Why does so many people here hate PUFAs?!

[softlysoftly]

One big problem is this attempt to connect PUFAs to heart disease, the actual outcome evidence does not support it; in fact, it like strongly supports the opposite.

Replacement of SFAs with PUFAs has a consistent protective effect on CVD.
https://pubmed.ncbi.nlm.nih.gov/30019767/

A systematic review of the effect of dietary saturated and polyunsaturated fat on heart disease - PubMed

Reducing saturated fat and replacing it with carbohydrate will not lower CHD events or CVD mortality although it will reduce total mortality. Replacing saturated fat with PUFA, MUFA or high-quality carbohydrate will lower CHD events.

pubmed.ncbi.nlm.nih.gov

This is likely due to a few different mechanisms, the first being that SFAs reliably increase blood LDL cholesterol levels and by default Apolipoprotein B (ApoB) which is thought to be a major factor contributing to atherosclerosis and CVD (more discussion on this later). Replacement of SFAs with PUFAs (particularly omega-3 PUFAs) has been shown to have a protective effect on CVD, likely by lowering LDL, ApoB, reducing inflammation, and various other proposed mechanisms.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719153/

This even holds true in a meta-analysis of CVD risk and linoleic acid intake.
https://pubmed.ncbi.nlm.nih.gov/32020162/

Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies - PubMed

In prospective observational studies, dietary LA intake is inversely associated with CHD risk in a dose-response manner. These data provide support for current recommendations to replace saturated fat with polyunsaturated fat for primary prevention of CHD.

pubmed.ncbi.nlm.nih.gov

Omega 3 PUFAs do appear to reduce risk in RCTs.

The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials - PubMed

Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. The suggestion of benefits reported in earlier meta-analyses is due to the inclusion of inadequately...

pubmed.ncbi.nlm.nih.gov

The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials - PubMed

Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. The suggestion of benefits reported in earlier meta-analyses is due to the inclusion of inadequately...

pubmed.ncbi.nlm.nih.gov

N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials - PubMed

This meta-analysis suggests that dietary and non-dietary intake of n-3 polyunsaturated fatty acids reduces overall mortality, mortality due to myocardial infarction, and sudden death in patients with coronary heart disease.

pubmed.ncbi.nlm.nih.gov

While randomized controlled trials are the gold standard in research, we cannot neglect their limitations, especially when it comes to subject number and time duration. Compare this with the cohort studies on the effects of replacing SFA with PUFA that demonstrate quite a powerful protective effect of replacing SFA with PUFA that appears to be dose dependent.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451787/

Further, even when specifically looking at omega 6 PUFAs there is a protective effect when replacing SFA with them.

Association between Plasma N-6 Polyunsaturated Fatty Acids Levels and the Risk of Cardiovascular Disease in a Community-based Cohort Study - Scientific Reports

Most studies support that saturated fatty acid replacement with polyunsaturated fatty acids (PUFAs) may reduce the risk of cardiovascular diseases (CVDs) and put emphasis on the effects of N-3 PUFAs. The reported relationships between N-6 PUFAs and CVD risks vary. We aimed to examine the...

www.nature.com

In this cohort study, those with higher blood levels of omega 6 PUFAs had a 50% lower risk of a CVD incident during a 35 year follow up.


TLDR: All of this to bring it back to the topic that saturated fat supposedly is good for you while PUFAs are bad. There is no hard evidence to back this up. People attempt to draw a mechanistic link between PUFA oxidation and CVD while ignoring the fact that saturated fat has a much STRONGER mechanistic link to CVD, which is backed up by actual outcome data in humans. Meanwhile, we not only have mechanistic data showing saturated fat can damage the arterial wall, but we also have outcome data and MR data across multiple lines of evidence showing saturated fat and LDL are most likely causal for CVD. There is no evidence that I am aware of demonstrating that PUFAs are casual for CVD, and if anything, they likely have a protective effect.

@ChristianChad @RabidRosaries @Moggable @russiancel

 

[ChristianChad]

Go ahead and eat PUFA, see how u feel.

 

[Matthias8272]

i thought you said pua ignore this

 

[softlysoftly]

Go ahead and eat PUFA, see how u feel.

Data > feelings

 

[Moggie]

comes from people listening to that oldcel Ray Peat

 

[softlysoftly]

I come with evidence while cope artists like @ChristianChad and @Prettyboy go with broscience and pseudointellectual bs

comes from people listening to that oldcel Ray Peat

no wonder lol
the retards on this place are so gullible

 

[softlysoftly]

One big problem is this attempt to connect PUFAs to heart disease, the actual outcome evidence does not support it; in fact, it like strongly supports the opposite.

Replacement of SFAs with PUFAs has a consistent protective effect on CVD.
https://pubmed.ncbi.nlm.nih.gov/30019767/

A systematic review of the effect of dietary saturated and polyunsaturated fat on heart disease - PubMed

Reducing saturated fat and replacing it with carbohydrate will not lower CHD events or CVD mortality although it will reduce total mortality. Replacing saturated fat with PUFA, MUFA or high-quality carbohydrate will lower CHD events.

pubmed.ncbi.nlm.nih.gov

This is likely due to a few different mechanisms, the first being that SFAs reliably increase blood LDL cholesterol levels and by default Apolipoprotein B (ApoB) which is thought to be a major factor contributing to atherosclerosis and CVD (more discussion on this later). Replacement of SFAs with PUFAs (particularly omega-3 PUFAs) has been shown to have a protective effect on CVD, likely by lowering LDL, ApoB, reducing inflammation, and various other proposed mechanisms.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719153/

This even holds true in a meta-analysis of CVD risk and linoleic acid intake.
https://pubmed.ncbi.nlm.nih.gov/32020162/

Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies - PubMed

In prospective observational studies, dietary LA intake is inversely associated with CHD risk in a dose-response manner. These data provide support for current recommendations to replace saturated fat with polyunsaturated fat for primary prevention of CHD.

pubmed.ncbi.nlm.nih.gov

Omega 3 PUFAs do appear to reduce risk in RCTs.

The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials - PubMed

Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. The suggestion of benefits reported in earlier meta-analyses is due to the inclusion of inadequately...

pubmed.ncbi.nlm.nih.gov

The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials - PubMed

Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. The suggestion of benefits reported in earlier meta-analyses is due to the inclusion of inadequately...

pubmed.ncbi.nlm.nih.gov

N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials - PubMed

This meta-analysis suggests that dietary and non-dietary intake of n-3 polyunsaturated fatty acids reduces overall mortality, mortality due to myocardial infarction, and sudden death in patients with coronary heart disease.

pubmed.ncbi.nlm.nih.gov

While randomized controlled trials are the gold standard in research, we cannot neglect their limitations, especially when it comes to subject number and time duration. Compare this with the cohort studies on the effects of replacing SFA with PUFA that demonstrate quite a powerful protective effect of replacing SFA with PUFA that appears to be dose dependent.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451787/

Further, even when specifically looking at omega 6 PUFAs there is a protective effect when replacing SFA with them.

Association between Plasma N-6 Polyunsaturated Fatty Acids Levels and the Risk of Cardiovascular Disease in a Community-based Cohort Study - Scientific Reports

Most studies support that saturated fatty acid replacement with polyunsaturated fatty acids (PUFAs) may reduce the risk of cardiovascular diseases (CVDs) and put emphasis on the effects of N-3 PUFAs. The reported relationships between N-6 PUFAs and CVD risks vary. We aimed to examine the...

www.nature.com

In this cohort study, those with higher blood levels of omega 6 PUFAs had a 50% lower risk of a CVD incident during a 35 year follow up.


TLDR: All of this to bring it back to the topic that saturated fat supposedly is good for you while PUFAs are bad. There is no hard evidence to back this up. People attempt to draw a mechanistic link between PUFA oxidation and CVD while ignoring the fact that saturated fat has a much STRONGER mechanistic link to CVD, which is backed up by actual outcome data in humans. Meanwhile, we not only have mechanistic data showing saturated fat can damage the arterial wall, but we also have outcome data and MR data across multiple lines of evidence showing saturated fat and LDL are most likely causal for CVD. There is no evidence that I am aware of demonstrating that PUFAs are casual for CVD, and if anything, they likely have a protective effect.

@ChristianChad @RabidRosaries @Moggable @russiancel

@DrTony thoughts?

 

[ChristianChad]

I come with evidence while cope artists like @ChristianChad and @Prettyboy go with broscience and pseudointellectual bs

no wonder lol
the retards on this place are so gullible

Eat exactly as recommended by the guidelines set by your doctors and government, WHO and the FDA

 

[softlysoftly]

Eat exactly as recommended by the guidelines set by your doctors and government, WHO and the FDA

pathetic strawman attempt go kys you low iq rat

 

[ChristianChad]

pathetic strawman attempt go kys you low iq rat

These guidelines are backed by endless research. Are you retarded?

 

[softlysoftly]

These guidelines are backed by endless research. Are you retarded?

Respond to my OP with like peer reviewed research and evidence to dispute or gtfoh you slimy low iq misinformation spreading weasel

 

[Moggie]

Eat exactly as recommended by the guidelines set by your doctors and government, WHO and the FDA

Some government dietary guidelines are actually good tbh

 

[Deleted member 5815]

pufa consumption keeps going up yet cardiovascular disease rates are still steadily rising, linoleic acid concentration in human fat cells has increased almost 25x in the last 50 years

look how little pufas we consumed 100 years ago and all throughout history, the fats we consumed were saturated fats and we had much less cardiovascular incidents

also im sure some of these studies assume it reduces risks of cardiovascular disease because it reduces total serum cholesterol level which they associate with cvd risk, not because the people studied were dying

This trial showed a "22% higher death rate for each 30 ng / dL reduction in cholesterol" when saturated fat was replaced with linoleic acid



everyone can play this stupid posting studies game but at the end of the day just eat the natural diet you were supposed to eat

 

[ChristianChad]

Respond to my OP with like peer reviewed research and evidence to dispute or gtfoh you slimy low iq misinformation spreading weasel

Ur op is a copy paste from some blog I'm not going to put effort into countering that faggot, do some more research first.

 

[softlysoftly]

@mods pin this thread to show forum how they have been fooled into thinking pufas are 'bad' and 'villainous'
@Lorsss @PapiMew @tyronelite @Gargantuan @Kingkellz @her

 

[ChristianChad]

Some government dietary guidelines are actually good tbh

Please tell tbh

 

[Hero of the Imperium]

Saturated is not safe as you age, although some is necessary for good hormonal levels

PUFA main problem is they oxidize easily. This seems to be an inherent chemical property. The idea then is they develop free radicals, are ingested, digested, absorbed, and there are enough free radicals in the bloodstream distributed across the body to cause damage

Vegetable oil consumption has been correlated with lowered testosterone

Some omega 3s seem good of course. Make sure of no mercury and other contamination.

 

[softlysoftly]

Ur op is a copy paste from some blog I'm not going to put effort into countering that faggot, do some more research first.

Please tell tbh

I presented you with research now its your turn or just admit defeat and that you promote bs from ray peat

 

[Moggie]

View attachment 1845870


pufa consumption keeps going up yet cardiovascular disease rates are still steadily rising, linoleic acid concentration in human fat cells has increased almost 25x in the last 50 years

look how little pufas we consumed 100 years ago and all throughout history, the fats we consumed were saturated fats and we had much less cardiovascular incidents

also im sure some of these studies assume it reduces risks of cardiovascular disease because it reduces total serum cholesterol level which they associate with cvd risk, not because the people studied were dying

View attachment 1845879

This trial showed a "22% higher death rate for each 30 ng / dL reduction in cholesterol" when saturated fat was replaced with linoleic acid



everyone can play this stupid posting studies game but at the end of the day just eat the natural diet you were supposed to eat

I am sure there are other charts that could overlap with increased cardiovascular disease rates like miles driven in cars per year or total number of fast food restaraunts.

 

[ChristianChad]

I presented you with research now its your turn or just admit defeat and that you promote bs from ray peat

You're a disingenuous troll faggot

 

[Deleted member 5815]

I am sure there are other charts that could overlap with increased cardiovascular disease rates like miles driven in cars per year or total number of fast food restaraunts.

the food they serve in restaurants is very high in pufas it should be protective

 

[softlysoftly]

pufa consumption keeps going up yet cardiovascular disease rates are still steadily rising, linoleic acid concentration in human fat cells has increased almost 25x in the last 50 years

look how little pufas we consumed 100 years ago and all throughout history, the fats we consumed were saturated fats and we had much less cardiovascular incidents

correlation =/= causation

everyone can play this stupid posting studies game but at the end of the day just eat the natural diet you were supposed to eat

my point is to say
There is no evidence that I am aware of demonstrating that PUFAs are casual for CVD, and if anything, they likely have a protective effect.

The idea then is they develop free radicals, are ingested, digested, absorbed, and there are enough free radicals in the bloodstream distributed across the body to cause damage

muh idea
show me the human RCT to prove this 'idea' until then shut it

Has been correlated with lowered testosterone

correlation =/= causation

 

[Deleted member 5815]

correlation =/= causation

arent all your studies are based on correlation = causation

 

[Hero of the Imperium]

correlation =/= causation

my point is to say
There is no evidence that I am aware of demonstrating that PUFAs are casual for CVD, and if anything, they likely have a protective effect.

muh idea
show me the human RCT to prove this 'idea' until then shut it

correlation =/= causation

You are coping. Don't confuse omega 6s with omega 3s. Remember the only reason for omega 3 rep, besides making money selling them, is because they are not omega 6s

 

[softlysoftly]

You're a disingenuous troll faggot

you replied to my thread 7 times so far and not one reply includes any peer reviewed research or human evidence data

the food they serve in restaurants is very high in pufas it should be protective

nice try
food served in restaurants are often processed and high calorie and hyperpalatable with insufficient micronutrition those are the main issues

 

[softlysoftly]

You are coping.

no
post studies or stfu

Don't confuse omega 6s with omega 3s.

im not you the confused one here nigga

 

[Moggie]

Please tell tbh

Norwegian, Italian, Polish and Swiss guidelines seem fine to me, though the restrictions on red meat all call for are overzealous.

 

[PURE ARYAN GENETICS]

it's ok bro just eat the seed oil that was invented 100 years ago, heat treated 5 times, deodorized and put into plastic containers and rest happy knowing that shlomo has your back with his studies

 

[Hero of the Imperium]

no
post studies or stfu

im not you the confused one here nigga

There are plenty of studies, go read since you are so motivated. The good ones you are posting are omega 3s lol

 

[ChristianChad]

Norwegian, Italian, Polish and Swiss guidelines seem fine to me, though the restrictions on red meat all call for are overzealous.

Probably because there's no Jew whore in charge of making the guidelines

 

[Moggie]

Probably because there's no Jew whore in charge of making the guidelines

Israel has Replaced the Food Pyramid with a NEW Food Rainbow | ShemeshPhone

The recommended nutritional guidelines are based on the Mediterranean diet, scientifically proven to contribute to health and disease prevention. Learn more inside!

www.shemesh.co.il

https://www.gov.il/en/departments/news/08062021-01

 

[softlysoftly]

it's ok bro just eat the seed oil that was invented 100 years ago, heat treated 5 times, deodorized and put into plastic containers and rest happy knowing that shlomo has your back with his studies

There are plenty of studies, go read since you are so motivated. The good ones you are posting are omega 3s lol

mindless rambling but not one research study to dispute

 

[ChristianChad]

Israel has Replaced the Food Pyramid with a NEW Food Rainbow | ShemeshPhone

The recommended nutritional guidelines are based on the Mediterranean diet, scientifically proven to contribute to health and disease prevention. Learn more inside!

www.shemesh.co.il

https://www.gov.il/en/departments/news/08062021-01

I remember in school we had that food rainbow even before it was implemented, right next to the rainbow of sexuality and foreskin jar

 

[BrickTop]

We need to encourage/gaslight Seed Oil consumption so we can decrease competition.

I think OP has accidentally stumbled upon a noble cause, despite his premature retardation.

 

[BrickTop]

mindless rambling but not one research study to dispute

Make sure to take your mRNA gene modifiying clot shot along with your tablespoons of canola oil

 

[jaw_is_law]

cope

 

[jaw_is_law]

We need to encourage/gaslight Seed Oil consumption so we can decrease competition.

I think OP has accidentally stumbled upon a noble cause, despite his premature retardation.

yes the more people are eating mcdonalds and seed oils the less competition

 

[softlysoftly]

despite his premature retardation.

says the keboard warrior who like talks shit with no degree in nutrional sciences and doesn't post a single piece of evidence to dispute what I said

Make sure to take your mRNA gene modifiying clot shot along with your tablespoons of canola oil

not vaxxed good job assuming like the retard you are

cope

how? prove it

 

[jaw_is_law]

how? prove it

"vegetable oil is good bro"

 

[Deleted member 16220]

What the fuck is a pufa??

 

[BrickTop]

says the keboard warrior who like talks shit with no degree in nutrional sciences and doesn't post a single piece of evidence to dispute what I said

not vaxxed good job assuming like the retard you are

how? prove it

Frontiers | The Relationship Between Linoleic Acid Intake and Psychological Disorders in Adults

BackgroundThe association between linoleic acid (LA) intake and mental disorders has not been extensively studied in Middle-Eastern populations. We investiga...

www.frontiersin.org

https://www.sciencedirect.com/science/article/abs/pii/S0899900721002562?via%3Dihub

Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice

Abstract. Soybean oil consumption has increased greatly in the past half-century and is linked to obesity and diabetes. To test the hypothesis that soybean

academic.oup.com

https://www.cell.com/cell-reports/f...m/retrieve/pii/S2211124722008002?showall=true

Here you go pufa faggot. There's some sTuDiEs

 

[BrickTop]

says the keboard warrior who like talks shit with no degree in nutrional sciences and doesn't post a single piece of evidence to dispute what I said

not vaxxed good job assuming like the retard you are

how? prove it

https://www.nature.com/articles/s41598-019-39767-1

Effects of polyunsaturated fatty acids on hibernation and torpor: a review and hypothesis | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Polyunsaturated fatty acids (PUFAs) can have strong effects on hibernation and daily torpor in mammals. High dietary PUFA contents were found to increase proneness for torpor, decrease body temperatures, prolong torpor bout duration, and attenuate hibernation mass loss. The mechanism by which...

journals.physiology.org

Polyunsaturated fatty acids, membrane organization, T cells, and antigen presentation

ABSTRACT. Dietary supplementation with polyunsaturated fatty acids (PUFAs), especially those of the n−3 class, has immunosuppressive effects on both innate and

academic.oup.com

https://journals.physiology.org/doi/full/10.1152/ajpendo.00235.2020

Cooking with vegetable oils releases toxic cancer-causing chemicals, say experts

Scientists warn against the dangers of frying food in sunflower oil and corn oil over claims they release toxic chemicals linked to cancer

www.telegraph.co.uk

Omega-3, omega-6 and total dietary polyunsaturated fat on cancer incidence: systematic review and meta-analysis of randomised trials - British Journal of Cancer

The relationship between long-chain omega-3 (LCn3), alpha-linolenic acid (ALA), omega-6 and total polyunsaturated fatty acid (PUFA) intakes and cancer risk is unclear. We searched Medline, Embase, CENTRAL and trials registries for RCTs comparing higher with lower LCn3, ALA, omega-6 and/or total...

www.nature.com

Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case–control study within a European prospective cohort study | Gut

Do both heterocyclic amines and omega-6 polyunsaturated fatty acids contribute to the incidence of breast cancer in postmenopausal women of the Malmö diet and cancer cohort? - PubMed

Heterocyclic amines (HAs), formed when meat and fish are cooked at high temperatures, have been linked to mammary gland cancer in rats, and some epidemiological studies indicate increased breast cancer risk by consumption of well-done meat. The epidemiological evidence linking HAs per se to...

pubmed.ncbi.nlm.nih.gov

Fat Intake and Risk of Skin Cancer in U.S. Adults - PubMed

<span><b>Background:</b> Fat intake has been associated with certain cancers, including colorectal, breast, and prostate cancers. However, literature on dietary fat and skin cancer has been limited.<b>Methods:</b> We examined the association between fat intake and risk of skin cancer including...

pubmed.ncbi.nlm.nih.gov

Increased Serum Dihomo-γ-linolenic Acid Levels Are Associated with Obesity, Body Fat Accumulation, and Insulin Resistance in Japanese Patients with Type 2 Diabetes - PubMed

Objective To clarify the associations between serum omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acid (PUFA) levels and obesity-related metabolic abnormalities in patients with type 2 diabetes. Methods and Materials Data from 225 Japanese patients with type 2 diabetes were...

pubmed.ncbi.nlm.nih.gov

Lipoxygenase drives lipidomic and metabolic reprogramming in ischemic heart failure

After myocardial infarction (MI), delayed progression or reversal of cardiac remodeling is a prime target to limit advanced chronic heart failure (HF). However, the temporal kinetics of lipidomic and systemic metabolic signaling is unclear in HF. There is no consensus on metabolic and lipidomic...

www.metabolismjournal.com

You can check these out but I'd prefer you stay with your original hypothesis and drink your seed oils so your progeny never come into existence.

 

[softlysoftly]

https://www.nature.com/articles/s41598-019-39767-1

Effects of polyunsaturated fatty acids on hibernation and torpor: a review and hypothesis | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Polyunsaturated fatty acids (PUFAs) can have strong effects on hibernation and daily torpor in mammals. High dietary PUFA contents were found to increase proneness for torpor, decrease body temperatures, prolong torpor bout duration, and attenuate hibernation mass loss. The mechanism by which...

journals.physiology.org

Polyunsaturated fatty acids, membrane organization, T cells, and antigen presentation

ABSTRACT. Dietary supplementation with polyunsaturated fatty acids (PUFAs), especially those of the n−3 class, has immunosuppressive effects on both innate and

academic.oup.com

https://journals.physiology.org/doi/full/10.1152/ajpendo.00235.2020

Cooking with vegetable oils releases toxic cancer-causing chemicals, say experts

Scientists warn against the dangers of frying food in sunflower oil and corn oil over claims they release toxic chemicals linked to cancer

www.telegraph.co.uk

Omega-3, omega-6 and total dietary polyunsaturated fat on cancer incidence: systematic review and meta-analysis of randomised trials - British Journal of Cancer

The relationship between long-chain omega-3 (LCn3), alpha-linolenic acid (ALA), omega-6 and total polyunsaturated fatty acid (PUFA) intakes and cancer risk is unclear. We searched Medline, Embase, CENTRAL and trials registries for RCTs comparing higher with lower LCn3, ALA, omega-6 and/or total...

www.nature.com

Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case–control study within a European prospective cohort study | Gut

Do both heterocyclic amines and omega-6 polyunsaturated fatty acids contribute to the incidence of breast cancer in postmenopausal women of the Malmö diet and cancer cohort? - PubMed

Heterocyclic amines (HAs), formed when meat and fish are cooked at high temperatures, have been linked to mammary gland cancer in rats, and some epidemiological studies indicate increased breast cancer risk by consumption of well-done meat. The epidemiological evidence linking HAs per se to...

pubmed.ncbi.nlm.nih.gov

Fat Intake and Risk of Skin Cancer in U.S. Adults - PubMed

<span><b>Background:</b> Fat intake has been associated with certain cancers, including colorectal, breast, and prostate cancers. However, literature on dietary fat and skin cancer has been limited.<b>Methods:</b> We examined the association between fat intake and risk of skin cancer including...

pubmed.ncbi.nlm.nih.gov

Increased Serum Dihomo-γ-linolenic Acid Levels Are Associated with Obesity, Body Fat Accumulation, and Insulin Resistance in Japanese Patients with Type 2 Diabetes - PubMed

Objective To clarify the associations between serum omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acid (PUFA) levels and obesity-related metabolic abnormalities in patients with type 2 diabetes. Methods and Materials Data from 225 Japanese patients with type 2 diabetes were...

pubmed.ncbi.nlm.nih.gov

Lipoxygenase drives lipidomic and metabolic reprogramming in ischemic heart failure

After myocardial infarction (MI), delayed progression or reversal of cardiac remodeling is a prime target to limit advanced chronic heart failure (HF). However, the temporal kinetics of lipidomic and systemic metabolic signaling is unclear in HF. There is no consensus on metabolic and lipidomic...

www.metabolismjournal.com

You can check these out but I'd prefer you stay with your original hypothesis and drink your seed oils so your progeny never come into existence.

at least you tried so I'll give you that but if you ever bothered to read into the studies you posted it either evaluates something irrelevant, pure correlation, or done on unhealthy patients with some pre-existing ailment or disease

once again my stance goes like this:
All of this to bring it back to the topic that saturated fat supposedly is good for you while PUFAs are bad. There is no hard evidence to back this up. People attempt to draw a mechanistic link between PUFA oxidation and CVD while ignoring the fact that saturated fat has a much STRONGER mechanistic link to CVD, which is backed up by actual outcome data in humans. Meanwhile, we not only have mechanistic data showing saturated fat can damage the arterial wall, but we also have outcome data and MR data across multiple lines of evidence showing saturated fat and LDL are most likely causal for CVD. There is no evidence that I am aware of demonstrating that PUFAs are casual for CVD, and if anything, they likely have a protective effect.

 

[Deleted member 21297]

One big problem is this attempt to connect PUFAs to heart disease, the actual outcome evidence does not support it; in fact, it like strongly supports the opposite.

Replacement of SFAs with PUFAs has a consistent protective effect on CVD.
https://pubmed.ncbi.nlm.nih.gov/30019767/

A systematic review of the effect of dietary saturated and polyunsaturated fat on heart disease - PubMed

Reducing saturated fat and replacing it with carbohydrate will not lower CHD events or CVD mortality although it will reduce total mortality. Replacing saturated fat with PUFA, MUFA or high-quality carbohydrate will lower CHD events.

pubmed.ncbi.nlm.nih.gov

This is likely due to a few different mechanisms, the first being that SFAs reliably increase blood LDL cholesterol levels and by default Apolipoprotein B (ApoB) which is thought to be a major factor contributing to atherosclerosis and CVD (more discussion on this later). Replacement of SFAs with PUFAs (particularly omega-3 PUFAs) has been shown to have a protective effect on CVD, likely by lowering LDL, ApoB, reducing inflammation, and various other proposed mechanisms.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719153/

This even holds true in a meta-analysis of CVD risk and linoleic acid intake.
https://pubmed.ncbi.nlm.nih.gov/32020162/

Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies - PubMed

In prospective observational studies, dietary LA intake is inversely associated with CHD risk in a dose-response manner. These data provide support for current recommendations to replace saturated fat with polyunsaturated fat for primary prevention of CHD.

pubmed.ncbi.nlm.nih.gov

Omega 3 PUFAs do appear to reduce risk in RCTs.

The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials - PubMed

Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. The suggestion of benefits reported in earlier meta-analyses is due to the inclusion of inadequately...

pubmed.ncbi.nlm.nih.gov

The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials - PubMed

Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. The suggestion of benefits reported in earlier meta-analyses is due to the inclusion of inadequately...

pubmed.ncbi.nlm.nih.gov

N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials - PubMed

This meta-analysis suggests that dietary and non-dietary intake of n-3 polyunsaturated fatty acids reduces overall mortality, mortality due to myocardial infarction, and sudden death in patients with coronary heart disease.

pubmed.ncbi.nlm.nih.gov

While randomized controlled trials are the gold standard in research, we cannot neglect their limitations, especially when it comes to subject number and time duration. Compare this with the cohort studies on the effects of replacing SFA with PUFA that demonstrate quite a powerful protective effect of replacing SFA with PUFA that appears to be dose dependent.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451787/

Further, even when specifically looking at omega 6 PUFAs there is a protective effect when replacing SFA with them.

Association between Plasma N-6 Polyunsaturated Fatty Acids Levels and the Risk of Cardiovascular Disease in a Community-based Cohort Study - Scientific Reports

Most studies support that saturated fatty acid replacement with polyunsaturated fatty acids (PUFAs) may reduce the risk of cardiovascular diseases (CVDs) and put emphasis on the effects of N-3 PUFAs. The reported relationships between N-6 PUFAs and CVD risks vary. We aimed to examine the...

www.nature.com

In this cohort study, those with higher blood levels of omega 6 PUFAs had a 50% lower risk of a CVD incident during a 35 year follow up.


TLDR: All of this to bring it back to the topic that saturated fat supposedly is good for you while PUFAs are bad. There is no hard evidence to back this up. People attempt to draw a mechanistic link between PUFA oxidation and CVD while ignoring the fact that saturated fat has a much STRONGER mechanistic link to CVD, which is backed up by actual outcome data in humans. Meanwhile, we not only have mechanistic data showing saturated fat can damage the arterial wall, but we also have outcome data and MR data across multiple lines of evidence showing saturated fat and LDL are most likely causal for CVD. There is no evidence that I am aware of demonstrating that PUFAs are casual for CVD, and if anything, they likely have a protective effect.

@ChristianChad @RabidRosaries @Moggable @russiancel

i dont know what any of this means sorry

 

[SteveRogers]

You are fucking stupid.

Keep eating PUFAs though, please nigga.
While you rot from the inside out, I’ll be happily eating all of the saturated animal fat possible, literally slurping blood and fat straight from the source

Muh “Why does so many people here hate PUFAs?!” - it’s “do” and it’s because they’re extremely toxic, poison.

 

[SteveRogers]

Data > feelings

A true slave.

 

[Laikyn]

 

[softlysoftly]

because they’re extremely toxic, poison

provide the proof show the evidence to dispute what I posted
I made claims then like backed it up with evidence now why can't you do the same?

A true slave.

I am slave to being an objective thinker

View attachment 1847933

goofy charts showing weak correlations
did you know that like both murders and ice cream sales go up in the summer I guess ice cream must be causing murder huh? no its just correlation and correlation =/= causation

 

[incel194012940]

these small molecule groups are mostly cope, you eat 100 you don’t even think of that fuck with you. If you think that you need to be autistically obsessed with nutrition just to be somewhat healthy it over.

If you exercise that is something more associated with stopping heart disease than any fatty acid or cope extract.

imo a flavorless oil goes against the point of cooking with an oil.

I guess if you want to add calories while adding nothing else? or if you like peanut butter. Lol at this retard argument when ray peat people refuse to eat a single walnut and avoid chicken.

it's ok bro just eat the seed oil that was invented 100 years ago, heat treated 5 times, deodorized and put into plastic containers and rest happy knowing that shlomo has your back with his studies

I am an incel who need to feel superior to others, and persecuted for that, despite having nothing, so sometimes I will pretend I avoid eating out because of pufa instead of having no money.

 

[GGalex]

One big problem is this attempt to connect PUFAs to heart disease, the actual outcome evidence does not support it; in fact, it like strongly supports the opposite.

Replacement of SFAs with PUFAs has a consistent protective effect on CVD.
https://pubmed.ncbi.nlm.nih.gov/30019767/

A systematic review of the effect of dietary saturated and polyunsaturated fat on heart disease - PubMed

Reducing saturated fat and replacing it with carbohydrate will not lower CHD events or CVD mortality although it will reduce total mortality. Replacing saturated fat with PUFA, MUFA or high-quality carbohydrate will lower CHD events.

pubmed.ncbi.nlm.nih.gov

This is likely due to a few different mechanisms, the first being that SFAs reliably increase blood LDL cholesterol levels and by default Apolipoprotein B (ApoB) which is thought to be a major factor contributing to atherosclerosis and CVD (more discussion on this later). Replacement of SFAs with PUFAs (particularly omega-3 PUFAs) has been shown to have a protective effect on CVD, likely by lowering LDL, ApoB, reducing inflammation, and various other proposed mechanisms.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719153/

This even holds true in a meta-analysis of CVD risk and linoleic acid intake.
https://pubmed.ncbi.nlm.nih.gov/32020162/

Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies - PubMed

In prospective observational studies, dietary LA intake is inversely associated with CHD risk in a dose-response manner. These data provide support for current recommendations to replace saturated fat with polyunsaturated fat for primary prevention of CHD.

pubmed.ncbi.nlm.nih.gov

Omega 3 PUFAs do appear to reduce risk in RCTs.

The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials - PubMed

Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. The suggestion of benefits reported in earlier meta-analyses is due to the inclusion of inadequately...

pubmed.ncbi.nlm.nih.gov

The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials - PubMed

Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. The suggestion of benefits reported in earlier meta-analyses is due to the inclusion of inadequately...

pubmed.ncbi.nlm.nih.gov

N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials - PubMed

This meta-analysis suggests that dietary and non-dietary intake of n-3 polyunsaturated fatty acids reduces overall mortality, mortality due to myocardial infarction, and sudden death in patients with coronary heart disease.

pubmed.ncbi.nlm.nih.gov

While randomized controlled trials are the gold standard in research, we cannot neglect their limitations, especially when it comes to subject number and time duration. Compare this with the cohort studies on the effects of replacing SFA with PUFA that demonstrate quite a powerful protective effect of replacing SFA with PUFA that appears to be dose dependent.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451787/

Further, even when specifically looking at omega 6 PUFAs there is a protective effect when replacing SFA with them.

Association between Plasma N-6 Polyunsaturated Fatty Acids Levels and the Risk of Cardiovascular Disease in a Community-based Cohort Study - Scientific Reports

Most studies support that saturated fatty acid replacement with polyunsaturated fatty acids (PUFAs) may reduce the risk of cardiovascular diseases (CVDs) and put emphasis on the effects of N-3 PUFAs. The reported relationships between N-6 PUFAs and CVD risks vary. We aimed to examine the...

www.nature.com

In this cohort study, those with higher blood levels of omega 6 PUFAs had a 50% lower risk of a CVD incident during a 35 year follow up.


TLDR: All of this to bring it back to the topic that saturated fat supposedly is good for you while PUFAs are bad. There is no hard evidence to back this up. People attempt to draw a mechanistic link between PUFA oxidation and CVD while ignoring the fact that saturated fat has a much STRONGER mechanistic link to CVD, which is backed up by actual outcome data in humans. Meanwhile, we not only have mechanistic data showing saturated fat can damage the arterial wall, but we also have outcome data and MR data across multiple lines of evidence showing saturated fat and LDL are most likely causal for CVD. There is no evidence that I am aware of demonstrating that PUFAs are casual for CVD, and if anything, they likely have a protective effect.

@ChristianChad @RabidRosaries @Moggable @russiancel