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Osie
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THIS IS NOT MY INFORMATION. This is a summarized version of DatBTrue's Thread.
In comparison to synthetic GH administration, we find that:
22iu of synthetic GH results in 495 - 585 ng/ml
Saturation doses (100 mcg) of GHRH & GHRP once a day result in 130 - 170 ng/ml
These results indicate that 22iu is between 3.8 and 3.4 more efficacious than a single administration of GHRH & GHRP which means that a single dose of GHRH & GHRP has the potential to produce better than the equivalent of 5iu of GH in plasma.
A dosing protocol of GHRH + GHRP at saturation dose, administered 3 times per day has the potential to exceed the equivalent of 15iu.
Total GH Release:
When CJC-1295 was administered at 30mcg/kg; 60mcg/kg; 125mcg/kg and 250mcg/kg the total GH levels (area under the curve (AUC)) were respectively:
AUC: 758, 969, 977, and 1370 ng/ml per hour
Keep in mind that for an 80kg adult, the 30mcg/kg dosing amounts to 2.4mgs of CJC-1295 per week, and the 60mcg/kg dosing amounts to 4.8mgs of CJC-1295. So 2.4 mgs of CJC-1295 produced an AUC of 758 ng/ml per hour.
When synthetic Growth Hormone (Humatrope) was administered at the equivalent of 22iu (in someone weighing 80+ kg) the following GH levels (area under the curve (AUC)) were reached:
AUC Intramuscular: 495 +/- 106
AUC Subcutaneous: 585 +/- 90
Peak Concentration:
However, the GH release pattern results in a much higher mean maximum concentration for the GH administration than the CJC-1295 administration.
The GH study resulted in peaks of 53 to 63 ng/ml.
The CJC-1295 study resulted in dose-respected peaks of 6.6; 9.6; 9.9; 13.3 ng/ml.
Total GH Release:
The Alfonso Leal-Cerro study demonstrated the following GH release:
GHRH by itself dosed at 100mcg resulted in:
(AUC) 120 minutes = 1420 ± 330 ng/ml when we convert that to AUC measured in hours we get about: 25 ng/ml
GHRP-6 by itself dosed at 100mcg resulted in:
(AUC) 120 minutes = 2278 ± 290 ng/ml when we convert that to AUC measured in hours we get about: 40 ng/ml
GHRH + GHRP-6 dosed together at 100mcg each resulted in:
(AUC) 120 minutes = 7332 ± 592 ng/ml when we convert that to AUC measured in hours we get about: 130 ng/ml
The Bowers study demonstrated that a small dose of GHRP (.1mcg/kg) added to a saturation dose of GHRH (1mcg/kg) resulted in the following GH release:
(AUC) 120 minutes = 10,065 ng/ml when we convert that to AUC measured in hours we get about: 170 ng/ml
In comparison to synthetic GH administration, we find that:
22iu of synthetic GH results in 495 - 585 ng/ml
Saturation doses of GHRH & GHRP result in 130 - 170 ng/ml
These results indicate that 22iu is between 3.8 and 3.4 more efficacious than a single administration of GHRH & GHRP which means that a single dose of GHRH & GHRP has the potential to produce better than the equivalent of 5iu of GH in plasma.
A dosing protocol of GHRH + GHRP at saturation dose, administered 3 times per day has the potential to exceed the equivalent of 15iu.
Peak Concentration:
From the graphs, it is easy to see that GHRH+GHRP results in short-term peaks of 80 to 130 ng/ml.
While the synthetic GH study resulted in less pronounced peaks of 53 to 63 ng/ml of longer duration.
CONCLUSION:
THOSE SAYING HGH OR NOTHING MIGHT'VE BEEN WRONG. This has been quite interesting. If anyone finds more information from the original thread, please make a thread on here about it as the original one is very long.
TLDR:
In comparison to synthetic GH administration, we find that:
22iu of synthetic GH results in 495 - 585 ng/ml
Saturation doses (100 mcg) of GHRH & GHRP once a day result in 130 - 170 ng/ml
These results indicate that 22iu is between 3.8 and 3.4 more efficacious than a single administration of GHRH & GHRP which means that a single dose of GHRH & GHRP has the potential to produce better than the equivalent of 5iu of GH in plasma.
A dosing protocol of GHRH + GHRP at saturation dose, administered 3 times per day has the potential to exceed the equivalent of 15iu.
Comparing GH administration to CJC-1295 administration
Total GH Release:
When CJC-1295 was administered at 30mcg/kg; 60mcg/kg; 125mcg/kg and 250mcg/kg the total GH levels (area under the curve (AUC)) were respectively:
AUC: 758, 969, 977, and 1370 ng/ml per hour
Keep in mind that for an 80kg adult, the 30mcg/kg dosing amounts to 2.4mgs of CJC-1295 per week, and the 60mcg/kg dosing amounts to 4.8mgs of CJC-1295. So 2.4 mgs of CJC-1295 produced an AUC of 758 ng/ml per hour.
When synthetic Growth Hormone (Humatrope) was administered at the equivalent of 22iu (in someone weighing 80+ kg) the following GH levels (area under the curve (AUC)) were reached:
AUC Intramuscular: 495 +/- 106
AUC Subcutaneous: 585 +/- 90
Peak Concentration:
However, the GH release pattern results in a much higher mean maximum concentration for the GH administration than the CJC-1295 administration.
The GH study resulted in peaks of 53 to 63 ng/ml.
The CJC-1295 study resulted in dose-respected peaks of 6.6; 9.6; 9.9; 13.3 ng/ml.
Total GH Release:
The Alfonso Leal-Cerro study demonstrated the following GH release:
GHRH by itself dosed at 100mcg resulted in:
(AUC) 120 minutes = 1420 ± 330 ng/ml when we convert that to AUC measured in hours we get about: 25 ng/ml
GHRP-6 by itself dosed at 100mcg resulted in:
(AUC) 120 minutes = 2278 ± 290 ng/ml when we convert that to AUC measured in hours we get about: 40 ng/ml
GHRH + GHRP-6 dosed together at 100mcg each resulted in:
(AUC) 120 minutes = 7332 ± 592 ng/ml when we convert that to AUC measured in hours we get about: 130 ng/ml
The Bowers study demonstrated that a small dose of GHRP (.1mcg/kg) added to a saturation dose of GHRH (1mcg/kg) resulted in the following GH release:
(AUC) 120 minutes = 10,065 ng/ml when we convert that to AUC measured in hours we get about: 170 ng/ml
In comparison to synthetic GH administration, we find that:
22iu of synthetic GH results in 495 - 585 ng/ml
Saturation doses of GHRH & GHRP result in 130 - 170 ng/ml
These results indicate that 22iu is between 3.8 and 3.4 more efficacious than a single administration of GHRH & GHRP which means that a single dose of GHRH & GHRP has the potential to produce better than the equivalent of 5iu of GH in plasma.
A dosing protocol of GHRH + GHRP at saturation dose, administered 3 times per day has the potential to exceed the equivalent of 15iu.
Peak Concentration:
From the graphs, it is easy to see that GHRH+GHRP results in short-term peaks of 80 to 130 ng/ml.
While the synthetic GH study resulted in less pronounced peaks of 53 to 63 ng/ml of longer duration.
CONCLUSION:
THOSE SAYING HGH OR NOTHING MIGHT'VE BEEN WRONG. This has been quite interesting. If anyone finds more information from the original thread, please make a thread on here about it as the original one is very long.
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