Guide Collagen Maxxing: The Evidence-Based Guide

To fully optimize our skin's ability to promote collagen production, we need to understand the process of collagen synthesis on a fundamental level. When mRNA moves into the cytoplasm and interacts with ribosomes, both magnesium and zinc are needed for translation to occur. After translation, this polypeptide chain travels to the endoplasmic reticulum (ER). The polypeptide chain undergoes enzymatic modifications, including hydroxylation of proline and lysine which requires iron and vitamin C as cofactors (and oxygen). This process creates procollagen which is released from the fibroblast. The ends of the procollagen molecule are removed by peptidases and the molecule becomes tropocollagen. Tropocollagen undergoes covalent bonding through lysyl oxidase and this creates a collagen fibril. tl;dr magnesium, zinc, iron, vitamin C are necessary co-factors.

Now I know PSL autists are obsessed with carotenoids. Beta-carotene increases type I procollagen mRNA levels, but procollagen is a precursor and not collagen itself so this will not give us noticeable enough results. We need to upregulate gene expression in order to synthesize a functional product. Astaxanthin with hydrolyzed collagen upregulates type I procollagen gene expression and decreases MMP-1 and -12. MMP-1, the prototypical MMP, degrades collagen types 1 and 3. Polyphenols will take this a step further within the sub-class of proanthocyanidins. Specifically, pycnogenol stimulates type I collagen synthesis in subjects’ skin by increasing gene expression by 41%. tl;dr astaxanthin, collagen peptides, and pycnogenol (OPCs).

The main goal should be to find exogenous ways to stimulate type I collagen synthesis since it’s the most abundant collagen found in the skin, and it is the most significant one we lose as we age. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells. Processed panax ginseng, sun ginseng stimulates type I collagen by regulating MMP-1 and TIMP-1 expression in human dermal fibroblasts. 10-hydroxy-2-decenoic acid, a characteristic constituent of lipids from honeybee royal jelly extract, stimulates normal human dermal fibroblast cell lines and produce transforming growth factor(TGF) β1, a cytokine that stimulates collagen synthesis. Aloe vera is already mentioned on this forum, but the polysaccharide acemannan in aloe is what causes collagen biosynthesis. tl;dr orthosilicic acid (BioSil), red panax ginseng, honeybee royal jelly extract, and aloe vera.

There are other nutraceuticals, but all the oral supplements I listed are the most evidence-based to promote collagen production. When it comes to skincare, water is wet. But tretinoin increases type I and type III collagen as well as inhibits the expression of MMP-1, which I mentioned breaks down collagen. Topical vitamin C also stimulates type I and type III collagen synthesis. Vitamin C suppresses MMPs responsible for collagen degradation and increases the tissue inhibitor of MMPs, as well as mRNA levels of collagens I and III. Ferulic acid stabilizes solutions of vitamins C and E and doubles its photoprotection of skin so if you’re buying a vitamin C serum without it then it’s over for you. The vitamin C serum also must have a pH below 3.5 for effective penetration. Ascorbic acid serums must be at least 10% to be effective. The maximum amount of ascorbic acid penetration was seen at 20% with a pH of 3.2, so a vitamin C serum with this concentration will give you the best results. Topical 5% niacinamide may stimulate collagen synthesis and the epidermal proteins. Apparently niacinamide had no strong documented effect on collagen, but a study showed that niacinamide was able to increase dermal matrix collagen production. 20% Glycolic acid treatment also increases type I collagen mRNA and hyaluronic acid content of human skin. tl;dr 0.025%+ tretinoin, 20% vitamin c with e and ferulic acid, 5% niacinamide, 20% glycolic acid peels.

For cosmetic peptides, @x30001 would often shill the use of GHK-cu since copper peptides do stimulate collagen synthesis by a noticeable percent. But if they’re overused, GHK-cu can cause more damage than good (can cause a crepey skin texture). So no need to use it yet since you’re all still teencels. Also there are better proven peptides for collagenmaxxing pursuits. Matrixyl 3000 (trademark for palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7) stimulates type I collagen, fibronectin, and hyaluronic acid. The 8% concentration is the highest concentration proven to be effective in vivo. Matrixyl synthe'6 (trademark for palmitoyl tripeptide-38) stimulates type I, type III, and type IV collagen, as well as fibronectin and hyaluronic acid. The 2% concentration is the highest concentration proven to be effective in vivo. The original Matrixyl (trademark for palmitoyl pentapeptide-4) also stimulates collagen types I, III, and IV, as well as elastin and fibronectin. Tetrapeptide-21 and EGF (human oligopeptide-1) are also often sought after by the foid skincare community. tl;dr matrixyl, matrixyl 3000, matrixyl synthe'6, tetrapeptide-21, and egf.

Another skincare ingredient this site has never heard of is centella asiatica extract or madecassosides. Madecassosides stimulate type I collagen synthesis in human dermal fibroblast cells. Referring back to process of collagen synthesis, centella asiatica increased the metabolism of lysine and proline, the amino acids that I mentioned that build the collagen molecule. In addition, these compounds increased the synthesis of tropocollagen and mucopolysaccharide in the connective tissues. You need to find a cream with at least 0.1% madecassosides.

As a reminder for sunscreen, it needs to be SPF 50+ PA++++. UVA rays cause tanning, hyperpigmentation, fine lines and wrinkles, while UVB causes sunburn. SPF only rates UVB, while the PA system (or PPD) rates UVA. The sunscreen should consist of photostable UV filters too so ingredients like zinc oxide and titanium dioxide mog oxybenzone and benzophenone.

Use https://incidecoder.com/ if you need help finding specific ingredients, but this thread was just an overview for a future thread that will go over the routine.

Sources:
https://www.ncbi.nlm.nih.gov/books/NBK507709/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390761/
https://www.pycnogenol.com/fileadmi...chures/Pycnogenol_OralSkinCare_EN_161_WEB.pdf
https://pubmed.ncbi.nlm.nih.gov/12633784/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659568/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583892/
https://pubmed.ncbi.nlm.nih.gov/11407971/
https://pubmed.ncbi.nlm.nih.gov/16185284/
https://kindofstephen.com/skin-penetration-of-ascorbic-acid/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921764/
https://pubmed.ncbi.nlm.nih.gov/11359487/
http://www.smartskincare.com/treatments/topical/Matrixyl3000report.pdf
http://www.beautyandskin.co.nz/i/images/matrixylsynth6copy.pdf

Everyone who asked to be tagged and a couple others:
@mido the slayer, @Don't Forget to mew, @Dyorotic2, @ThreadMatters, @GarouTheIncel, @Tortereeno, @looksaboveeverything, @alexjones, @Merlix, @Good_Little_Goy, @Lorsss, @her, @Kingkellz
 
TakaTeo

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To fully optimize our skin's ability to promote collagen production, we need to understand the process of collagen synthesis on a fundamental level. When mRNA moves into the cytoplasm and interacts with ribosomes, both magnesium and zinc are needed for translation to occur. After translation, this polypeptide chain travels to the endoplasmic reticulum (ER). The polypeptide chain undergoes enzymatic modifications, including hydroxylation of proline and lysine which requires iron and vitamin C as cofactors (and oxygen). This process creates procollagen which is released from the fibroblast. The ends of the procollagen molecule are removed by peptidases and the molecule becomes tropocollagen. Tropocollagen undergoes covalent bonding through lysyl oxidase and this creates a collagen fibril. tl;dr magnesium, zinc, iron, vitamin C are necessary co-factors.

Now I know PSL autists are obsessed with carotenoids. Beta-carotene increases type I procollagen mRNA levels, but procollagen is a precursor and not collagen itself so this will not give us noticeable enough results. We need to upregulate gene expression in order to synthesize a functional product. Astaxanthin with hydrolyzed collagen upregulates type I procollagen gene expression and decreases MMP-1 and -12. MMP-1, the prototypical MMP, degrades collagen types 1 and 3. Polyphenols will take this a step further within the sub-class of proanthocyanidins. Specifically, pycnogenol stimulates type I collagen synthesis in subjects’ skin by increasing gene expression by 41%. tl;dr astaxanthin, collagen peptides, and pycnogenol (OPCs).

The main goal should be to find exogenous ways to stimulate type I collagen synthesis since it’s the most abundant collagen found in the skin, and it is the most significant one we lose as we age. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells. Processed panax ginseng, sun ginseng stimulates type I collagen by regulating MMP-1 and TIMP-1 expression in human dermal fibroblasts. 10-hydroxy-2-decenoic acid, a characteristic constituent of lipids from honeybee royal jelly extract, stimulates normal human dermal fibroblast cell lines and produce transforming growth factor(TGF) β1, a cytokine that stimulates collagen synthesis. Aloe vera is already mentioned on this forum, but the polysaccharide acemannan in aloe is what causes collagen biosynthesis. tl;dr orthosilicic acid (BioSil), red panax ginseng, honeybee royal jelly extract, and aloe vera.

There are other nutraceuticals, but all the oral supplements I listed are the most evidence-based to promote collagen production. When it comes to skincare, water is wet. But tretinoin increases type I and type III collagen as well as inhibits the expression of MMP-1, which I mentioned breaks down collagen. Topical vitamin C also stimulates type I and type III collagen synthesis. Vitamin C suppresses MMPs responsible for collagen degradation and increases the tissue inhibitor of MMPs, as well as mRNA levels of collagens I and III. Ferulic acid stabilizes solutions of vitamins C and E and doubles its photoprotection of skin so if you’re buying a vitamin C serum without it then it’s over for you. The vitamin C serum also must have a pH below 3.5 for effective penetration. Ascorbic acid serums must be at least 10% to be effective. The maximum amount of ascorbic acid penetration was seen at 20% with a pH of 3.2, so a vitamin C serum with this concentration will give you the best results. Topical 5% niacinamide may stimulate collagen synthesis and the epidermal proteins. Apparently niacinamide had no strong documented effect on collagen, but a study showed that niacinamide was able to increase dermal matrix collagen production. 20% Glycolic acid treatment also increases type I collagen mRNA and hyaluronic acid content of human skin. tl;dr 0.025%+ tretinoin, 20% vitamin c with e and ferulic acid, 5% niacinamide, 20% glycolic acid peels.

For cosmetic peptides, @x30001 would often shill the use of GHK-cu since copper peptides do stimulate collagen synthesis by a noticeable percent. But if they’re overused, GHK-cu can cause more damage than good (can cause a crepey skin texture). So no need to use it yet since you’re all still teencels. Also there are better proven peptides for collagenmaxxing pursuits. Matrixyl 3000 (trademark for palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7) stimulates type I collagen, fibronectin, and hyaluronic acid. The 8% concentration is the highest concentration proven to be effective in vivo. Matrixyl synthe'6 (trademark for palmitoyl tripeptide-38) stimulates type I, type III, and type IV collagen, as well as fibronectin and hyaluronic acid. The 2% concentration is the highest concentration proven to be effective in vivo. The original Matrixyl (trademark for palmitoyl pentapeptide-4) also stimulates collagen types I, III, and IV, as well as elastin and fibronectin. Tetrapeptide-21 and EGF (human oligopeptide-1) are also often sought after by the foid skincare community. tl;dr matrixyl, matrixyl 3000, matrixyl synthe'6, tetrapeptide-21, and egf.

Another skincare ingredient this site has never heard of is centella asiatica extract or madecassosides. Madecassosides stimulate type I collagen synthesis in human dermal fibroblast cells. Referring back to process of collagen synthesis, centella asiatica increased the metabolism of lysine and proline, the amino acids that I mentioned that build the collagen molecule. In addition, these compounds increased the synthesis of tropocollagen and mucopolysaccharide in the connective tissues. You need to find a cream with at least 0.1% madecassosides.

As a reminder for sunscreen, it needs to be SPF 50+ PA++++. UVA rays cause tanning, hyperpigmentation, fine lines and wrinkles, while UVB causes sunburn. SPF only rates UVB, while the PA system (or PPD) rates UVA. The sunscreen should consist of photostable UV filters too so ingredients like zinc oxide and titanium dioxide mog oxybenzone and benzophenone.

Use https://incidecoder.com/ if you need help finding specific ingredients, but this thread was just an overview for a future thread that will go over the routine.

Sources:
https://www.ncbi.nlm.nih.gov/books/NBK507709/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390761/
https://www.pycnogenol.com/fileadmi...chures/Pycnogenol_OralSkinCare_EN_161_WEB.pdf
https://pubmed.ncbi.nlm.nih.gov/12633784/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659568/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583892/
https://pubmed.ncbi.nlm.nih.gov/11407971/
https://pubmed.ncbi.nlm.nih.gov/16185284/
https://kindofstephen.com/skin-penetration-of-ascorbic-acid/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921764/
https://pubmed.ncbi.nlm.nih.gov/11359487/
http://www.smartskincare.com/treatments/topical/Matrixyl3000report.pdf
http://www.beautyandskin.co.nz/i/images/matrixylsynth6copy.pdf

Everyone who asked to be tagged and a couple others:
@mido the slayer, @Don't Forget to mew, @Dyorotic2, @ThreadMatters, @GarouTheIncel, @Tortereeno, @looksaboveeverything, @alexjones, @Merlix, @Good_Little_Goy, @Lorsss, @her, @Kingkellz
good thread. one thing i noticed personally was low dose anavars skin benefits. it made my skin feel amazing and look super good. no acne at all skin was literally glowing. (10mgs split into 2 5mgs doses a day)
 
Soalian

Soalian

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good thread. one thing i noticed personally was low dose anavars skin benefits. it made my skin feel amazing and look super good. no acne at all skin was literally glowing. (10mgs split into 2 5mgs doses a day)
Anavar 10mg is a very low-dose, normal dosage for bodybuilding purposes is about 25-50mg daily.
 
Soalian

Soalian

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Ok guys, how do I try to regain good skin collagen, after a corticosteroid course on my nose only (4 weeks betamethasone) destroyed collagen for the entire face ?
 
J

JawGuyFatFaceGuy

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Ok guys, how do I try to regain good skin collagen, after a corticosteroid course on my nose only (4 weeks betamethasone) destroyed collagen for the entire face ?

i need collagen too
 
HighIQcel

HighIQcel

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Ok guys, how do I try to regain good skin collagen, after a corticosteroid course on my nose only (4 weeks betamethasone) destroyed collagen for the entire face ?
Why did you use corticosteroid to your nose? For what?
 
Baldingman1998

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I'm too retared to know what to do with this information. You have so many ingredients and I'm 99% sure most sunscreens have only a couple of them. So which are the most important?
 
Soalian

Soalian

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Does anyone here have experience with FRAXEL, or co2 fractional laser ?
 
Last edited:
nastynas

nastynas

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very good thread but a lot of products tbh.Ü

still appreciate the work for giving the whole stash though.
 
HighIQcel

HighIQcel

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does masturbation affect your collagen?
 
Mr_Norwood

Mr_Norwood

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I read a study that eating gelatin (beef) is good for C production


 
D

Deleted member 10136

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tag me on the routine thread please
edit: my bad didnt see this is old
 
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Need2Ascend

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Ok guys, how do I try to regain good skin collagen, after a corticosteroid course on my nose only (4 weeks betamethasone) destroyed collagen for the entire face ?
Tretinoin bro
 
N

Need2Ascend

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ok, what is retin-a then lol ?
Bro lol, you are on this forum for 2 years and don't know what retin-a is, what did you even do here the whole time
 
Schönling

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784ECDD7 B737 4796 AA6E 34A01A0ABDF3
r/splendida stole your whole flow
 
King Solomon

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My skincare collagen production daily routine

1.) Plant based mostly raw organic whole foods diet (red veggies, dark green veggies, orange veggies and fruits,complete proteins foods like hemp seeds and sprouted qinoa or lentils, berries, and citris fruits
2.) Manuka honey face mask every other day: best natural topical that increases collagen
3.) Avacado oil mixed with Aragon oil for high SPF and increases collagen. Over 90% of skin aging is due to the sun so protect your face as much as possible. Carrot seed oil is great as it has a very high SPF.
4.) Derma rolling: no other method increases collagen production as fast as derma rolling which can also get rid of wrinkles, large pores and deep scars and increases hair growth. I use a 0.5 mm derma roller on my entire face (horizontal, vertical, and diagonal 10 times each direction at least 1-2 times per week.
5.) Sufficient clean water and sleep every day.
6.) White Tea: most powerfull tea for increasing collagen and Elastin.
7.) Daily Cold Showers.
8.) Grounding aka Earthing: This thins the blood and increases bloodflow in the face. It promotes healing and healthy skin.

I'm going to be 36 years old but I'm constantly told I look no older than 21 years of age. I also don't drink, smoke, or do any drugs and I practice smemen retention (going on 4 years of practicing this and a current 90 day streak.

That's pretty much it, 100% all natural baby.
 
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Diremeyer

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To fully optimize our skin's ability to promote collagen production, we need to understand the process of collagen synthesis on a fundamental level. When mRNA moves into the cytoplasm and interacts with ribosomes, both magnesium and zinc are needed for translation to occur. After translation, this polypeptide chain travels to the endoplasmic reticulum (ER). The polypeptide chain undergoes enzymatic modifications, including hydroxylation of proline and lysine which requires iron and vitamin C as cofactors (and oxygen). This process creates procollagen which is released from the fibroblast. The ends of the procollagen molecule are removed by peptidases and the molecule becomes tropocollagen. Tropocollagen undergoes covalent bonding through lysyl oxidase and this creates a collagen fibril. tl;dr magnesium, zinc, iron, vitamin C are necessary co-factors.

Now I know PSL autists are obsessed with carotenoids. Beta-carotene increases type I procollagen mRNA levels, but procollagen is a precursor and not collagen itself so this will not give us noticeable enough results. We need to upregulate gene expression in order to synthesize a functional product. Astaxanthin with hydrolyzed collagen upregulates type I procollagen gene expression and decreases MMP-1 and -12. MMP-1, the prototypical MMP, degrades collagen types 1 and 3. Polyphenols will take this a step further within the sub-class of proanthocyanidins. Specifically, pycnogenol stimulates type I collagen synthesis in subjects’ skin by increasing gene expression by 41%. tl;dr astaxanthin, collagen peptides, and pycnogenol (OPCs).

The main goal should be to find exogenous ways to stimulate type I collagen synthesis since it’s the most abundant collagen found in the skin, and it is the most significant one we lose as we age. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells. Processed panax ginseng, sun ginseng stimulates type I collagen by regulating MMP-1 and TIMP-1 expression in human dermal fibroblasts. 10-hydroxy-2-decenoic acid, a characteristic constituent of lipids from honeybee royal jelly extract, stimulates normal human dermal fibroblast cell lines and produce transforming growth factor(TGF) β1, a cytokine that stimulates collagen synthesis. Aloe vera is already mentioned on this forum, but the polysaccharide acemannan in aloe is what causes collagen biosynthesis. tl;dr orthosilicic acid (BioSil), red panax ginseng, honeybee royal jelly extract, and aloe vera.

There are other nutraceuticals, but all the oral supplements I listed are the most evidence-based to promote collagen production. When it comes to skincare, water is wet. But tretinoin increases type I and type III collagen as well as inhibits the expression of MMP-1, which I mentioned breaks down collagen. Topical vitamin C also stimulates type I and type III collagen synthesis. Vitamin C suppresses MMPs responsible for collagen degradation and increases the tissue inhibitor of MMPs, as well as mRNA levels of collagens I and III. Ferulic acid stabilizes solutions of vitamins C and E and doubles its photoprotection of skin so if you’re buying a vitamin C serum without it then it’s over for you. The vitamin C serum also must have a pH below 3.5 for effective penetration. Ascorbic acid serums must be at least 10% to be effective. The maximum amount of ascorbic acid penetration was seen at 20% with a pH of 3.2, so a vitamin C serum with this concentration will give you the best results. Topical 5% niacinamide may stimulate collagen synthesis and the epidermal proteins. Apparently niacinamide had no strong documented effect on collagen, but a study showed that niacinamide was able to increase dermal matrix collagen production. 20% Glycolic acid treatment also increases type I collagen mRNA and hyaluronic acid content of human skin. tl;dr 0.025%+ tretinoin, 20% vitamin c with e and ferulic acid, 5% niacinamide, 20% glycolic acid peels.

For cosmetic peptides, @x30001 would often shill the use of GHK-cu since copper peptides do stimulate collagen synthesis by a noticeable percent. But if they’re overused, GHK-cu can cause more damage than good (can cause a crepey skin texture). So no need to use it yet since you’re all still teencels. Also there are better proven peptides for collagenmaxxing pursuits. Matrixyl 3000 (trademark for palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7) stimulates type I collagen, fibronectin, and hyaluronic acid. The 8% concentration is the highest concentration proven to be effective in vivo. Matrixyl synthe'6 (trademark for palmitoyl tripeptide-38) stimulates type I, type III, and type IV collagen, as well as fibronectin and hyaluronic acid. The 2% concentration is the highest concentration proven to be effective in vivo. The original Matrixyl (trademark for palmitoyl pentapeptide-4) also stimulates collagen types I, III, and IV, as well as elastin and fibronectin. Tetrapeptide-21 and EGF (human oligopeptide-1) are also often sought after by the foid skincare community. tl;dr matrixyl, matrixyl 3000, matrixyl synthe'6, tetrapeptide-21, and egf.

Another skincare ingredient this site has never heard of is centella asiatica extract or madecassosides. Madecassosides stimulate type I collagen synthesis in human dermal fibroblast cells. Referring back to process of collagen synthesis, centella asiatica increased the metabolism of lysine and proline, the amino acids that I mentioned that build the collagen molecule. In addition, these compounds increased the synthesis of tropocollagen and mucopolysaccharide in the connective tissues. You need to find a cream with at least 0.1% madecassosides.

As a reminder for sunscreen, it needs to be SPF 50+ PA++++. UVA rays cause tanning, hyperpigmentation, fine lines and wrinkles, while UVB causes sunburn. SPF only rates UVB, while the PA system (or PPD) rates UVA. The sunscreen should consist of photostable UV filters too so ingredients like zinc oxide and titanium dioxide mog oxybenzone and benzophenone.

Use https://incidecoder.com/ if you need help finding specific ingredients, but this thread was just an overview for a future thread that will go over the routine.

Sources:
https://www.ncbi.nlm.nih.gov/books/NBK507709/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390761/
https://www.pycnogenol.com/fileadmi...chures/Pycnogenol_OralSkinCare_EN_161_WEB.pdf
https://pubmed.ncbi.nlm.nih.gov/12633784/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659568/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583892/
https://pubmed.ncbi.nlm.nih.gov/11407971/
https://pubmed.ncbi.nlm.nih.gov/16185284/
https://kindofstephen.com/skin-penetration-of-ascorbic-acid/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921764/
https://pubmed.ncbi.nlm.nih.gov/11359487/
http://www.smartskincare.com/treatments/topical/Matrixyl3000report.pdf
http://www.beautyandskin.co.nz/i/images/matrixylsynth6copy.pdf

Everyone who asked to be tagged and a couple others:
@mido the slayer, @Don't Forget to mew, @Dyorotic2, @ThreadMatters, @GarouTheIncel, @Tortereeno, @looksaboveeverything, @alexjones, @Merlix, @Good_Little_Goy, @Lorsss, @her, @Kingkellz

Wasted money, wasted time. Go to a dermatologist and ask for either laser or chemical peel or microneedling and you'd get way better results collagen wise. And looks wise. It's dismal this is "Best of the Best".
 
D

Diremeyer

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To fully optimize our skin's ability to promote collagen production, we need to understand the process of collagen synthesis on a fundamental level. (...) tl;dr magnesium, zinc, iron, vitamin C are necessary co-factors.

No we don't. The bottleneck isn't "magnesium, zinc, iron, vitamin C are necessary co-factors." The bottleneck is fucked up genes in the skin, primarily caused by sun damage.

The main goal should be to find exogenous ways to stimulate type I collagen synthesis since it’s the most abundant collagen found in the skin, and it is the most significant one we lose as we age. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells. Processed panax ginseng, sun ginseng stimulates type I collagen by regulating MMP-1 and TIMP-1 expression in human dermal fibroblasts. 10-hydroxy-2-decenoic acid, a characteristic constituent of lipids from honeybee royal jelly extract, stimulates normal human dermal fibroblast cell lines and produce transforming growth factor(TGF) β1, a cytokine that stimulates collagen synthesis. Aloe vera is already mentioned on this forum, but the polysaccharide acemannan in aloe is what causes collagen biosynthesis. tl;dr orthosilicic acid (BioSil), red panax ginseng, honeybee royal jelly extract, and aloe vera.

Wasted money. In vitro and in vivo differs. Spend the money on microneedling, chemical peel or laser, which is proven to boost collagen, boost looks. In real life. All you quote is lab crap, that is in vitro.

There are other nutraceuticals, but all the oral supplements I listed are the most evidence-based to promote collagen production. When it comes to skincare, water is wet. But tretinoin increases type I and type III collagen as well as inhibits the expression of MMP-1, which I mentioned breaks down collagen. Topical vitamin C also stimulates type I and type III collagen synthesis. Vitamin C suppresses MMPs responsible for collagen degradation and increases the tissue inhibitor of MMPs, as well as mRNA levels of collagens I and III.

It's such weak evidence topical vitamin C does anything but empty your wallet.

For cosmetic peptides, @x30001 would often shill the use of GHK-cu since copper peptides do stimulate collagen synthesis by a noticeable percent. But if they’re overused, GHK-cu can cause more damage than good (can cause a crepey skin texture). So no need to use it yet since you’re all still teencels. Also there are better proven peptides for collagenmaxxing pursuits. Matrixyl 3000 (trademark for palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7) stimulates type I collagen, fibronectin, and hyaluronic acid. The 8% concentration is the highest concentration proven to be effective in vivo. Matrixyl synthe'6 (trademark for palmitoyl tripeptide-38) stimulates type I, type III, and type IV collagen, as well as fibronectin and hyaluronic acid. The 2% concentration is the highest concentration proven to be effective in vivo. The original Matrixyl (trademark for palmitoyl pentapeptide-4) also stimulates collagen types I, III, and IV, as well as elastin and fibronectin. Tetrapeptide-21 and EGF (human oligopeptide-1) are also often sought after by the foid skincare community. tl;dr matrixyl, matrixyl 3000, matrixyl synthe'6, tetrapeptide-21, and egf.

Blah blah blah. The truth is the body «decides» at any given time how much collagen is REQUIRED. That's the bottleneck. These substances does little if the body doesn't signal it REQUIRES more collagen. To make the body produce more collagen what works is damaging the skin with chemical peels, lasers or microneedling. The body then repairs by making more collagen.


As a reminder for sunscreen, it needs to be SPF 50+ PA++++. UVA rays cause tanning, hyperpigmentation, fine lines and wrinkles, while UVB causes sunburn. SPF only rates UVB, while the PA system (or PPD) rates UVA. The sunscreen should consist of photostable UV filters too so ingredients like zinc oxide and titanium dioxide mog oxybenzone and benzophenone.

Yeah that's right. Go for zinc oxide, or titanium oxide! But the real way UV fucks up your collagen is DESTORYING DNA in the skin. DNA has the recipe for collagen. When the recipe gets fucked up, the collagen produced gets fucked up. That's the MAIN REASON the body has good collagen at birth, and crappy collagen at old age. Staying out of the sun when damage done doesn't work. You can see how UV fucks up your ability to make collagen by comparing gramps back to his face. The back is more or less intact, the face is wizened.

It's dismal this thread is "Best of the Best"

@mido the slayer, @Don't Forget to mew, @Dyorotic2, @ThreadMatters, @GarouTheIncel, @Tortereeno, @looksaboveeverything, @alexjones, @Merlix, @Good_Little_Goy, @Lorsss, @her, @Kingkellz
 
J

JawGuyFatFaceGuy

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Wasted money, wasted time. Go to a dermatologist and ask for either laser or chemical peel or microneedling and you'd get way better results collagen wise. And looks wise. It's dismal this is "Best of the Best".
Which chemical peel?
 
D

Deleted member 14323

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No we don't. The bottleneck isn't "magnesium, zinc, iron, vitamin C are necessary co-factors." The bottleneck is fucked up genes in the skin, primarily caused by sun damage.



Wasted money. In vitro and in vivo differs. Spend the money on microneedling, chemical peel or laser, which is proven to boost collagen, boost looks. In real life. All you quote is lab crap, that is in vitro.



It's such weak evidence topical vitamin C does anything but empty your wallet.



Blah blah blah. The truth is the body «decides» at any given time how much collagen is REQUIRED. That's the bottleneck. These substances does little if the body doesn't signal it REQUIRES more collagen. To make the body produce more collagen what works is damaging the skin with chemical peels, lasers or microneedling. The body then repairs by making more collagen.




Yeah that's right. Go for zinc oxide, or titanium oxide! But the real way UV fucks up your collagen is DESTORYING DNA in the skin. DNA has the recipe for collagen. When the recipe gets fucked up, the collagen produced gets fucked up. That's the MAIN REASON the body has good collagen at birth, and crappy collagen at old age. Staying out of the sun when damage done doesn't work. You can see how UV fucks up your ability to make collagen by comparing gramps back to his face. The back is more or less intact, the face is wizened.

It's dismal this thread is "Best of the Best"

@mido the slayer, @Don't Forget to mew, @Dyorotic2, @ThreadMatters, @GarouTheIncel, @Tortereeno, @looksaboveeverything, @alexjones, @Merlix, @Good_Little_Goy, @Lorsss, @her, @Kingkellz
you're talking to a brick wall, the guy roped.
 
D

Diremeyer

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@JawGuyFatFaceGuy The more a chemical peel strips away skin, the more skin growth (i.e. collagen growth). That said they don't do much compared to lasers and microneedling, however they do more than most of the mumbo jumbo ITT.
 
LooksJourney

LooksJourney

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So this guy killed himself or what?
 
Baldingman1998

Baldingman1998

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My skincare collagen production daily routine

1.) Plant based mostly raw organic whole foods diet (red veggies, dark green veggies, orange veggies and fruits,complete proteins foods like hemp seeds and sprouted qinoa or lentils, berries, and citris fruits
2.) Manuka honey face mask every other day: best natural topical that increases collagen
3.) Avacado oil mixed with Aragon oil for high SPF and increases collagen. Over 90% of skin aging is due to the sun so protect your face as much as possible. Carrot seed oil is great as it has a very high SPF.
4.) Derma rolling: no other method increases collagen production as fast as derma rolling which can also get rid of wrinkles, large pores and deep scars and increases hair growth. I use a 0.5 mm derma roller on my entire face (horizontal, vertical, and diagonal 10 times each direction at least 1-2 times per week.
5.) Sufficient clean water and sleep every day.
6.) White Tea: most powerfull tea for increasing collagen and Elastin.
7.) Daily Cold Showers.
8.) Grounding aka Earthing: This thins the blood and increases bloodflow in the face. It promotes healing and healthy skin.

I'm going to be 36 years old but I'm constantly told I look no older than 21 years of age. I also don't drink, smoke, or do any drugs and I practice smemen retention (going on 4 years of practicing this and a current 90 day streak.

That's pretty much it, 100% all natural baby.
Lost me at vegan. Jfl
 
Soalian

Soalian

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Beyond what dosages Testosterone injections will mess up with collagen synthesis?

I find it touted everywhere but don'tknow if there's reliable sources and/or studies behind this claim.
 
H

hairyballscel

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No we don't. The bottleneck isn't "magnesium, zinc, iron, vitamin C are necessary co-factors." The bottleneck is fucked up genes in the skin, primarily caused by sun damage.



Wasted money. In vitro and in vivo differs. Spend the money on microneedling, chemical peel or laser, which is proven to boost collagen, boost looks. In real life. All you quote is lab crap, that is in vitro.



It's such weak evidence topical vitamin C does anything but empty your wallet.



Blah blah blah. The truth is the body «decides» at any given time how much collagen is REQUIRED. That's the bottleneck. These substances does little if the body doesn't signal it REQUIRES more collagen. To make the body produce more collagen what works is damaging the skin with chemical peels, lasers or microneedling. The body then repairs by making more collagen.




Yeah that's right. Go for zinc oxide, or titanium oxide! But the real way UV fucks up your collagen is DESTORYING DNA in the skin. DNA has the recipe for collagen. When the recipe gets fucked up, the collagen produced gets fucked up. That's the MAIN REASON the body has good collagen at birth, and crappy collagen at old age. Staying out of the sun when damage done doesn't work. You can see how UV fucks up your ability to make collagen by comparing gramps back to his face. The back is more or less intact, the face is wizened.

It's dismal this thread is "Best of the Best"

@mido the slayer, @Don't Forget to mew, @Dyorotic2, @ThreadMatters, @GarouTheIncel, @Tortereeno, @looksaboveeverything, @alexjones, @Merlix, @Good_Little_Goy, @Lorsss, @her, @Kingkellz
what do you recommend for collagen maxxing? and how do you go about repairing skin damage from the sun? i've burnt in the sun so many times to point where im peeling tbh
 
D

Diremeyer

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what do you recommend for collagen maxxing? and how do you go about repairing skin damage from the sun? i've burnt in the sun so many times to point where im peeling tbh
Lasers, lasers. @Soalian made a thread on it. Ask a laser doctor, chances are you'd get the most bang for your bucks with co2 fractional
 
Reckless Turtle

Reckless Turtle

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As a reminder for sunscreen, it needs to be SPF 50+ PA++++. UVA rays cause tanning, hyperpigmentation, fine lines and wrinkles, while UVB causes sunburn. SPF only rates UVB, while the PA system (or PPD) rates UVA. The sunscreen should consist of photostable UV filters too so ingredients like zinc oxide and titanium dioxide mog oxybenzone and benzophenone.
I've seen multiple people claiming that SPF 30 is sufficient for anti-aging. This is news to me.
 
AscendingHero

AscendingHero

Opportunities dont happen, you create them
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Cope

Cope

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No we don't. The bottleneck isn't "magnesium, zinc, iron, vitamin C are necessary co-factors." The bottleneck is fucked up genes in the skin, primarily caused by sun damage.



Wasted money. In vitro and in vivo differs. Spend the money on microneedling, chemical peel or laser, which is proven to boost collagen, boost looks. In real life. All you quote is lab crap, that is in vitro.



It's such weak evidence topical vitamin C does anything but empty your wallet.



Blah blah blah. The truth is the body «decides» at any given time how much collagen is REQUIRED. That's the bottleneck. These substances does little if the body doesn't signal it REQUIRES more collagen. To make the body produce more collagen what works is damaging the skin with chemical peels, lasers or microneedling. The body then repairs by making more collagen.




Yeah that's right. Go for zinc oxide, or titanium oxide! But the real way UV fucks up your collagen is DESTORYING DNA in the skin. DNA has the recipe for collagen. When the recipe gets fucked up, the collagen produced gets fucked up. That's the MAIN REASON the body has good collagen at birth, and crappy collagen at old age. Staying out of the sun when damage done doesn't work. You can see how UV fucks up your ability to make collagen by comparing gramps back to his face. The back is more or less intact, the face is wizened.

It's dismal this thread is "Best of the Best"

@mido the slayer, @Don't Forget to mew, @Dyorotic2, @ThreadMatters, @GarouTheIncel, @Tortereeno, @looksaboveeverything, @alexjones, @Merlix, @Good_Little_Goy, @Lorsss, @her, @Kingkellz
lmao This absolute manchild went out of his way to @ mention a bunch of users and no one gave a fuck :lul:.

Why try to put this much effort into trying to debunk my thread? This faggot is literally acting like I fucked his bitch or something.

Blah blah blah. The truth is the body «decides» at any given time how much collagen is REQUIRED. That's the bottleneck. These substances does little if the body doesn't signal it REQUIRES more collagen. To make the body produce more collagen what works is damaging the skin with chemical peels, lasers or microneedling. The body then repairs by making more collagen.
:feelsuhh: I literally mentioned 20% glycolic acid peels. Everyone on this site already knows that microneedling and lasers helps promote collagen synthesis, that thread was made a year ago before mine: https://looksmax.org/threads/collagen-maxing-guide.28058/.

This thread was just to offer other alternatives to collagenmaxxing that hadn't been mentioned yet. All the skincare products I mentioned are proven to work and I and others can attest to that. I'm currently 26 years old and people tell me I could still be a sophomore in high school.
 
AscendingHero

AscendingHero

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lmao This absolute manchild went out of his way to @ mention a bunch of users and no one gave a fuck :lul:.

Why try to put this much effort into trying to debunk my thread? This faggot is literally acting like I fucked his bitch or something.


:feelsuhh: I literally mentioned 20% glycolic acid peels. Everyone on this site already knows that microneedling and lasers helps promote collagen synthesis, that thread was made a year ago before mine: https://looksmax.org/threads/collagen-maxing-guide.28058/.

This thread was just to offer other alternatives to collagenmaxxing that hadn't been mentioned yet. All the skincare products I mentioned are proven to work and I and others can attest to that. I'm currently 26 years old and people tell me I could still be a sophomore in high school.
OMG THE LEGEND HAS RETURNED, been looking to contact u for a while brother, finally ur back.

Are you in open in pms?
 

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