Nigga became jealous
Nobody is saying you did nun but don't act like I just changed font size and color here and there
I fucked jonas mom
Not cool Your a cuck
To be fair, you have to have a very high IQ to be into cuckolding. The fetish is extremely subtle, and without a solid grasp of theoretical physics most of your wife's orgasms will go over a typical chad’s head. There’s also my wife's boyfriend's nihilistic outlook, which is deftly woven into his characterisation- his personal philosophy draws heavily from BDSM literature, for instance. The cucks understand this stuff; they have the intellectual capacity to truly appreciate the depths of these fetishes, to realise that they’re not just arousing- they say something deep about LIFE. As a consequence people who dislike cuckolding truly ARE idiots- of course they wouldn’t appreciate, for instance, the pleasure in the cuck's existential catchphrase “Would you like to ♥♥♥♥ my wife?,” which itself is a cryptic reference to Turgenev’s Russian epic Wives and Boyfriends. I’m smirking right now just imagining one of those addlepated simpletons scratching their heads in confusion as Daily Beast’s genius wit unfolds itself on their beds. What fools.. how I pity them.And yes, by the way, i DO have a cuckolding tattoo. And no, you cannot see it. It’s for the men's eyes only- and even then they have to demonstrate that they’re able to make my wife orgasm beforehand. Nothin personnel kid
God tier threadLeanmaxxing: 8 Strategies for Fat Loss
by @Jonas2k7 & @20/04/2008
What is the bare minimum you can do to still experience significant and rapid fat loss? What gives you the biggest bang for your buck?
This thread will discuss only exclusive methods, nothing water to be seen here.
1. Take collagen to drop fat
Collagen can be a powerful tool for losing fat. Research shows that it significantly aids in muscle building, strength gains and fat reduction.
This isn't just because it's high in glycine and proline or because it's low in inflammatory amino acids like methionine, tryptophan and cysteine, it's primarily due to its content of bioactive peptides. Collagen contains various short peptides, especially hydroxyproline (Hyp)-containing ones, such as:
- Prolyl-hydroxyproline (Pro-Hyp)
- Alanine-Hyp
- Proline-Hyp
- Alanine-Hydroxyproline-Glycine
- Serine-Hydroxyproline-Glycine
- Phenylalanine-Hyp
- Gly-Pro-Hyp
- Isoleucine-Hyp
- Leucine-Hyp
These peptides are what contribute the most to the anabolic and shredding effects of collagen. Although this list might not cover all the peptides in collagen, it highlights those currently recognized for their potential in muscle building and fat loss. So collagen is much more important than just the free amino acids, glycine, proline or hydroxyproline.
Most studies use around 15g of collagen daily, but for optimal results, it's recommended to increase this to 30g or even 50g per day.
2. Use Red light to release fat
Red light and near-infrared light are highly beneficial to the body, as they promote cellular function. This means they speed up metabolism, increase energy expenditure, boost thyroid hormone and testosterone production, lower stress, promote blood flow, speed up wound healing, reduce wrinkles, improve sleep and exercise performance, etc. The list goes on.
Red light also promotes local lipolysis where it’s applied, aiding in targeted fat loss and overall fat reduction. It can even be used on the face to reduce puffiness and fat in that area.
Investing in a high-quality red light device can have a significant impact on your health and fat loss. It’s an investment worth making, as it’s essential for taking your health to the next level.
3. Get sunlight
Sunlight is so much more than just vitamin D, red light or near infra-red light. There are so many things you can do while being outside in the sun such as grounding, being active, inhaling calming compounds of nature and many more.
Sunlight increases the release of dopamine, and dopamine speeds up the metabolism and the desire to move and be active. Sunlight can also promote blood flow, sweating and the detoxification of toxins that might be hindering fat loss.
4. Walk in nature
Walking in nature is much more beneficial than just walking on a treadmill. Besides being outdoors in the sun and experiencing grounding, being in nature stimulates the brain significantly more and nearly doubles energy expenditure.
When you walk in nature, you burn more calories and enjoy additional benefits, such as reduced stress, increased dopamine levels, earthing, inhaling clean air, and enhanced brain stimulation.
5. Block EMF because it inhibits fat loss
Over the past few decades EMF exposure has increased astronomically. In fact it has increased by a quintillion times (that’s a 1 with 18 zeros) according to Dr. Joseph Mercola.
WiFi modems, cellphone towers and dirty electricity all emit EMF, which activates voltage-gated calcium channels (VGCCs) in the body. These channels allow calcium to enter and accumulate inside cells.
This excess calcium puts the cell in an excited state, leading to several negative effects. Intracellular calcium inhibits lipolysis (the breakdown of fat) in fat tissue, promotes lipogenesis (the conversion of carbohydrates to fat), and disrupts proper glucose oxidation.
As a result, there is less release of fat from fat stores, increased fat synthesis from carbohydrates and reduced oxidation of both fat and glucose in the cells.
So EMF exposure can contribute to fat retention. Fortunately, we can take steps to mitigate these effects through supplements and lifestyle changes that help counteract EMF exposure.
Here are some ways to protect yourself against the dangers of EMF:
1) Calcium Channel Blockers
EMF exposure activates voltage-gated calcium channels (VGCCs), allowing excess calcium into cells, leading to cellular stress and fat storage. Using calcium antagonists can help inhibit these channels.
Note for gear users: Consider supplementing with DHEA.
2) Inhibit Nitric Oxide Synthesis with Methylene Blue
Methylene blue can block the synthesis of nitric oxide (NO), which when elevated can hinder fat loss by boosting ATP and CO2 production. Excess NO is detrimental to fat loss.
3) Fix Mitochondrial Function
Improving mitochondrial function is key to reducing oxidative stress and enhancing ATP production. A combination of methylene blue, vitamin C, vitamin K2 and succinic acid can help repair the electron transport chain (ETC). Exercise, proper sleep and stress management are also crucial for promoting healthy mitochondria. Adequate ATP levels are essential for calcium transport out of cells, preventing calcium buildup even when VGCCs are blocked.
4) Activate Nrf2 Pathway
Nrf2 (a transcription factor) helps activate over 500 genes, reduces inflammation, improves mitochondrial function and stimulates autophagy. It lowers peroxynitrite production by inhibiting iNOS and COX-2. Compounds that activate Nrf2 are genereally turmeric, cruciferous vegetables, sulfur-rich foods and various quinones (like CoQ10 and PQQ).
A few compounds that promote Nrf2 include:
- Turmeric
- Cruciferous foods
- Sulfur rich foods
- Quinones
- Anthraquinone found in aloe latex, senna, rhubarb, cascara buckthorn, fungi, lichens and some insects.
- Naphthoquinone (Vitamin K is a derivative of 1,4-naphthoquinone). Other natural naphtoquinones include juglone (found in black walnut), lapachol (pau d arco tea),
- Benzoquinone. Ubiquinone (CoQ10) is a naturally occurring 1,4-benzoquinone.
- Pyrroloquinoline quinone (PQQ) found in kiwi fruit.
- γ (gamma) and δ (delta) tocopherols
- α-lipoic acid
- Carotenoids
- Olives and olive oil due to being rich in phenolics and terpenoids
- Purple sweet potatoes due to anthocyanin phenolics
- Quercetin
- Apigenin
- Naringenin
- Sulforaphane
- Shikonin (natural anthraquinone derivative) lowers estrogen by modulating an estrogen enzyme by down-regulating the expression of steroid sulfatase, it's essential for estrogen biosynthesis.
Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer - PubMed
Exposure to higher levels of estrogen produces genotoxic metabolites that can stimulate mammary tumorigenesis. Induction of NF-E2-related factor 2 (NRF2)-dependent detoxifying enzymes (e.g., NAD(P)H-quinone oxidoreductase 1 (NQO1)) is considered an important mechanism of protection against...pubmed.ncbi.nlm.nih.gov
5) Inhibit NMDA Receptors
NMDA receptor activation increases intracellular calcium. Glutamate, the main NMDA agonist, rises in low ATP states, worsening calcium buildup. Magnesium and Theanine are two of the best natural NMDA receptor antagonists. Ketamine is a very effective and relatively safe drug that blocks the NMDA receptor.
6) Induce Mitochondrial Uncoupling
Mitochondrial uncoupling proteins (UCPs) reduce oxidative phosphorylation, lowering oxidative stress and preventing excess calcium entry. Moderate uncoupling can be induced with supplements like adrenal cortex extract, thyroid hormones (T4 and T3), calcium and progesterone. Caution is needed with strong uncouplers like DNP, which can cause lethal overheating.
Other methods to induce UCP are:
- large doses of aspirin
- methylene blue
- salt
- red meat
- lots of glucose with fats and spices.
- Curcumin
Let me say it again: If you get an excess of uncoupling, you can actually die of heat. This is how people die that overdose on DNP.
Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells - PubMed
An increase in the cytoplasmic-free Ca(2+) concentration mediates cellular responses to environmental signals that influence a range of processes, including gene expression, motility, secretion of hormones and neurotransmitters, changes in energy metabolism, and apoptosis. Mitochondria play...
That’s why DNP is so effective but very unsafe, whereas Niclosamide appears to be effective and much safer.
Goodbye buddy boyos @appealmaxed @craven
6. Avoid toxins
Just like EMF our environment, food, air and water have dramatically increased in toxins like heavy metals, mold, plastic, pharmaceutical drugs (birth control, SSRI, etc.), food additives, colourants, flavourings, cosmetics, omega 6 rich rancid vegetable oils/foods and more.
The list is way too long, but I’ll list a few:
- Heavy metals – Present in the air, dental fillings, water pipes, paints and many other building materials.
- Mold – Present in coffee, cocoa, grains and other products that aren’t properly stored. Animals that eat moldy grains (like all of them basically) have these toxic compounds in their fat and products such as eggs and milk and milk products. It’s also present where it’s damp and dark like in the bathroom, under wooden floors, in the ceiling, etc.
- Pharmaceutical drugs – Mostly present in our water, as well as in the sea creatures we eat that live close to the shore.
- Plastics – Everywhere basically. Stopping the use of plastic products and using an activated charcoal filter can help you get rid of the majority of plastics.
- Food additives, colourants & flavourings – Present in most foods and drinks. You’ll be surprised that it’s even present in “natural” foods, such as thickeners in yoghurt and cottage cheese, colourants in fruit juice & meat, flavour enhancers in baked goods, meats, drinks, etc.
- Cosmetics – Chances are that the shampoo, shaving cream, aftershave and deodorant you’re getting at your local store is choke-full of harmful chemicals. Instead of spending hours on hours staring at the labels in the shop looking like a weirdo, just invest a little more and get complete natural ingredients instead. They work just as well if not better.
- Omega 6 rich rancid oils/foods – Oils such as canola, soy, safflower, corn, sunflower, etc. are used as food preservatives in natural foods such as dried fruits, “healthy” chips and more. They are best to be avoided. Even animals that eat whole grains are being overloaded with these estrogenic and harmful oils. For this one it is worth staring at the back of labels looking like a weirdo to get safe food.
Avoiding all these toxins will take a huge strain off of your body which will then allow inflammation to drop, your gut to function better, mood to lift and fat loss to commence.
But don’t feel overwhelmed, think of it this way: All you’re doing is eliminating things and replacing a few. So it’s not like you are overhauling your whole life. You are just making smart subtractions and a few replacements.
7. Balance blood sugar & optimize glucose oxidation
All kinds of issues occur when we cannot utilize the glucose we consume. The glucose oxidation pathway seems pretty fragile and any disruption to the pathway causes issues such as:
- Excess fat gain
- Elevated lactate
- Fatty liver
- Fatigue
- Excess levels of cortisol
- Struggling to build muscle
That is why so many people these days benefit from reducing carb intake. Not because carbs are bad, it’s just that their body’s glucose utilization pathway is functioning suboptimally.
First we have to provide the necessary substrates to ensure proper glucose oxidation. There are 3 important steps for that. The first is the pyruvate dehydrogenase (PDH), where pyruvate (the breakdown product of glucose) is shuttled into the Kreb cycle. The second is the Kreb cycle itself and step number three is the electron transport chain, where the electrons “harvested” from the glucose are passed along to drive the creation of energy (ATP).
Step 1:
The first step can be quite challenging for a lot of people because of these reasons:
- Excess free fatty acids that inhibit this enzyme.
- Elevated NADH:NAD ratio due to faulty electron transport chain or low NAD+ levels.
- Vitamin and mineral deficiency such as vitamin B1, B3, B5 and magnesium.
Blocking excess FFAs with aspirin, supplementing niacinamide to increase NAD+ and taking high doses of vitamin B1 (around 300-600mg) and magnesium (200mg-2g) can greatly speed up this step.
Step 2:
The Kreb cycle itself is rarely a major issue if all the minerals and vitamins that are needed (vit B1, B3, B5, iron, magnesium and manganese) for proper functioning are present. However, high levels of oxidative stress can stop one of the first enzymes called aconitase, leading citrate to be used for the synthesis of fat (lipogenesis), instead of the Kreb cycle functioning normally.
Lowering oxidative stress is the key for normal Kreb cycle function.
Step 3:
Most people also have a major hiccup at this step. Most of the time it’s due to:
- Oxidized cardiolipin due to elevated oxidative stress
- Excess nitric oxide, which blocks complex IV
- Excess polyunsaturated fats in the cell membranes, allowing electron leak and oxidative stress
So it really comes down to elevated oxidative stress and this leads to a host of negatives, such as oxidized cardiolipin, cell membranes, enzymes, etc. and then fission has to step in to clear the damage and as a result, you end up with an excess of small and toxic mitochondria that overwhelms mitophagy, as seen in diabetes.
What we can do is lower oxidative stress, supply mitochondrial antioxidants and use alternative electron carriers.
To do that we can take:
- Vitamin C, vitamin E, alpha-lipoic acid (ALA) and CoQ10 (ubiquinone, not ubiquinol)
- Succinic acid (it rescues defective complex I and II)
- Methylene blue (it rescues defective complex (possibly I), II & III and speeds up complex IV)
- Vitamin K2 (rescues defective complex III)
- Red light (speeds up complex IV)
8. Lowering cortisol levels
Cortisol affects fat storage, lipogenesis, lypolysis and appetite. Here are some methods on lowering cortisol levels, excluding all the water stuff like sleep obviously:
- Ashwagandha (300-600mg)
- Phosphatidyl Serine (400-1200mg)
- Emodin (250-500mg)
- L-Theanine (200-400mg)
- Melatonin (3-100mg)
- Magnesium (400-2000mg)
- Testosterone (Over 150mg weekly)
- Oxandrolone (5-20mg daily)
Thirty Hertz Heartbreakers: @PsychoH @Angutoid @Always Stay You @mathis @4lt.Real @sb23 @mewcel420
Cool niggas list: @NZb6Air @moreplatesmoreweigh @MA_ascender @halloweed @truthhurts @billymidnight @itzyaboyJJ @CookieGuy @wastedspermcel @chudlite @Thebuffdon690 @chadintraining @silently_said @RealFunkyFlamingo @org3cel.RR
Can you tell me the cons of drinking calories ?
yawn thread nglLeanmaxxing: 8 Strategies for Fat Loss
by @Jonas2k7 & @20/04/2008
What is the bare minimum you can do to still experience significant and rapid fat loss? What gives you the biggest bang for your buck?
This thread will discuss only exclusive methods, nothing water to be seen here.
1. Take collagen to drop fat
Collagen can be a powerful tool for losing fat. Research shows that it significantly aids in muscle building, strength gains and fat reduction.
This isn't just because it's high in glycine and proline or because it's low in inflammatory amino acids like methionine, tryptophan and cysteine, it's primarily due to its content of bioactive peptides. Collagen contains various short peptides, especially hydroxyproline (Hyp)-containing ones, such as:
- Prolyl-hydroxyproline (Pro-Hyp)
- Alanine-Hyp
- Proline-Hyp
- Alanine-Hydroxyproline-Glycine
- Serine-Hydroxyproline-Glycine
- Phenylalanine-Hyp
- Gly-Pro-Hyp
- Isoleucine-Hyp
- Leucine-Hyp
These peptides are what contribute the most to the anabolic and shredding effects of collagen. Although this list might not cover all the peptides in collagen, it highlights those currently recognized for their potential in muscle building and fat loss. So collagen is much more important than just the free amino acids, glycine, proline or hydroxyproline.
Most studies use around 15g of collagen daily, but for optimal results, it's recommended to increase this to 30g or even 50g per day.
2. Use Red light to release fat
Red light and near-infrared light are highly beneficial to the body, as they promote cellular function. This means they speed up metabolism, increase energy expenditure, boost thyroid hormone and testosterone production, lower stress, promote blood flow, speed up wound healing, reduce wrinkles, improve sleep and exercise performance, etc. The list goes on.
Red light also promotes local lipolysis where it’s applied, aiding in targeted fat loss and overall fat reduction. It can even be used on the face to reduce puffiness and fat in that area.
Investing in a high-quality red light device can have a significant impact on your health and fat loss. It’s an investment worth making, as it’s essential for taking your health to the next level.
3. Get sunlight
Sunlight is so much more than just vitamin D, red light or near infra-red light. There are so many things you can do while being outside in the sun such as grounding, being active, inhaling calming compounds of nature and many more.
Sunlight increases the release of dopamine, and dopamine speeds up the metabolism and the desire to move and be active. Sunlight can also promote blood flow, sweating and the detoxification of toxins that might be hindering fat loss.
4. Walk in nature
Walking in nature is much more beneficial than just walking on a treadmill. Besides being outdoors in the sun and experiencing grounding, being in nature stimulates the brain significantly more and nearly doubles energy expenditure.
When you walk in nature, you burn more calories and enjoy additional benefits, such as reduced stress, increased dopamine levels, earthing, inhaling clean air, and enhanced brain stimulation.
5. Block EMF because it inhibits fat loss
Over the past few decades EMF exposure has increased astronomically. In fact it has increased by a quintillion times (that’s a 1 with 18 zeros) according to Dr. Joseph Mercola.
WiFi modems, cellphone towers and dirty electricity all emit EMF, which activates voltage-gated calcium channels (VGCCs) in the body. These channels allow calcium to enter and accumulate inside cells.
This excess calcium puts the cell in an excited state, leading to several negative effects. Intracellular calcium inhibits lipolysis (the breakdown of fat) in fat tissue, promotes lipogenesis (the conversion of carbohydrates to fat), and disrupts proper glucose oxidation.
As a result, there is less release of fat from fat stores, increased fat synthesis from carbohydrates and reduced oxidation of both fat and glucose in the cells.
So EMF exposure can contribute to fat retention. Fortunately, we can take steps to mitigate these effects through supplements and lifestyle changes that help counteract EMF exposure.
Here are some ways to protect yourself against the dangers of EMF:
1) Calcium Channel Blockers
EMF exposure activates voltage-gated calcium channels (VGCCs), allowing excess calcium into cells, leading to cellular stress and fat storage. Using calcium antagonists can help inhibit these channels.
Note for gear users: Consider supplementing with DHEA.
2) Inhibit Nitric Oxide Synthesis with Methylene Blue
Methylene blue can block the synthesis of nitric oxide (NO), which when elevated can hinder fat loss by boosting ATP and CO2 production. Excess NO is detrimental to fat loss.
3) Fix Mitochondrial Function
Improving mitochondrial function is key to reducing oxidative stress and enhancing ATP production. A combination of methylene blue, vitamin C, vitamin K2 and succinic acid can help repair the electron transport chain (ETC). Exercise, proper sleep and stress management are also crucial for promoting healthy mitochondria. Adequate ATP levels are essential for calcium transport out of cells, preventing calcium buildup even when VGCCs are blocked.
4) Activate Nrf2 Pathway
Nrf2 (a transcription factor) helps activate over 500 genes, reduces inflammation, improves mitochondrial function and stimulates autophagy. It lowers peroxynitrite production by inhibiting iNOS and COX-2. Compounds that activate Nrf2 are genereally turmeric, cruciferous vegetables, sulfur-rich foods and various quinones (like CoQ10 and PQQ).
A few compounds that promote Nrf2 include:
- Turmeric
- Cruciferous foods
- Sulfur rich foods
- Quinones
- Anthraquinone found in aloe latex, senna, rhubarb, cascara buckthorn, fungi, lichens and some insects.
- Naphthoquinone (Vitamin K is a derivative of 1,4-naphthoquinone). Other natural naphtoquinones include juglone (found in black walnut), lapachol (pau d arco tea),
- Benzoquinone. Ubiquinone (CoQ10) is a naturally occurring 1,4-benzoquinone.
- Pyrroloquinoline quinone (PQQ) found in kiwi fruit.
- γ (gamma) and δ (delta) tocopherols
- α-lipoic acid
- Carotenoids
- Olives and olive oil due to being rich in phenolics and terpenoids
- Purple sweet potatoes due to anthocyanin phenolics
- Quercetin
- Apigenin
- Naringenin
- Sulforaphane
- Shikonin (natural anthraquinone derivative) lowers estrogen by modulating an estrogen enzyme by down-regulating the expression of steroid sulfatase, it's essential for estrogen biosynthesis.
Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer - PubMed
Exposure to higher levels of estrogen produces genotoxic metabolites that can stimulate mammary tumorigenesis. Induction of NF-E2-related factor 2 (NRF2)-dependent detoxifying enzymes (e.g., NAD(P)H-quinone oxidoreductase 1 (NQO1)) is considered an important mechanism of protection against...
5) Inhibit NMDA Receptors
NMDA receptor activation increases intracellular calcium. Glutamate, the main NMDA agonist, rises in low ATP states, worsening calcium buildup. Magnesium and Theanine are two of the best natural NMDA receptor antagonists. Ketamine is a very effective and relatively safe drug that blocks the NMDA receptor.
6) Induce Mitochondrial Uncoupling
Mitochondrial uncoupling proteins (UCPs) reduce oxidative phosphorylation, lowering oxidative stress and preventing excess calcium entry. Moderate uncoupling can be induced with supplements like adrenal cortex extract, thyroid hormones (T4 and T3), calcium and progesterone. Caution is needed with strong uncouplers like DNP, which can cause lethal overheating.
Other methods to induce UCP are:
- large doses of aspirin
- methylene blue
- salt
- red meat
- lots of glucose with fats and spices.
- Curcumin
Let me say it again: If you get an excess of uncoupling, you can actually die of heat. This is how people die that overdose on DNP.
Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells - PubMed
An increase in the cytoplasmic-free Ca(2+) concentration mediates cellular responses to environmental signals that influence a range of processes, including gene expression, motility, secretion of hormones and neurotransmitters, changes in energy metabolism, and apoptosis. Mitochondria play...
That’s why DNP is so effective but very unsafe, whereas Niclosamide appears to be effective and much safer.
Goodbye buddy boyos @appealmaxed @craven
6. Avoid toxins
Just like EMF our environment, food, air and water have dramatically increased in toxins like heavy metals, mold, plastic, pharmaceutical drugs (birth control, SSRI, etc.), food additives, colourants, flavourings, cosmetics, omega 6 rich rancid vegetable oils/foods and more.
The list is way too long, but I’ll list a few:
- Heavy metals – Present in the air, dental fillings, water pipes, paints and many other building materials.
- Mold – Present in coffee, cocoa, grains and other products that aren’t properly stored. Animals that eat moldy grains (like all of them basically) have these toxic compounds in their fat and products such as eggs and milk and milk products. It’s also present where it’s damp and dark like in the bathroom, under wooden floors, in the ceiling, etc.
- Pharmaceutical drugs – Mostly present in our water, as well as in the sea creatures we eat that live close to the shore.
- Plastics – Everywhere basically. Stopping the use of plastic products and using an activated charcoal filter can help you get rid of the majority of plastics.
- Food additives, colourants & flavourings – Present in most foods and drinks. You’ll be surprised that it’s even present in “natural” foods, such as thickeners in yoghurt and cottage cheese, colourants in fruit juice & meat, flavour enhancers in baked goods, meats, drinks, etc.
- Cosmetics – Chances are that the shampoo, shaving cream, aftershave and deodorant you’re getting at your local store is choke-full of harmful chemicals. Instead of spending hours on hours staring at the labels in the shop looking like a weirdo, just invest a little more and get complete natural ingredients instead. They work just as well if not better.
- Omega 6 rich rancid oils/foods – Oils such as canola, soy, safflower, corn, sunflower, etc. are used as food preservatives in natural foods such as dried fruits, “healthy” chips and more. They are best to be avoided. Even animals that eat whole grains are being overloaded with these estrogenic and harmful oils. For this one it is worth staring at the back of labels looking like a weirdo to get safe food.
Avoiding all these toxins will take a huge strain off of your body which will then allow inflammation to drop, your gut to function better, mood to lift and fat loss to commence.
But don’t feel overwhelmed, think of it this way: All you’re doing is eliminating things and replacing a few. So it’s not like you are overhauling your whole life. You are just making smart subtractions and a few replacements.
7. Balance blood sugar & optimize glucose oxidation
All kinds of issues occur when we cannot utilize the glucose we consume. The glucose oxidation pathway seems pretty fragile and any disruption to the pathway causes issues such as:
- Excess fat gain
- Elevated lactate
- Fatty liver
- Fatigue
- Excess levels of cortisol
- Struggling to build muscle
That is why so many people these days benefit from reducing carb intake. Not because carbs are bad, it’s just that their body’s glucose utilization pathway is functioning suboptimally.
First we have to provide the necessary substrates to ensure proper glucose oxidation. There are 3 important steps for that. The first is the pyruvate dehydrogenase (PDH), where pyruvate (the breakdown product of glucose) is shuttled into the Kreb cycle. The second is the Kreb cycle itself and step number three is the electron transport chain, where the electrons “harvested” from the glucose are passed along to drive the creation of energy (ATP).
Step 1:
The first step can be quite challenging for a lot of people because of these reasons:
- Excess free fatty acids that inhibit this enzyme.
- Elevated NADH:NAD ratio due to faulty electron transport chain or low NAD+ levels.
- Vitamin and mineral deficiency such as vitamin B1, B3, B5 and magnesium.
Blocking excess FFAs with aspirin, supplementing niacinamide to increase NAD+ and taking high doses of vitamin B1 (around 300-600mg) and magnesium (200mg-2g) can greatly speed up this step.
Step 2:
The Kreb cycle itself is rarely a major issue if all the minerals and vitamins that are needed (vit B1, B3, B5, iron, magnesium and manganese) for proper functioning are present. However, high levels of oxidative stress can stop one of the first enzymes called aconitase, leading citrate to be used for the synthesis of fat (lipogenesis), instead of the Kreb cycle functioning normally.
Lowering oxidative stress is the key for normal Kreb cycle function.
Step 3:
Most people also have a major hiccup at this step. Most of the time it’s due to:
- Oxidized cardiolipin due to elevated oxidative stress
- Excess nitric oxide, which blocks complex IV
- Excess polyunsaturated fats in the cell membranes, allowing electron leak and oxidative stress
So it really comes down to elevated oxidative stress and this leads to a host of negatives, such as oxidized cardiolipin, cell membranes, enzymes, etc. and then fission has to step in to clear the damage and as a result, you end up with an excess of small and toxic mitochondria that overwhelms mitophagy, as seen in diabetes.
What we can do is lower oxidative stress, supply mitochondrial antioxidants and use alternative electron carriers.
To do that we can take:
- Vitamin C, vitamin E, alpha-lipoic acid (ALA) and CoQ10 (ubiquinone, not ubiquinol)
- Succinic acid (it rescues defective complex I and II)
- Methylene blue (it rescues defective complex (possibly I), II & III and speeds up complex IV)
- Vitamin K2 (rescues defective complex III)
- Red light (speeds up complex IV)
8. Lowering cortisol levels
Cortisol affects fat storage, lipogenesis, lypolysis and appetite. Here are some methods on lowering cortisol levels, excluding all the water stuff like sleep obviously:
- Ashwagandha (300-600mg)
- Phosphatidyl Serine (400-1200mg)
- Emodin (250-500mg)
- L-Theanine (200-400mg)
- Melatonin (3-100mg)
- Magnesium (400-2000mg)
- Testosterone (Over 150mg weekly)
- Oxandrolone (5-20mg daily)
Thirty Hertz Heartbreakers: @PsychoH @Angutoid @Always Stay You @mathis @4lt.Real @sb23 @mewcel420
Cool niggas list: @NZb6Air @moreplatesmoreweigh @MA_ascender @halloweed @truthhurts @billymidnight @itzyaboyJJ @CookieGuy @wastedspermcel @chudlite @Thebuffdon690 @chadintraining @silently_said @RealFunkyFlamingo @org3cel.RR
bookmarked and repped. gg!Leanmaxxing: 8 Strategies for Fat Loss
by @Jonas2k7 & @20/04/2008
What is the bare minimum you can do to still experience significant and rapid fat loss? What gives you the biggest bang for your buck?
This thread will discuss only exclusive methods, nothing water to be seen here.
1. Take collagen to drop fat
Collagen can be a powerful tool for losing fat. Research shows that it significantly aids in muscle building, strength gains and fat reduction.
This isn't just because it's high in glycine and proline or because it's low in inflammatory amino acids like methionine, tryptophan and cysteine, it's primarily due to its content of bioactive peptides. Collagen contains various short peptides, especially hydroxyproline (Hyp)-containing ones, such as:
- Prolyl-hydroxyproline (Pro-Hyp)
- Alanine-Hyp
- Proline-Hyp
- Alanine-Hydroxyproline-Glycine
- Serine-Hydroxyproline-Glycine
- Phenylalanine-Hyp
- Gly-Pro-Hyp
- Isoleucine-Hyp
- Leucine-Hyp
These peptides are what contribute the most to the anabolic and shredding effects of collagen. Although this list might not cover all the peptides in collagen, it highlights those currently recognized for their potential in muscle building and fat loss. So collagen is much more important than just the free amino acids, glycine, proline or hydroxyproline.
Most studies use around 15g of collagen daily, but for optimal results, it's recommended to increase this to 30g or even 50g per day.
2. Use Red light to release fat
Red light and near-infrared light are highly beneficial to the body, as they promote cellular function. This means they speed up metabolism, increase energy expenditure, boost thyroid hormone and testosterone production, lower stress, promote blood flow, speed up wound healing, reduce wrinkles, improve sleep and exercise performance, etc. The list goes on.
Red light also promotes local lipolysis where it’s applied, aiding in targeted fat loss and overall fat reduction. It can even be used on the face to reduce puffiness and fat in that area.
Investing in a high-quality red light device can have a significant impact on your health and fat loss. It’s an investment worth making, as it’s essential for taking your health to the next level.
3. Get sunlight
Sunlight is so much more than just vitamin D, red light or near infra-red light. There are so many things you can do while being outside in the sun such as grounding, being active, inhaling calming compounds of nature and many more.
Sunlight increases the release of dopamine, and dopamine speeds up the metabolism and the desire to move and be active. Sunlight can also promote blood flow, sweating and the detoxification of toxins that might be hindering fat loss.
4. Walk in nature
Walking in nature is much more beneficial than just walking on a treadmill. Besides being outdoors in the sun and experiencing grounding, being in nature stimulates the brain significantly more and nearly doubles energy expenditure.
When you walk in nature, you burn more calories and enjoy additional benefits, such as reduced stress, increased dopamine levels, earthing, inhaling clean air, and enhanced brain stimulation.
5. Block EMF because it inhibits fat loss
Over the past few decades EMF exposure has increased astronomically. In fact it has increased by a quintillion times (that’s a 1 with 18 zeros) according to Dr. Joseph Mercola.
WiFi modems, cellphone towers and dirty electricity all emit EMF, which activates voltage-gated calcium channels (VGCCs) in the body. These channels allow calcium to enter and accumulate inside cells.
This excess calcium puts the cell in an excited state, leading to several negative effects. Intracellular calcium inhibits lipolysis (the breakdown of fat) in fat tissue, promotes lipogenesis (the conversion of carbohydrates to fat), and disrupts proper glucose oxidation.
As a result, there is less release of fat from fat stores, increased fat synthesis from carbohydrates and reduced oxidation of both fat and glucose in the cells.
So EMF exposure can contribute to fat retention. Fortunately, we can take steps to mitigate these effects through supplements and lifestyle changes that help counteract EMF exposure.
Here are some ways to protect yourself against the dangers of EMF:
1) Calcium Channel Blockers
EMF exposure activates voltage-gated calcium channels (VGCCs), allowing excess calcium into cells, leading to cellular stress and fat storage. Using calcium antagonists can help inhibit these channels.
Note for gear users: Consider supplementing with DHEA.
2) Inhibit Nitric Oxide Synthesis with Methylene Blue
Methylene blue can block the synthesis of nitric oxide (NO), which when elevated can hinder fat loss by boosting ATP and CO2 production. Excess NO is detrimental to fat loss.
3) Fix Mitochondrial Function
Improving mitochondrial function is key to reducing oxidative stress and enhancing ATP production. A combination of methylene blue, vitamin C, vitamin K2 and succinic acid can help repair the electron transport chain (ETC). Exercise, proper sleep and stress management are also crucial for promoting healthy mitochondria. Adequate ATP levels are essential for calcium transport out of cells, preventing calcium buildup even when VGCCs are blocked.
4) Activate Nrf2 Pathway
Nrf2 (a transcription factor) helps activate over 500 genes, reduces inflammation, improves mitochondrial function and stimulates autophagy. It lowers peroxynitrite production by inhibiting iNOS and COX-2. Compounds that activate Nrf2 are genereally turmeric, cruciferous vegetables, sulfur-rich foods and various quinones (like CoQ10 and PQQ).
A few compounds that promote Nrf2 include:
- Turmeric
- Cruciferous foods
- Sulfur rich foods
- Quinones
- Anthraquinone found in aloe latex, senna, rhubarb, cascara buckthorn, fungi, lichens and some insects.
- Naphthoquinone (Vitamin K is a derivative of 1,4-naphthoquinone). Other natural naphtoquinones include juglone (found in black walnut), lapachol (pau d arco tea),
- Benzoquinone. Ubiquinone (CoQ10) is a naturally occurring 1,4-benzoquinone.
- Pyrroloquinoline quinone (PQQ) found in kiwi fruit.
- γ (gamma) and δ (delta) tocopherols
- α-lipoic acid
- Carotenoids
- Olives and olive oil due to being rich in phenolics and terpenoids
- Purple sweet potatoes due to anthocyanin phenolics
- Quercetin
- Apigenin
- Naringenin
- Sulforaphane
- Shikonin (natural anthraquinone derivative) lowers estrogen by modulating an estrogen enzyme by down-regulating the expression of steroid sulfatase, it's essential for estrogen biosynthesis.
Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer - PubMed
Exposure to higher levels of estrogen produces genotoxic metabolites that can stimulate mammary tumorigenesis. Induction of NF-E2-related factor 2 (NRF2)-dependent detoxifying enzymes (e.g., NAD(P)H-quinone oxidoreductase 1 (NQO1)) is considered an important mechanism of protection against...
5) Inhibit NMDA Receptors
NMDA receptor activation increases intracellular calcium. Glutamate, the main NMDA agonist, rises in low ATP states, worsening calcium buildup. Magnesium and Theanine are two of the best natural NMDA receptor antagonists. Ketamine is a very effective and relatively safe drug that blocks the NMDA receptor.
6) Induce Mitochondrial Uncoupling
Mitochondrial uncoupling proteins (UCPs) reduce oxidative phosphorylation, lowering oxidative stress and preventing excess calcium entry. Moderate uncoupling can be induced with supplements like adrenal cortex extract, thyroid hormones (T4 and T3), calcium and progesterone. Caution is needed with strong uncouplers like DNP, which can cause lethal overheating.
Other methods to induce UCP are:
- large doses of aspirin
- methylene blue
- salt
- red meat
- lots of glucose with fats and spices.
- Curcumin
Let me say it again: If you get an excess of uncoupling, you can actually die of heat. This is how people die that overdose on DNP.
Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells - PubMed
An increase in the cytoplasmic-free Ca(2+) concentration mediates cellular responses to environmental signals that influence a range of processes, including gene expression, motility, secretion of hormones and neurotransmitters, changes in energy metabolism, and apoptosis. Mitochondria play...
That’s why DNP is so effective but very unsafe, whereas Niclosamide appears to be effective and much safer.
Goodbye buddy boyos @appealmaxed @craven
6. Avoid toxins
Just like EMF our environment, food, air and water have dramatically increased in toxins like heavy metals, mold, plastic, pharmaceutical drugs (birth control, SSRI, etc.), food additives, colourants, flavourings, cosmetics, omega 6 rich rancid vegetable oils/foods and more.
The list is way too long, but I’ll list a few:
- Heavy metals – Present in the air, dental fillings, water pipes, paints and many other building materials.
- Mold – Present in coffee, cocoa, grains and other products that aren’t properly stored. Animals that eat moldy grains (like all of them basically) have these toxic compounds in their fat and products such as eggs and milk and milk products. It’s also present where it’s damp and dark like in the bathroom, under wooden floors, in the ceiling, etc.
- Pharmaceutical drugs – Mostly present in our water, as well as in the sea creatures we eat that live close to the shore.
- Plastics – Everywhere basically. Stopping the use of plastic products and using an activated charcoal filter can help you get rid of the majority of plastics.
- Food additives, colourants & flavourings – Present in most foods and drinks. You’ll be surprised that it’s even present in “natural” foods, such as thickeners in yoghurt and cottage cheese, colourants in fruit juice & meat, flavour enhancers in baked goods, meats, drinks, etc.
- Cosmetics – Chances are that the shampoo, shaving cream, aftershave and deodorant you’re getting at your local store is choke-full of harmful chemicals. Instead of spending hours on hours staring at the labels in the shop looking like a weirdo, just invest a little more and get complete natural ingredients instead. They work just as well if not better.
- Omega 6 rich rancid oils/foods – Oils such as canola, soy, safflower, corn, sunflower, etc. are used as food preservatives in natural foods such as dried fruits, “healthy” chips and more. They are best to be avoided. Even animals that eat whole grains are being overloaded with these estrogenic and harmful oils. For this one it is worth staring at the back of labels looking like a weirdo to get safe food.
Avoiding all these toxins will take a huge strain off of your body which will then allow inflammation to drop, your gut to function better, mood to lift and fat loss to commence.
But don’t feel overwhelmed, think of it this way: All you’re doing is eliminating things and replacing a few. So it’s not like you are overhauling your whole life. You are just making smart subtractions and a few replacements.
7. Balance blood sugar & optimize glucose oxidation
All kinds of issues occur when we cannot utilize the glucose we consume. The glucose oxidation pathway seems pretty fragile and any disruption to the pathway causes issues such as:
- Excess fat gain
- Elevated lactate
- Fatty liver
- Fatigue
- Excess levels of cortisol
- Struggling to build muscle
That is why so many people these days benefit from reducing carb intake. Not because carbs are bad, it’s just that their body’s glucose utilization pathway is functioning suboptimally.
First we have to provide the necessary substrates to ensure proper glucose oxidation. There are 3 important steps for that. The first is the pyruvate dehydrogenase (PDH), where pyruvate (the breakdown product of glucose) is shuttled into the Kreb cycle. The second is the Kreb cycle itself and step number three is the electron transport chain, where the electrons “harvested” from the glucose are passed along to drive the creation of energy (ATP).
Step 1:
The first step can be quite challenging for a lot of people because of these reasons:
- Excess free fatty acids that inhibit this enzyme.
- Elevated NADH:NAD ratio due to faulty electron transport chain or low NAD+ levels.
- Vitamin and mineral deficiency such as vitamin B1, B3, B5 and magnesium.
Blocking excess FFAs with aspirin, supplementing niacinamide to increase NAD+ and taking high doses of vitamin B1 (around 300-600mg) and magnesium (200mg-2g) can greatly speed up this step.
Step 2:
The Kreb cycle itself is rarely a major issue if all the minerals and vitamins that are needed (vit B1, B3, B5, iron, magnesium and manganese) for proper functioning are present. However, high levels of oxidative stress can stop one of the first enzymes called aconitase, leading citrate to be used for the synthesis of fat (lipogenesis), instead of the Kreb cycle functioning normally.
Lowering oxidative stress is the key for normal Kreb cycle function.
Step 3:
Most people also have a major hiccup at this step. Most of the time it’s due to:
- Oxidized cardiolipin due to elevated oxidative stress
- Excess nitric oxide, which blocks complex IV
- Excess polyunsaturated fats in the cell membranes, allowing electron leak and oxidative stress
So it really comes down to elevated oxidative stress and this leads to a host of negatives, such as oxidized cardiolipin, cell membranes, enzymes, etc. and then fission has to step in to clear the damage and as a result, you end up with an excess of small and toxic mitochondria that overwhelms mitophagy, as seen in diabetes.
What we can do is lower oxidative stress, supply mitochondrial antioxidants and use alternative electron carriers.
To do that we can take:
- Vitamin C, vitamin E, alpha-lipoic acid (ALA) and CoQ10 (ubiquinone, not ubiquinol)
- Succinic acid (it rescues defective complex I and II)
- Methylene blue (it rescues defective complex (possibly I), II & III and speeds up complex IV)
- Vitamin K2 (rescues defective complex III)
- Red light (speeds up complex IV)
8. Lowering cortisol levels
Cortisol affects fat storage, lipogenesis, lypolysis and appetite. Here are some methods on lowering cortisol levels, excluding all the water stuff like sleep obviously:
- Ashwagandha (300-600mg)
- Phosphatidyl Serine (400-1200mg)
- Emodin (250-500mg)
- L-Theanine (200-400mg)
- Melatonin (3-100mg)
- Magnesium (400-2000mg)
- Testosterone (Over 150mg weekly)
- Oxandrolone (5-20mg daily)
Thirty Hertz Heartbreakers: @PsychoH @Angutoid @Always Stay You @mathis @4lt.Real @sb23 @mewcel420
Cool niggas list: @NZb6Air @moreplatesmoreweigh @MA_ascender @halloweed @truthhurts @billymidnight @itzyaboyJJ @CookieGuy @wastedspermcel @chudlite @Thebuffdon690 @chadintraining @silently_said @RealFunkyFlamingo @org3cel.RR
good thread skimmed it allLeanmaxxing: 8 Strategies for Fat Loss
by @Jonas2k7 & @20/04/2008
What is the bare minimum you can do to still experience significant and rapid fat loss? What gives you the biggest bang for your buck?
This thread will discuss only exclusive methods, nothing water to be seen here.
1. Take collagen to drop fat
Collagen can be a powerful tool for losing fat. Research shows that it significantly aids in muscle building, strength gains and fat reduction.
This isn't just because it's high in glycine and proline or because it's low in inflammatory amino acids like methionine, tryptophan and cysteine, it's primarily due to its content of bioactive peptides. Collagen contains various short peptides, especially hydroxyproline (Hyp)-containing ones, such as:
- Prolyl-hydroxyproline (Pro-Hyp)
- Alanine-Hyp
- Proline-Hyp
- Alanine-Hydroxyproline-Glycine
- Serine-Hydroxyproline-Glycine
- Phenylalanine-Hyp
- Gly-Pro-Hyp
- Isoleucine-Hyp
- Leucine-Hyp
These peptides are what contribute the most to the anabolic and shredding effects of collagen. Although this list might not cover all the peptides in collagen, it highlights those currently recognized for their potential in muscle building and fat loss. So collagen is much more important than just the free amino acids, glycine, proline or hydroxyproline.
Most studies use around 15g of collagen daily, but for optimal results, it's recommended to increase this to 30g or even 50g per day.
2. Use Red light to release fat
Red light and near-infrared light are highly beneficial to the body, as they promote cellular function. This means they speed up metabolism, increase energy expenditure, boost thyroid hormone and testosterone production, lower stress, promote blood flow, speed up wound healing, reduce wrinkles, improve sleep and exercise performance, etc. The list goes on.
Red light also promotes local lipolysis where it’s applied, aiding in targeted fat loss and overall fat reduction. It can even be used on the face to reduce puffiness and fat in that area.
Investing in a high-quality red light device can have a significant impact on your health and fat loss. It’s an investment worth making, as it’s essential for taking your health to the next level.
3. Get sunlight
Sunlight is so much more than just vitamin D, red light or near infra-red light. There are so many things you can do while being outside in the sun such as grounding, being active, inhaling calming compounds of nature and many more.
Sunlight increases the release of dopamine, and dopamine speeds up the metabolism and the desire to move and be active. Sunlight can also promote blood flow, sweating and the detoxification of toxins that might be hindering fat loss.
4. Walk in nature
Walking in nature is much more beneficial than just walking on a treadmill. Besides being outdoors in the sun and experiencing grounding, being in nature stimulates the brain significantly more and nearly doubles energy expenditure.
When you walk in nature, you burn more calories and enjoy additional benefits, such as reduced stress, increased dopamine levels, earthing, inhaling clean air, and enhanced brain stimulation.
5. Block EMF because it inhibits fat loss
Over the past few decades EMF exposure has increased astronomically. In fact it has increased by a quintillion times (that’s a 1 with 18 zeros) according to Dr. Joseph Mercola.
WiFi modems, cellphone towers and dirty electricity all emit EMF, which activates voltage-gated calcium channels (VGCCs) in the body. These channels allow calcium to enter and accumulate inside cells.
This excess calcium puts the cell in an excited state, leading to several negative effects. Intracellular calcium inhibits lipolysis (the breakdown of fat) in fat tissue, promotes lipogenesis (the conversion of carbohydrates to fat), and disrupts proper glucose oxidation.
As a result, there is less release of fat from fat stores, increased fat synthesis from carbohydrates and reduced oxidation of both fat and glucose in the cells.
So EMF exposure can contribute to fat retention. Fortunately, we can take steps to mitigate these effects through supplements and lifestyle changes that help counteract EMF exposure.
Here are some ways to protect yourself against the dangers of EMF:
1) Calcium Channel Blockers
EMF exposure activates voltage-gated calcium channels (VGCCs), allowing excess calcium into cells, leading to cellular stress and fat storage. Using calcium antagonists can help inhibit these channels.
Note for gear users: Consider supplementing with DHEA.
2) Inhibit Nitric Oxide Synthesis with Methylene Blue
Methylene blue can block the synthesis of nitric oxide (NO), which when elevated can hinder fat loss by boosting ATP and CO2 production. Excess NO is detrimental to fat loss.
3) Fix Mitochondrial Function
Improving mitochondrial function is key to reducing oxidative stress and enhancing ATP production. A combination of methylene blue, vitamin C, vitamin K2 and succinic acid can help repair the electron transport chain (ETC). Exercise, proper sleep and stress management are also crucial for promoting healthy mitochondria. Adequate ATP levels are essential for calcium transport out of cells, preventing calcium buildup even when VGCCs are blocked.
4) Activate Nrf2 Pathway
Nrf2 (a transcription factor) helps activate over 500 genes, reduces inflammation, improves mitochondrial function and stimulates autophagy. It lowers peroxynitrite production by inhibiting iNOS and COX-2. Compounds that activate Nrf2 are genereally turmeric, cruciferous vegetables, sulfur-rich foods and various quinones (like CoQ10 and PQQ).
A few compounds that promote Nrf2 include:
- Turmeric
- Cruciferous foods
- Sulfur rich foods
- Quinones
- Anthraquinone found in aloe latex, senna, rhubarb, cascara buckthorn, fungi, lichens and some insects.
- Naphthoquinone (Vitamin K is a derivative of 1,4-naphthoquinone). Other natural naphtoquinones include juglone (found in black walnut), lapachol (pau d arco tea),
- Benzoquinone. Ubiquinone (CoQ10) is a naturally occurring 1,4-benzoquinone.
- Pyrroloquinoline quinone (PQQ) found in kiwi fruit.
- γ (gamma) and δ (delta) tocopherols
- α-lipoic acid
- Carotenoids
- Olives and olive oil due to being rich in phenolics and terpenoids
- Purple sweet potatoes due to anthocyanin phenolics
- Quercetin
- Apigenin
- Naringenin
- Sulforaphane
- Shikonin (natural anthraquinone derivative) lowers estrogen by modulating an estrogen enzyme by down-regulating the expression of steroid sulfatase, it's essential for estrogen biosynthesis.
Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer - PubMed
Exposure to higher levels of estrogen produces genotoxic metabolites that can stimulate mammary tumorigenesis. Induction of NF-E2-related factor 2 (NRF2)-dependent detoxifying enzymes (e.g., NAD(P)H-quinone oxidoreductase 1 (NQO1)) is considered an important mechanism of protection against...
5) Inhibit NMDA Receptors
NMDA receptor activation increases intracellular calcium. Glutamate, the main NMDA agonist, rises in low ATP states, worsening calcium buildup. Magnesium and Theanine are two of the best natural NMDA receptor antagonists. Ketamine is a very effective and relatively safe drug that blocks the NMDA receptor.
6) Induce Mitochondrial Uncoupling
Mitochondrial uncoupling proteins (UCPs) reduce oxidative phosphorylation, lowering oxidative stress and preventing excess calcium entry. Moderate uncoupling can be induced with supplements like adrenal cortex extract, thyroid hormones (T4 and T3), calcium and progesterone. Caution is needed with strong uncouplers like DNP, which can cause lethal overheating.
Other methods to induce UCP are:
- large doses of aspirin
- methylene blue
- salt
- red meat
- lots of glucose with fats and spices.
- Curcumin
Let me say it again: If you get an excess of uncoupling, you can actually die of heat. This is how people die that overdose on DNP.
Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells - PubMed
An increase in the cytoplasmic-free Ca(2+) concentration mediates cellular responses to environmental signals that influence a range of processes, including gene expression, motility, secretion of hormones and neurotransmitters, changes in energy metabolism, and apoptosis. Mitochondria play...
That’s why DNP is so effective but very unsafe, whereas Niclosamide appears to be effective and much safer.
Goodbye buddy boyos @appealmaxed @craven
6. Avoid toxins
Just like EMF our environment, food, air and water have dramatically increased in toxins like heavy metals, mold, plastic, pharmaceutical drugs (birth control, SSRI, etc.), food additives, colourants, flavourings, cosmetics, omega 6 rich rancid vegetable oils/foods and more.
The list is way too long, but I’ll list a few:
- Heavy metals – Present in the air, dental fillings, water pipes, paints and many other building materials.
- Mold – Present in coffee, cocoa, grains and other products that aren’t properly stored. Animals that eat moldy grains (like all of them basically) have these toxic compounds in their fat and products such as eggs and milk and milk products. It’s also present where it’s damp and dark like in the bathroom, under wooden floors, in the ceiling, etc.
- Pharmaceutical drugs – Mostly present in our water, as well as in the sea creatures we eat that live close to the shore.
- Plastics – Everywhere basically. Stopping the use of plastic products and using an activated charcoal filter can help you get rid of the majority of plastics.
- Food additives, colourants & flavourings – Present in most foods and drinks. You’ll be surprised that it’s even present in “natural” foods, such as thickeners in yoghurt and cottage cheese, colourants in fruit juice & meat, flavour enhancers in baked goods, meats, drinks, etc.
- Cosmetics – Chances are that the shampoo, shaving cream, aftershave and deodorant you’re getting at your local store is choke-full of harmful chemicals. Instead of spending hours on hours staring at the labels in the shop looking like a weirdo, just invest a little more and get complete natural ingredients instead. They work just as well if not better.
- Omega 6 rich rancid oils/foods – Oils such as canola, soy, safflower, corn, sunflower, etc. are used as food preservatives in natural foods such as dried fruits, “healthy” chips and more. They are best to be avoided. Even animals that eat whole grains are being overloaded with these estrogenic and harmful oils. For this one it is worth staring at the back of labels looking like a weirdo to get safe food.
Avoiding all these toxins will take a huge strain off of your body which will then allow inflammation to drop, your gut to function better, mood to lift and fat loss to commence.
But don’t feel overwhelmed, think of it this way: All you’re doing is eliminating things and replacing a few. So it’s not like you are overhauling your whole life. You are just making smart subtractions and a few replacements.
7. Balance blood sugar & optimize glucose oxidation
All kinds of issues occur when we cannot utilize the glucose we consume. The glucose oxidation pathway seems pretty fragile and any disruption to the pathway causes issues such as:
- Excess fat gain
- Elevated lactate
- Fatty liver
- Fatigue
- Excess levels of cortisol
- Struggling to build muscle
That is why so many people these days benefit from reducing carb intake. Not because carbs are bad, it’s just that their body’s glucose utilization pathway is functioning suboptimally.
First we have to provide the necessary substrates to ensure proper glucose oxidation. There are 3 important steps for that. The first is the pyruvate dehydrogenase (PDH), where pyruvate (the breakdown product of glucose) is shuttled into the Kreb cycle. The second is the Kreb cycle itself and step number three is the electron transport chain, where the electrons “harvested” from the glucose are passed along to drive the creation of energy (ATP).
Step 1:
The first step can be quite challenging for a lot of people because of these reasons:
- Excess free fatty acids that inhibit this enzyme.
- Elevated NADH:NAD ratio due to faulty electron transport chain or low NAD+ levels.
- Vitamin and mineral deficiency such as vitamin B1, B3, B5 and magnesium.
Blocking excess FFAs with aspirin, supplementing niacinamide to increase NAD+ and taking high doses of vitamin B1 (around 300-600mg) and magnesium (200mg-2g) can greatly speed up this step.
Step 2:
The Kreb cycle itself is rarely a major issue if all the minerals and vitamins that are needed (vit B1, B3, B5, iron, magnesium and manganese) for proper functioning are present. However, high levels of oxidative stress can stop one of the first enzymes called aconitase, leading citrate to be used for the synthesis of fat (lipogenesis), instead of the Kreb cycle functioning normally.
Lowering oxidative stress is the key for normal Kreb cycle function.
Step 3:
Most people also have a major hiccup at this step. Most of the time it’s due to:
- Oxidized cardiolipin due to elevated oxidative stress
- Excess nitric oxide, which blocks complex IV
- Excess polyunsaturated fats in the cell membranes, allowing electron leak and oxidative stress
So it really comes down to elevated oxidative stress and this leads to a host of negatives, such as oxidized cardiolipin, cell membranes, enzymes, etc. and then fission has to step in to clear the damage and as a result, you end up with an excess of small and toxic mitochondria that overwhelms mitophagy, as seen in diabetes.
What we can do is lower oxidative stress, supply mitochondrial antioxidants and use alternative electron carriers.
To do that we can take:
- Vitamin C, vitamin E, alpha-lipoic acid (ALA) and CoQ10 (ubiquinone, not ubiquinol)
- Succinic acid (it rescues defective complex I and II)
- Methylene blue (it rescues defective complex (possibly I), II & III and speeds up complex IV)
- Vitamin K2 (rescues defective complex III)
- Red light (speeds up complex IV)
8. Lowering cortisol levels
Cortisol affects fat storage, lipogenesis, lypolysis and appetite. Here are some methods on lowering cortisol levels, excluding all the water stuff like sleep obviously:
- Ashwagandha (300-600mg)
- Phosphatidyl Serine (400-1200mg)
- Emodin (250-500mg)
- L-Theanine (200-400mg)
- Melatonin (3-100mg)
- Magnesium (400-2000mg)
- Testosterone (Over 150mg weekly)
- Oxandrolone (5-20mg daily)
Thirty Hertz Heartbreakers: @PsychoH @Angutoid @Always Stay You @mathis @4lt.Real @sb23 @mewcel420
Cool niggas list: @NZb6Air @moreplatesmoreweigh @MA_ascender @halloweed @truthhurts @billymidnight @itzyaboyJJ @CookieGuy @wastedspermcel @chudlite @Thebuffdon690 @chadintraining @silently_said @RealFunkyFlamingo @org3cel.RR
Anything but a fucking calorie deficit.Leanmaxxing: 8 Strategies for Fat Loss
by @Jonas2k7 & @20/04/2008
What is the bare minimum you can do to still experience significant and rapid fat loss? What gives you the biggest bang for your buck?
This thread will discuss only exclusive methods, nothing water to be seen here.
1. Take collagen to drop fat
Collagen can be a powerful tool for losing fat. Research shows that it significantly aids in muscle building, strength gains and fat reduction.
This isn't just because it's high in glycine and proline or because it's low in inflammatory amino acids like methionine, tryptophan and cysteine, it's primarily due to its content of bioactive peptides. Collagen contains various short peptides, especially hydroxyproline (Hyp)-containing ones, such as:
- Prolyl-hydroxyproline (Pro-Hyp)
- Alanine-Hyp
- Proline-Hyp
- Alanine-Hydroxyproline-Glycine
- Serine-Hydroxyproline-Glycine
- Phenylalanine-Hyp
- Gly-Pro-Hyp
- Isoleucine-Hyp
- Leucine-Hyp
These peptides are what contribute the most to the anabolic and shredding effects of collagen. Although this list might not cover all the peptides in collagen, it highlights those currently recognized for their potential in muscle building and fat loss. So collagen is much more important than just the free amino acids, glycine, proline or hydroxyproline.
Most studies use around 15g of collagen daily, but for optimal results, it's recommended to increase this to 30g or even 50g per day.
2. Use Red light to release fat
Red light and near-infrared light are highly beneficial to the body, as they promote cellular function. This means they speed up metabolism, increase energy expenditure, boost thyroid hormone and testosterone production, lower stress, promote blood flow, speed up wound healing, reduce wrinkles, improve sleep and exercise performance, etc. The list goes on.
Red light also promotes local lipolysis where it’s applied, aiding in targeted fat loss and overall fat reduction. It can even be used on the face to reduce puffiness and fat in that area.
Investing in a high-quality red light device can have a significant impact on your health and fat loss. It’s an investment worth making, as it’s essential for taking your health to the next level.
3. Get sunlight
Sunlight is so much more than just vitamin D, red light or near infra-red light. There are so many things you can do while being outside in the sun such as grounding, being active, inhaling calming compounds of nature and many more.
Sunlight increases the release of dopamine, and dopamine speeds up the metabolism and the desire to move and be active. Sunlight can also promote blood flow, sweating and the detoxification of toxins that might be hindering fat loss.
4. Walk in nature
Walking in nature is much more beneficial than just walking on a treadmill. Besides being outdoors in the sun and experiencing grounding, being in nature stimulates the brain significantly more and nearly doubles energy expenditure.
When you walk in nature, you burn more calories and enjoy additional benefits, such as reduced stress, increased dopamine levels, earthing, inhaling clean air, and enhanced brain stimulation.
5. Block EMF because it inhibits fat loss
Over the past few decades EMF exposure has increased astronomically. In fact it has increased by a quintillion times (that’s a 1 with 18 zeros) according to Dr. Joseph Mercola.
WiFi modems, cellphone towers and dirty electricity all emit EMF, which activates voltage-gated calcium channels (VGCCs) in the body. These channels allow calcium to enter and accumulate inside cells.
This excess calcium puts the cell in an excited state, leading to several negative effects. Intracellular calcium inhibits lipolysis (the breakdown of fat) in fat tissue, promotes lipogenesis (the conversion of carbohydrates to fat), and disrupts proper glucose oxidation.
As a result, there is less release of fat from fat stores, increased fat synthesis from carbohydrates and reduced oxidation of both fat and glucose in the cells.
So EMF exposure can contribute to fat retention. Fortunately, we can take steps to mitigate these effects through supplements and lifestyle changes that help counteract EMF exposure.
Here are some ways to protect yourself against the dangers of EMF:
1) Calcium Channel Blockers
EMF exposure activates voltage-gated calcium channels (VGCCs), allowing excess calcium into cells, leading to cellular stress and fat storage. Using calcium antagonists can help inhibit these channels.
Note for gear users: Consider supplementing with DHEA.
2) Inhibit Nitric Oxide Synthesis with Methylene Blue
Methylene blue can block the synthesis of nitric oxide (NO), which when elevated can hinder fat loss by boosting ATP and CO2 production. Excess NO is detrimental to fat loss.
3) Fix Mitochondrial Function
Improving mitochondrial function is key to reducing oxidative stress and enhancing ATP production. A combination of methylene blue, vitamin C, vitamin K2 and succinic acid can help repair the electron transport chain (ETC). Exercise, proper sleep and stress management are also crucial for promoting healthy mitochondria. Adequate ATP levels are essential for calcium transport out of cells, preventing calcium buildup even when VGCCs are blocked.
4) Activate Nrf2 Pathway
Nrf2 (a transcription factor) helps activate over 500 genes, reduces inflammation, improves mitochondrial function and stimulates autophagy. It lowers peroxynitrite production by inhibiting iNOS and COX-2. Compounds that activate Nrf2 are genereally turmeric, cruciferous vegetables, sulfur-rich foods and various quinones (like CoQ10 and PQQ).
A few compounds that promote Nrf2 include:
- Turmeric
- Cruciferous foods
- Sulfur rich foods
- Quinones
- Anthraquinone found in aloe latex, senna, rhubarb, cascara buckthorn, fungi, lichens and some insects.
- Naphthoquinone (Vitamin K is a derivative of 1,4-naphthoquinone). Other natural naphtoquinones include juglone (found in black walnut), lapachol (pau d arco tea),
- Benzoquinone. Ubiquinone (CoQ10) is a naturally occurring 1,4-benzoquinone.
- Pyrroloquinoline quinone (PQQ) found in kiwi fruit.
- γ (gamma) and δ (delta) tocopherols
- α-lipoic acid
- Carotenoids
- Olives and olive oil due to being rich in phenolics and terpenoids
- Purple sweet potatoes due to anthocyanin phenolics
- Quercetin
- Apigenin
- Naringenin
- Sulforaphane
- Shikonin (natural anthraquinone derivative) lowers estrogen by modulating an estrogen enzyme by down-regulating the expression of steroid sulfatase, it's essential for estrogen biosynthesis.
Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer - PubMed
Exposure to higher levels of estrogen produces genotoxic metabolites that can stimulate mammary tumorigenesis. Induction of NF-E2-related factor 2 (NRF2)-dependent detoxifying enzymes (e.g., NAD(P)H-quinone oxidoreductase 1 (NQO1)) is considered an important mechanism of protection against...
5) Inhibit NMDA Receptors
NMDA receptor activation increases intracellular calcium. Glutamate, the main NMDA agonist, rises in low ATP states, worsening calcium buildup. Magnesium and Theanine are two of the best natural NMDA receptor antagonists. Ketamine is a very effective and relatively safe drug that blocks the NMDA receptor.
6) Induce Mitochondrial Uncoupling
Mitochondrial uncoupling proteins (UCPs) reduce oxidative phosphorylation, lowering oxidative stress and preventing excess calcium entry. Moderate uncoupling can be induced with supplements like adrenal cortex extract, thyroid hormones (T4 and T3), calcium and progesterone. Caution is needed with strong uncouplers like DNP, which can cause lethal overheating.
Other methods to induce UCP are:
- large doses of aspirin
- methylene blue
- salt
- red meat
- lots of glucose with fats and spices.
- Curcumin
Let me say it again: If you get an excess of uncoupling, you can actually die of heat. This is how people die that overdose on DNP.
Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells - PubMed
An increase in the cytoplasmic-free Ca(2+) concentration mediates cellular responses to environmental signals that influence a range of processes, including gene expression, motility, secretion of hormones and neurotransmitters, changes in energy metabolism, and apoptosis. Mitochondria play...
That’s why DNP is so effective but very unsafe, whereas Niclosamide appears to be effective and much safer.
Goodbye buddy boyos @appealmaxed @craven
6. Avoid toxins
Just like EMF our environment, food, air and water have dramatically increased in toxins like heavy metals, mold, plastic, pharmaceutical drugs (birth control, SSRI, etc.), food additives, colourants, flavourings, cosmetics, omega 6 rich rancid vegetable oils/foods and more.
The list is way too long, but I’ll list a few:
- Heavy metals – Present in the air, dental fillings, water pipes, paints and many other building materials.
- Mold – Present in coffee, cocoa, grains and other products that aren’t properly stored. Animals that eat moldy grains (like all of them basically) have these toxic compounds in their fat and products such as eggs and milk and milk products. It’s also present where it’s damp and dark like in the bathroom, under wooden floors, in the ceiling, etc.
- Pharmaceutical drugs – Mostly present in our water, as well as in the sea creatures we eat that live close to the shore.
- Plastics – Everywhere basically. Stopping the use of plastic products and using an activated charcoal filter can help you get rid of the majority of plastics.
- Food additives, colourants & flavourings – Present in most foods and drinks. You’ll be surprised that it’s even present in “natural” foods, such as thickeners in yoghurt and cottage cheese, colourants in fruit juice & meat, flavour enhancers in baked goods, meats, drinks, etc.
- Cosmetics – Chances are that the shampoo, shaving cream, aftershave and deodorant you’re getting at your local store is choke-full of harmful chemicals. Instead of spending hours on hours staring at the labels in the shop looking like a weirdo, just invest a little more and get complete natural ingredients instead. They work just as well if not better.
- Omega 6 rich rancid oils/foods – Oils such as canola, soy, safflower, corn, sunflower, etc. are used as food preservatives in natural foods such as dried fruits, “healthy” chips and more. They are best to be avoided. Even animals that eat whole grains are being overloaded with these estrogenic and harmful oils. For this one it is worth staring at the back of labels looking like a weirdo to get safe food.
Avoiding all these toxins will take a huge strain off of your body which will then allow inflammation to drop, your gut to function better, mood to lift and fat loss to commence.
But don’t feel overwhelmed, think of it this way: All you’re doing is eliminating things and replacing a few. So it’s not like you are overhauling your whole life. You are just making smart subtractions and a few replacements.
7. Balance blood sugar & optimize glucose oxidation
All kinds of issues occur when we cannot utilize the glucose we consume. The glucose oxidation pathway seems pretty fragile and any disruption to the pathway causes issues such as:
- Excess fat gain
- Elevated lactate
- Fatty liver
- Fatigue
- Excess levels of cortisol
- Struggling to build muscle
That is why so many people these days benefit from reducing carb intake. Not because carbs are bad, it’s just that their body’s glucose utilization pathway is functioning suboptimally.
First we have to provide the necessary substrates to ensure proper glucose oxidation. There are 3 important steps for that. The first is the pyruvate dehydrogenase (PDH), where pyruvate (the breakdown product of glucose) is shuttled into the Kreb cycle. The second is the Kreb cycle itself and step number three is the electron transport chain, where the electrons “harvested” from the glucose are passed along to drive the creation of energy (ATP).
Step 1:
The first step can be quite challenging for a lot of people because of these reasons:
- Excess free fatty acids that inhibit this enzyme.
- Elevated NADH:NAD ratio due to faulty electron transport chain or low NAD+ levels.
- Vitamin and mineral deficiency such as vitamin B1, B3, B5 and magnesium.
Blocking excess FFAs with aspirin, supplementing niacinamide to increase NAD+ and taking high doses of vitamin B1 (around 300-600mg) and magnesium (200mg-2g) can greatly speed up this step.
Step 2:
The Kreb cycle itself is rarely a major issue if all the minerals and vitamins that are needed (vit B1, B3, B5, iron, magnesium and manganese) for proper functioning are present. However, high levels of oxidative stress can stop one of the first enzymes called aconitase, leading citrate to be used for the synthesis of fat (lipogenesis), instead of the Kreb cycle functioning normally.
Lowering oxidative stress is the key for normal Kreb cycle function.
Step 3:
Most people also have a major hiccup at this step. Most of the time it’s due to:
- Oxidized cardiolipin due to elevated oxidative stress
- Excess nitric oxide, which blocks complex IV
- Excess polyunsaturated fats in the cell membranes, allowing electron leak and oxidative stress
So it really comes down to elevated oxidative stress and this leads to a host of negatives, such as oxidized cardiolipin, cell membranes, enzymes, etc. and then fission has to step in to clear the damage and as a result, you end up with an excess of small and toxic mitochondria that overwhelms mitophagy, as seen in diabetes.
What we can do is lower oxidative stress, supply mitochondrial antioxidants and use alternative electron carriers.
To do that we can take:
- Vitamin C, vitamin E, alpha-lipoic acid (ALA) and CoQ10 (ubiquinone, not ubiquinol)
- Succinic acid (it rescues defective complex I and II)
- Methylene blue (it rescues defective complex (possibly I), II & III and speeds up complex IV)
- Vitamin K2 (rescues defective complex III)
- Red light (speeds up complex IV)
8. Lowering cortisol levels
Cortisol affects fat storage, lipogenesis, lypolysis and appetite. Here are some methods on lowering cortisol levels, excluding all the water stuff like sleep obviously:
- Ashwagandha (300-600mg)
- Phosphatidyl Serine (400-1200mg)
- Emodin (250-500mg)
- L-Theanine (200-400mg)
- Melatonin (3-100mg)
- Magnesium (400-2000mg)
- Testosterone (Over 150mg weekly)
- Oxandrolone (5-20mg daily)
Thirty Hertz Heartbreakers: @PsychoH @Angutoid @Always Stay You @mathis @4lt.Real @sb23 @mewcel420
Cool niggas list: @NZb6Air @moreplatesmoreweigh @MA_ascender @halloweed @truthhurts @billymidnight @itzyaboyJJ @CookieGuy @wastedspermcel @chudlite @Thebuffdon690 @chadintraining @silently_said @RealFunkyFlamingo @org3cel.RR
love thisLeanmaxxing: 8 Strategies for Fat Loss
by @Jonas2k7 & @20/04/2008
What is the bare minimum you can do to still experience significant and rapid fat loss? What gives you the biggest bang for your buck?
This thread will discuss only exclusive methods, nothing water to be seen here.
1. Take collagen to drop fat
Collagen can be a powerful tool for losing fat. Research shows that it significantly aids in muscle building, strength gains and fat reduction.
This isn't just because it's high in glycine and proline or because it's low in inflammatory amino acids like methionine, tryptophan and cysteine, it's primarily due to its content of bioactive peptides. Collagen contains various short peptides, especially hydroxyproline (Hyp)-containing ones, such as:
- Prolyl-hydroxyproline (Pro-Hyp)
- Alanine-Hyp
- Proline-Hyp
- Alanine-Hydroxyproline-Glycine
- Serine-Hydroxyproline-Glycine
- Phenylalanine-Hyp
- Gly-Pro-Hyp
- Isoleucine-Hyp
- Leucine-Hyp
These peptides are what contribute the most to the anabolic and shredding effects of collagen. Although this list might not cover all the peptides in collagen, it highlights those currently recognized for their potential in muscle building and fat loss. So collagen is much more important than just the free amino acids, glycine, proline or hydroxyproline.
Most studies use around 15g of collagen daily, but for optimal results, it's recommended to increase this to 30g or even 50g per day.
2. Use Red light to release fat
Red light and near-infrared light are highly beneficial to the body, as they promote cellular function. This means they speed up metabolism, increase energy expenditure, boost thyroid hormone and testosterone production, lower stress, promote blood flow, speed up wound healing, reduce wrinkles, improve sleep and exercise performance, etc. The list goes on.
Red light also promotes local lipolysis where it’s applied, aiding in targeted fat loss and overall fat reduction. It can even be used on the face to reduce puffiness and fat in that area.
Investing in a high-quality red light device can have a significant impact on your health and fat loss. It’s an investment worth making, as it’s essential for taking your health to the next level.
3. Get sunlight
Sunlight is so much more than just vitamin D, red light or near infra-red light. There are so many things you can do while being outside in the sun such as grounding, being active, inhaling calming compounds of nature and many more.
Sunlight increases the release of dopamine, and dopamine speeds up the metabolism and the desire to move and be active. Sunlight can also promote blood flow, sweating and the detoxification of toxins that might be hindering fat loss.
4. Walk in nature
Walking in nature is much more beneficial than just walking on a treadmill. Besides being outdoors in the sun and experiencing grounding, being in nature stimulates the brain significantly more and nearly doubles energy expenditure.
When you walk in nature, you burn more calories and enjoy additional benefits, such as reduced stress, increased dopamine levels, earthing, inhaling clean air, and enhanced brain stimulation.
5. Block EMF because it inhibits fat loss
Over the past few decades EMF exposure has increased astronomically. In fact it has increased by a quintillion times (that’s a 1 with 18 zeros) according to Dr. Joseph Mercola.
WiFi modems, cellphone towers and dirty electricity all emit EMF, which activates voltage-gated calcium channels (VGCCs) in the body. These channels allow calcium to enter and accumulate inside cells.
This excess calcium puts the cell in an excited state, leading to several negative effects. Intracellular calcium inhibits lipolysis (the breakdown of fat) in fat tissue, promotes lipogenesis (the conversion of carbohydrates to fat), and disrupts proper glucose oxidation.
As a result, there is less release of fat from fat stores, increased fat synthesis from carbohydrates and reduced oxidation of both fat and glucose in the cells.
So EMF exposure can contribute to fat retention. Fortunately, we can take steps to mitigate these effects through supplements and lifestyle changes that help counteract EMF exposure.
Here are some ways to protect yourself against the dangers of EMF:
1) Calcium Channel Blockers
EMF exposure activates voltage-gated calcium channels (VGCCs), allowing excess calcium into cells, leading to cellular stress and fat storage. Using calcium antagonists can help inhibit these channels.
Note for gear users: Consider supplementing with DHEA.
2) Inhibit Nitric Oxide Synthesis with Methylene Blue
Methylene blue can block the synthesis of nitric oxide (NO), which when elevated can hinder fat loss by boosting ATP and CO2 production. Excess NO is detrimental to fat loss.
3) Fix Mitochondrial Function
Improving mitochondrial function is key to reducing oxidative stress and enhancing ATP production. A combination of methylene blue, vitamin C, vitamin K2 and succinic acid can help repair the electron transport chain (ETC). Exercise, proper sleep and stress management are also crucial for promoting healthy mitochondria. Adequate ATP levels are essential for calcium transport out of cells, preventing calcium buildup even when VGCCs are blocked.
4) Activate Nrf2 Pathway
Nrf2 (a transcription factor) helps activate over 500 genes, reduces inflammation, improves mitochondrial function and stimulates autophagy. It lowers peroxynitrite production by inhibiting iNOS and COX-2. Compounds that activate Nrf2 are genereally turmeric, cruciferous vegetables, sulfur-rich foods and various quinones (like CoQ10 and PQQ).
A few compounds that promote Nrf2 include:
- Turmeric
- Cruciferous foods
- Sulfur rich foods
- Quinones
- Anthraquinone found in aloe latex, senna, rhubarb, cascara buckthorn, fungi, lichens and some insects.
- Naphthoquinone (Vitamin K is a derivative of 1,4-naphthoquinone). Other natural naphtoquinones include juglone (found in black walnut), lapachol (pau d arco tea),
- Benzoquinone. Ubiquinone (CoQ10) is a naturally occurring 1,4-benzoquinone.
- Pyrroloquinoline quinone (PQQ) found in kiwi fruit.
- γ (gamma) and δ (delta) tocopherols
- α-lipoic acid
- Carotenoids
- Olives and olive oil due to being rich in phenolics and terpenoids
- Purple sweet potatoes due to anthocyanin phenolics
- Quercetin
- Apigenin
- Naringenin
- Sulforaphane
- Shikonin (natural anthraquinone derivative) lowers estrogen by modulating an estrogen enzyme by down-regulating the expression of steroid sulfatase, it's essential for estrogen biosynthesis.
Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer - PubMed
Exposure to higher levels of estrogen produces genotoxic metabolites that can stimulate mammary tumorigenesis. Induction of NF-E2-related factor 2 (NRF2)-dependent detoxifying enzymes (e.g., NAD(P)H-quinone oxidoreductase 1 (NQO1)) is considered an important mechanism of protection against...
5) Inhibit NMDA Receptors
NMDA receptor activation increases intracellular calcium. Glutamate, the main NMDA agonist, rises in low ATP states, worsening calcium buildup. Magnesium and Theanine are two of the best natural NMDA receptor antagonists. Ketamine is a very effective and relatively safe drug that blocks the NMDA receptor.
6) Induce Mitochondrial Uncoupling
Mitochondrial uncoupling proteins (UCPs) reduce oxidative phosphorylation, lowering oxidative stress and preventing excess calcium entry. Moderate uncoupling can be induced with supplements like adrenal cortex extract, thyroid hormones (T4 and T3), calcium and progesterone. Caution is needed with strong uncouplers like DNP, which can cause lethal overheating.
Other methods to induce UCP are:
- large doses of aspirin
- methylene blue
- salt
- red meat
- lots of glucose with fats and spices.
- Curcumin
Let me say it again: If you get an excess of uncoupling, you can actually die of heat. This is how people die that overdose on DNP.
Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells - PubMed
An increase in the cytoplasmic-free Ca(2+) concentration mediates cellular responses to environmental signals that influence a range of processes, including gene expression, motility, secretion of hormones and neurotransmitters, changes in energy metabolism, and apoptosis. Mitochondria play...
That’s why DNP is so effective but very unsafe, whereas Niclosamide appears to be effective and much safer.
Goodbye buddy boyos @appealmaxed @craven
6. Avoid toxins
Just like EMF our environment, food, air and water have dramatically increased in toxins like heavy metals, mold, plastic, pharmaceutical drugs (birth control, SSRI, etc.), food additives, colourants, flavourings, cosmetics, omega 6 rich rancid vegetable oils/foods and more.
The list is way too long, but I’ll list a few:
- Heavy metals – Present in the air, dental fillings, water pipes, paints and many other building materials.
- Mold – Present in coffee, cocoa, grains and other products that aren’t properly stored. Animals that eat moldy grains (like all of them basically) have these toxic compounds in their fat and products such as eggs and milk and milk products. It’s also present where it’s damp and dark like in the bathroom, under wooden floors, in the ceiling, etc.
- Pharmaceutical drugs – Mostly present in our water, as well as in the sea creatures we eat that live close to the shore.
- Plastics – Everywhere basically. Stopping the use of plastic products and using an activated charcoal filter can help you get rid of the majority of plastics.
- Food additives, colourants & flavourings – Present in most foods and drinks. You’ll be surprised that it’s even present in “natural” foods, such as thickeners in yoghurt and cottage cheese, colourants in fruit juice & meat, flavour enhancers in baked goods, meats, drinks, etc.
- Cosmetics – Chances are that the shampoo, shaving cream, aftershave and deodorant you’re getting at your local store is choke-full of harmful chemicals. Instead of spending hours on hours staring at the labels in the shop looking like a weirdo, just invest a little more and get complete natural ingredients instead. They work just as well if not better.
- Omega 6 rich rancid oils/foods – Oils such as canola, soy, safflower, corn, sunflower, etc. are used as food preservatives in natural foods such as dried fruits, “healthy” chips and more. They are best to be avoided. Even animals that eat whole grains are being overloaded with these estrogenic and harmful oils. For this one it is worth staring at the back of labels looking like a weirdo to get safe food.
Avoiding all these toxins will take a huge strain off of your body which will then allow inflammation to drop, your gut to function better, mood to lift and fat loss to commence.
But don’t feel overwhelmed, think of it this way: All you’re doing is eliminating things and replacing a few. So it’s not like you are overhauling your whole life. You are just making smart subtractions and a few replacements.
7. Balance blood sugar & optimize glucose oxidation
All kinds of issues occur when we cannot utilize the glucose we consume. The glucose oxidation pathway seems pretty fragile and any disruption to the pathway causes issues such as:
- Excess fat gain
- Elevated lactate
- Fatty liver
- Fatigue
- Excess levels of cortisol
- Struggling to build muscle
That is why so many people these days benefit from reducing carb intake. Not because carbs are bad, it’s just that their body’s glucose utilization pathway is functioning suboptimally.
First we have to provide the necessary substrates to ensure proper glucose oxidation. There are 3 important steps for that. The first is the pyruvate dehydrogenase (PDH), where pyruvate (the breakdown product of glucose) is shuttled into the Kreb cycle. The second is the Kreb cycle itself and step number three is the electron transport chain, where the electrons “harvested” from the glucose are passed along to drive the creation of energy (ATP).
Step 1:
The first step can be quite challenging for a lot of people because of these reasons:
- Excess free fatty acids that inhibit this enzyme.
- Elevated NADH:NAD ratio due to faulty electron transport chain or low NAD+ levels.
- Vitamin and mineral deficiency such as vitamin B1, B3, B5 and magnesium.
Blocking excess FFAs with aspirin, supplementing niacinamide to increase NAD+ and taking high doses of vitamin B1 (around 300-600mg) and magnesium (200mg-2g) can greatly speed up this step.
Step 2:
The Kreb cycle itself is rarely a major issue if all the minerals and vitamins that are needed (vit B1, B3, B5, iron, magnesium and manganese) for proper functioning are present. However, high levels of oxidative stress can stop one of the first enzymes called aconitase, leading citrate to be used for the synthesis of fat (lipogenesis), instead of the Kreb cycle functioning normally.
Lowering oxidative stress is the key for normal Kreb cycle function.
Step 3:
Most people also have a major hiccup at this step. Most of the time it’s due to:
- Oxidized cardiolipin due to elevated oxidative stress
- Excess nitric oxide, which blocks complex IV
- Excess polyunsaturated fats in the cell membranes, allowing electron leak and oxidative stress
So it really comes down to elevated oxidative stress and this leads to a host of negatives, such as oxidized cardiolipin, cell membranes, enzymes, etc. and then fission has to step in to clear the damage and as a result, you end up with an excess of small and toxic mitochondria that overwhelms mitophagy, as seen in diabetes.
What we can do is lower oxidative stress, supply mitochondrial antioxidants and use alternative electron carriers.
To do that we can take:
- Vitamin C, vitamin E, alpha-lipoic acid (ALA) and CoQ10 (ubiquinone, not ubiquinol)
- Succinic acid (it rescues defective complex I and II)
- Methylene blue (it rescues defective complex (possibly I), II & III and speeds up complex IV)
- Vitamin K2 (rescues defective complex III)
- Red light (speeds up complex IV)
8. Lowering cortisol levels
Cortisol affects fat storage, lipogenesis, lypolysis and appetite. Here are some methods on lowering cortisol levels, excluding all the water stuff like sleep obviously:
- Ashwagandha (300-600mg)
- Phosphatidyl Serine (400-1200mg)
- Emodin (250-500mg)
- L-Theanine (200-400mg)
- Melatonin (3-100mg)
- Magnesium (400-2000mg)
- Testosterone (Over 150mg weekly)
- Oxandrolone (5-20mg daily)
Thirty Hertz Heartbreakers: @PsychoH @Angutoid @Always Stay You @mathis @4lt.Real @sb23 @mewcel420
Cool niggas list: @NZb6Air @moreplatesmoreweigh @MA_ascender @halloweed @truthhurts @billymidnight @itzyaboyJJ @CookieGuy @wastedspermcel @chudlite @Thebuffdon690 @chadintraining @silently_said @RealFunkyFlamingo @org3cel.RR
