Bewusst
dead inside
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Fasting serum insulin levels are inversely and significantly related to SHBG levels (study).
Which also explains the increased SHBG levels commonly seen in type 1 diabetics (those who no longer make enough endogenous insulin) vs type 2 diabetics (insulin resistance with normal pancreatic insulin production) and non-diabetics. I.e. more insulin = less SHBG and vice versa. Bad news for the ketocels.
Low glycemic load diets are also associated with higher SHBG levels and a high glycemic load diet led to significantly lower SHBG levels in this study on hormonal markers of acne vulgaris. Which is why muh “avoid sugar” might help somewhat for acne, but only because of higher SHBG levels aka less free, bioavailable testosterone (bad) and therefore less sebaceous gland activity.
Monosaccharides such as glucose and fructose inhibit human SHBG synthesis in the liver of genetically modified mice, according to this study.
According to the in vitro study discussed further below (same link) with human liver cancer cells, SHBG levels were cut in half when glucose was added to the culture medium but insulin alone didn’t affect SHBG levels. Also, insulin + glucose together did not result in a greater reduction in SHBG levels than glucose alone, which suggests that it’s SIMPLE SUGAR which reduces SHBG synthesis, not insulin.
Keep in mind tho that the two studies from the last link I shared (with transgenic mice and in vitro) are not human in vivo studies, so you might not be able to translate them to us 100%.
tl;dr: adequate sugar intake might actually work in your favor and lower your SHBG levels
Which also explains the increased SHBG levels commonly seen in type 1 diabetics (those who no longer make enough endogenous insulin) vs type 2 diabetics (insulin resistance with normal pancreatic insulin production) and non-diabetics. I.e. more insulin = less SHBG and vice versa. Bad news for the ketocels.
Low glycemic load diets are also associated with higher SHBG levels and a high glycemic load diet led to significantly lower SHBG levels in this study on hormonal markers of acne vulgaris. Which is why muh “avoid sugar” might help somewhat for acne, but only because of higher SHBG levels aka less free, bioavailable testosterone (bad) and therefore less sebaceous gland activity.
Monosaccharides such as glucose and fructose inhibit human SHBG synthesis in the liver of genetically modified mice, according to this study.
According to the in vitro study discussed further below (same link) with human liver cancer cells, SHBG levels were cut in half when glucose was added to the culture medium but insulin alone didn’t affect SHBG levels. Also, insulin + glucose together did not result in a greater reduction in SHBG levels than glucose alone, which suggests that it’s SIMPLE SUGAR which reduces SHBG synthesis, not insulin.
Keep in mind tho that the two studies from the last link I shared (with transgenic mice and in vitro) are not human in vivo studies, so you might not be able to translate them to us 100%.
tl;dr: adequate sugar intake might actually work in your favor and lower your SHBG levels