Whats with the igf-1 LR3 hate?

[hej1377]

Now ive seen a lot of people calling it shit and not just new users, now ive done quite a bit of research on the compound and i cant find a valid reason to hate on it. Now it just seems more likely that im just wrong due to the amount of lr3 haters and ive just missed something but i cant find what ive missed do could someone help clear this up

Insulin-like growth factor-I and more potent variants restore growth of diabetic rats without inducing all characteristic insulin effects - PubMed

The effects of graded doses of insulin-like growth factor-I (IGF-I) and two variants which bind poorly to IGF-binding proteins were investigated in 160 g streptozotocin-induced diabetic rats. The two variants were the truncated form, des(1-3)IGF-I, and another with arginine at residue 3 and an...

pubmed.ncbi.nlm.nih.gov

Heres a study that showed lr3 being able to cause growth 3x better than native igf and its better dor protein synthesis

Also the reduced binding to igfbp's should mean that it more easily stimulates tissues that is more reliant on free range igf,like muscle and not cartiledge so you have a smaller risk of getting a jew nose

ttheres a study that also comfirms the claim that its more stable and more effective for igfr activation and also repair and cause more growth promotion

Design and characterisation of long-R3-insulin-like growth factor-I muteins which show resistance to pepsin digestion - PubMed

Site-directed mutagenesis was used to construct pepsin-resistant, single-point mutations of the N-terminal extended IGF-I analogue, long-R3-IGF-I. In order to identify the most susceptible sites, the kinetics of long-R3-IGF-I digestion by purified porcine pepsin were determined. Pepsin initially...

pubmed.ncbi.nlm.nih.gov

And igfr are replaced often which avoids quick desensitization and downstream effects recover quickly dince phophate,the main molecule in the pi3k/act pathways protein has a short halflife so rapid signaling can happen and youll recover quick,just let the deug clear in your system wait a bit and go on again to avoid having desensitized cells and therefore wasting your money

And even if the desensitization or negative feedback was an issue you could do a much lower dosage so it stimulates igfr's to ish the same degree of native igf which should be cheaper you get the other mentioned benefits

Please tell me if i have in fact missed something and provide the evidence

 

[Amex.]

Are you suggesting it grows bone/helps height or you are just saying its good for muscle?

 

[hej1377]

Are you suggesting it grows bone/helps height or you are just saying its good for muscle?

Muscle, im even suggesting that its bad for tissues like bone or cartilage compared to native igf which is beneficial in a bodybuilding context

 

[Amex.]

Muscle, im even suggesting that its bad for tissues like bone or cartilage compared to native igf which is beneficial in a bodybuilding context

Tbh i agree, i think it does actually work for muscle, ive tried it 2 cycles 1 month each and been doing the same exact workout routine and both times i cycled it i had at least 20% more growth than usual and progressed faster , it wasnt really magical but it helped a bit also im not sure if placebo but it made me eat more right after injection and have a better pump

It just doesnt help with bones or height

 

[bddcoper]

Tbh i agree, i think it does actually work for muscle, ive tried it 2 cycles 1 month each and been doing the same exact workout routine and both times i cycled it i had at least 20% more growth than usual and progressed faster , it wasnt really magical but it helped a bit also im not sure if placebo but it made me eat more right after injection and have a better pump

It just doesnt help with bones or height

is it worth running with cjc no dac + ipa or should it be ran separately? i feel like running both is counterintuitive but people online say its okay. maybe lr3 in the morning and cjc + ipa at night?

 

[hej1377]

is it worth running with cjc no dac + ipa or should it be ran separately? i feel like running both is counterintuitive but people online say its okay. maybe lr3 in the morning and cjc + ipa at night?

No the igf lr3 will still be in your system for days after the last injection and make the cjc and ipa way less effective