To fully optimize our skin's ability to promote collagen production, we need to understand the process of collagen synthesis on a fundamental level. When mRNA moves into the cytoplasm and interacts with ribosomes, both magnesium and zinc are needed for translation to occur. After translation, this polypeptide chain travels to the endoplasmic reticulum (ER). The polypeptide chain undergoes enzymatic modifications, including hydroxylation of proline and lysine which requires iron and vitamin C as cofactors (and oxygen). This process creates procollagen which is released from the fibroblast. The ends of the procollagen molecule are removed by peptidases and the molecule becomes tropocollagen. Tropocollagen undergoes covalent bonding through lysyl oxidase and this creates a collagen fibril. tl;dr magnesium, zinc, iron, vitamin C are necessary co-factors.
Now I know PSL autists are obsessed with carotenoids. Beta-carotene increases type I procollagen mRNA levels, but procollagen is a precursor and not collagen itself so this will not give us noticeable enough results. We need to upregulate gene expression in order to synthesize a functional product. Astaxanthin with hydrolyzed collagen upregulates type I procollagen gene expression and decreases MMP-1 and -12. MMP-1, the prototypical MMP, degrades collagen types 1 and 3. Polyphenols will take this a step further within the sub-class of proanthocyanidins. Specifically, pycnogenol stimulates type I collagen synthesis in subjects’ skin by increasing gene expression by 41%. tl;dr astaxanthin, collagen peptides, and pycnogenol (OPCs).
The main goal should be to find exogenous ways to stimulate type I collagen synthesis since it’s the most abundant collagen found in the skin, and it is the most significant one we lose as we age. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells. Processed panax ginseng, sun ginseng stimulates type I collagen by regulating MMP-1 and TIMP-1 expression in human dermal fibroblasts. 10-hydroxy-2-decenoic acid, a characteristic constituent of lipids from honeybee royal jelly extract, stimulates normal human dermal fibroblast cell lines and produce transforming growth factor(TGF) β1, a cytokine that stimulates collagen synthesis. Aloe vera is already mentioned on this forum, but the polysaccharide acemannan in aloe is what causes collagen biosynthesis. tl;dr orthosilicic acid (BioSil), red panax ginseng, honeybee royal jelly extract, and aloe vera.
There are other nutraceuticals, but all the oral supplements I listed are the most evidence-based to promote collagen production. When it comes to skincare, water is wet. But tretinoin increases type I and type III collagen as well as inhibits the expression of MMP-1, which I mentioned breaks down collagen. Topical vitamin C also stimulates type I and type III collagen synthesis. Vitamin C suppresses MMPs responsible for collagen degradation and increases the tissue inhibitor of MMPs, as well as mRNA levels of collagens I and III. Ferulic acid stabilizes solutions of vitamins C and E and doubles its photoprotection of skin so if you’re buying a vitamin C serum without it then it’s over for you. The vitamin C serum also must have a pH below 3.5 for effective penetration. Ascorbic acid serums must be at least 10% to be effective. The maximum amount of ascorbic acid penetration was seen at 20% with a pH of 3.2, so a vitamin C serum with this concentration will give you the best results. Topical 5% niacinamide may stimulate collagen synthesis and the epidermal proteins. Apparently niacinamide had no strong documented effect on collagen, but a study showed that niacinamide was able to increase dermal matrix collagen production. 20% Glycolic acid treatment also increases type I collagen mRNA and hyaluronic acid content of human skin. tl;dr 0.025%+ tretinoin, 20% vitamin c with e and ferulic acid, 5% niacinamide, 20% glycolic acid peels.
For cosmetic peptides, @x30001 would often shill the use of GHK-cu since copper peptides do stimulate collagen synthesis by a noticeable percent. But if they’re overused, GHK-cu can cause more damage than good (can cause a crepey skin texture). So no need to use it yet since you’re all still teencels. Also there are better proven peptides for collagenmaxxing pursuits. Matrixyl 3000 (trademark for palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7) stimulates type I collagen, fibronectin, and hyaluronic acid. The 8% concentration is the highest concentration proven to be effective in vivo. Matrixyl synthe'6 (trademark for palmitoyl tripeptide-38) stimulates type I, type III, and type IV collagen, as well as fibronectin and hyaluronic acid. The 2% concentration is the highest concentration proven to be effective in vivo. The original Matrixyl (trademark for palmitoyl pentapeptide-4) also stimulates collagen types I, III, and IV, as well as elastin and fibronectin. Tetrapeptide-21 and EGF (human oligopeptide-1) are also often sought after by the foid skincare community. tl;dr matrixyl, matrixyl 3000, matrixyl synthe'6, tetrapeptide-21, and egf.
Another skincare ingredient this site has never heard of is centella asiatica extract or madecassosides. Madecassosides stimulate type I collagen synthesis in human dermal fibroblast cells. Referring back to process of collagen synthesis, centella asiatica increased the metabolism of lysine and proline, the amino acids that I mentioned that build the collagen molecule. In addition, these compounds increased the synthesis of tropocollagen and mucopolysaccharide in the connective tissues. You need to find a cream with at least 0.1% madecassosides.
As a reminder for sunscreen, it needs to be SPF 50+ PA++++. UVA rays cause tanning, hyperpigmentation, fine lines and wrinkles, while UVB causes sunburn. SPF only rates UVB, while the PA system (or PPD) rates UVA. The sunscreen should consist of photostable UV filters too so ingredients like zinc oxide and titanium dioxide mog oxybenzone and benzophenone.
Use https://incidecoder.com/ if you need help finding specific ingredients, but this thread was just an overview for a future thread that will go over the routine.
Sources:
https://www.ncbi.nlm.nih.gov/books/NBK507709/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390761/
https://www.pycnogenol.com/fileadmi...chures/Pycnogenol_OralSkinCare_EN_161_WEB.pdf
https://pubmed.ncbi.nlm.nih.gov/12633784/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659568/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583892/
https://pubmed.ncbi.nlm.nih.gov/11407971/
https://pubmed.ncbi.nlm.nih.gov/16185284/
https://kindofstephen.com/skin-penetration-of-ascorbic-acid/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921764/
https://pubmed.ncbi.nlm.nih.gov/11359487/
http://www.smartskincare.com/treatments/topical/Matrixyl3000report.pdf
http://www.beautyandskin.co.nz/i/images/matrixylsynth6copy.pdf
Everyone who asked to be tagged and a couple others:
@mido the slayer, @Don't Forget to mew, @Dyorotic2, @ThreadMatters, @GarouTheIncel, @Tortereeno, @looksaboveeverything, @alexjones, @Merlix, @Good_Little_Goy, @Lorsss, @her, @Kingkellz
Now I know PSL autists are obsessed with carotenoids. Beta-carotene increases type I procollagen mRNA levels, but procollagen is a precursor and not collagen itself so this will not give us noticeable enough results. We need to upregulate gene expression in order to synthesize a functional product. Astaxanthin with hydrolyzed collagen upregulates type I procollagen gene expression and decreases MMP-1 and -12. MMP-1, the prototypical MMP, degrades collagen types 1 and 3. Polyphenols will take this a step further within the sub-class of proanthocyanidins. Specifically, pycnogenol stimulates type I collagen synthesis in subjects’ skin by increasing gene expression by 41%. tl;dr astaxanthin, collagen peptides, and pycnogenol (OPCs).
The main goal should be to find exogenous ways to stimulate type I collagen synthesis since it’s the most abundant collagen found in the skin, and it is the most significant one we lose as we age. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells. Processed panax ginseng, sun ginseng stimulates type I collagen by regulating MMP-1 and TIMP-1 expression in human dermal fibroblasts. 10-hydroxy-2-decenoic acid, a characteristic constituent of lipids from honeybee royal jelly extract, stimulates normal human dermal fibroblast cell lines and produce transforming growth factor(TGF) β1, a cytokine that stimulates collagen synthesis. Aloe vera is already mentioned on this forum, but the polysaccharide acemannan in aloe is what causes collagen biosynthesis. tl;dr orthosilicic acid (BioSil), red panax ginseng, honeybee royal jelly extract, and aloe vera.
There are other nutraceuticals, but all the oral supplements I listed are the most evidence-based to promote collagen production. When it comes to skincare, water is wet. But tretinoin increases type I and type III collagen as well as inhibits the expression of MMP-1, which I mentioned breaks down collagen. Topical vitamin C also stimulates type I and type III collagen synthesis. Vitamin C suppresses MMPs responsible for collagen degradation and increases the tissue inhibitor of MMPs, as well as mRNA levels of collagens I and III. Ferulic acid stabilizes solutions of vitamins C and E and doubles its photoprotection of skin so if you’re buying a vitamin C serum without it then it’s over for you. The vitamin C serum also must have a pH below 3.5 for effective penetration. Ascorbic acid serums must be at least 10% to be effective. The maximum amount of ascorbic acid penetration was seen at 20% with a pH of 3.2, so a vitamin C serum with this concentration will give you the best results. Topical 5% niacinamide may stimulate collagen synthesis and the epidermal proteins. Apparently niacinamide had no strong documented effect on collagen, but a study showed that niacinamide was able to increase dermal matrix collagen production. 20% Glycolic acid treatment also increases type I collagen mRNA and hyaluronic acid content of human skin. tl;dr 0.025%+ tretinoin, 20% vitamin c with e and ferulic acid, 5% niacinamide, 20% glycolic acid peels.
For cosmetic peptides, @x30001 would often shill the use of GHK-cu since copper peptides do stimulate collagen synthesis by a noticeable percent. But if they’re overused, GHK-cu can cause more damage than good (can cause a crepey skin texture). So no need to use it yet since you’re all still teencels. Also there are better proven peptides for collagenmaxxing pursuits. Matrixyl 3000 (trademark for palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7) stimulates type I collagen, fibronectin, and hyaluronic acid. The 8% concentration is the highest concentration proven to be effective in vivo. Matrixyl synthe'6 (trademark for palmitoyl tripeptide-38) stimulates type I, type III, and type IV collagen, as well as fibronectin and hyaluronic acid. The 2% concentration is the highest concentration proven to be effective in vivo. The original Matrixyl (trademark for palmitoyl pentapeptide-4) also stimulates collagen types I, III, and IV, as well as elastin and fibronectin. Tetrapeptide-21 and EGF (human oligopeptide-1) are also often sought after by the foid skincare community. tl;dr matrixyl, matrixyl 3000, matrixyl synthe'6, tetrapeptide-21, and egf.
Another skincare ingredient this site has never heard of is centella asiatica extract or madecassosides. Madecassosides stimulate type I collagen synthesis in human dermal fibroblast cells. Referring back to process of collagen synthesis, centella asiatica increased the metabolism of lysine and proline, the amino acids that I mentioned that build the collagen molecule. In addition, these compounds increased the synthesis of tropocollagen and mucopolysaccharide in the connective tissues. You need to find a cream with at least 0.1% madecassosides.
As a reminder for sunscreen, it needs to be SPF 50+ PA++++. UVA rays cause tanning, hyperpigmentation, fine lines and wrinkles, while UVB causes sunburn. SPF only rates UVB, while the PA system (or PPD) rates UVA. The sunscreen should consist of photostable UV filters too so ingredients like zinc oxide and titanium dioxide mog oxybenzone and benzophenone.
Use https://incidecoder.com/ if you need help finding specific ingredients, but this thread was just an overview for a future thread that will go over the routine.
Sources:
https://www.ncbi.nlm.nih.gov/books/NBK507709/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390761/
https://www.pycnogenol.com/fileadmi...chures/Pycnogenol_OralSkinCare_EN_161_WEB.pdf
https://pubmed.ncbi.nlm.nih.gov/12633784/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659568/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583892/
https://pubmed.ncbi.nlm.nih.gov/11407971/
https://pubmed.ncbi.nlm.nih.gov/16185284/
https://kindofstephen.com/skin-penetration-of-ascorbic-acid/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921764/
https://pubmed.ncbi.nlm.nih.gov/11359487/
http://www.smartskincare.com/treatments/topical/Matrixyl3000report.pdf
http://www.beautyandskin.co.nz/i/images/matrixylsynth6copy.pdf
Everyone who asked to be tagged and a couple others:
@mido the slayer, @Don't Forget to mew, @Dyorotic2, @ThreadMatters, @GarouTheIncel, @Tortereeno, @looksaboveeverything, @alexjones, @Merlix, @Good_Little_Goy, @Lorsss, @her, @Kingkellz
