TrueCurryCel13
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Eyelashes and eyebrows were never a problem for me
elxbp
shape your reality
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The truth about ... - The new thread series, AMA
The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...looksmax.org
Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.
Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.
This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.
History
Minoxidil was developed for antihypertensive and vasodilative purposes.
View attachment 3682339
Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.
It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.
Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC
Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...pmc.ncbi.nlm.nih.gov
And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.
Appeal in PSL-Spaces
The other use case beside hypertension is hair growth.
Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.
That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.
The other use case is like I mentioned previously, growing the hairs in your eye area.
View attachment 3682266
It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.
There are two ways you can grow them via Minoxidil: Topical and Oral.
Topical
Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.
Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).
HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC
Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...
Oral
Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.
[Brutal UEE right there, just look at the lashes duh]
View attachment 3682288
Biology
The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.
This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.
View attachment 3682292
I'll try to keep it short:
- Minoxidil vasodilates blood vessels
- Activation of RAAS
- Aldosterone increase
- Sodium, potassium and water retention
In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.
This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?
View attachment 3682392
Conclusion
The only possible solution to solve the bloat is using an aldosterone-antagonist.
View attachment 3682299
In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.
TL;DR: There are only two viable options now:
- Topical Minoxidil on eyebrows, which also affects your lashes.
- Oral Minoxidil only in combination with an aldosterone-antagonist.
I hope you learned something new today.
Feel free to AMA.
@halloweed @menas @Zagro @Drugsmaxxer
Do you think frauding eyelashes with mascara is a valid alternative? I have long lashes but they go from black to blond quickly.
My bones arent visible unless I'm really lean, so the bloating side effect of oral min seems like its not worth it
didikunt
live larp lift
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The truth about ... - The new thread series, AMA
The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...
Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.
Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.
This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.
History
Minoxidil was developed for antihypertensive and vasodilative purposes.
View attachment 3682339
Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.
It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.
Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC
Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...
And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.
Appeal in PSL-Spaces
The other use case beside hypertension is hair growth.
Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.
That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.
The other use case is like I mentioned previously, growing the hairs in your eye area.
View attachment 3682266
It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.
There are two ways you can grow them via Minoxidil: Topical and Oral.
Topical
Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.
Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).
HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC
Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...
Oral
Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.
[Brutal UEE right there, just look at the lashes duh
View attachment 3682288
Biology
The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.
This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.
View attachment 3682292
I'll try to keep it short:
- Minoxidil vasodilates blood vessels
- Activation of RAAS
- Aldosterone increase
- Sodium, potassium and water retention
In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.
This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?
View attachment 3682392
Conclusion
The only possible solution to solve the bloat is using an aldosterone-antagonist.
View attachment 3682299
In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.
TL;DR: There are only two viable options now:
- Topical Minoxidil on eyebrows, which also affects your lashes.
- Oral Minoxidil only in combination with an aldosterone-antagonist.
I hope you learned something new today.
Feel free to AMA.
@halloweed @menas @Zagro @Drugsmaxxer
Still a great thread bump
justinAnomaly
Zephir
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how do u make these threads, i wanna be a contributor too one dayThanks man. Go read the thread y'all.
aibekk
Iron
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The truth about ... - The new thread series, AMA
The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...
Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.
Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.
This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.
History
Minoxidil was developed for antihypertensive and vasodilative purposes.
View attachment 3682339
Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.
It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.
Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC
Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...
And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.
Appeal in PSL-Spaces
The other use case beside hypertension is hair growth.
Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.
That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.
The other use case is like I mentioned previously, growing the hairs in your eye area.
View attachment 3682266
It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.
There are two ways you can grow them via Minoxidil: Topical and Oral.
Topical
Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.
Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).
HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC
Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...
Oral
Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.
[Brutal UEE right there, just look at the lashes duh
View attachment 3682288
Biology
The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.
This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.
View attachment 3682292
I'll try to keep it short:
- Minoxidil vasodilates blood vessels
- Activation of RAAS
- Aldosterone increase
- Sodium, potassium and water retention
In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.
Это означает, что приходится идти на большой компромисс: рост волос или отёк . Что вы выберете: отсутствие задержки жидкости или редкие ресницы?
View attachment 3682392
[/СПОЙЛЕР]
Заключение
Единственное возможное решение проблемы вздутия живота — использование антагониста альдостерона .
View attachment 3682299
Теоретически, использование антагониста альдостерона, такого как эплеренон или спиронолактон, должно сработать, но даже в этом случае существует немало косвенных свидетельств того, что это неэффективно .
Вкратце: сейчас есть только два жизнеспособных варианта:
[/СПОЙЛЕР]
- Нанесение миноксидила на брови местно, что также влияет на ресницы.
- Миноксидил для приема внутрь только в сочетании с антагонистом альдостерона.
Надеюсь, вы сегодня узнали что-то новое.
Не стесняйтесь задавать вопросы.
@halloweed @menas @Zagro @Drugsmaxxer
[/СПОЙЛЕР]
i using minoxidil 2 mounths and i having bloated face every single day on morning, i have problems with breathe from nose. So that bloat face from minoxidil or breath problem?
IbalmeHponeMin
LDAR
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@swaggymoqxcz you faggot think you know everything? If you think we're lying kys you faggot grey
D
Deleted member 381176
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nigga what I'm not even acussing you or even calling you stuff nigger youre so weak your ego shattered, average org rotter
IbalmeHponeMin
LDAR
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Idc you faggot kys with that knowledge
D
Deleted member 381176
Suicidal boy
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you're not that special nigger you're only a human die fuckass ego man, your ego weak as hell I wasn't even rude DNR nigger
IbalmeHponeMin
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TL;DNR
Roid_fapist
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if you use topical won’t it affect your upper eyelid fat poorly since in the thread it’s said to remove the upper eyelid fat in return giving more upper eyelid exposure your eyelashes would help slightly but still I don’t know if I only get the fat loss from my upper eye if I put it on my eyelashes as well compared to only putting it on my eyebrows
deteq.
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Mirin
BasedPsychiatrist
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Great thread, but why would you even suggest spironolactone to counteract aldosterone? This shit is one of the worst looksmin you can find (if you are a male).
Primalslayer
eye area is law
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The truth about ... - The new thread series, AMA
The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...
Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.
Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.
This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.
History
Minoxidil was developed for antihypertensive and vasodilative purposes.
View attachment 3682339
Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.
It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.
Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC
Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...
And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.
Appeal in PSL-Spaces
The other use case beside hypertension is hair growth.
Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.
That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.
The other use case is like I mentioned previously, growing the hairs in your eye area.
View attachment 3682266
It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.
There are two ways you can grow them via Minoxidil: Topical and Oral.
Topical
Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.
Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).
HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC
Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...
Oral
Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.
[Brutal UEE right there, just look at the lashes duh
View attachment 3682288
Biology
The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.
This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.
View attachment 3682292
I'll try to keep it short:
- Minoxidil vasodilates blood vessels
- Activation of RAAS
- Aldosterone increase
- Sodium, potassium and water retention
In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.
This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?
View attachment 3682392
Conclusion
The only possible solution to solve the bloat is using an aldosterone-antagonist.
View attachment 3682299
In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.
TL;DR: There are only two viable options now:
- Topical Minoxidil on eyebrows, which also affects your lashes.
- Oral Minoxidil only in combination with an aldosterone-antagonist.
I hope you learned something new today.
Feel free to AMA.
@halloweed @menas @Zagro @Drugsmaxxer
just have european genetics
A
arimidex
Iron
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The truth about ... - The new thread series, AMA
The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...
Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.
Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.
This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.
History
Minoxidil was developed for antihypertensive and vasodilative purposes.
View attachment 3682339
Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.
It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.
Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC
Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...
And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.
Appeal in PSL-Spaces
The other use case beside hypertension is hair growth.
Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.
That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.
The other use case is like I mentioned previously, growing the hairs in your eye area.
View attachment 3682266
It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.
There are two ways you can grow them via Minoxidil: Topical and Oral.
Topical
Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.
Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).
HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC
Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...
Oral
Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.
[Brutal UEE right there, just look at the lashes duh
View attachment 3682288
Biology
The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.
This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.
View attachment 3682292
I'll try to keep it short:
- Minoxidil vasodilates blood vessels
- Activation of RAAS
- Aldosterone increase
- Sodium, potassium and water retention
In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.
This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?
View attachment 3682392
Conclusion
The only possible solution to solve the bloat is using an aldosterone-antagonist.
View attachment 3682299
In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.
TL;DR: There are only two viable options now:
- Topical Minoxidil on eyebrows, which also affects your lashes.
- Oral Minoxidil only in combination with an aldosterone-antagonist.
I hope you learned something new today.
Feel free to AMA.
@halloweed @menas @Zagro @Drugsmaxxer
Will applying on eyebrows cause upper eyelid fat loss
D
Deleted member 10300
Mostly just loafing around
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The truth about ... - The new thread series, AMA
The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...
Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.
Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.
This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.
History
Minoxidil was developed for antihypertensive and vasodilative purposes.
View attachment 3682339
Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.
It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.
Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC
Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...
And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.
Appeal in PSL-Spaces
The other use case beside hypertension is hair growth.
Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.
That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.
The other use case is like I mentioned previously, growing the hairs in your eye area.
View attachment 3682266
It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.
There are two ways you can grow them via Minoxidil: Topical and Oral.
Topical
Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.
Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).
HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC
Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...
Oral
Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.
[Brutal UEE right there, just look at the lashes duh
View attachment 3682288
Biology
The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.
This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.
View attachment 3682292
I'll try to keep it short:
- Minoxidil vasodilates blood vessels
- Activation of RAAS
- Aldosterone increase
- Sodium, potassium and water retention
In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.
This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?
View attachment 3682392
Conclusion
The only possible solution to solve the bloat is using an aldosterone-antagonist.
View attachment 3682299
In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.
TL;DR: There are only two viable options now:
- Topical Minoxidil on eyebrows, which also affects your lashes.
- Oral Minoxidil only in combination with an aldosterone-antagonist.
I hope you learned something new today.
Feel free to AMA.
@halloweed @menas @Zagro @Drugsmaxxer
Since womem don't care about less than 18% bodyfat then drop to 15% to let a bloating margin theory
tesertrue
ru/eng, ltn
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good thread
Bipolar2Cel
Master
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I take 0.75-1 mg sublingual/oral (I try to take it sublingually but no doubt some is swallowed and absorbed orally) with no issues, zero bloat. Works terrific for eyelashes and still works on my scalp, however I am bit of a hyper-responder because even topical application on my scalp affected my eyelashes and hair length across my body lol, maybe that is why this low of a dose works for me.
Bipolar2Cel
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I can tell it works on my scalp because minoxidil always gives me an intense hair follicle itch here and there on my scalp and temples/forehead area lol. It feels pretty good and that is how I know minoxidil is doing work there too. I am on 0.5 mg dutasteride 2-3x a week also.
MirinDNR
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JFL
klqa
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Cool
wxtr
Remind me to rep
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Should i use minox for wye brows?
stacylover
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The truth about ... - The new thread series, AMA
The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...
Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.
Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.
This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.
History
Minoxidil was developed for antihypertensive and vasodilative purposes.
View attachment 3682339
Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.
It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.
Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC
Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...
And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.
Appeal in PSL-Spaces
The other use case beside hypertension is hair growth.
Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.
That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.
The other use case is like I mentioned previously, growing the hairs in your eye area.
View attachment 3682266
It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.
There are two ways you can grow them via Minoxidil: Topical and Oral.
Topical
Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.
Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).
HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC
Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...
Oral
Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.
[Brutal UEE right there, just look at the lashes duh
View attachment 3682288
Biology
The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.
This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.
View attachment 3682292
I'll try to keep it short:
- Minoxidil vasodilates blood vessels
- Activation of RAAS
- Aldosterone increase
- Sodium, potassium and water retention
In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.
This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?
View attachment 3682392
Conclusion
The only possible solution to solve the bloat is using an aldosterone-antagonist.
View attachment 3682299
In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.
TL;DR: There are only two viable options now:
- Topical Minoxidil on eyebrows, which also affects your lashes.
- Oral Minoxidil only in combination with an aldosterone-antagonist.
I hope you learned something new today.
Feel free to AMA.
@halloweed @menas @Zagro @Drugsmaxxer
Mirin
newgenlm
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The truth about ... - The new thread series, AMA
The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...
Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.
Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.
This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.
History
Minoxidil was developed for antihypertensive and vasodilative purposes.
View attachment 3682339
Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.
It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.
Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC
Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...
And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.
Appeal in PSL-Spaces
The other use case beside hypertension is hair growth.
Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.
That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.
The other use case is like I mentioned previously, growing the hairs in your eye area.
View attachment 3682266
It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.
There are two ways you can grow them via Minoxidil: Topical and Oral.
Topical
Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.
Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).
HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC
Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...
Oral
Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.
[Brutal UEE right there, just look at the lashes duh
View attachment 3682288
Biology
The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.
This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.
View attachment 3682292
I'll try to keep it short:
- Minoxidil vasodilates blood vessels
- Activation of RAAS
- Aldosterone increase
- Sodium, potassium and water retention
In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.
This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?
View attachment 3682392
Conclusion
The only possible solution to solve the bloat is using an aldosterone-antagonist.
View attachment 3682299
In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.
TL;DR: There are only two viable options now:
- Topical Minoxidil on eyebrows, which also affects your lashes.
- Oral Minoxidil only in combination with an aldosterone-antagonist.
I hope you learned something new today.
Feel free to AMA.
@halloweed @menas @Zagro @Drugsmaxxer
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malizone
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why is this botb wtf
kxverse7
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Does the bloat will go away after I'll finish my minox cycle?
oculus
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the only way to hope is to get terminal hairs but i highly doubt
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dnr but bookmarked for later
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Should i use minox for eye brows or no
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