is everything, fucking fantastic thanks a ton dude
You seriously deserve that "contributor" title around here, cheers

 

[SoundnVision]

There isn't any logic behind why taking lower doses has lower risks of side effects other than its lower efficacy. Higher doses of finasteride blocks slightly more serum DHT but block more than 5% of scalp DHT. That 5% extra block of scalp DHT is way more important than you think. If it was insignificant there would be any reason to use Dut because 0.5mg Dut only blocks 10% more scalp DHT more than 1mg fin.

View attachment 3714135

We care about scalp DHT. For example 2.5 Dut decreases serum DHT by only 4% more than 0.5mg (96% vs 92%) but it’s scalp reduction is 30% more than 0.5mg

How much more scalp DHT does 5mg finasteride block compared with 1mg?
And how much compared with 0.5 mg dutasteride?

 

[chadisbeingmade]

How much more scalp DHT does 5mg finasteride block compared with 1mg?
And how much compared with 0.5 mg dutasteride?

There’s no point going to 5mg it’s a waste of money. 2.5mg is the max anyone needs to go.

with 0.5mg Dut ED you will have 92% serum DHT suppression and on 2.5mg ED you would have 96% serum DHT suppression. So 4% change. For scalp DHT levels on 0.5mg ED you’d have ~50% suppression where as 2.5mg ED you’d get ~80% scalp DHT suppression.

If you can there isn’t any real reason not to be using 2.5mg Dut compared to 0.5mg.

 

[SoundnVision]

There’s no point going to 5mg it’s a waste of money. 2.5mg is the max anyone needs to go.

with 0.5mg Dut ED you will have 92% serum DHT suppression and on 2.5mg ED you would have 96% serum DHT suppression. So 4% change. For scalp DHT levels on 0.5mg ED you’d have ~50% suppression where as 2.5mg ED you’d get ~80% scalp DHT suppression.

If you can there isn’t any real reason not to be using 2.5mg Dut compared to 0.5mg.

I mean 5mg finasteride. And it would be worth it because you can cycle it unlike DUT. Meaning of you want to feel hornier for a few weeks you can just stop taking them get back on it.
DUT it's not possible because of it's very long half life.

 

[chadisbeingmade]

I mean 5mg finasteride. And it would be worth it because you can cycle it unlike DUT. Meaning of you want to feel hornier for a few weeks you can just stop taking them get back on it.
DUT it's not possible because of it's very long half life.

Yeah Dut half life is 4-5 weeks. So essentially takes 6 months to fully leave your system, I would think. That being said Ashton Kusher was on Dut for 10 years and conceived 3 months after. Any trace of 5ar inhibition is enough to fuck up sperm parameters. If he was confident enough to conceive, the levels of Dutasteride were most likely insignificant.

It’s about 5% difference at the scalp. 1mg vs 5mg Fin.

You are better off using RU with 1mg Fin and take care of scalp testosterone as well any residual DHT left. You would be able to stop Fin and continue the RU without any potential of exacerbating loss also.

RU + Fin combo mogs Dut 2.5mg solo.

 

[SoundnVision]

Yeah Dut half life is 4-5 weeks. So essentially takes 6 months to fully leave your system, I would think. That being said Ashton Kusher was on Dut for 10 years and conceived 3 months after. Any trace of 5ar inhibition is enough to fuck up sperm parameters. If he was confident enough to conceive, the levels of Dutasteride were most likely insignificant.

It’s about 5% difference at the scalp. 1mg vs 5mg Fin.

View attachment 3714303

You are better off using RU with 1mg Fin and take care of scalp testosterone as well any residual DHT left. You would be able to stop Fin and continue the RU without any potential of exacerbating loss also.

RU + Fin combo mogs Dut 2.5mg solo.

So bring my hair to as good stage as possible then just maintain with RU?
I used it years ago but I got bad chest pains

 

[chadisbeingmade]

So bring my hair to as good stage as possible then just maintain with RU?
I used it years ago but I got bad chest pains

What I’m saying is use both, and for periods you want to stop Fin continue then RU so hair loss doesn’t progress rapidly.

I had some chest pain when I was rubbing it on white my fingers. Now I apply and make sure it only touches my scalp and have had 0 sides. Not touching it ensures it doesn’t go systematic.

 

[Snicket]

Yeah Dut half life is 4-5 weeks. So essentially takes 6 months to fully leave your system, I would think. That being said Ashton Kusher was on Dut for 10 years and conceived 3 months after. Any trace of 5ar inhibition is enough to fuck up sperm parameters. If he was confident enough to conceive, the levels of Dutasteride were most likely insignificant.

It’s about 5% difference at the scalp. 1mg vs 5mg Fin.

View attachment 3714303

You are better off using RU with 1mg Fin and take care of scalp testosterone as well any residual DHT left. You would be able to stop Fin and continue the RU without any potential of exacerbating loss also.

RU + Fin combo mogs Dut 2.5mg solo.

Wait, I thought finasteride only suppressed around 30-40% scalp DHT - even on 5mg.
The numbers you're providing are much higher.

 

[chadisbeingmade]

Wait, I thought finasteride only suppressed around 30-40% scalp DHT - even on 5mg.
The numbers you're providing are much higher.

I’ve seen 2 numbers. 40% here.

The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride - PubMed

Dutasteride increases scalp hair growth in men with MPHL. Type 1 and type 2 5alpha-reductase may be important in the pathogenesis and treatment of MPHL.

pubmed.ncbi.nlm.nih.gov

and 70% with 5mg here.

The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia - PubMed

In this study, doses of finasteride as low as 0.2 mg per day maximally decreased both scalp skin and serum DHT levels. These data support the rationale used to conduct clinical trials in men with male pattern hair loss at doses of finasteride between 0.2 and 5 mg.

pubmed.ncbi.nlm.nih.gov

The second study is a bit confusing multiple Dut studies show 50% suppression at 0.5mg and 80% at 2.5mg. With Dutasteride being significantly more potent than Fin.

 

[Snicket]

I’ve seen 2 numbers. 40% here.

The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride - PubMed

Dutasteride increases scalp hair growth in men with MPHL. Type 1 and type 2 5alpha-reductase may be important in the pathogenesis and treatment of MPHL.

pubmed.ncbi.nlm.nih.gov

I have the full paper for the first one.
It was hidden behind a paywall or academic institutional access.

You probably had access it to it already

Could be useful anyway for others. I have attached it anyway.

and 70% with 5mg here.

The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia - PubMed

In this study, doses of finasteride as low as 0.2 mg per day maximally decreased both scalp skin and serum DHT levels. These data support the rationale used to conduct clinical trials in men with male pattern hair loss at doses of finasteride between 0.2 and 5 mg.

pubmed.ncbi.nlm.nih.gov

The second study is a bit consuming multiple Dut studies show 50% suppression at 0.5mg and 80% at 2.5mg. With Dutasteride being significantly more potent than Fin.

It's interesting why there are such large discrepancies.

 

[chadisbeingmade]

I have the full paper for the first one.
It was hidden behind a paywall or academic institutional access.

You probably had access it to it already

Could be useful anyway for others. I have attached it anyway.


It's interesting why there are such large discrepancies.

Despite it being confusing about the actual scalp suppression, if you have RU in your stack I don’t think you will run into any issues regarding hair loss. Wether you decide to use RU+Fin or RU+Dut your pretty much still have a solid bulletproof stack. RU is hella powerful, and often the key for some people’s regrowth who aren’t getting results on Fin, or Fin+minoxx

I’m pretty certain that RU and Fin would mog Dut solo tbh.

 

[SoundnVision]

What I’m saying is use both, and for periods you want to stop Fin continue then RU so hair loss doesn’t progress rapidly.

I had some chest pain when I was rubbing it on white my fingers. Now I apply and make sure it only touches my scalp and have had 0 sides. Not touching it ensures it doesn’t go systematic.

Where do you buy it?

 

[Arthur the Egyptian]

@chadisbeingmade
Non of my family is bald but I have High natural hairline
Should I worry about hair lose?
or keep saving for hairline lowering

 

[chadisbeingmade]

@chadisbeingmade
Non of my family is bald but I have High natural hairline
Should I worry about hair lose?
or keep saving for hairline lowering

Just keep a watch out on your hairline and make sure you don’t progress. Balding genes are extremely random and can skip generations. And by the time most people actually notice loss, they have some regrowth to do. Prevention is always best. You can take Fin as a precaution and still save for hairline lowering.

 

[Arthur the Egyptian]

Just keep a watch out on your hairline and make sure you don’t progress. Balding genes are extremely random and can skip generations. And by the time most people actually notice loss, they have some regrowth to do. Prevention is always best. You can take Fin as a precaution and still save for hairline lowering.

Thanks Chad !