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aestheticsrespecter
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I've been passively observing the discussion over DHT and 5-ar inhibitors like fin and dut and everybody is talking about dick development/function, male pattern baldness, osteogenesis, clavicles, etc., etc., etc.
What nobody is discussing is the high density of androgen receptors in the brain, primarily in the pre-frontal cortex and hippocampus that, when starved of DHT, end up suffering neuronal death, and can lead to the development of MCI (Mild Cognitive impairment) which is a major precursor to Alzheimer's Dementia.
NIH Source: ------------------------------------
Effects of dihydrotestosterone on synaptic plasticity of the hippocampus in mild cognitive impairment male SAMP8 mice
--------------------------------------------------
"Thus, androgen depletion impaired the synaptic plasticity in the hippocampus of SAMP8 and accelerated the development of Alzheimer's disease (AD)-like neuropathology, suggesting that a similar mechanism may underlie the increased risk for AD in men with low testosterone."
"In addition, #DHT regulated #synapticplasticity in the #hippocampus of mild cognitive impairment (MCI) SAMP8 mice and delayed the progression of the disease to Alzheimer's dementia."
"Research on testosterone and its metabolite DHT in rodent and human brains has indicated that reduced brain function is closely related to androgen loss."
"DHT improves the aging mice hippocampus-dependent spatial cognitive ability, and castration increases learning and memory disorders."
Depriving your brain of this hormone for 40+ years seems like a guaranteed way to affect cognition.
This makes logical sense when you consider the fact that the incidence rate of Alzheimer's-dementia in women is double that of men (we are the androgenic (and resultingly bald) sex).
The only caveat I was considering was that perhaps exogenous test could replace the function of DHT, but I'd imagine the androgen receptors in the brain are only DHT sensitive, just as they are in the scalp and face. Thoughts on this?
Perhaps fin is weak enough to maintain enough of a DHT blood-serum level to support cognition and synaptic plasticity. Thoughts on this?
I am not necessarily pro or anti-DHT. I am past puberty so I am largely unconcerned with dick growth, bone ossification, and emotional regulation regarding dut, and I def want to save my hair and skin, but not at the expense of my cognitive faculties.
Apologies for my lack of knowledge in physiology/neurology, I'm a law student.
Anyone with insight please share.
Tagging people who I've seen weigh in on this subject b4: @sb23 @NZb6Air @wastedspermcel @MA_ascender @moreplatesmoreweigh @20/04/2008 @halloweed @piec @Dyorotic @cyprian_tomaszewski @noodlelover @DR. NICKGA @appeal @premedmogger
What nobody is discussing is the high density of androgen receptors in the brain, primarily in the pre-frontal cortex and hippocampus that, when starved of DHT, end up suffering neuronal death, and can lead to the development of MCI (Mild Cognitive impairment) which is a major precursor to Alzheimer's Dementia.
NIH Source: ------------------------------------
Effects of dihydrotestosterone on synaptic plasticity of the hippocampus in mild cognitive impairment male SAMP8 mice
--------------------------------------------------
"Thus, androgen depletion impaired the synaptic plasticity in the hippocampus of SAMP8 and accelerated the development of Alzheimer's disease (AD)-like neuropathology, suggesting that a similar mechanism may underlie the increased risk for AD in men with low testosterone."
"In addition, #DHT regulated #synapticplasticity in the #hippocampus of mild cognitive impairment (MCI) SAMP8 mice and delayed the progression of the disease to Alzheimer's dementia."
"Research on testosterone and its metabolite DHT in rodent and human brains has indicated that reduced brain function is closely related to androgen loss."
"DHT improves the aging mice hippocampus-dependent spatial cognitive ability, and castration increases learning and memory disorders."
Depriving your brain of this hormone for 40+ years seems like a guaranteed way to affect cognition.
This makes logical sense when you consider the fact that the incidence rate of Alzheimer's-dementia in women is double that of men (we are the androgenic (and resultingly bald) sex).
The only caveat I was considering was that perhaps exogenous test could replace the function of DHT, but I'd imagine the androgen receptors in the brain are only DHT sensitive, just as they are in the scalp and face. Thoughts on this?
Perhaps fin is weak enough to maintain enough of a DHT blood-serum level to support cognition and synaptic plasticity. Thoughts on this?
I am not necessarily pro or anti-DHT. I am past puberty so I am largely unconcerned with dick growth, bone ossification, and emotional regulation regarding dut, and I def want to save my hair and skin, but not at the expense of my cognitive faculties.
Apologies for my lack of knowledge in physiology/neurology, I'm a law student.
Anyone with insight please share.
Tagging people who I've seen weigh in on this subject b4: @sb23 @NZb6Air @wastedspermcel @MA_ascender @moreplatesmoreweigh @20/04/2008 @halloweed @piec @Dyorotic @cyprian_tomaszewski @noodlelover @DR. NICKGA @appeal @premedmogger
