Why HGH is cope and will NOT work for you!!!! (HGH USERS GTFIH!!!)

A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.


2. What the Studies ACTUALLY Show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:




VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):


B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.


3. Why HGH does NOT work for healthy normal children with PROOF

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:



  • GH does not create new growth potential.
    The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
  • GH cannot override genetic determinants of stature.
    Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
  • Endocrine feedback loops limit excessive growth signaling.
    The GH–IGF-1 axis is tightly regulated:
    • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
    • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
  • Physiologic ceiling effect.
    In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration
EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.


4. Why people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.


5. What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

  • Insulin resistance
  • Increased risk of type 2 diabetes
  • Fluid retention and edema
  • Joint pain
  • Carpal tunnel syndrome
  • Hip growth plate injury
  • Benign intracranial hypertension (severe headaches and vision changes)
  • Abnormal IGF‑1 elevations
  • Theoretical increased cancer risk due to chronic IGF‑1 stimulation
​

6. Summary

HGH only works in:

  • Documented GH deficiency
  • Select ISS cases


HGH does NOT:

  • Make normal kids taller than their genetics allow
  • Extend growth plates
  • Increase final adult height
  • Create height out of nowhere
If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.
 
Last edited:
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lowkey was bouta buy some hgh, thanks for the heads up
 
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self_hatred said:
lowkey was bouta buy some hgh, thanks for the heads up
Click to expand...
hgh isnt cope, u can still gain height with it but there are other stuff you need to do for it to actually work. That's what most ppl get wrong, ima make a thread abt it later
 
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Reactions: Ahmed88
xqBandit said:
hgh isnt cope, u can still gain height with it but there are other stuff you need to do for it to actually work. That's what most ppl get wrong, ima make a thread abt it later
Click to expand...
Wrong
 
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the tall niggas always tryna stop the short niggas from getting taller
 
  • JFL
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  • +1
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some people really was thinking that hgh will increase their height in adult age?
 
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doesent
Ahmed88 said:
A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.


2. What the Studies ACTUALLY Show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:




VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):


B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.


3. Why HGH does NOT work for healthy normal children with PROOF

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:



  • GH does not create new growth potential.
    The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
  • GH cannot override genetic determinants of stature.
    Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
  • Endocrine feedback loops limit excessive growth signaling.
    The GH–IGF-1 axis is tightly regulated:
    • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
    • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
  • Physiologic ceiling effect.
    In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration
EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.


4. Why people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.


5. What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

  • Insulin resistance
  • Increased risk of type 2 diabetes
  • Fluid retention and edema
  • Joint pain
  • Carpal tunnel syndrome
  • Hip growth plate injury
  • Benign intracranial hypertension (severe headaches and vision changes)
  • Abnormal IGF‑1 elevations
  • Theoretical increased cancer risk due to chronic IGF‑1 stimulation
​

6. Summary

HGH only works in:

  • Documented GH deficiency
  • Select ISS cases


HGH does NOT:

  • Make normal kids taller than their genetics allow
  • Extend growth plates
  • Increase final adult height
  • Create height out of nowhere
If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.
[/SPOILE
your chances of hitting your genetic limit is basically 0 and hgh helps hit genetic limit so hgh growing fram and bones u cant get what hgh gives naturally
Click to expand...
 
  • JFL
Reactions: Ahmed88
dk14gm said:
but bro my friend says that hgh reaches your genetic limit because the chances of u hitiing genetic limit naturally are basically zero
Click to expand...
That's not true, there's 0 evidence suggesting that

It's actually the opposite
 
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dk14gm said:
can you explain if u dont mind cause he says otherwise
Click to expand...
There's 0 evidence suggesting that we don't reach our genetic height, in the modern world systems like advanced healthcare, equipment etc. allows us to maximise our full genetic potential
 
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Reactions: shedontluv-U
Ahmed88 said:
There's 0 evidence suggesting that we don't reach our genetic height, in the modern world systems like advanced healthcare, equipment etc. allows us to maximise our full genetic potential
Click to expand...
my friend said that our limit is gone and we didnt have the right nutrition in early puberty like 99% of other people , and h say advanced healthcare which is ?
 
dk14gm said:
my friend said that our limit is gone and we didnt have the right nutrition in early puberty like 99% of other people , and h say advanced healthcare which is ?
Click to expand...
Send the fucking sources nigga
,,Right nutrition"
it's a proven fact that people nowadays have more nutrition, then others
 
  • +1
Reactions: shedontluv-U
Ahmed88 said:
Send the fucking sources nigga
,,Right nutrition"
it's a proven fact that people nowadays have more nutrition, then others
Click to expand...
u mention advanced healthcare and stuff, and that is?
 
Would you still reccomend taking it for an increase in muscle mass or is that also retarded?
 
  • JFL
Reactions: Ahmed88
If you're still in puberty would you still use it for facial development not for height?
 
  • JFL
Reactions: Ahmed88
Ahmed88 said:
A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.


2. What the Studies ACTUALLY Show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:




VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):


B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.


3. Why HGH does NOT work for healthy normal children with PROOF

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:



  • GH does not create new growth potential.
    The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
  • GH cannot override genetic determinants of stature.
    Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
  • Endocrine feedback loops limit excessive growth signaling.
    The GH–IGF-1 axis is tightly regulated:
    • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
    • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
  • Physiologic ceiling effect.
    In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration
EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.


4. Why people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.


5. What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

  • Insulin resistance
  • Increased risk of type 2 diabetes
  • Fluid retention and edema
  • Joint pain
  • Carpal tunnel syndrome
  • Hip growth plate injury
  • Benign intracranial hypertension (severe headaches and vision changes)
  • Abnormal IGF‑1 elevations
  • Theoretical increased cancer risk due to chronic IGF‑1 stimulation
​

6. Summary

HGH only works in:

  • Documented GH deficiency
  • Select ISS cases


HGH does NOT:

  • Make normal kids taller than their genetics allow
  • Extend growth plates
  • Increase final adult height
  • Create height out of nowhere
If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.
Click to expand...
Enlighten us with an alternative
 
Ahmed88 said:
A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.


2. What the Studies ACTUALLY Show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:




VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):


B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.


3. Why HGH does NOT work for healthy normal children with PROOF

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:



  • GH does not create new growth potential.
    The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
  • GH cannot override genetic determinants of stature.
    Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
  • Endocrine feedback loops limit excessive growth signaling.
    The GH–IGF-1 axis is tightly regulated:
    • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
    • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
  • Physiologic ceiling effect.
    In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration
EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.


4. Why people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.


5. What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

  • Insulin resistance
  • Increased risk of type 2 diabetes
  • Fluid retention and edema
  • Joint pain
  • Carpal tunnel syndrome
  • Hip growth plate injury
  • Benign intracranial hypertension (severe headaches and vision changes)
  • Abnormal IGF‑1 elevations
  • Theoretical increased cancer risk due to chronic IGF‑1 stimulation
​

6. Summary

HGH only works in:

  • Documented GH deficiency
  • Select ISS cases


HGH does NOT:

  • Make normal kids taller than their genetics allow
  • Extend growth plates
  • Increase final adult height
  • Create height out of nowhere
If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.
Click to expand...
What about the literally documented kids with

Pituitary tumors that gained height with growth plates open and they gained upwards to 5 inches:feelswhy:​

 
itsoverformr said:
What about the literally documented kids with

Pituitary tumors that gained height with growth plates open and they gained upwards to 5 inches:feelswhy:​

Click to expand...
Thats continous amounts of hgh 24/7, the tumor ignores the negative feedback loop, you would need to inject hgh multiple times a
day at 5, for 15 years, the effects of the tumor is exactly the kind of thing our body is trying to stop us from, so you can't compare that to a normal human because our body fights agaisnt developing gigantism


But if you want, your free to try to give yourself acromegaly
 
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Ahmed88 said:
Thats continous amounts of hgh 24/7, the tumor ignores the negative feedback loop, you would need to inject hgh multiple times a
day at 5, for 15 years, the effects of the tumor is exactly the kind of thing our body is trying to stop us from, so you can't compare that to a normal human because our body fights agaisnt developing gigantism


But if you want, your free to try to give yourself acromegaly
Click to expand...
acromegaly is caused by tumor so you cant get it from injecting
 
itsoverformr said:
acromegaly is caused by tumor so you cant get it from injecting
Click to expand...
Partially right, but you did

Debunked your point

You could technically get gigantism if you injected 40iu every hour for 15 years

Noones tried it but you're free to try

You will live a severly painful short liife, with enlarged organs, edema, severe muscle pain, looking like a mountain ogre and probably drop dead by 40
 
  • +1
Reactions: shedontluv-U
Looker14y said:
muscle and water weight + he said heigth im 90% sure it impacts density and size
correct me if im wrong
Click to expand...
nigga just pulling shit outta nowhere and says "correct me if im wrong" :feelskek:
 
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mirin the effort
 
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khrome said:
nigga just pulling shit outta nowhere and says "correct me if im wrong" :feelskek:
Click to expand...
first of all i wasnt talking to you dumbass, and second the "correct me if im wrong" was because his wording was wierd and I dont want to have misunderstandings with someone who has half a brain, unlike you clearly. dont ever reply to any of my threads again tiktokcel of doom and despair:feelswhy:
 
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Reactions: Ahmed88
Looker14y said:
I dont want to have misunderstandings with someone who has half a brain, unlike you clearly.
Click to expand...
brudda i have a misunderstanding with you?
can you speak english please lmfao
 
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Reactions: strongmtn and Ahmed88
khrome said:
brudda i have a misunderstanding with you?
can you speak english please lmfao
Click to expand...
I was talking about who I was originaly answering too which is why i wrote it like that following proper grammar rules?, implying that you have no brain, is that too much to understand? My point stands
 
  • +1
Reactions: Ahmed88
Ahmed88 said:
A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.


2. What the Studies ACTUALLY Show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:




VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):


B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.


3. Why HGH does NOT work for healthy normal children with PROOF

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:



  • GH does not create new growth potential.
    The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
  • GH cannot override genetic determinants of stature.
    Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
  • Endocrine feedback loops limit excessive growth signaling.
    The GH–IGF-1 axis is tightly regulated:
    • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
    • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
  • Physiologic ceiling effect.
    In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration
EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.


4. Why people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.


5. What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

  • Insulin resistance
  • Increased risk of type 2 diabetes
  • Fluid retention and edema
  • Joint pain
  • Carpal tunnel syndrome
  • Hip growth plate injury
  • Benign intracranial hypertension (severe headaches and vision changes)
  • Abnormal IGF‑1 elevations
  • Theoretical increased cancer risk due to chronic IGF‑1 stimulation
​

6. Summary

HGH only works in:

  • Documented GH deficiency
  • Select ISS cases


HGH does NOT:

  • Make normal kids taller than their genetics allow
  • Extend growth plates
  • Increase final adult height
  • Create height out of nowhere
If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.
Click to expand...
“B-but my aromasin!!”
 
  • JFL
Reactions: Ahmed88
How do u explain korean kids all of a sudden growing to 6"2 becquse their 5"5 farmer parents injected them w hgh when they were kids
 
Ahmed88 said:
A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.


2. What the Studies ACTUALLY Show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:




VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):


B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.


3. Why HGH does NOT work for healthy normal children with PROOF

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:



  • GH does not create new growth potential.
    The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
  • GH cannot override genetic determinants of stature.
    Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
  • Endocrine feedback loops limit excessive growth signaling.
    The GH–IGF-1 axis is tightly regulated:
    • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
    • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
  • Physiologic ceiling effect.
    In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration
EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.


4. Why people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.


5. What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

  • Insulin resistance
  • Increased risk of type 2 diabetes
  • Fluid retention and edema
  • Joint pain
  • Carpal tunnel syndrome
  • Hip growth plate injury
  • Benign intracranial hypertension (severe headaches and vision changes)
  • Abnormal IGF‑1 elevations
  • Theoretical increased cancer risk due to chronic IGF‑1 stimulation
​

6. Summary

HGH only works in:

  • Documented GH deficiency
  • Select ISS cases


HGH does NOT:

  • Make normal kids taller than their genetics allow
  • Extend growth plates
  • Increase final adult height
  • Create height out of nowhere
If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.
Click to expand...
Fucking retard hgh and ai can deffo work ig u use 10+ ius ur just a retard that looks at wrong studies to fit his narrative
 
chudcel25 said:
How do u explain korean kids all of a sudden growing to 6"2 becquse their 5"5 farmer parents injected them w hgh when they were kids
Click to expand...
Never happened
 
Ahmed88 said:
A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.


2. What the Studies ACTUALLY Show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:




VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):


B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.


3. Why HGH does NOT work for healthy normal children with PROOF

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:



  • GH does not create new growth potential.
    The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
  • GH cannot override genetic determinants of stature.
    Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
  • Endocrine feedback loops limit excessive growth signaling.
    The GH–IGF-1 axis is tightly regulated:
    • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
    • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
  • Physiologic ceiling effect.
    In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration
EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.


4. Why people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.


5. What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

  • Insulin resistance
  • Increased risk of type 2 diabetes
  • Fluid retention and edema
  • Joint pain
  • Carpal tunnel syndrome
  • Hip growth plate injury
  • Benign intracranial hypertension (severe headaches and vision changes)
  • Abnormal IGF‑1 elevations
  • Theoretical increased cancer risk due to chronic IGF‑1 stimulation
​

6. Summary

HGH only works in:

  • Documented GH deficiency
  • Select ISS cases


HGH does NOT:

  • Make normal kids taller than their genetics allow
  • Extend growth plates
  • Increase final adult height
  • Create height out of nowhere
If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.
Click to expand...
ok mr high iq how to increase fah
 
Ahmed88 said:
A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.


2. What the Studies ACTUALLY Show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:




VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):


B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.


3. Why HGH does NOT work for healthy normal children with PROOF

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:



  • GH does not create new growth potential.
    The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
  • GH cannot override genetic determinants of stature.
    Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
  • Endocrine feedback loops limit excessive growth signaling.
    The GH–IGF-1 axis is tightly regulated:
    • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
    • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
  • Physiologic ceiling effect.
    In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration
EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.


4. Why people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.


5. What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

  • Insulin resistance
  • Increased risk of type 2 diabetes
  • Fluid retention and edema
  • Joint pain
  • Carpal tunnel syndrome
  • Hip growth plate injury
  • Benign intracranial hypertension (severe headaches and vision changes)
  • Abnormal IGF‑1 elevations
  • Theoretical increased cancer risk due to chronic IGF‑1 stimulation
​

6. Summary

HGH only works in:

  • Documented GH deficiency
  • Select ISS cases


HGH does NOT:

  • Make normal kids taller than their genetics allow
  • Extend growth plates
  • Increase final adult height
  • Create height out of nowhere
If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.
Click to expand...
hard dnr
 
  • Ugh..
Reactions: Ahmed88
worst thread ive seen in a while
 
  • +1
  • Ugh..
Reactions: fraudster#1, 16youngcell and Ahmed88
16youngcell said:
hard dnr
Click to expand...
I could care less if ,,16young,,cell" with 9 posts reads my threads or not, i just know you're a retarded tiktokfag, blasting hgh cause clavicular said it gives ,,muh bones"
 
  • Ugh..
Reactions: 16youngcell
Ahmed88 said:
I could care less if ,,16young,,cell" with 9 posts reads my threads or not, i just know you're a retarded tiktokfag, blasting hgh cause clavicular said it gives ,,muh bones"
Click to expand...
Yeah because i care about my looksmax.org forum account rep stats and join date. ur a retard who prob hasnt ran gh themselves theres literally tons of studys showing it improved AFH at 8+ ius nightly if plates r open. now if you pair gh with an actuall height stack then itll be usefull.
 
16youngcell said:
Yeah because i care about my looksmax.org forum account rep stats and join date. ur a retard who prob hasnt ran gh themselves theres literally tons of studys showing it improved AFH at 8+ ius nightly if plates r open. now if you pair gh with an actuall height stack then itll be usefull.
Click to expand...
Then send the studies, instead of being a retarded faggot spamming a new buzzword he heard, ill debunk every retarded point of yours, you autistic fuck


,,muh hgh works"
But doesn't provide a claim, everyone knows you're a retarded faggot, who has no idea what he's saying
 
Ahmed88 said:
Why is every turkish mf, obsessed with fucking hgh, like holy shit is height in turkey that bad
Click to expand...
Nigga has studied me @Starborn
He knows of my hatred of turks and tried to ragebait me with it
this would work on a fool like starborn
 
  • JFL
Reactions: Starborn, 16youngcell and Ahmed88
Grievous said:
Nigga has studied me @Starborn
He knows of my hatred of turks and tried to ragebait me with it
this would work on a fool like starborn
Click to expand...
DUDE? FUCK YOU
 
  • JFL
Reactions: Ahmed88
Ahmed88 said:
Why is every turkish mf, obsessed with fucking hgh, like holy shit is height in turkey that bad
Click to expand...
Ahmed88 said:
Then send the studies, instead of being a retarded faggot spamming a new buzzword he heard, ill debunk every retarded point of yours, you autistic fuck


,,muh hgh works"
But doesn't provide a claim, everyone knows you're a retarded faggot, who has no idea what he's saying
Click to expand...
Okay ill agree on one thing, maybe hgh by itself barely serves any benefit by itself, but if paired with infigratinib and ai, it is definitly a + on height by centimeters or even inch+ if ur lucky
 
  • JFL
Reactions: Ahmed88
16youngcell said:
Okay ill agree on one thing, maybe hgh by itself barely serves any benefit by itself, but if paired with infigratinib and ai, it is definitly a + on height by centimeters or even inch+ if ur lucky
Click to expand...
No, fgfr3s inhibitors do not work, for the same reason as hgh, and since you need an overactive fgfr3 for it to work in the first place

Ai also does not work, you need e2 for multiple reasons, like bone, libido, brain health and even height, even if you didn't care that you're going to be a boneless, asexual, manlet retard, for it to stop closing your growth plates even by a milisecond, you would to nuke your e2 to a level not possible with normal medication in todays era, even if you somehow managed to do it you would probably still end up shorter, because like i said you need e2 for height
 
topology said:
Not at all..? It's over simplified and not actually representative of the truth.


There are 3 types of bone types. It doesn't paint the full picture.


Endocrine feedback and receptor desensitization cause diminishing returns on GH/IGF-1 signaling, but they do not eliminate supraphysiologic effects, only blunts them. What you stated is very misleading to make your point sound like it has more merit than it actually does.


The point is you have many gaps in what you say. It's obvious it's from ChatGPT. You try to explain everything but fail to explain the actual logical gaps.


No, you didn't. Your argument holds no merit. No doctor would agree with you.


Gigantism proves that..?

:lul::lul::lul::lul:

The average replications done by progenitors is orders of magnitudes smaller than the genetic celling. The progenitors can replicate about 10-100x more depending on the person. The limit is NEVER things like SHOX, FGFR3, etc.

Gigantism proves this, bub. And before "The loop is ruined!!!" It doesn't matter, the loop can be bypassed via inputting more largely, the increase is also logarithmic, we wouldn't need gigantism levels to be much taller. The current limit is due to the PTHrP levels. Go and do some research.


Go ahead and link sources showing how using growth hormone to up the replication will cause them to progress faster and not get a net gain. I do not want a link to the replication limit.

You literally debunked this point below. You're using GPT and not realizing you contradict yourself.


Doesn't matter..?


The arguments have no merit. The things you stated are incorrect and/or misleading. Go ahead and debunk me.


You can..?

PTHrP can be injected near the growth plate and it would work upon it..
E2 being lowered would increase efficiency. This one is obviously the easiest to accomplish.
Vismodegib for example would decrease IHH.

The argument here isn't even to encourage that but rather to show you're wrong biologically.


How is that wrong.? Height is polygenetic like you mentioned. Hormone levels are only outside the normal range when a condition occurs. It's not like you can be between 1 unit - 100,000 units naturally.. The normal range is irrelevant. The conditions even prove my point more. It shows more/less GH will cause height differences.


Not an argument..? What I stated is the truth. Doesn't matter if it's unhealthy by any standard.


wnt/B-catenin only is able to override SOX9 assuming it has high levels for long enough.. The current limitations is the PTHrP levels. wnt/b-catenin does not cause the main transition currently. There is a clear hierarchy when talking about SOX9, you moron. It directly inhibits the job of Wnt/B-catenin. Also, you're acting like the pathway isn't easily fixable. You can make it self destruct via axins.


There was no point being made. E2 only lowers predicted height as it impacts PTHrP. SOX9 is a result of the PTHrP loop. Do you know anything about this subject..? Wnt/B-catenin makes the transcription factors within the nucleus.. SOX9 inhibits it.. See the link..? It's all connected, it's not individualized.


Gigantism is driven by excess GH acting through the GH–IGF-1 axis, which increases chondrocyte proliferation and slightly increases hypertrophic expansion at the growth plate. That is sufficient on its own to produce extreme growth, and pretending otherwise just shows how much of a moron you are.

Growth plate closure is primarily regulated by Estrogen, not GH, which is why conditions with impaired estrogen signaling continue growing despite normal or even low GH.

GH/IGF-1 does not inherently accelerate senescence, it amplifies growth velocity, while closure depends on estrogen-mediated depletion of the progenitor pool and differentiation dynamics.

Yes, feedback loops and receptor desensitization exist, but they impose diminishing returns, not a hard stop, otherwise disorders like Gigantism wouldn’t reach extreme heights.

Claiming that “all hormones/pathways must be disrupted” conflicts secondary tumor effects with the primary mechanism. Isolated GH excess is both clinically and mechanistically sufficient. This is proven.


You're overstating it. E2 modulates the GH/IGF-1 axis, it's not the depending factor. Also, this is IRRELEVANT as we're assuming it's synthetic hormones. Low E2 levels largely don't affect the chondrocyte proliferative zone receptors. Your argument doesn't have any merit. They would continue dividing and only IF E2 is too low would it cause in issue in later stages, not the proliferation. Increasing SOX9 would actually improve growth plate organization too :lul::lul::lul: It would cause more ECM to be made which causes the pre hypertrophic phase to go more smoothly. The structural issues as a result wouldn't occur until much later.



The "studies" don't administer anything to healthy children and even if they did, it wouldn't be enough...? You linked no studies showing what I was asking for..



This is factually false. Go ahead and provide your source. Growth hormone therapy is given to anyone who is short enough, you don't require a condition.



The thing that makes them turn is going down the PTHrP gradient like you said.. This literally works against your argument. You said GH makes your cells transition sooner. The genetic limits are nowhere near what natural humans are at. Therefore, increasing SOX9 would increase replication and make you taller. The structural issues would not arise until much later as I stated before more SOX9 means more ECM.



You can increase proliferation.. That means more cells.. That means more height.. The limit currently is not the genetic celling you're talking about.. That's the issue within your argument.. No argument was made for plate lifespan..

The final height would be higher as you make more cells. Follow the logic..?

Also, I'm not even sure what you're trying to get at. This debunks your whole HGH makes transitioning happens faster argument.



I'd like to make a comment specifically on this.

This is my entire point..?

More cells = more height. Nothing negative is affected.. Yikes.



SHOX, FGFR3, etc are not the celling. I don't know where you got that idea from. Gigantism proves this as it doesn't impact the genetic code..



Maybe because it debunks everything you said..?




And that can be replicated..? It would once again only blunt it but still allow you to climb levels.. Yikes.



You're using normal genetics to try and explain a synthetic hormonal approach..? :lul::lul::lul::lul::lul::lul::lul: All the loops can be bypassed, get a grip.


The proliferative stage would be optimized with SOX9.

Guess what..? SOX9 makes more ECM. ECM is what is needed for the pre hypertrophic phase.

You could easily combine it with a bone stack to manage the bone issues/terminal differentiation issue too. Not sure what argument this even is.



Gigantism shows that more IGF-1 and GH means being taller. If I can prove you can raise levels way above the normal would you concede..? You wouldn't, that's the issue. The tumor doesn't impact anything major, it would be obvious if it had.



You didn't even provide an argument. You said "Gigantism = not normal so not applied to normal kids. We also don't know what gigantism is. Growth plates aren't something you can program."

Literal GPT arguments. This is exactly what GPT pushes back on when you provide an argument to it. Get a grip, it's so obvious what you're doing.
Click to expand...
Ive spent a little over an hour reading through this thread trying to understand this. I never realized how deep all of this goes. You seem extremely knowledgeable along with megapro981, and I was wondering the best course of action to get taller. Im 16 and went through puberty extremely late. Would letrozole, anastrozole or even Aromasin combined with hgh or igf1-lr3 help me squeeze out even an extra inch or 2? If this isn't even the right pathway, could you please give me some insight on how?
 
topology said:
Not at all..? It's over simplified and not actually representative of the truth.


There are 3 types of bone types. It doesn't paint the full picture.


Endocrine feedback and receptor desensitization cause diminishing returns on GH/IGF-1 signaling, but they do not eliminate supraphysiologic effects, only blunts them. What you stated is very misleading to make your point sound like it has more merit than it actually does.


The point is you have many gaps in what you say. It's obvious it's from ChatGPT. You try to explain everything but fail to explain the actual logical gaps.


No, you didn't. Your argument holds no merit. No doctor would agree with you.


Gigantism proves that..?

:lul::lul::lul::lul:

The average replications done by progenitors is orders of magnitudes smaller than the genetic celling. The progenitors can replicate about 10-100x more depending on the person. The limit is NEVER things like SHOX, FGFR3, etc.

Gigantism proves this, bub. And before "The loop is ruined!!!" It doesn't matter, the loop can be bypassed via inputting more largely, the increase is also logarithmic, we wouldn't need gigantism levels to be much taller. The current limit is due to the PTHrP levels. Go and do some research.


Go ahead and link sources showing how using growth hormone to up the replication will cause them to progress faster and not get a net gain. I do not want a link to the replication limit.

You literally debunked this point below. You're using GPT and not realizing you contradict yourself.


Doesn't matter..?


The arguments have no merit. The things you stated are incorrect and/or misleading. Go ahead and debunk me.


You can..?

PTHrP can be injected near the growth plate and it would work upon it..
E2 being lowered would increase efficiency. This one is obviously the easiest to accomplish.
Vismodegib for example would decrease IHH.

The argument here isn't even to encourage that but rather to show you're wrong biologically.


How is that wrong.? Height is polygenetic like you mentioned. Hormone levels are only outside the normal range when a condition occurs. It's not like you can be between 1 unit - 100,000 units naturally.. The normal range is irrelevant. The conditions even prove my point more. It shows more/less GH will cause height differences.


Not an argument..? What I stated is the truth. Doesn't matter if it's unhealthy by any standard.


wnt/B-catenin only is able to override SOX9 assuming it has high levels for long enough.. The current limitations is the PTHrP levels. wnt/b-catenin does not cause the main transition currently. There is a clear hierarchy when talking about SOX9, you moron. It directly inhibits the job of Wnt/B-catenin. Also, you're acting like the pathway isn't easily fixable. You can make it self destruct via axins.


There was no point being made. E2 only lowers predicted height as it impacts PTHrP. SOX9 is a result of the PTHrP loop. Do you know anything about this subject..? Wnt/B-catenin makes the transcription factors within the nucleus.. SOX9 inhibits it.. See the link..? It's all connected, it's not individualized.


Gigantism is driven by excess GH acting through the GH–IGF-1 axis, which increases chondrocyte proliferation and slightly increases hypertrophic expansion at the growth plate. That is sufficient on its own to produce extreme growth, and pretending otherwise just shows how much of a moron you are.

Growth plate closure is primarily regulated by Estrogen, not GH, which is why conditions with impaired estrogen signaling continue growing despite normal or even low GH.

GH/IGF-1 does not inherently accelerate senescence, it amplifies growth velocity, while closure depends on estrogen-mediated depletion of the progenitor pool and differentiation dynamics.

Yes, feedback loops and receptor desensitization exist, but they impose diminishing returns, not a hard stop, otherwise disorders like Gigantism wouldn’t reach extreme heights.

Claiming that “all hormones/pathways must be disrupted” conflicts secondary tumor effects with the primary mechanism. Isolated GH excess is both clinically and mechanistically sufficient. This is proven.


You're overstating it. E2 modulates the GH/IGF-1 axis, it's not the depending factor. Also, this is IRRELEVANT as we're assuming it's synthetic hormones. Low E2 levels largely don't affect the chondrocyte proliferative zone receptors. Your argument doesn't have any merit. They would continue dividing and only IF E2 is too low would it cause in issue in later stages, not the proliferation. Increasing SOX9 would actually improve growth plate organization too :lul::lul::lul: It would cause more ECM to be made which causes the pre hypertrophic phase to go more smoothly. The structural issues as a result wouldn't occur until much later.



The "studies" don't administer anything to healthy children and even if they did, it wouldn't be enough...? You linked no studies showing what I was asking for..



This is factually false. Go ahead and provide your source. Growth hormone therapy is given to anyone who is short enough, you don't require a condition.



The thing that makes them turn is going down the PTHrP gradient like you said.. This literally works against your argument. You said GH makes your cells transition sooner. The genetic limits are nowhere near what natural humans are at. Therefore, increasing SOX9 would increase replication and make you taller. The structural issues would not arise until much later as I stated before more SOX9 means more ECM.



You can increase proliferation.. That means more cells.. That means more height.. The limit currently is not the genetic celling you're talking about.. That's the issue within your argument.. No argument was made for plate lifespan..

The final height would be higher as you make more cells. Follow the logic..?

Also, I'm not even sure what you're trying to get at. This debunks your whole HGH makes transitioning happens faster argument.



I'd like to make a comment specifically on this.

This is my entire point..?

More cells = more height. Nothing negative is affected.. Yikes.



SHOX, FGFR3, etc are not the celling. I don't know where you got that idea from. Gigantism proves this as it doesn't impact the genetic code..



Maybe because it debunks everything you said..?




And that can be replicated..? It would once again only blunt it but still allow you to climb levels.. Yikes.



You're using normal genetics to try and explain a synthetic hormonal approach..? :lul::lul::lul::lul::lul::lul::lul: All the loops can be bypassed, get a grip.


The proliferative stage would be optimized with SOX9.

Guess what..? SOX9 makes more ECM. ECM is what is needed for the pre hypertrophic phase.

You could easily combine it with a bone stack to manage the bone issues/terminal differentiation issue too. Not sure what argument this even is.



Gigantism shows that more IGF-1 and GH means being taller. If I can prove you can raise levels way above the normal would you concede..? You wouldn't, that's the issue. The tumor doesn't impact anything major, it would be obvious if it had.



You didn't even provide an argument. You said "Gigantism = not normal so not applied to normal kids. We also don't know what gigantism is. Growth plates aren't something you can program."

Literal GPT arguments. This is exactly what GPT pushes back on when you provide an argument to it. Get a grip, it's so obvious what you're doing.
Click to expand...
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